Research Topics
| John Y KaoSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Somatostatin inhibits dendritic cell responsiveness to Helicobacter pyloriJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 6520A MSRB 1, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0650, USA
Regul Pept 134:23-9. 2006..pylori; a possible mechanism by which IL-4 mediates resolution of gastritis. We suggest that octreotide may be effective in treating immune-mediated diseases of the stomach...
Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in miceJohn Y Kao
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
Gastroenterology 138:1046-54. 2010..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...- Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defenseJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
Am J Physiol Gastrointest Liver Physiol 291:G73-81. 2006..lwoffi. Our findings suggest that dendritic cells participate in the host immune response against H. pylori and that their suppression by H. pylori may explain why infected hosts fail to prevent bacterial colonization... - Aberrant T helper cell response in tumor-bearing mice limits the efficacy of dendritic cell vaccineJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0682, USA
Immunol Lett 105:16-25. 2006..These results suggest that the presence of tumor in the host induces an aberrant CD4+ T cell response to DC vaccine, which may contribute to the failure of the vaccine to eradicate established tumors... - Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitisJay Luther
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
Gut 60:1479-86. 2011..However, the mechanism for the observed inverse association between H pylori and IBD has not been described... - Helicobacter pylori-pulsed dendritic cells induce H. pylori-specific immunity in miceMin Zhang
Department of Internal Medicine Gastroenterology Division, University of Michigan, Ann Arbor, Michigan 48109, USA
Helicobacter 13:200-8. 2008..The growing concern over the emergence of antibiotic-resistant Helicobacter pylori infection is propelling the development of an efficacious vaccine to control this highly adaptive organism... - Helicobacter pylori outer membrane protein 18 (Hp1125) induces dendritic cell maturation and functionSivaprakash Rathinavelu
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Helicobacter 10:424-32. 2005..pylori proteins by sera from infected patients. In contrast to the high molecular weight proteins, serologic responses to small molecular weight proteins provide assessment of current infection with H. pylori and also of its eradication... - Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapyKatie L Mason
Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Infect Immun 80:3371-80. 2012..Previous studies have focused on the ability of bacteria to alter C. albicans; this study addresses the ability of C. albicans to alter the bacterial microbiota during nonpathogenic colonization... - Expression of a soluble TGF-beta receptor by tumor cells enhances dendritic cell/tumor fusion vaccine efficacyMin Zhang
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 181:3690-7. 2008..We conclude that the blockade of tumor-derived TGF-beta reduces Treg induction by the DC/tumor fusion vaccine and enhances antitumor immunity. This may be an effective strategy to enhance human DC-based antitumor vaccines... - Butyrate increases IL-23 production by stimulated dendritic cellsBradford E Berndt
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
Am J Physiol Gastrointest Liver Physiol 303:G1384-92. 2012..Our study highlights a novel effect of butyrate in upregulating IL-23 production of activated DCs and demonstrates a difference in the host response to the oral vs. systemic route of butyrate administration... - Helicobacter pylori DNA's anti-inflammatory effect on experimental colitisStephanie Y Owyang
Department of Internal Medicine, Gastroenterology Division, University of Michigan, Ann Arbor, MI USA
Gut Microbes 3:168-71. 2012..In conclusion, the findings of this addendum strengthen the evidence for unique immunoregulatory properties of the H. pylori genome and revealed the importance of TLR-9 mediated mechanism in the pathogenesis of IBD... - IRAK-M modulates expression of IL-10 and cell surface markers CD80 and MHC II after bacterial re-stimulation of tolerized dendritic cellsTyler S Cole
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, United States
Immunol Lett 144:49-59. 2012.... - Superior efficacy of dendritic cell-tumor fusion vaccine compared with tumor lysate-pulsed dendritic cell vaccine in colon cancerJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0650, USA
Immunol Lett 101:154-9. 2005..Our results suggest the DC/tumor fusion vaccine is more potent against colon cancer than the lysate-pulsed DC vaccine. These fusion cells have the distinct advantage of prolonged interaction with tumor antigens in vivo... - Treatment of Helicobacter gastritis with IL-4 requires somatostatinYana Zavros
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:12944-9. 2003..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells... - Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestinePeter D R Higgins
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
