Y James Kang


Affiliation: University of Louisville
Country: USA


  1. Zhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, et al. The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemia. Metallomics. 2016;8:654-62 pubmed publisher
    ..This copper-dependent dysregulation of angiogenic gene expression would contribute to the pathogenesis of myocardial ischemic infarction. ..
  2. Liu Y, Xiao Y, Liu J, Feng L, Kang Y. Copper-induced reduction in myocardial fibrosis is associated with increased matrix metalloproteins in a rat model of cardiac hypertrophy. Metallomics. 2018;10:201-208 pubmed publisher
    ..The data thus demonstrated that the reduction in cardiac fibrosis by TETA-induced Cu repletion is associated at least in part with an enhanced MMP-2 activity, leading to collagen degradation. ..
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    Wang T, Li R, Lin C, Sun M, Kang Y. Brief Communication: Copper suppression of vascular endothelial growth factor receptor-2 is involved in the regression of cardiomyocyte hypertrophy. Exp Biol Med (Maywood). 2014;239:948-953 pubmed
  4. Kang Y. Herbogenomics: from traditional Chinese medicine to novel therapeutics. Exp Biol Med (Maywood). 2008;233:1059-65 pubmed publisher
    ..This process thus establishes a herbogenomics approach to understand mechanisms of action of TCM and to identify effective molecular targets for the discovery and development of novel therapeutics. ..
  5. Shi F, Sheng Q, Xu X, Huang W, Kang Y. Zinc supplementation suppresses the progression of bile duct ligation-induced liver fibrosis in mice. Exp Biol Med (Maywood). 2015;240:1197-204 pubmed publisher
    ..Therefore, the results demonstrate that zinc supplementation suppresses BDL-induced liver fibrosis through both inhibiting collagen production and enhancing collagen degradation. ..
  6. Li X, Han P, Guo Y, Sun H, Xiao Y, Kang Y. An improved technique for cerebrospinal fluid collection of cisterna magna in Rhesus monkeys. J Neurosci Methods. 2015;249:59-65 pubmed publisher
    ..This improved technique not only avoids blood contamination of CSF, but also prevents brainstem injury during the process of CSF collection. It is recommended for adaptation for CSF collection in monkeys. ..
  7. Li R, Bourcy K, Wang T, Sun M, Kang Y. The involvement of vimentin in copper-induced regression of cardiomyocyte hypertrophy. Metallomics. 2015;7:1331-7 pubmed publisher
    ..This study demonstrates that vimentin is critically involved in the VEGFR-1 mediated activation of the PKG-1 signaling pathway, leading to regression of cardiomyocyte hypertrophy. ..
  8. Cheng X, Hou J, Liu J, Sun X, Sheng Q, Han P, et al. Safety Evaluation of Sevoflurane as Anesthetic Agent in Mouse Model of Myocardial Ischemic Infarction. Cardiovasc Toxicol. 2017;17:150-156 pubmed publisher
    ..These analyses indicate that in comparison with currently available agent etomidate, sevoflurane should not be applied to patients with myocardial infarction or other cardiac events. ..
  9. Dong D, Xu X, Yin W, Kang Y. Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells. Metallomics. 2014;6:554-9 pubmed publisher
    ..This study thus demonstrated that changes in copper concentrations alter the protein levels, but not the mRNA levels, of copper chaperones, suggesting a role of copper in the post-translational modification of these proteins. ..

More Information


  1. Sun M, Zuo X, Li R, Wang T, Kang Y. Vascular endothelial growth factor recovers suppressed cytochrome c oxidase activity by restoring copper availability in hypertrophic cardiomyocytes. Exp Biol Med (Maywood). 2014;239:1671-7 pubmed publisher
    ..This study thus demonstrates that VEGF recovers PE-suppressed COX activity by restoring Cu availability and VEGF suppression of ROS accumulation and homocysteine elevation would contribute to the increased Cu availability. ..
  2. Liang K, Ding X, Lin C, Kang Y. Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1. Exp Biol Med (Maywood). 2015;240:1446-51 pubmed publisher
    ..This work demonstrates that the nuclear entry of FIH-1 depends on HIF-1α. Cu deficiency caused a decrease of HIF-1α, leading to suppression of FIH-1 entry to the nucleus. ..
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    Kang Y, Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med. 2005;26:391-404 pubmed
    ..Zn has a high potential to be developed as an effective agent in the prevention and treatment of ALD. ..
  4. Wang L, Ge Y, Kang Y. Featured Article: Effect of copper on nuclear translocation of copper chaperone for superoxide dismutase-1. Exp Biol Med (Maywood). 2016;241:1483-8 pubmed publisher
    ..The nuclear translocation of CCS-1 is copper dependent, but the nuclear translocation of copper could take place alternatively in a CCS-1-independent pathway. ..
  5. Xiao Y, Liu Y, Liu J, Kang Y. The Association Between Myocardial Fibrosis and Depressed Capillary Density in Rat Model of Left Ventricular Hypertrophy. Cardiovasc Toxicol. 2018;18:304-311 pubmed publisher
    ..The results indicated that the posterior and lateral walls were more vulnerable to fibrogenesis post-pressure overload-induced cardiac hypertrophy, which was associated with the depressed angiogenesis in these two regions. ..