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Genomes and Genes | Scott E KanoskiSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Publications
Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt SignalingScott E Kanoski
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
Biol Psychiatry 73:915-23. 2013....- Cognitive and neuronal systems underlying obesityScott E Kanoski
University of Pennsylvania, Department of Psychology, Philadelphia, PA 19104, United States
Physiol Behav 106:337-44. 2012.... - Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4Scott E Kanoski
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Endocrinology 152:3103-12. 2011..Conclusion: Food intake suppression after peripheral administration of exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation... - Hippocampal leptin signaling reduces food intake and modulates food-related memory processingScott E Kanoski
Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 36:1859-70. 2011..To conclude, the results support a role for hippocampal leptin signaling in the control of food intake and food-related memory processing... 
The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the ratScott E Kanoski
Department of Psychological Sciences, Purdue University, West Lafayette, IN 19104 6241, USA
J Alzheimers Dis 21:207-19. 2010..These results indicate that hippocampal function may be particularly vulnerable to disruption by HE-diets, and this disruption may be related to impaired BBB integrity...- Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy dietScott E Kanoski
Department of Psychological Sciences and the Ingestive Behavior Research Center, West Lafayette, Indiana, USA
J Exp Psychol Anim Behav Process 36:313-9. 2010..The results suggest that the processes underlying spatial memory may be especially sensitive to disruption following intake of HE diets... - Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiencyBart C De Jonghe
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia PA, USA
Am J Physiol Endocrinol Metab 303:E644-51. 2012..These studies are the first to show that hindbrain administration of leptin or a melanocortin receptor agonist alters energy balance in mice likely via participation of hindbrain POMC neurons... - The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1Matthew R Hayes
Translational Neuroscience Program, Dept of Psychiatry, Perelman School of Medicine at the Univ of Pennsylvania, TRL Bldg, Office 2219, 125 South 31st St, Philadelphia, PA 19104, USA
Am J Physiol Regul Integr Comp Physiol 301:R1479-85. 2011.... - Hippocampal lesions impair retention of discriminative responding based on energy state cuesTerry L Davidson
Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907, USA
Behav Neurosci 124:97-105. 2010..The results suggest that the inhibition of appetitive behavior by energy state signals may depend, in part, on the hippocampus... - The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutideScott E Kanoski
Department of Psychology, School of Art and Science, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuropharmacology 62:1916-27. 2012.... - Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulationTerry L Davidson
Department of Psychological Sciences and the Ingestive Behavior Research Center, Purdue University, West Lafayette, Indiana 47907, USA
Hippocampus 19:235-52. 2009..These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher-order learning and memory processes that contribute to the control of appetitive and consummatory behavior... - TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptinAndrea M Spaeth
Dept of Psychology, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Am J Physiol Endocrinol Metab 302:E1252-60. 2012..Collectively, these results indicate that TrkB-mediated signaling in the mNTS negatively regulates food intake and, in part, the intake inhibitory effects of leptin administered into the NTS... - Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signalsScott E Kanoski
Dept of Psychology, School of Arts and Sciences, Univ of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104, USA
Am J Physiol Endocrinol Metab 303:E496-503. 2012..Overall, these findings deepen the understanding of the distributed neuronal systems and behavioral mechanisms that mediate the effects of leptin receptor signaling on the control of food intake... - Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in ratsMatthew R Hayes
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Obesity (Silver Spring) 19:1342-9. 2011..i.d.) and liraglutide (q.d.), lead to comparable and pronounced suppression of food intake and body weight in DIO rats, suggesting a potential role for these drugs as a clinical tool for obesity treatment... - Interoceptive "satiety" signals produced by leptin and CCKScott E Kanoski
Ingestive Behavior Research Center, Purdue University, IN 47906, USA
Peptides 28:988-1002. 2007..These findings suggest a role for both leptin and CCK in the production of sensory consequences that correspond to "satiety"... - Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesityScott E Kanoski
University of Pennsylvania, Department of Psychology, Philadelphia, PA, United States
Physiol Behav 103:59-68. 2011.... - Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activationMatthew R Hayes
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Cell Metab 13:320-30. 2011..Pharmacotherapies targeting these signaling pathways, which mediate intake-suppressive effects of CNS GLP-1R activation, may prove efficacious in treating obesity... - Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposureBart C De Jonghe
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Physiol Endocrinol Metab 300:E1002-11. 2011..These data show that PTP1B in POMC neurons plays a role in short-term cold-induced reduction of SPA and may influence cold-induced thermogenesis via enhanced activation of the thyroid axis... 
Memory inhibition and energy regulationT L Davidson
Ingestive Behavior Research Center, Purdue University, United States Department of Psychological Sciences, Purdue University, United States
Physiol Behav 86:731-46. 2005..We conclude by offering a preliminary account of how consumption of foods high in saturated fats might lead to impaired hippocampal function, reduced ability to inhibit caloric intake and, ultimately, to increased body weight...- The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the ratScott E Kanoski
The Ingestive Behavior Research Center, Purdue University, IN, USA
Behav Brain Res 182:57-66. 2007..The results suggest that consumption of the HFD diet may have had enduring effects on learning processes, some of which may contribute to the control of intake regulation... - A potential role for the hippocampus in energy intake and body weight regulationTerry L Davidson
Department of Psychological Sciences, Ingestive Behavior Research Center, Purdue University, West Lafayette, IN, USA
Curr Opin Pharmacol 7:613-6. 2007..The present paper summarizes these findings and ideas and considers the hypothesis that excessive caloric intake and obesity may be produced by dietary and other factors that are known to alter hippocampal functioning... - Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intakeNaomi J McKay
Behavioral Neuroscience Program, Department of Psychology, The State University of New York at Buffalo, Buffalo, New York 14260, USA
Am J Physiol Regul Integr Comp Physiol 301:R1755-64. 2011..Overall, these results show that GLP-1R agonists have a hypodipsic effect that is independent of GLP-1R-mediated effects on food intake, and this occurs, in part, through central nervous system GLP-1R activation... - Role of the glucagon-like-peptide-1 receptor in the control of energy balanceMatthew R Hayes
Department of Psychology, School of Arts and Sciences, University of Pennsylvania, 3720 Walnut Street, Philadelphia, PA 19104, USA
Physiol Behav 100:503-10. 2010..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009... - The interoceptive cue properties of ghrelin generalize to cues produced by food deprivationT L Davidson
Ingestive Behavior Research Center, Purdue University, 703 Third Street, West Lafayette, IN 47907, USA
Peptides 26:1602-10. 2005..These results support the notion that endogenous ghrelin contributes to an interoceptive hunger cue, and that this may be a mechanism by which ghrelin influences food intake and appetitive behavior...