Y James Kang

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice
    Jason C Lambert
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 164:1959-66. 2004
  2. ncbi request reprint Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 332:853-8. 2005
  3. pmc Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury
    Ye Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Am J Pathol 167:17-26. 2005
  4. pmc Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice
    Steve Lancel
    Cardiovascular Medicine Section, Department of Medicine, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
    Circ Res 107:228-32. 2010
  5. pmc Homocysteine restricts copper availability leading to suppression of cytochrome C oxidase activity in phenylephrine-treated cardiomyocytes
    Xiao Zuo
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 8:e67549. 2013
  6. pmc Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice
    Youchun Jiang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Exp Med 204:657-66. 2007
  7. pmc Disturbance of copper homeostasis is a mechanism for homocysteine-induced vascular endothelial cell injury
    Daoyin Dong
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 8:e76209. 2013
  8. ncbi request reprint Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells
    Daoyin Dong
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Metallomics 6:554-9. 2014
  9. ncbi request reprint Metallothionein redox cycle and function
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR 530, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 231:1459-67. 2006
  10. ncbi request reprint Cardiac hypertrophy: a risk factor for QT-prolongation and cardiac sudden death
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Pathol 34:58-66. 2006

Collaborators

Detail Information

Publications75

  1. pmc Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice
    Jason C Lambert
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 164:1959-66. 2004
    ..These results thus demonstrate that zinc preservation of intestinal structural integrity is associated with suppression of endotoxemia and liver injury induced by acute exposure to ethanol and the zinc protection is independent of MT...
  2. ncbi request reprint Metallothionein transfers zinc to mitochondrial aconitase through a direct interaction in mouse hearts
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 332:853-8. 2005
    ..The m-aconitase, not the cytosolic aconitase (c-aconitase), was co-immunoprecipitated with MT. This study demonstrates that MT transfers zinc to m-aconitase through a direct interaction...
  3. pmc Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury
    Ye Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Am J Pathol 167:17-26. 2005
    ..Overexpressing cardiac MT significantly protects the heart from diabetes-induced injury...
  4. pmc Oxidative posttranslational modifications mediate decreased SERCA activity and myocyte dysfunction in Galphaq-overexpressing mice
    Steve Lancel
    Cardiovascular Medicine Section, Department of Medicine, Boston University Medical Center, 88 E Newton St, Boston, MA 02118, USA
    Circ Res 107:228-32. 2010
    ..Mice with cardiac myocyte-specific overexpression of Galphaq develop progressive left ventricular failure associated with myocyte contractile dysfunction and calcium dysregulation...
  5. pmc Homocysteine restricts copper availability leading to suppression of cytochrome C oxidase activity in phenylephrine-treated cardiomyocytes
    Xiao Zuo
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 8:e67549. 2013
    ..Therefore, PE-induced elevation of homocysteine restricts Cu availability through its interaction with Cu and suppression of Cu chaperones, leading to the decrease in CCO enzyme activity. ..
  6. pmc Dietary copper supplementation reverses hypertrophic cardiomyopathy induced by chronic pressure overload in mice
    Youchun Jiang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Exp Med 204:657-66. 2007
    ..Therefore, dietary Cu supplementation improves the condition of hypertrophic cardiomyopathy at least in part through CCS-mediated HIF-1alpha activation of VEGF expression and angiogenesis...
  7. pmc Disturbance of copper homeostasis is a mechanism for homocysteine-induced vascular endothelial cell injury
    Daoyin Dong
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 8:e76209. 2013
    ..The study thus demonstrated that Hcy disturbs Cu homeostasis and limits the availability of Cu to critical molecules such as COX17 and CCO, leading to mitochondrial dysfunction and endothelial cell injury. ..
  8. ncbi request reprint Changes in copper concentrations affect the protein levels but not the mRNA levels of copper chaperones in human umbilical vein endothelial cells
    Daoyin Dong
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Metallomics 6:554-9. 2014
    ..This study thus demonstrated that changes in copper concentrations alter the protein levels, but not the mRNA levels, of copper chaperones, suggesting a role of copper in the post-translational modification of these proteins. ..
  9. ncbi request reprint Metallothionein redox cycle and function
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR 530, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 231:1459-67. 2006
    ..This MT redox cycle may play a crucial role in MT biologic function. It may link to the homeostasis of essential metals, detoxification of toxic metals and protection against oxidative stress...
