John Y Kao

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
  2. ncbi request reprint Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006
  3. ncbi request reprint Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520A MSRB 1, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0650, USA
    Regul Pept 134:23-9. 2006
  4. ncbi request reprint Aberrant T helper cell response in tumor-bearing mice limits the efficacy of dendritic cell vaccine
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Immunol Lett 105:16-25. 2006
  5. pmc TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice
    Xia Sun
    Department of Pharmacology, School of Medicine, Shandong University, Jinan, Shandong, China Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e74595. 2013
  6. pmc Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis
    Jay Luther
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
    Gut 60:1479-86. 2011
  7. pmc Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice
    Min Zhang
    Department of Internal Medicine Gastroenterology Division, University of Michigan, Ann Arbor, Michigan 48109, USA
    Helicobacter 13:200-8. 2008
  8. ncbi request reprint Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function
    Sivaprakash Rathinavelu
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Helicobacter 10:424-32. 2005
  9. pmc Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets
    Mohamad El-Zaatari
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58935. 2013
  10. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012

Research Grants

Collaborators

Detail Information

Publications36

  1. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    ..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
  2. ncbi request reprint Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006
    ..lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization...
  3. ncbi request reprint Somatostatin inhibits dendritic cell responsiveness to Helicobacter pylori
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520A MSRB 1, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0650, USA
    Regul Pept 134:23-9. 2006
    ..pylori; a possible mechanism by which IL-4 mediates resolution of gastritis. We suggest that octreotide may be effective in treating immune-mediated diseases of the stomach...
  4. ncbi request reprint Aberrant T helper cell response in tumor-bearing mice limits the efficacy of dendritic cell vaccine
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
    Immunol Lett 105:16-25. 2006
    ..These results suggest that the presence of tumor in the host induces an aberrant CD4+ T cell response to DC vaccine, which may contribute to the failure of the vaccine to eradicate established tumors...
  5. pmc TLR2 mediates Helicobacter pylori-induced tolerogenic immune response in mice
    Xia Sun
    Department of Pharmacology, School of Medicine, Shandong University, Jinan, Shandong, China Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e74595. 2013
    ..Our data indicate that H. pylori mediates immune tolerance through TLR2-derived signals and inhibits Th1 immunity, thus evading host defense. TLR2 may be an important target in the modulation of the host response to H. pylori. ..
  6. pmc Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis
    Jay Luther
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
    Gut 60:1479-86. 2011
    ..However, the mechanism for the observed inverse association between H pylori and IBD has not been described...
  7. pmc Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in mice
    Min Zhang
    Department of Internal Medicine Gastroenterology Division, University of Michigan, Ann Arbor, Michigan 48109, USA
    Helicobacter 13:200-8. 2008
    ..The growing concern over the emergence of antibiotic-resistant Helicobacter pylori infection is propelling the development of an efficacious vaccine to control this highly adaptive organism...
  8. ncbi request reprint Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and function
    Sivaprakash Rathinavelu
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Helicobacter 10:424-32. 2005
    ..pylori proteins by sera from infected patients. In contrast to the high molecular weight proteins, serologic responses to small molecular weight proteins provide assessment of current infection with H. pylori and also of its eradication...
  9. pmc Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets
    Mohamad El-Zaatari
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e58935. 2013
    ....
  10. pmc Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy
    Katie L Mason
    Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Infect Immun 80:3371-80. 2012
    ..Previous studies have focused on the ability of bacteria to alter C. albicans; this study addresses the ability of C. albicans to alter the bacterial microbiota during nonpathogenic colonization...
