S Kang

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Safe treatment of head/neck AD with tacrolimus ointment
    S Kang
    Department of Dermatology, University of Michigan Medical Center, 1618 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0314, USA
    J Dermatolog Treat 14:86-94. 2003
  2. ncbi request reprint Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial
    Sewon Kang
    University of Michigan School of Medicine, Department of Dermatology, Ann Arbor, USA
    J Am Acad Dermatol 49:83-90. 2003
  3. ncbi request reprint A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage
    Sewon Kang
    University of Michigan Medical Center, Department of Dermatology, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 52:268-74. 2005
  4. pmc Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro
    J Varani
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109, USA
    Am J Pathol 158:931-42. 2001
  5. ncbi request reprint Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
    J Varani
    Departments of Pathology and Dermatology, The University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    J Invest Dermatol 114:480-6. 2000
  6. pmc Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, 1150 W Medical Center Dr, Medical Science I, Room 6447, Ann Arbor, Michigan 48109 0609, USA
    Am J Pathol 169:482-90. 2006
  7. ncbi request reprint Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
    J Invest Dermatol 117:219-26. 2001
  8. ncbi request reprint Human psoriatic skin in organ culture: comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor
    J Varani
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Pathobiology 66:253-9. 1998
  9. doi request reprint Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo
    Laure Rittie
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0609, USA
    Arch Dermatol 144:1129-40. 2008
  10. pmc Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo
    G J Fisher
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Clin Invest 101:1432-40. 1998

Detail Information

Publications82

  1. ncbi request reprint Safe treatment of head/neck AD with tacrolimus ointment
    S Kang
    Department of Dermatology, University of Michigan Medical Center, 1618 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0314, USA
    J Dermatolog Treat 14:86-94. 2003
    ..Atopic dermatitis(AD) with head and neck involvement is common and therapeutically challenging...
  2. ncbi request reprint Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial
    Sewon Kang
    University of Michigan School of Medicine, Department of Dermatology, Ann Arbor, USA
    J Am Acad Dermatol 49:83-90. 2003
    ..Adapalene is a synthetic retinoid with an established clinical efficacy against acne and good local tolerability. Its effectiveness in the treatment of photodamaged skin has not been studied...
  3. ncbi request reprint A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage
    Sewon Kang
    University of Michigan Medical Center, Department of Dermatology, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 52:268-74. 2005
    ..Previous studies indicate that tazarotene is efficacious in reducing signs of photodamage. Objective We sought to confirm the efficacy and tolerability of tazarotene 0.1% cream in the treatment of facial photodamage...
  4. pmc Inhibition of type I procollagen synthesis by damaged collagen in photoaged skin and by collagenase-degraded collagen in vitro
    J Varani
    Department of Pathology, The University of Michigan Medical School, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109, USA
    Am J Pathol 158:931-42. 2001
    ....
  5. ncbi request reprint Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin
    J Varani
    Departments of Pathology and Dermatology, The University of Michigan, Medical School, Ann Arbor, MI 48109, USA
    J Invest Dermatol 114:480-6. 2000
    ..In addition, vitamin A treatment reduces matrix metalloproteinase expression and stimulates collagen synthesis in naturally aged, sun-protected skin, as it does in photoaged skin...
  6. pmc Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, 1150 W Medical Center Dr, Medical Science I, Room 6447, Ann Arbor, Michigan 48109 0609, USA
    Am J Pathol 169:482-90. 2006
    ..These data identify CYR61 as a pivotal regulator of collagen production and degradation in aged and photoaged human skin...
  7. ncbi request reprint Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo
    G J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
    J Invest Dermatol 117:219-26. 2001
    ..Although ultraviolet irradiation induces both MMP-1 and MMP-8, ultraviolet-induced collagen degradation is initiated primarily by MMP-1, with little, if any, contribution by MMP-8...
  8. ncbi request reprint Human psoriatic skin in organ culture: comparison with normal skin exposed to exogenous growth factors and effects of an antibody to the EGF receptor
    J Varani
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Pathobiology 66:253-9. 1998
    ..They also suggest that organ culture may provide a useful tool with which to elucidate the pathophysiological mechanisms of altered keratinocyte proliferation and differentiation in psoriasis...