  10. ncbi request reprint Cardiac hypertrophy: a risk factor for QT-prolongation and cardiac sudden death
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Toxicol Pathol 34:58-66. 2006
    ..The adaptation of new approaches such as functional genomics and proteomics will further advance our knowledge of heart hypertrophy...
  11. ncbi request reprint Zinc prevention and treatment of alcoholic liver disease
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Mol Aspects Med 26:391-404. 2005
    ..Zn has a high potential to be developed as an effective agent in the prevention and treatment of ALD...
  12. ncbi request reprint Changes in the gene expression associated with carbon tetrachloride-induced liver fibrosis persist after cessation of dosing in mice
    Youchun Jiang
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Toxicol Sci 79:404-10. 2004
    ..Most of these changes are recoverable upon withdrawal of the toxic insult. However, liver fibrosis is a prolonged change both in gene expression and histopathological alterations...
  13. doi request reprint Copper and homocysteine in cardiovascular diseases
    Y James Kang
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    Pharmacol Ther 129:321-31. 2011
    ..A comprehensive understanding of Cu speciation and a development of selective modulation of Cu coordination to Cu-binding molecules to avoid Cu-Hcy complex formation would effectively improve the condition of cardiovascular disease...
  14. ncbi request reprint Herbogenomics: from traditional Chinese medicine to novel therapeutics
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd St, MDR 530, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 233:1059-65. 2008
    ..This process thus establishes a herbogenomics approach to understand mechanisms of action of TCM and to identify effective molecular targets for the discovery and development of novel therapeutics...
  15. pmc Changes in copper and zinc status and response to dietary copper deficiency in metallothionein-overexpressing transgenic mouse heart
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Nutr Biochem 18:714-8. 2007
    ..These results suggest that elevation in zinc but not in copper in the heart may be involved in the MT inhibition of copper deficiency-induced cardiac hypertrophy...
  16. ncbi request reprint Antioxidant defense against anthracycline cardiotoxicity by metallothionein
    Y James Kang
    University of Louisville School of Medicine, 511 S Floyd St, MDR530, Louisville, KY 40202, USA
    Cardiovasc Toxicol 7:95-100. 2007
    ..In addition, MT posttranslationally modulates critical proteins involved in mitochondrial respiration and energy metabolism. All of these processes constitute the mechanisms by which MT protects from anthracycline cardiotoxicity...
  17. pmc Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    Zhanxiang Zhou
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
    Am J Pathol 166:1681-90. 2005
    ..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways...
  18. pmc Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Hepatology 50:1241-50. 2009
    ..Consequently, zinc deprivation caused cellular accumulation of lipid droplets, triglycerides and free fatty acids in the HepG2 cells...
  19. ncbi request reprint Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    J Am Coll Cardiol 48:1688-97. 2006
    ..We aimed to test whether attenuation of early-phase cardiac cell death can prevent diabetic cardiomyopathy...
  20. pmc Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation
    Lipeng Wang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Pathol 167:337-44. 2005
    ....
  21. pmc Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Pathol 164:1547-56. 2004
    ..Thus, zinc may be beneficial in the treatment of LPS-induced liver injuries, such as sepsis and alcoholism...
  22. ncbi request reprint Marginal dietary copper restriction induces cardiomyopathy in rats
    Yan Li
    Department of Medicine, University of Louisville School of Medicine, KY 40202, USA
    J Nutr 135:2130-6. 2005
    ..5 or 3.0 mg Cu/kg diet. These results demonstrate that, in the absence of most indications of systemic Cu deficiency, heart morphology and function are sensitive to marginal Cu deficiency...
  23. ncbi request reprint Metallothionein disulfides are present in metallothionein-overexpressing transgenic mouse heart and increase under conditions of oxidative stress
    Wenke Feng
    Department of Medicine, University of Louisville, KY 40292, USA
    J Biol Chem 281:681-7. 2006
    ..Additional zinc release from MT under oxidative stress conditions is accompanied by more MT disulfide bond formation...
  24. pmc Role of copper and homocysteine in pressure overload heart failure
    William M Hughes
    Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    Cardiovasc Toxicol 8:137-44. 2008
    ..In conclusion, our data suggest that copper supplement helps improve cardiac function in a pressure overload dilated cardiomyopathic heart...
