Scott E Kanoski

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 73:915-23. 2013
  2. pmc Cognitive and neuronal systems underlying obesity
    Scott E Kanoski
    University of Pennsylvania, Department of Psychology, Philadelphia, PA 19104, United States
    Physiol Behav 106:337-44. 2012
  3. pmc Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    Scott E Kanoski
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:3103-12. 2011
  4. pmc Hippocampal leptin signaling reduces food intake and modulates food-related memory processing
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 36:1859-70. 2011
  5. doi request reprint The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    Scott E Kanoski
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104 6241, USA
    J Alzheimers Dis 21:207-19. 2010
  6. doi request reprint Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet
    Scott E Kanoski
    Department of Psychological Sciences and the Ingestive Behavior Research Center, West Lafayette, Indiana, USA
    J Exp Psychol Anim Behav Process 36:313-9. 2010
  7. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012
  8. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
  9. pmc Hippocampal lesions impair retention of discriminative responding based on energy state cues
    Terry L Davidson
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Behav Neurosci 124:97-105. 2010
  10. doi request reprint The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012

Collaborators

Detail Information

Publications24

  1. pmc Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 73:915-23. 2013
    ....
  2. pmc Cognitive and neuronal systems underlying obesity
    Scott E Kanoski
    University of Pennsylvania, Department of Psychology, Philadelphia, PA 19104, United States
    Physiol Behav 106:337-44. 2012
    ....
  3. pmc Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    Scott E Kanoski
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:3103-12. 2011
    ..Conclusion: Food intake suppression after peripheral administration of exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation...
  4. pmc Hippocampal leptin signaling reduces food intake and modulates food-related memory processing
    Scott E Kanoski
    Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
    Neuropsychopharmacology 36:1859-70. 2011
    ..To conclude, the results support a role for hippocampal leptin signaling in the control of food intake and food-related memory processing...
  5. doi request reprint The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat
    Scott E Kanoski
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104 6241, USA
    J Alzheimers Dis 21:207-19. 2010
    ..These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity...
  6. doi request reprint Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet
    Scott E Kanoski
    Department of Psychological Sciences and the Ingestive Behavior Research Center, West Lafayette, Indiana, USA
    J Exp Psychol Anim Behav Process 36:313-9. 2010
    ..The results suggest that the processes underlying spatial memory may be especially sensitive to disruption following intake of HE diets...
  7. pmc Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
    Am J Physiol Endocrinol Metab 303:E644-51. 2012
    ..These studies are the first to show that hindbrain administration of leptin or a melanocortin receptor agonist alters energy balance in mice likely via participation of hindbrain POMC neurons...
  8. pmc The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1
    Matthew R Hayes
    Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011
    ....
  9. pmc Hippocampal lesions impair retention of discriminative responding based on energy state cues
    Terry L Davidson
    Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Behav Neurosci 124:97-105. 2010
    ..The results suggest that the inhibition of appetitive behavior by energy state signals may depend, in part, on the hippocampus...
  10. doi request reprint The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
    Scott E Kanoski
    Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 62:1916-27. 2012
    ....
  11. pmc Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation
    Terry L Davidson
    Department of Psychological Sciences and the Ingestive Behavior Research Center, Purdue University, West Lafayette, Indiana 47907, USA
    Hippocampus 19:235-52. 2009
    ..These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher-order learning and memory processes that contribute to the control of appetitive and consummatory behavior...
  12. pmc TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin
    Andrea M Spaeth
    Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 302:E1252-60. 2012
    ..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS...
  13. pmc Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
    Scott E Kanoski
    Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 303:E496-503. 2012
    ..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake...
  14. doi request reprint Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1342-9. 2011
    ..i.d.) and liraglutide (q.d.), lead to comparable and pronounced suppression of food intake and body weight in DIO rats, suggesting a potential role for these drugs as a clinical tool for obesity treatment...
  15. pmc Interoceptive "satiety" signals produced by leptin and CCK
    Scott E Kanoski
    Ingestive Behavior Research Center, Purdue University, IN 47906, USA
    Peptides 28:988-1002. 2007
    ..p.) and found significant intake suppression and generalization of discrimination with both doses of CCK-8. These findings suggest a role for both leptin and CCK in the production of sensory consequences that correspond to "satiety"...
  16. pmc Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity
    Scott E Kanoski
    University of Pennsylvania, Department of Psychology, Philadelphia, PA, United States
    Physiol Behav 103:59-68. 2011
    ....
  17. pmc Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Cell Metab 13:320-30. 2011
    ..Pharmacotherapies targeting these signaling pathways, which mediate intake-suppressive effects of CNS GLP-1R activation, may prove efficacious in treating obesity...
  18. pmc Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
    Bart C De Jonghe
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 300:E1002-11. 2011
    ..These data show that PTP1B in POMC neurons plays a role in short-term cold-induced reduction of SPA and may influence cold-induced thermogenesis via enhanced activation of the thyroid axis...
  19. ncbi request reprint Memory inhibition and energy regulation
    T L Davidson
    Ingestive Behavior Research Center, Purdue University, United States Department of Psychological Sciences, Purdue University, United States
    Physiol Behav 86:731-46. 2005
    ..We conclude by offering a preliminary account of how consumption of foods high in saturated fats might lead to impaired hippocampal function, reduced ability to inhibit caloric intake and, ultimately, to increased body weight...
  20. pmc The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat
    Scott E Kanoski
    The Ingestive Behavior Research Center, Purdue University, IN, USA
    Behav Brain Res 182:57-66. 2007
    ..The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation...
  21. pmc A potential role for the hippocampus in energy intake and body weight regulation
    Terry L Davidson
    Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN, USA
    Curr Opin Pharmacol 7:613-6. 2007
    ..The present paper summarizes these findings and ideas and considers the hypothesis that excessive caloric intake and obesity may be produced by dietary and other factors that are known to alter hippocampal functioning...
  22. pmc Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake
    Naomi J McKay
    Behavioral Neuroscience Program, Department of Psychology, The State University of New York at Buffalo, Buffalo, New York 14260, USA
    Am J Physiol Regul Integr Comp Physiol 301:R1755-64. 2011
    ..Overall, these results show that GLP-1R agonists have a hypodipsic effect that is independent of GLP-1R-mediated effects on food intake, and this occurs, in part, through central nervous system GLP-1R activation...
  23. pmc Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    Matthew R Hayes
    Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
    Physiol Behav 100:503-10. 2010
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009...
  24. ncbi request reprint The interoceptive cue properties of ghrelin generalize to cues produced by food deprivation
    T L Davidson
    Ingestive Behavior Research Center, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
    Peptides 26:1602-10. 2005
    ..These results support the notion that endogenous ghrelin contributes to an interoceptive hunger cue, and that this may be a mechanism by which ghrelin influences food intake and appetitive behavior...