  9. doi request reprint Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo
    Laure Rittie
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0609, USA
    Arch Dermatol 144:1129-40. 2008
    ..To evaluate the effectiveness of topical estradiol in stimulating collagen I and III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men...
  10. pmc Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo
    G J Fisher
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Clin Invest 101:1432-40. 1998
    ..Inhibition of c-Jun induction likely contributes to the previously reported prevention by tRA of UV induction of AP-1-regulated matrix-degrading metalloproteinases in human skin...
  11. ncbi request reprint 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin
    X Y Li
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Endocrinol 13:1686-94. 1999
    ..D3 exerts dual positive influences on its nuclear receptor, simultaneously stimulating VDR transactivation activity and retarding VDR degradation...
  12. ncbi request reprint Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study
    Nicholas Lowe
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USA
    J Cosmet Laser Ther 6:79-85. 2004
    ..To compare the efficacy and tolerability of tazarotene 0.1% cream and tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin...
  13. ncbi request reprint Heparin-binding epidermal-growth-factor-like growth factor activation of keratinocyte ErbB receptors Mediates epidermal hyperplasia, a prominent side-effect of retinoid therapy
    J Varani
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 117:1335-41. 2001
    ..Taken together, these data indicate (i) that retinoid-induced epidermal hyperplasia in human skin proceeds through c-erbB, and (ii) that HB-EGF-like growth factor is one of the c-erbB ligands mediating this effect...
  14. ncbi request reprint Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily f
    S Kang
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Arch Dermatol 137:1597-604. 2001
    ..To assess the safety and efficacy of 4 concentrations of tazarotene cream in the treatment of facial photodamage...
  15. ncbi request reprint Calcipotriene-induced improvement in psoriasis is associated with reduced interleukin-8 and increased interleukin-10 levels within lesions
    S Kang
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109 0314, USA
    Br J Dermatol 138:77-83. 1998
    ..The changes in the level of these two cytokines provide further evidence for immunological changes as a significant part of the mechanism of action of calcipotriene in psoriasis...
  16. ncbi request reprint Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial
    Sewon Kang
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Clin Dermatol 6:245-53. 2005
    ..Recently, we conducted a 2-year placebo-controlled study of tretinoin emollient cream 0.05%, including histopathologic assessment of safety and analysis of markers of collagen deposition...
  17. ncbi request reprint Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin
    Meghan Brennan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Photochem Photobiol 78:43-8. 2003
    ..These findings strongly implicate MMP-1 rather than MMP-13 as the major collagenolytic enzyme responsible for collagen damage in photoaging...
  18. pmc Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Pathol 165:741-51. 2004
    ..UV-induced down-regulation of TbetaRII, with attendant reduction of type I procollagen production, is a critical molecular mechanism in the pathophysiology of photoaging...
  19. doi request reprint Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for use
    Amy S Paller
    Department of Dermatology, Northwestern University s Feinberg Medical School Children s Memorial Hospital, 676 North St Clair St, Suite 1600, Chicago, IL 60611, USA
    Pediatrics 122:e1210-8. 2008
    ....
  20. ncbi request reprint Photoaging: pathogenesis, prevention, and treatment
    S Kang
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Clin Geriatr Med 17:643-59, v-vi. 2001
    ..This article summarizes evidence mainly from studies of human volunteers that provide the basis for the current model of photoaging and the effects of tretinoin...
  21. ncbi request reprint Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in children
    S Kang
    University of Michigan Medical Center, Ann Arbor 48109 0314, USA
    J Am Acad Dermatol 44:S58-64. 2001
    ..Effectiveness of tacrolimus was maintained with prolonged daily use. Tacrolimus ointment (0.1%) is safe and effective for long-term treatment of atopic dermatitis in children...