  25. ncbi request reprint Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 232:622-8. 2007
    ..These results suggest that zinc protects against TNF-alpha hepatotoxicity, at least partially, through preservation of the zinc finger protein HNF-4alpha...
  26. doi request reprint Cytochrome c oxidase is essential for copper-induced regression of cardiomyocyte hypertrophy
    Xiao Zuo
    Regenerative Medicine Research Center and Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China
    Cardiovasc Toxicol 10:208-15. 2010
    ..This study demonstrates that both Cu and VEGF can restore COX activity that is depressed in hypertrophic cardiomyocytes, and COX plays a determinant role in both Cu- and VEGF-induced regression of cardiomyocyte hypertrophy...
  27. pmc Antiapoptotic effect and inhibition of ischemia/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 163:1579-86. 2003
    ..The antiapoptotic effect of MT likely results from the suppression of oxidative stress and correlates with the inhibition of myocardial infarction...
  28. ncbi request reprint Regression of dietary copper restriction-induced cardiomyopathy by copper repletion in mice
    Laila Elsherif
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Nutr 134:855-60. 2004
    ....
  29. doi request reprint Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure
    Zhanxiang Zhou
    The University of Louisville School of Medicine, Department of Medicine, 511 South Floyd Street, MDR Room 529, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 233:540-8. 2008
    ..In conclusion, zinc supplementation prevented hepatocyte apoptosis in mice subjected to long-term ethanol exposure, and the action of zinc is likely through suppression of oxidative stress and death receptor-mediated pathways...
  30. ncbi request reprint Myocardial oxidative stress and toxicity induced by acute ethanol exposure in mice
    Muralidhar Kannan
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Kentucky 40202, USA
    Exp Biol Med (Maywood) 229:553-9. 2004
    ..A rapid decrease in mitochondrial GSH content may be partially responsible for the observed mitochondrial damage...
  31. ncbi request reprint S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville College of Medicine, Louisville, KY, USA
    Hepatology 40:989-97. 2004
    ..These data further support improving the S-adenosylmethionine-to-SAH ratio and removal of intracellular SAH as potential therapeutic options in alcoholic liver disease...
  32. pmc Cardiac-specific overexpression of HIF-1{alpha} prevents deterioration of glycolytic pathway and cardiac remodeling in streptozotocin-induced diabetic mice
    Wanli Xue
    Departments of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Am J Pathol 177:97-105. 2010
    ..Therefore, elevation of HIF-1alpha provides a cardiac protection from diabetic-induced impairment in glucose metabolism and angiogenesis via up-regulation of HIF-1 target genes...
  33. pmc Copper reverses cardiomyocyte hypertrophy through vascular endothelial growth factor-mediated reduction in the cell size
    Yang Zhou
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Mol Cell Cardiol 45:106-17. 2008
    ..2 microg/ml reversed cell hypertrophy as the same as copper did. This study demonstrates that both copper and VEGF reduce the size of hypertrophied cardiomyocytes, and copper regression of cardiac hypertrophy is VEGF-dependent...
  34. ncbi request reprint Modulation of cytochrome C oxidase-va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity
    Kevyn E Merten
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, 511 South Floyd Street, MDR 530, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 315:1314-9. 2005
    ..Because CCO-Va is a critical component in the mitochondrial electron transport chain, the results suggest that the cardioprotective effect of MT may be related to an increased expression or a differential modification of CCO-Va...
  35. pmc Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA
    Am J Pathol 172:916-25. 2008
    ....
  36. pmc Copper regulation of hypoxia-inducible factor-1 activity
    Wenke Feng
    Departments of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Mol Pharmacol 75:174-82. 2009
    ..This study thus defines that copper is required for HIF-1 activation through the regulation of HIF-1alpha binding to the HRE and the formation of the HIF-1 transcriptional complex...
  37. ncbi request reprint Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd St, MDR 533, Louisville, KY 40202, USA
    Diabetes 54:1829-37. 2005
    ..These results thus suggest that metallothionein prevention of diabetic cardiomyopathy is mediated, at least in part, by suppression of superoxide generation and associated nitrosative damage...
  38. ncbi request reprint Congestive heart failure in copper-deficient mice
    Laila Elsherif
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 228:811-7. 2003
    ..This study shows that CuD leads to systolic and diastolic dysfunction in association with histopathological changes, which are indices commonly used to diagnose congestive heart failure...