Inflamm Bowel Dis 17:1398-408. 2011..The aim of this study was to determine whether prior H. pylori infection acts at a distance to modulate the immune response of S.typhimurium-induced colitis... - Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccineJohn Y Kao
Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0650, USA
J Immunol 170:3806-11. 2003..These data suggest that tumor-derived TGF-beta reduces the efficacy of DC/tumor fusion vaccine via an in vivo mechanism. Neutralization of TGF-beta produced by the fusion cells may enhance the effectiveness of DC-based immunotherapy... - Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinomaYana Zavros
Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
Oncogene 24:2354-66. 2005..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin... - Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritisKatie L Mason
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Infect Immun 80:150-8. 2012..albicans. Altogether, these data implicate a dichotomy between C. albicans colonization and gastric disease that is bacterial microbiome dependent... - Inflammation and cancer III. Somatostatin and the innate immune systemYana Zavros
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Physiol Gastrointest Liver Physiol 286:G698-701. 2004..However, it was not until recently that the immunoregulation of gastric somatostatin was studied in vivo. This theme article discusses the role of somatostatin as an immunoregulatory peptide during gastritis... - Expression of Fas ligand is not a main mechanism used by tumors to counteract antitumor immunityChuan-Min Chen
Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Front Biosci 9:448-56. 2004..We concluded that FasL expression is not a main mechanism that tumors use to counteract antitumor immunity... - Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitisNabeetha A Nagalingam
Department of Microbiology and Molecular Genetics, Michigan State University, Ann Arbor, Michigan, USA
Inflamm Bowel Dis 17:917-26. 2011.... - Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsetsMohamad El-Zaatari
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 8:e58935. 2013.... 
Intestinal dysbiosis in inflammatory bowel diseaseNirmal Kaur
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA
Gut Microbes 2:211-6. 2011..Further research to understand the causal relationship between dysbiosis and IBD are needed to better guide clinical practice in using probiotics...- Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propriaWilliam J Zacharias
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
Gastroenterology 138:2368-77, 2377.e1-4. 2010..Here, we investigated the effects of chronic Hh inhibition in vivo and profiled molecular pathways acutely modulated by Hh signaling in the intestinal mesenchyme... - Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protectionLongchuan Bai
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Gastroenterology 131:841-52. 2006..HDACi induction of the cyclin-dependent kinase inhibitor p21(waf1) has been shown to require ataxia-telangiectasia mutated (ATM). Nevertheless, how ATM participates in p21(waf1) gene expression has not been defined... - Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literatureJay Luther
University of Michigan Medical Center, Ann Arbor, Michigan, USA
Inflamm Bowel Dis 16:1077-84. 2010..Numerous observational studies have investigated the association between H. pylori infection and inflammatory bowel disease (IBD). Our aim was to perform a systematic review and meta-analysis of this association... - Overview of gut immunologyKatie Lynn Mason
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Adv Exp Med Biol 635:1-14. 2008..The mechanisms of induction tolerance are currently poorly understood; however, this tolerant environment limits potentially damaging inflammatory responses to inappropriate stimuli... - Anaplastic lymphoma masquerading as sclerosing mesenteritis: a case reportJay Luther
Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109 5682, USA
J Gastrointest Cancer 43:364-6. 2012..Sclerosing mesenteritis is a rare fibroinflammatory disease of unknown pathogenesis and etiology. Although more commonly benign in its clinical course, sclerosing mesenteritis can mimic certain malignant disorders, such as lymphoma... - A pilot study of the association of low plasma adiponectin and Barrett's esophagusJoel H Rubenstein
Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA
Am J Gastroenterol 103:1358-64. 2008..We aimed to estimate the effect of circulating adiponectin on the risk of Barrett's esophagus (BE), an accepted precursor of EAC, controlling for GERD symptoms and other potential confounders... - The role of dendritic cells in the development of acute dextran sulfate sodium colitisBradford E Berndt
Gastroenterology Division, Department of Internal Medicine
J Immunol 179:6255-62. 2007..We conclude that DCs are critical in the development of acute dextran sulfate sodium colitis and may serve a key role in immune balance of the gut mucosa...
Research Grants
- Adaptive immune mechanism in acute H. pylori infectionJohn Kao; Fiscal Year: 2007..pylori-induced chronic gastritis which may lead to novel targets or vaccine strategies for the prevention or treatment of emerging antibioticresistant H. pylori. ..