  22. ncbi request reprint Connective tissue growth factor: expression in human skin in vivo and inhibition by ultraviolet irradiation
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Invest Dermatol 118:402-8. 2002
    ..Ultraviolet reduction of connective tissue growth factor expression may contribute to reduced procollagen synthesis observed in ultraviolet-irradiated normal human skin and human skin fibroblasts...
  23. ncbi request reprint Prolonged occlusion in the treatment of psoriasis: a clinical and immunohistologic study
    C E Griffiths
    Department of Dermatology, University of Michigan Medical Center, Ann Arbor
    J Am Acad Dermatol 32:618-22. 1995
    ..An occlusive dressing that is both cosmetically acceptable and long term is needed for psoriasis treatment. The mechanisms that underlie the efficacy of occlusion in psoriasis are unknown...
  24. pmc Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo
    Sewon Kang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Pathol 166:1691-9. 2005
    ..This new knowledge enables a rational strategy for development of pharmacological agents that can target the inflammation and matrix remodeling that occurs in severe acne...
  25. ncbi request reprint Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis
    Soyun Cho
    Department of Dermatology, University of Michigan Medical School, USA
    J Am Acad Dermatol 53:769-74. 2005
    ..Risk of photocarcinogenesis and the relevance of collagen in wrinkle effacement are two issues related to prolonged use of retinoic acid (RA) that have not been fully addressed...
  26. pmc Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation
    James Varani
    Department of Pathology, The University of Michigan, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109 USA
    Am J Pathol 168:1861-8. 2006
    ..Based on the findings presented here, we conclude that reduced collagen synthesis in chronologically aged skin reflects at least two different underlying mechanisms: cellular fibroblast aging and a lower level of mechanical stimulation...
  27. ncbi request reprint Microdermabrasion with and without aluminum oxide crystal abrasion: a comparative molecular analysis of dermal remodeling
    Darius J Karimipour
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Am Acad Dermatol 54:405-10. 2006
    ..Microdermabrasion is a popular method of superficial skin resurfacing with effects on dermal remodeling...
  28. ncbi request reprint Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo
    Laure Rittie
    Department of Dermatology, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan 48109 0609, USA
    J Invest Dermatol 126:732-9. 2006
    ..These data demonstrate the central role of EGFR activation in retinoid-induced epidermal hyperplasia, and suggest that EGFR inhibitors can mitigate retinoid-induced scaling...
  29. ncbi request reprint Dermal matrix remodeling after nonablative laser therapy
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA
    J Am Acad Dermatol 53:775-82. 2005
    ..Nonablative laser therapy is widely practiced for cutaneous rejuvenation. We sought to quantify dermal molecular changes after exposure of photodamaged skin to nonablative laser energy...
  30. ncbi request reprint The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 55:402-7. 2006
    ..The mechanisms involved in laser-mediated hair removal remain unclear. One means of reducing hair growth is alteration of follicular stem cells...
  31. ncbi request reprint A randomized, controlled, split-face clinical trial of 1320-nm Nd:YAG laser therapy in the treatment of acne vulgaris
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 56:432-8. 2007
    ..There is a need for additional effective treatments for acne vulgaris. Laser therapy has been explored as a therapeutic option for acne, but rigorously designed studies in this area have been limited...
  32. doi request reprint Ultraviolet irradiation induces CYR61/CCN1, a mediator of collagen homeostasis, through activation of transcription factor AP-1 in human skin fibroblasts
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, 1301 E Catherine, Ann Arbor, MI 48109, USA
    J Invest Dermatol 130:1697-706. 2010
    ..These data show that CYR61 is transcriptionally regulated by UV irradiation through transcription factor AP-1, and mediates altered collagen homeostasis that occurs in response to UV irradiation in human skin fibroblasts...
  33. ncbi request reprint Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin
    Laure Rittie
    Department of Dermatology, University of Michigan, Ann Arbor, MI, USA
    Aging Cell 8:738-51. 2009
    ..Together with previously reported knock-out mouse results, these data suggest a role for Hh signaling in maintaining bulge cell phenotype in young and aged human skin...