  39. ncbi request reprint Suppression of Fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis
    Jason C Lambert
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 228:406-12. 2003
    ..These results demonstrate that zinc is a potent inhibitor of acute ethanol-induced liver apoptosis, and this effect occurs primarily through zinc interference with Fas ligand pathway and the suppression of caspase-3...
  40. pmc Decreases in electrocardiographic R-wave amplitude and QT interval predict myocardial ischemic infarction in Rhesus monkeys with left anterior descending artery ligation
    Xiaorong Sun
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    PLoS ONE 8:e71876. 2013
    ..Validation of these parameters in clinical studies would greatly help identifying patients with myocardial ischemia at high risk for the subsequent development of myocardial infarction. ..
  41. doi request reprint Electrocardiographic characterization of rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation
    Pingliang Yang
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China
    Cardiovasc Toxicol 11:365-72. 2011
    ..This model would also provide an excellent tool for drug discovery and development for cardiac disease...
  42. ncbi request reprint Zinc inhibits doxorubicin-activated calcineurin signal transduction pathway in H9c2 embryonic rat cardiac cells
    Kevyn E Merten
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 232:682-9. 2007
    ..It had been shown previously that calcineurin is also not necessary for DOX-induced H9c2 cell hypertrophy.)...
  43. pmc A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 525, Louisville, KY, USA
    Am J Pathol 163:1137-46. 2003
    ....
  44. ncbi request reprint Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model
    Ye Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
    Cardiovasc Toxicol 3:363-72. 2003
    ..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines...
  45. pmc Regression of copper-deficient heart hypertrophy: reduction in the size of hypertrophic cardiomyocytes
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Nutr Biochem 20:621-8. 2009
    ....
  46. doi request reprint Metallothionein gene transfection reverses the phenotype of activated human hepatic stellate cells
    Xinhua Xu
    Regenerative Medicine Research Center, Sichuan University West China Hospital, Chengdu, Sichuan, China
    J Pharmacol Exp Ther 346:48-53. 2013
    ..This study demonstrates that reversal of the phenotype of activated HSCs, particularly the upregulation of collagenases, is likely to be involved in the resolution of liver fibrosis observed in MT gene therapy...
  47. ncbi request reprint Inhibition of tumor necrosis factor-alpha-dependent cardiomyocyte apoptosis by metallothionein
    Jon B Klein
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Cardiovasc Toxicol 2:209-18. 2002
    ..This study thus suggests that p38 MAPK activation is likely involved in TNFinduced cardiomyocyte apoptosis, which is also related to reactive oxygen species accumulation...
  48. doi request reprint Copper chaperone for superoxide dismutase-1 transfers copper to mitochondria but does not affect cytochrome c oxidase activity
    Biao Wang
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Exp Biol Med (Maywood) 238:1017-23. 2013
    ..In addition, the COX17 not only functions in the copper shuttling to the CCO, but also may participate in the copper efflux from the mitochondria. ..
  49. doi request reprint Copper is required for cobalt-induced transcriptional activity of hypoxia-inducible factor-1
    Liying Qiu
    Regenerative Medicine Research Center, Sichuan University West China Hospital, Keyuan Road 4, Gaopeng Street, Chengdu, Sichuan, PR China 610041
    J Pharmacol Exp Ther 342:561-7. 2012
    ..The present study thus demonstrates that copper was required for cobalt-activated transcriptional activity of HIF-1, although copper did not affect cobalt-induced accumulation of HIF-1α in the cells...
  50. doi request reprint Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarction
    Yuping Xie
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Exp Biol Med (Maywood) 237:853-9. 2012
    ..The expression of TIMP1 was not changed. The data thus demonstrated that the collagen deposition in infarcted myocardium is correlated with an enhanced cross-linking capacity and a decreased degradation process...
  51. doi request reprint Copper stimulates growth of human umbilical vein endothelial cells in a vascular endothelial growth factor-independent pathway
    Shun Li
    Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    Exp Biol Med (Maywood) 237:77-82. 2012
    ..However, siRNA targeting eNOS completely blocked Cu reversal of TEPA inhibition of cell growth. The data demonstrate that Cu stimulation of HUVEC cell growth is VEGF-independent, but eNOS-dependent...
  52. ncbi request reprint Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice
    Jason C Lambert
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 305:880-6. 2003
    ..These results thus demonstrate that zinc prevention of increased intestinal permeability is importantly involved in the inhibition of acute ethanol-induced liver damage in mice...