  11. ncbi request reprint Expression of a soluble TGF-beta receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacy
    Min Zhang
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 181:3690-7. 2008
    ..We conclude that the blockade of tumor-derived TGF-beta reduces Treg induction by the DC/tumor fusion vaccine and enhances antitumor immunity. This may be an effective strategy to enhance human DC-based antitumor vaccines...
  12. pmc Butyrate increases IL-23 production by stimulated dendritic cells
    Bradford E Berndt
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1384-92. 2012
    ..Our study highlights a novel effect of butyrate in upregulating IL-23 production of activated DCs and demonstrates a difference in the host response to the oral vs. systemic route of butyrate administration...
  13. pmc Helicobacter pylori DNA's anti-inflammatory effect on experimental colitis
    Stephanie Y Owyang
    Department of Internal Medicine, Gastroenterology Division, University of Michigan, Ann Arbor, MI USA
    Gut Microbes 3:168-71. 2012
    ..In conclusion, the findings of this addendum strengthen the evidence for unique immunoregulatory properties of the H. pylori genome and revealed the importance of TLR-9 mediated mechanism in the pathogenesis of IBD...
  14. pmc IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cells
    Tyler S Cole
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, United States
    Immunol Lett 144:49-59. 2012
    ....
  15. pmc Treatment of Helicobacter gastritis with IL-4 requires somatostatin
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12944-9. 2003
    ..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells...
  16. ncbi request reprint Superior efficacy of dendritic cell-tumor fusion vaccine compared with tumor lysate-pulsed dendritic cell vaccine in colon cancer
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0650, USA
    Immunol Lett 101:154-9. 2005
    ..Our results suggest the DC/tumor fusion vaccine is more potent against colon cancer than the lysate-pulsed DC vaccine. These fusion cells have the distinct advantage of prolonged interaction with tumor antigens in vivo...
  17. pmc Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine
    Peter D R Higgins
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Inflamm Bowel Dis 17:1398-408. 2011
    ..The aim of this study was to determine whether prior H. pylori infection acts at a distance to modulate the immune response of S.typhimurium-induced colitis...
  18. ncbi request reprint Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccine
    John Y Kao
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650, USA
    J Immunol 170:3806-11. 2003
    ..These data suggest that tumor-derived TGF-beta reduces the efficacy of DC/tumor fusion vaccine via an in vivo mechanism. Neutralization of TGF-beta produced by the fusion cells may enhance the effectiveness of DC-based immunotherapy...
  19. ncbi request reprint Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
    ..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...
  20. pmc Association between Helicobacter pylori and Barrett's esophagus, erosive esophagitis, and gastroesophageal reflux symptoms
    Joel H Rubenstein
    Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan Electronic address
    Clin Gastroenterol Hepatol 12:239-45. 2014
    ..We aimed to determine whether H pylori infection is associated with GERD symptoms, erosive esophagitis, and Barrett's esophagus within the same cohort...
  21. pmc Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett's esophagus
    Joel H Rubenstein
    Center for Clinical Management Research, Ann Arbor Veterans Affairs Medical Center, Ann Arbor, Michigan Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan Electronic address
    Gastroenterology 145:1237-44.e1-5. 2013
    ..We assessed whether diabetes mellitus and serum levels of insulin, leptin, and ghrelin are associated with gastroesophageal reflux disease (GERD) and Barrett's esophagus...
  22. pmc Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis
    Katie L Mason
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Infect Immun 80:150-8. 2012
    ..albicans. Altogether, these data implicate a dichotomy between C. albicans colonization and gastric disease that is bacterial microbiome dependent...
  23. pmc Rifaximin alters intestinal bacteria and prevents stress-induced gut inflammation and visceral hyperalgesia in rats
    Dabo Xu
    Gastroenterology Research Unit, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
    Gastroenterology 146:484-96.e4. 2014
    ..We propose that rifaximin modulates the ileal bacterial community, reduces subclinical inflammation of the intestinal mucosa, and improves gut barrier function to reduce visceral hypersensitivity...
  24. pmc Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis
    Nabeetha A Nagalingam
    Department of Microbiology and Molecular Genetics, Michigan State University, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 17:917-26. 2011