  34. doi request reprint Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis
    Dana L Sachs
    Department of Dermatology, 1910 Taubman Center, University of Michigan Medical School, 1500 E Medical Center Dr, Ann Arbor, MI 48109 5314, USA
    Arch Dermatol 145:659-66. 2009
    ..To examine clinical and molecular changes after topical fluorouracil treatment of photodamaged human facial skin for actinic keratoses...
  35. pmc Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne
    Frank Wang
    Department of Dermatology, University of Michigan Medical School, 1618 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0314, USA
    J Am Acad Dermatol 61:252-8. 2009
    ..The CYP26 enzyme acts specifically on tRA, but not 13-cis RA (isotretinoin), a retinoid used to treat severe acne. However, 13-cis RA can isomerize to tRA, which can then be metabolized by CYP26...
  36. pmc Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin
    Gary J Fisher
    Department of Dermatology, Medical School, University of Michigan, Ann Arbor, Michigan 48109 5609, USA
    Am J Pathol 174:101-14. 2009
    ..These data extend the current understanding of the oxidative theory of aging beyond a cellular-centric view to include extracellular matrix and the critical role that connective tissue microenvironment plays in the biology of aging...
  37. doi request reprint Molecular effects of photodynamic therapy for photoaging
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, 1500 E Medical Center Dr, 1910 Taubman Center, Ann Arbor, MI 48109 0314, USA
    Arch Dermatol 144:1296-302. 2008
    ..To quantitatively examine the epidermal and dermal cellular and molecular changes that occur after photodynamic therapy of photodamaged human skin...
  38. ncbi request reprint In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin
    Frank Wang
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Dermatol 143:155-63. 2007
    ..To determine whether endogenous synthesis of new extracellular matrix may contribute to the degree and duration of clinical benefits derived from cross-linked hyaluronic acid dermal filler injections...
  39. pmc Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy
    Frank Wang
    Department of Dermatology, University of Michigan Medical School, 1618 A Alfred Taubman Healthcare Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Arch Dermatol 144:851-8. 2008
    ..To investigate the efficacy, potential limitations, and biological mechanisms of UV-A1 phototherapy for skin sclerosis due to collagen deposition disorders...
  40. doi request reprint Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo
    Thy Thy Do
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Am Acad Dermatol 58:603-8. 2008
    ..Inflammatory acne lesions are believed to derive from comedones; however, their evolution has not been rigorously studied...
  41. ncbi request reprint Effect of smoking on aging of photoprotected skin: evidence gathered using a new photonumeric scale
    Yolanda R Helfrich
    Department of Dermatology, University of Michigan, Ann Arbor 48109, USA
    Arch Dermatol 143:397-402. 2007
    ..To develop a reproducible photonumeric scale to assess photoprotected skin aging and to determine whether health and lifestyle factors, such as smoking, affect skin aging in photoprotected sites...
  42. doi request reprint Photodynamic therapy for acne vulgaris: a randomized, controlled, split-face clinical trial of topical aminolevulinic acid and pulsed dye laser therapy
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0314, USA
    J Cosmet Dermatol 9:28-34. 2010
    ..Interest in light-based acne treatments has increased, but few randomized, controlled clinical trials assessing the value of photodynamic therapy (PDT) for acne have been reported...
  43. ncbi request reprint The mechanism of action of topical retinoids
    Sewon Kang
    University of Michigan Medical Center, Ann Arbor, USA
    Cutis 75:10-3; discussion 13. 2005
    ..Three naturally occurring retinoids are reviewed...
  44. ncbi request reprint Effect of carbon dioxide laser resurfacing on epidermal p53 immunostaining in photodamaged skin
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, USA
    Arch Dermatol 140:1073-7. 2004
    ....
  45. ncbi request reprint Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin
    James Varani
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 122:1471-9. 2004
    ..We hypothesize that fibroblasts in severely damaged skin have less interaction with intact collagen and as a result experience a reduction in mechanical tension. Decreased collagen synthesis is (presumed to be) the result...