  53. pmc Metallothionein-independent zinc protection from alcoholic liver injury
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 160:2267-74. 2002
    ..However, MT is required to maintain high levels of zinc in the liver, suggesting that the protective action of MT in the liver is likely mediated by zinc...
  54. ncbi request reprint Dietary copper restriction-induced changes in myocardial gene expression and the effect of copper repletion
    Laila Elsherif
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 530, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 229:616-22. 2004
    ..The return to normal cardiac function by CuR may be a result of the favorable regression in gene expression of these critical components in myocardial tissue...
  55. ncbi request reprint Myocardial toxicity of arsenic trioxide in a mouse model
    Yan Li
    Department of Medicine, University of Louisville School of Medicine, KY 40202, USA
    Cardiovasc Toxicol 2:63-73. 2002
    ..Our study thus demonstrates that arsenic trioxide, in a dose that could produce clinically comparable serum concentrations to those observed in humans, causes cardiotoxicity...
  56. ncbi request reprint Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells: involvement of the phosphoinositide 3-kinase-Akt pathway
    Kevyn E Merten
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 530, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 319:934-40. 2006
    ..Rather, the PI3K-Akt signaling pathway seems to be more critically involved in DOX-induced hypertrophy...
  57. ncbi request reprint Metallothionein gene therapy for chemical-induced liver fibrosis in mice
    Youchun Jiang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Mol Ther 10:1130-9. 2004
    ..This study indicates that MT makes a critical contribution to the reversal of chemical-induced hepatic fibrosis and has therapeutic potential for patients with certain liver fibrosis...
  58. pmc Zinc deprivation mediates alcohol-induced hepatocyte IL-8 analog expression in rodents via an epigenetic mechanism
    Yantao Zhao
    Department of Medicine, The University of Louisville, Louisville, Kentucky, USA
    Am J Pathol 179:693-702. 2011
    ..In conclusion, inactivation of HDAC caused by zinc deprivation is a novel mechanism underlying IL-8 up-regulation in alcoholic hepatitis...
  59. ncbi request reprint Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity
    Xiuhua Sun
    Department of Medicine, University of Louisville School of Medicine, and Jewish Hospital Heart and Lung Institute, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 227:652-7. 2002
    ..However, MT can protect the heart from oxidative injury only if it is present prior to induction of oxidative stress...
  60. pmc Metallothionein rescues hypoxia-inducible factor-1 transcriptional activity in cardiomyocytes under diabetic conditions
    Wenke Feng
    Department of Medicine, University of Louisville School of Medicine, 511 S Floyd Street, MDR532, Louisville, KY 40202, USA
    Biochem Biophys Res Commun 360:286-9. 2007
    ..The addition of MT into the cultures of H9c2 cells relieved the HG suppression of hypoxia-induced luciferase activity. This study indicates that MT can rescue HIF-1 transcriptional activity in cardiomyocytes under diabetic conditions...
  61. ncbi request reprint Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, KY 40292, USA
    Cardiovasc Toxicol 2:253-61. 2002
    ..This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity...
  62. pmc Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway
    Yang Zhou
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Cardiovasc Res 84:54-63. 2009
    ....
  63. ncbi request reprint Association of metallothionein expression and lack of apoptosis with progression of carcinogenesis in Barrett's esophagus
    Yan Li
    Division of Gastroenterology Hepatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Exp Biol Med (Maywood) 228:286-92. 2003
    ..This study thus suggests that MT may contribute to cytoprotection, thereby inhibiting apoptosis and leading to carcinogenesis of Barrett's esophageal cells...
  64. ncbi request reprint Cell death and diabetic cardiomyopathy
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky 40292, USA
    Cardiovasc Toxicol 3:219-28. 2003
    ....
  65. ncbi request reprint Role of copper in angiogenesis and its medicinal implications
    Huiqi Xie
    Division of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Curr Med Chem 16:1304-14. 2009
    ..In this context, a development of diagnosis for copper metabolic changes as well as a tissue-specific copper manipulation would greatly benefit patients with an implication of copper manipulation therapy...
  66. pmc Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia
    Karni S Moshal
    Department of Physiology and Biophysics, University of Louisville School of Medicine, Kentucky 40202, USA
    Curr Neurovasc Res 4:289-94. 2007
    ..The signal transduction mechanisms in Hcy-induced matrix metalloproteinase (MMP) activation in cardiac connexin remodeling are discussed...