    ....
  25. ncbi request reprint Expression of Fas ligand is not a main mechanism used by tumors to counteract antitumor immunity
    Chuan Min Chen
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Front Biosci 9:448-56. 2004
    ..We concluded that FasL expression is not a main mechanism that tumors use to counteract antitumor immunity...
  26. ncbi request reprint Inflammation and cancer III. Somatostatin and the innate immune system
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Physiol Gastrointest Liver Physiol 286:G698-701. 2004
    ..However, it was not until recently that the immunoregulation of gastric somatostatin was studied in vivo. This theme article discusses the role of somatostatin as an immunoregulatory peptide during gastritis...
  27. doi request reprint Intestinal dysbiosis in inflammatory bowel disease
    Nirmal Kaur
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Gut Microbes 2:211-6. 2011
    ..Further research to understand the causal relationship between dysbiosis and IBD are needed to better guide clinical practice in using probiotics...
  28. ncbi request reprint Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection
    Longchuan Bai
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Gastroenterology 131:841-52. 2006
    ..HDACi induction of the cyclin-dependent kinase inhibitor p21(waf1) has been shown to require ataxia-telangiectasia mutated (ATM). Nevertheless, how ATM participates in p21(waf1) gene expression has not been defined...
  29. pmc Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria
    William J Zacharias
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Gastroenterology 138:2368-77, 2377.e1-4. 2010
    ..Here, we investigated the effects of chronic Hh inhibition in vivo and profiled molecular pathways acutely modulated by Hh signaling in the intestinal mesenchyme...
  30. pmc Murine colitis is mediated by vimentin
    Nirit Mor-Vaknin
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, MI 48109 5640, USA
    Sci Rep 3:1045. 2013
    ..Our results suggest that vimentin impedes bacterial killing and production of ROS, thereby contributing to the pathogenesis of acute colitis...
  31. doi request reprint Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature
    Jay Luther
    University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Inflamm Bowel Dis 16:1077-84. 2010
    ..Numerous observational studies have investigated the association between H. pylori infection and inflammatory bowel disease (IBD). Our aim was to perform a systematic review and meta-analysis of this association...
  32. pmc Depression, antidepressant medications, and risk of Clostridium difficile infection
    Mary A M Rogers
    Department of Internal Medicine, University of Michigan, 016 440E NCRC, Ann Arbor, MI 48109 2800, USA
    BMC Med 11:121. 2013
    ..Our objective was to evaluate whether depression or the use of anti-depressants altered the risk of developing CDI, using two distinct datasets and study designs...
  33. doi request reprint Overview of gut immunology
    Katie Lynn Mason
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Adv Exp Med Biol 635:1-14. 2008
    ..The mechanisms of induction tolerance are currently poorly understood; however, this tolerant environment limits potentially damaging inflammatory responses to inappropriate stimuli...
  34. pmc Anaplastic lymphoma masquerading as sclerosing mesenteritis: a case report
    Jay Luther
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
    J Gastrointest Cancer 43:364-6. 2012
    ..Sclerosing mesenteritis is a rare fibroinflammatory disease of unknown pathogenesis and etiology. Although more commonly benign in its clinical course, sclerosing mesenteritis can mimic certain malignant disorders, such as lymphoma...
  35. ncbi request reprint A pilot study of the association of low plasma adiponectin and Barrett's esophagus
    Joel H Rubenstein
    Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
    Am J Gastroenterol 103:1358-64. 2008
    ..We aimed to estimate the effect of circulating adiponectin on the risk of Barrett's esophagus (BE), an accepted precursor of EAC, controlling for GERD symptoms and other potential confounders...
  36. ncbi request reprint The role of dendritic cells in the development of acute dextran sulfate sodium colitis
    Bradford E Berndt
    Gastroenterology Division, Department of Internal Medicine
    J Immunol 179:6255-62. 2007
    ..We conclude that DCs are critical in the development of acute dextran sulfate sodium colitis and may serve a key role in immune balance of the gut mucosa...

Research Grants3

  1. Adaptive immune mechanism in acute H. pylori infection
    John Kao; Fiscal Year: 2007
    ..pylori-induced chronic gastritis which may lead to novel targets or vaccine strategies for the prevention or treatment of emerging antibioticresistant H. pylori. ..