Un Kang

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Activity enhances dopaminergic long-duration response in Parkinson disease
    Un Jung Kang
    Department of Neurology, The University of Chicago, Chicago, IL, USA
    Neurology 78:1146-9. 2012
  2. pmc Structural determinants of PINK1 topology and dual subcellular distribution
    William Lin
    Department of Neurology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    BMC Cell Biol 11:90. 2010
  3. ncbi request reprint Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease
    Un Jung Kang
    Department of Neurology and Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 54:S103-9. 2003
  4. pmc Dopamine-dependent motor learning: insight into levodopa's long-duration response
    Jeff A Beeler
    Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 67:639-47. 2010
  5. ncbi request reprint The surfactant poloxamer-188 protects against glutamate toxicity in the rat brain
    David M Frim
    Department of Surgery, Neurology, The University of Chicago Children s Hospital, MC 4066, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Neuroreport 15:171-4. 2004
  6. doi request reprint Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice
    Linan Chen
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:425-33. 2008
  7. ncbi request reprint Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice
    Linan Chen
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:21418-26. 2005
  8. doi request reprint A prospective blinded evaluation of deep brain stimulation for the treatment of secondary dystonia and primary torticollis syndromes
    Theresa E Pretto
    Department of Neurology, The University of Chicago, Illinois 60637, USA
    J Neurosurg 109:405-9. 2008
  9. ncbi request reprint Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats
    Daniel J Curry
    Departments of Surgery and Neurology, University of Chicago, Illinois 60637, USA
    J Neurosurg 101:91-6. 2004
  10. ncbi request reprint Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells
    Gi Ryang Kweon
    Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 279:51783-92. 2004

Collaborators

Detail Information

Publications25

  1. pmc Activity enhances dopaminergic long-duration response in Parkinson disease
    Un Jung Kang
    Department of Neurology, The University of Chicago, Chicago, IL, USA
    Neurology 78:1146-9. 2012
    ..By data-mining the motor task performance in dominant and nondominant hands of the subjects in a double-blind randomized trial of levodopa therapy, the effects of activity and dopamine therapy were examined...
  2. pmc Structural determinants of PINK1 topology and dual subcellular distribution
    William Lin
    Department of Neurology, University of Chicago Medical Center, Chicago, Illinois 60637, USA
    BMC Cell Biol 11:90. 2010
    ..We asked how the mitochondrial localization signal, the transmembrane domain, and the kinase domain participate in PINK1 localization...
  3. ncbi request reprint Potential of gene therapy for pediatric neurotransmitter diseases: lessons from Parkinson's disease
    Un Jung Kang
    Department of Neurology and Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 54:S103-9. 2003
    ..The optimal anatomical targets and proper timing of the gene replacement must be understood. Safety of gene therapy vehicles and the ability to regulate gene expression will be essential for eventual clinical application...
  4. pmc Dopamine-dependent motor learning: insight into levodopa's long-duration response
    Jeff A Beeler
    Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA
    Ann Neurol 67:639-47. 2010
    ..Dopamine (DA) is critical for motor performance, motor learning, and corticostriatal plasticity. The relationship between motor performance and learning, and the role of DA in the mediation of them, however, remain unclear...
  5. ncbi request reprint The surfactant poloxamer-188 protects against glutamate toxicity in the rat brain
    David M Frim
    Department of Surgery, Neurology, The University of Chicago Children s Hospital, MC 4066, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Neuroreport 15:171-4. 2004
    ..v. P-188 treatment; however, that comparison did not reach significance. This robust protection against glutamate toxicity may predict P-188-mediated neuroprotection against a broad range of clinically relevant neural insults...
  6. doi request reprint Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice
    Linan Chen
    Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:425-33. 2008
    ..The present study has significant clinical implications, because dopamine replacement therapy is the mainstay of PD treatment. In addition, our model provides an efficient in vivo approach to test therapeutic agents for PD...
  7. ncbi request reprint Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice
    Linan Chen
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:21418-26. 2005
    ..These data represent the in vivo evidence that loss of DJ-1 function alters nigrostriatal dopaminergic function and produces motor deficits...
  8. doi request reprint A prospective blinded evaluation of deep brain stimulation for the treatment of secondary dystonia and primary torticollis syndromes
    Theresa E Pretto
    Department of Neurology, The University of Chicago, Illinois 60637, USA
    J Neurosurg 109:405-9. 2008
    ....
  9. ncbi request reprint Surfactant poloxamer 188-related decreases in inflammation and tissue damage after experimental brain injury in rats
    Daniel J Curry
    Departments of Surgery and Neurology, University of Chicago, Illinois 60637, USA
    J Neurosurg 101:91-6. 2004
    ..The authors investigated the role of P- 188 in the reduction of tissue injury and macrophage response in a model of excitotoxic brain injury in the rat striatum...
  10. ncbi request reprint Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells
    Gi Ryang Kweon
    Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 279:51783-92. 2004
    ..Thus, intrinsic properties of individual cell types play important roles in determining the predominant mechanism of complex I inhibition-induced neurodegeneration...
  11. ncbi request reprint Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    Wonsuk Yang
    Department of Neurology, The University of Chicago, IL 60637, USA
    Hum Mol Genet 16:2900-10. 2007
    ..In conclusion, this study raises the possibility that environmental and genetic factors might cooperatively involve the mechanisms underlying proteasome impairment in PD brains...
  12. doi request reprint Effects of low to moderate acute doses of pramipexole on impulsivity and cognition in healthy volunteers
    Ajna Hamidovic
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    J Clin Psychopharmacol 28:45-51. 2008
    ..The sedative-like effects observed in this study may reflect presynaptic actions of the drug. Higher doses with postsynaptic actions may be needed to produce either behavioral or subjective stimulant-like effects...
  13. ncbi request reprint Identification and treatment of cervical and oromandibular dystonia in acutely brain-injured patients
    Steven E Lo
    Department of Neurology, Neurocritical Care and Acute Stroke Program, The University of Chicago and Pritzker School of Medicine, Chicago, IL 60637, USA
    Neurocrit Care 3:139-45. 2005
    ..In contrast, dystonia related to acute brain injuries is not well delineated. Our objective was to define in neurocritically ill patients the clinical characteristics of CD and OMD and to investigate the safety of BTx...
  14. ncbi request reprint Poloxamer 188 volumetrically decreases neuronal loss in the rat in a time-dependent manner
    Daniel J Curry
    Department of Surgery, University of Chicago, Chicago, Illinois, USA
    Neurosurgery 55:943-8; discussion 948-9. 2004
    ..This study investigated the usefulness and time dependence of intrathecal P-188 in protecting neurons in an in vivo model of excitotoxicity in the rat...
  15. pmc Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson's disease
    Yunmin Ding
    Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    Neurobiol Dis 27:11-23. 2007
    ....
  16. pmc Characterization of PINK1 processing, stability, and subcellular localization
    William Lin
    Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
    J Neurochem 106:464-74. 2008
    ..Our findings support a dual subcellular localization, implying that PINK1 can reside in the mitochondria and the cytosol. This raises intriguing functional roles that bridge these two cellular compartments...
  17. ncbi request reprint MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9
    Judith A Potashkin
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Brain Res 1182:1-10. 2007
    ..The data indicate that the pattern of splice isoforms of fosB and rgs9 reflects the brain's immediate and long-term responses to the physiological stress associated with Parkinsonism...
  18. pmc Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
    Arch Neurol 65:716-23. 2008
    ..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD...
  19. pmc Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta
    Seok Jong Hong
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Biol Chem 283:16860-7. 2008
    ..In summary, we propose that AP-2beta plays critical and distinctive roles in the NA phenotype specification in both the peripheral and central nervous system during development...
  20. pmc Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    S Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02178, USA
    J Neurochem 97:1467-80. 2006
    ..Taken together, our results demonstrate that genetic purification of neural precursor cells using FACS isolation can effectively remove unwanted proliferating cell types and avoid tumor formation after transplantation...
  21. pmc Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:1583-93. 2006
    ..We conclude that ES NPs maintain their developmental potential during in vitro expansion, whereas mouse E12.5 VM NPs do not...
  22. pmc Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells
    Dong Wook Kim
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02178, USA
    Stem Cells 24:557-67. 2006
    ....
  23. ncbi request reprint The effects of chronic L-DOPA therapy on pharmacodynamic parameters in a rat model of motor response fluctuations
    Eun Ah Lee
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Exp Neurol 184:304-12. 2003
    ..These observed changes do not mirror all aspects of motor response fluctuations in advanced PD patients and suggest differential contributions of dopaminergic treatment and lesion severity to motor complication patterns...
  24. ncbi request reprint Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
    Dong Youn Hwang
    Molecular Neurobiology Laboratories, McLean Hospital and Program in Neuroscience, Harvard Medical School, Belmont, MA 02478, USA
    Brain Res Mol Brain Res 114:123-31. 2003
    ....
  25. pmc Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons
    Sangmi Chung
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratory, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Eur J Neurosci 16:1829-38. 2002
    ....