  67. pmc Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets
    Jianglong Hou
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China
    Pharmacol Ther 135:337-54. 2012
    ..More exciting insights into the regression of pathological cardiac hypertrophy are emerging. The time of translating the concept of regression of pathological cardiac hypertrophy to clinical practice is coming...
  68. doi request reprint The significance of copper chelators in clinical and experimental application
    Xueqin Ding
    Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
    J Nutr Biochem 22:301-10. 2011
    ....
  69. ncbi request reprint Copper inhibition of hydrogen peroxide-induced hypertrophy in embryonic rat cardiac H9c2 cells
    Yang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 232:385-9. 2007
    ..The results thus demonstrated that VEGF is critically involved in copper inhibition of cell hypertrophy induced by hydrogen peroxide in the H9c2 cells...
  70. ncbi request reprint New understanding in cardiotoxicity
    Y James Kang
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd Street, MDR 530, Louisville, KY 40202, USA
    Curr Opin Drug Discov Devel 6:110-6. 2003
    ..Novel approaches, such as functional genomics, proteomics and metabonomics, should significantly improve our understanding of cardiotoxicity...
  71. ncbi request reprint Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway
    Lu Cai
    Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    Diabetes 51:1938-48. 2002
    ..Hyperglycemia-induced myocardial apoptosis is mediated, at least in part, by activation of the cytochrome c-activated caspase-3 pathway, which may be triggered by ROS derived from high levels of glucose...
  72. ncbi request reprint Inhibition of doxorubicin chronic toxicity in catalase-overexpressing transgenic mouse hearts
    Y James Kang
    Department of Medicine, University of Louisville School of Medicine, and Jewish Hospital Heart and Lung Institute, Louisville, KY 40202, USA
    Chem Res Toxicol 15:1-6. 2002
    ..The results indicate that catalase elevation in the heart prevents doxorubicin chronic cardiomyopathy...
  73. ncbi request reprint Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase
    Changxu Song
    Department of Physiology and Biophysics, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Heart Circ Physiol 282:H1166-71. 2002
    ..Together, these results illustrate that formation of a signaling module between PKCepsilon and Src involves specific domains within the two molecules and is governed by the molecular conformation of PKCepsilon...
  74. ncbi request reprint Metallothionein and liver cell regeneration
    M George Cherian
    Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Exp Biol Med (Maywood) 231:138-44. 2006
    ..Several studies have suggested a defective liver regeneration after an injury in MT-knockout mice. There is cumulative evidence that indicates an essential role for MT in liver cell regeneration...
  75. pmc Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 2035, MSC 9304, Bethesda, MD 20892 9304, USA
    Alcohol 42:349-61. 2008
    ..Thus reducing the number of intestinal Gram-negative bacteria and preserving intestinal permeability to endotoxin may attenuate alcoholic liver and other organ injuries...

Research Grants16

  1. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 2006
    ..abstract_text> ..
  2. Oxidative Stress and Heart Failure by Copper Restriction
    Y James Kang; Fiscal Year: 2010
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  3. Oxidative Stress and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2007
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  4. Oxidative Stess and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2004
    ..Importantly, the data obtained will provide valuable information for novel experimental as well as clinical approaches for possible interventions of the transition from heart hypertrophy to heart failure. ..
  5. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 2001
    ....
  6. Oxidative Stess and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2001
    ..Importantly, the data obtained will provide valuable information for novel experimental as well as clinical approaches for possible interventions of the transition from heart hypertrophy to heart failure. ..
  7. Oxidative Stess and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2002
    ..Importantly, the data obtained will provide valuable information for novel experimental as well as clinical approaches for possible interventions of the transition from heart hypertrophy to heart failure. ..
  8. Oxidative Stress and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2009
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  9. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 2000
    ....
  10. Oxidative Stess and Heart Failure by Copper Restriction
    Y Kang; Fiscal Year: 2003
    ..Importantly, the data obtained will provide valuable information for novel experimental as well as clinical approaches for possible interventions of the transition from heart hypertrophy to heart failure. ..
  11. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 2003
    ..abstract_text> ..
  12. METALLOTHIONEIN AND ADRIAMYCIN CARDIOTOXICITY
    Y Kang; Fiscal Year: 1999
    ....