  46. ncbi request reprint Phototherapy for scleroderma: biologic rationale, results, and promise
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, 48109 0609, USA
    Curr Opin Rheumatol 14:723-6. 2002
    ..Accumulating evidence indicates that UVA irradiation offers a genuine opportunity to ameliorate localized scleroderma and the cutaneous manifestations of systemic sclerosis...
  47. ncbi request reprint Connective tissue remodeling induced by carbon dioxide laser resurfacing of photodamaged human skin
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, USA
    Arch Dermatol 140:1326-32. 2004
    ..To quantitatively examine the dynamics of molecular alterations involved in dermal remodeling after carbon dioxide (CO(2)) laser resurfacing of photodamaged human skin...
  48. ncbi request reprint Mechanisms of photoaging and chronological skin aging
    Gary J Fisher
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Dermatol 138:1462-70. 2002
    ..This article reviews our current understanding and presents new data about the molecular pathways that mediate skin damage by UV irradiation and by the passage of time...
  49. ncbi request reprint A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin
    James Varani
    Department of Pathology, The University of Michigan, 1301 Catherine Rd Box 0602, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 313:56-63. 2005
    ..Together, these data suggest that Bz-423 has the potential to limit the untoward effects associated with topical retinoid treatment, and in addition, may have therapeutic effects against other forms of epidermal hyperplasia...
  50. ncbi request reprint Tretinoin treatment before carbon-dioxide laser resurfacing: a clinical and biochemical analysis
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 51:940-6. 2004
    ..Tretinoin is often prescribed before laser resurfacing in an attempt to enhance results...
  51. ncbi request reprint Topical N-acetyl cysteine and genistein prevent ultraviolet-light-induced signaling that leads to photoaging in human skin in vivo
    Sewon Kang
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 120:835-41. 2003
    ..These data indicate that compounds similar to genistein and n-acetyl cysteine, which possess tyrosine kinase inhibitory and/or antioxidant activities, may prevent photoaging...
  52. ncbi request reprint Microdermabrasion: a molecular analysis following a single treatment
    Darius J Karimipour
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0314, USA
    J Am Acad Dermatol 52:215-23. 2005
    ..Microdermabrasion is a popular method of superficial skin resurfacing. It is unclear if dermal remodeling actually occurs...
  53. ncbi request reprint Treatment of acne vulgaris with a pulsed dye laser: a randomized controlled trial
    Jeffrey S Orringer
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, USA
    JAMA 291:2834-9. 2004
    ..The high prevalence of acne vulgaris and its significant morbidity underscore the need for convenient, low-risk, and efficacious therapy. Treatment with various lasers has been reported to improve acne...
  54. ncbi request reprint Collagen degradation in aged/photodamaged skin in vivo and after exposure to matrix metalloproteinase-1 in vitro
    Suzanne E G Fligiel
    Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Invest Dermatol 120:842-8. 2003
    ..We suggest that collagen fragmentation in vivo could underlie the loss of collagen synthesis in photodamaged skin and, to a lesser extent perhaps, in aged skin...
  55. doi request reprint Etanercept suppresses regenerative hyperplasia in psoriasis by acutely downregulating epidermal expression of interleukin (IL)-19, IL-20 and IL-24
    F Wang
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    Br J Dermatol 167:92-102. 2012
    ..Psoriasis is a Th17/Th1-mediated skin disease that often responds to antitumour necrosis factor (TNF)-α therapies, such as etanercept...
  56. ncbi request reprint 1alpha,25-dihydroxycholecalciferol and cyclosporine suppress induction and promote resolution of psoriasis in human skin grafts transplanted on to SCID mice
    T N Dam
    Department of Dermatology, University of Michigan, Ann Arbor, USA
    J Invest Dermatol 113:1082-9. 1999
    ..Our results are consistent with the hypothesis that psoriasis may be induced by activated T lymphocytes, and indicate that novel immunomodulatory drugs can serve to inhibit the pathogenetic ability of immunocytes in psoriasis...