Research Grants23

  1. The neuroprotective effect of tetrahydrobiopterin
    Un Kang; Fiscal Year: 2007
    ..abstract_text> ..
  2. Neuroprotective mechanism of DJ-1 in Parkinson's disease
    Un Kang; Fiscal Year: 2007
    ..Since Parkinson's disease leads to significant disability in a significant portion of the elderly population, such findings will have a significant impact in public health. ..
  3. Striatal cholinergic neurons and L-DOPA induced dyskinesia
    Un Kang; Fiscal Year: 2009
    ..The research proposed here will provide insight with respect to cell signaling mechanisms involved in dyskinesia behavior and will facilitate identification of potential targets for the treatment of PD. ..
  4. Neuroprotective mechanism of DJ-1 in Parkinson's disease
    Un Jung Kang; Fiscal Year: 2010
    ..Since Parkinson's disease leads to significant disability in a significant portion of the elderly population, such findings will have a significant impact in public health. ..
  5. Striatal cholinergic neurons and L-DOPA induced dyskinesia
    Un Jung Kang; Fiscal Year: 2010
    ..The research proposed here will provide insight with respect to cell signaling mechanisms involved in dyskinesia behavior and will facilitate identification of potential targets for the treatment of PD. ..
  6. Dopamine regulation in parkinsonian rat by gene therapy
    Un Kang; Fiscal Year: 2006
    ....
  7. CATECHOLAMINE REGULATION IN GENETICALLY MODIFIED GRAFTS
    Un Kang; Fiscal Year: 2001
    ....
  8. Neuroprotective mechanism of DJ-1 in Parkinson's disease
    Un Kang; Fiscal Year: 2009
    ..Since Parkinson's disease leads to significant disability in a significant portion of the elderly population, such findings will have a significant impact in public health. ..