  57. ncbi request reprint Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses
    J E Wolf
    Department of Dermatology, Baylor College of Medicine, Houston, TX 77030 3411, USA
    Int J Dermatol 40:709-13. 2001
    ..Previous studies have demonstrated that 3% diclofenac in 2.5% hyaluronan gel is effective and well tolerated in the treatment of AK. The present study was designed to further explore the therapeutic potential of this gel...
  58. ncbi request reprint Improvement of naturally aged skin with vitamin A (retinol)
    Reza Kafi
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Arch Dermatol 143:606-12. 2007
    ..To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin...
  59. ncbi request reprint Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne
    John J DiGiovanna
    Division of Dermatopharmacology, Department of Dermatology, Brown Medical School Rhode Island Hospital, Providence, RI 02903, USA
    J Am Acad Dermatol 51:709-17. 2004
    ..The effect of short-term (4-5 months) therapy at the lower dose recommended for acne on bone development in younger, growing adolescent (12-17 years) patients has not been well studied...
  60. ncbi request reprint Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo
    Taihao Quan
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0609, USA
    J Invest Dermatol 119:499-506. 2002
    ....
  61. ncbi request reprint Topical becocalcidiol for the treatment of psoriasis vulgaris: a randomized, placebo-controlled, double-blind, multicentre study
    Y R Helfrich
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 0314, USA
    Br J Dermatol 157:369-74. 2007
    ..Becocalcidiol is a vitamin D(3) analogue which has not caused hypercalcaemia or significant irritation in preclinical trials...
  62. ncbi request reprint Retinoic acid isomers applied to human skin in vivo each induce a 4-hydroxylase that inactivates only trans retinoic acid
    E A Duell
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109 0528, USA
    J Invest Dermatol 106:316-20. 1996
    ....
  63. doi request reprint New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group
    Diane Thiboutot
    Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, USA
    J Am Acad Dermatol 60:S1-50. 2009
    ..As in the original supplement, the authors have based recommendations on published evidence as much as possible...
  64. ncbi request reprint UV-A1 phototherapy improves nephrogenic fibrosing dermopathy
    Reza Kafi
    University of Michigan Medical Center, Ann Arbor 48109, USA
    Arch Dermatol 140:1322-4. 2004
  65. ncbi request reprint 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-one (Bz-423), a benzodiazepine, suppresses keratinocyte proliferation and has antipsoriatic activity in the human skin-severe, combined immunodefici
    Narasimharao Bhagavathula
    Department of Pathology, The University of Michigan, 1301 Catherine Rd, Box 0602, Ann Arbor, MI 48109, USA
    J Pharmacol Exp Ther 324:938-47. 2008
    ....
  66. pmc Vascular tube formation on matrix metalloproteinase-1-damaged collagen
    J Varani
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Br J Cancer 98:1646-52. 2008
    ..Together, these studies suggest that damage to the collagenous matrix is itself an important inducer of new vessel formation...
  67. ncbi request reprint Treatment of hidradenitis suppurativa with infliximab in a patient with Crohn's disease
    Y L Rosi
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Dermatolog Treat 16:58-61. 2005
    ..Some of these autoinflammatory disorders have been successfully treated with anti-tumor necrosis factor antibodies...
  68. ncbi request reprint Ultraviolet modulation of human macrophage metalloelastase in human skin in vivo
    Jin Ho Chung
    Department of Dermatology, Seoul National University College of Medicine, and Syungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea
    J Invest Dermatol 119:507-12. 2002
    ..Association of human macrophage metalloelastase with elastotic material suggests that it may play an important role in the development of solar elastosis, the hallmark of sun-induced damage in human skin in vivo...
  69. doi request reprint Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: a randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle
    Debra Breneman
    University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Am Acad Dermatol 58:990-9. 2008
    ..Intermittent dosing of a topical calcineurin inhibitor for preventing atopic dermatitis (AD) disease relapse in patients with stabilized AD has not been evaluated...
  70. ncbi request reprint Double diagnosis in cancer patients and cutaneous reaction related to gemcitabine: CASE 3. Photo therapy recall with gemcitabine following ultraviolet B treatment
    Joanna Badger
    Stanford Medical Center, Stanford, CA, USA
    J Clin Oncol 23:7224-5. 2005
  71. ncbi request reprint Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: results of a multicenter, randomized double-blind, controlled study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 57:791-9. 2007
    ..A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for the once-daily treatment of acne...
  72. ncbi request reprint Combination therapy with adapalene gel 0.1% and doxycycline for severe acne vulgaris: a multicenter, investigator-blind, randomized, controlled study
    Diane M Thiboutot
    Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Skinmed 4:138-46. 2005
    ....
  73. ncbi request reprint Pan-selectin antagonism improves psoriasis manifestation in mice and man
    Markus Friedrich
    Department of Dermatology and Allergy, University Hospital Charite, Schumannstr 20 21, 10117 Berlin, Germany
    Arch Dermatol Res 297:345-51. 2006
    ..Assessment of safety parameters showed no abnormal findings. These data suggest that pan-selectin antagonism may be a promising strategy for the treatment of psoriasis and other inflammatory diseases...
  74. pmc Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
    J Clin Invest 117:803-11. 2007
    ..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection...
  75. ncbi request reprint Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study
    Diane M Thiboutot
    The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, USA
    Arch Dermatol 142:597-602. 2006
    ..To assess the maintenance effect of adapalene gel, 0.1%, relative to gel vehicle in subjects successfully treated in a previous 12-week study of adapalene-doxycycline, 100 mg, combination therapy...
  76. ncbi request reprint A randomized, open-label trial of continuous versus interrupted etanercept therapy in the treatment of psoriasis
    Angela Moore
    Arlington Center for Dermatology, TX 76011, USA
    J Am Acad Dermatol 56:598-603. 2007
    ..Although etanercept is used as a continuous therapy for moderate to severe plaque psoriasis, intermittent use may be necessary in some instances...
  77. ncbi request reprint A randomized trial of etanercept as monotherapy for psoriasis
    Alice B Gottlieb
    Clinical Research Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, 08901 0019, USA
    Arch Dermatol 139:1627-32; discussion 1632. 2003
    ..To determine safety and efficacy of monotherapy with etanercept...
  78. ncbi request reprint Clinical response to adalimumab treatment in patients with moderate to severe psoriasis: double-blind, randomized controlled trial and open-label extension study
    Kenneth B Gordon
    Division of Dermatology, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Skokie, IL 60077, USA
    J Am Acad Dermatol 55:598-606. 2006
    ..Tumor necrosis factor is pivotal in the pathogenesis of psoriasis. Adalimumab is a fully human monoclonal immunoglobulin G1 antibody that neutralizes tumor necrosis factor...
  79. ncbi request reprint Evaluation of safety and clinical activity of multiple doses of the anti-CD80 monoclonal antibody, galiximab, in patients with moderate to severe plaque psoriasis
    Alice B Gottlieb
    Clinical Research Center, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08901 0019, USA
    Clin Immunol 111:28-37. 2004
    ..Reduction in lesional, activated T cells induces improvement in psoriatic plaques. Galiximab (IDEC-114), an IgG(1) anti-CD80 antibody, binds to CD80, a costimulatory molecule involved in T-cell activation...
  80. ncbi request reprint A systemic type I 5 alpha-reductase inhibitor is ineffective in the treatment of acne vulgaris
    James Leyden
    University of Pennsylvania Hospital, 36th and Spruce Streets, Philadelphia, PA 19104, USA
    J Am Acad Dermatol 50:443-7. 2004
    ..These results indicate the need for further work at the molecular level to better understand the action of androgens on sebaceous gland function...
  81. ncbi request reprint Aging and photoaging
    Jin Ho Chung
    Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea
    J Am Acad Dermatol 49:690-7. 2003
  82. ncbi request reprint Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association "Administrative Regulations for Evidence-Based Clinical Practice Guidelines"
    Jon M Hanifin
    American Academy of Dermatology, PO Box 4014, Schaumburg, IL 60168 4014, USA
    J Am Acad Dermatol 50:391-404. 2004