M K Kang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival
    M K Kang
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Br J Cancer 96:126-33. 2007
  2. ncbi request reprint Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo
    Mo K Kang
    UCLA School of Dentistry, CHS 43 009, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Exp Cell Res 310:186-95. 2005
  3. ncbi request reprint Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells
    Mo K Kang
    School of Dentistry, University of California, Los Angeles, California 90095, USA
    J Cell Physiol 199:364-70. 2004
  4. pmc Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism
    W Chen
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Cell Death Dis 3:e450. 2012
  5. ncbi request reprint Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ
    H R Kim
    Dental Research Institute, University of California, Los Angeles, 90095, USA
    Clin Cancer Res 7:3079-86. 2001
  6. pmc Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells
    X Kang
    UCLA School of Dentistry, Los Angeles, CA, USA
    Oncogene 28:565-74. 2009
  7. pmc Bisphosphonates induce senescence in normal human oral keratinocytes
    R H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Dent Res 90:810-6. 2011
  8. ncbi request reprint Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes
    M K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles 90095, USA
    Crit Rev Oral Biol Med 12:38-54. 2001
  9. ncbi request reprint c-Myc and Sp1/3 are required for transactivation of hamster telomerase catalytic subunit gene promoter
    N H Park
    Dental and Craniofacial Research Institute, University of California, Los Angeles 90095 1668, USA
    Int J Oncol 19:755-61. 2001
  10. pmc Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
    K H Shin
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Br J Cancer 89:1473-8. 2003

Collaborators

Detail Information

Publications28

  1. pmc Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival
    M K Kang
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Br J Cancer 96:126-33. 2007
    ..Thus, our data suggest that Bmi-1 may act through p16(INK4A)-independent pathways to regulate cellular proliferation during oral cancer progression...
  2. ncbi request reprint Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo
    Mo K Kang
    UCLA School of Dentistry, CHS 43 009, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Exp Cell Res 310:186-95. 2005
    ..These results indicated that senescing NHOK accumulated oxidative DNA lesions in part due to increased level of endogenous ROS and impaired intranuclear translocation of hOGG1 enzyme upon exposure to oxidative stress...
  3. ncbi request reprint Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells
    Mo K Kang
    School of Dentistry, University of California, Los Angeles, California 90095, USA
    J Cell Physiol 199:364-70. 2004
    ..These results indicate that replicative senescence of NHOK is associated with loss of telomerase activity followed by limited telomere shortening...
  4. pmc Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism
    W Chen
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Cell Death Dis 3:e450. 2012
    ..These data indicate that GRHL2 impairs epidermal differentiation by inhibiting EDC gene expression through epigenetic mechanisms and support its role in the hyperproliferative skin diseases...
  5. ncbi request reprint Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ
    H R Kim
    Dental Research Institute, University of California, Los Angeles, 90095, USA
    Clin Cancer Res 7:3079-86. 2001
    ..CONCLUSIONS: These results indicate that enhanced expression of telomerase activity occurs early during human oral carcinogenesis and support the critical role of telomerase in the development of human oral cancer...
  6. pmc Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells
    X Kang
    UCLA School of Dentistry, Los Angeles, CA, USA
    Oncogene 28:565-74. 2009
    ..These results suggest a possible role of GRHL2 in telomerase activation during cellular immortalization...
  7. pmc Bisphosphonates induce senescence in normal human oral keratinocytes
    R H Kim
    UCLA School of Dentistry, Center for the Health Sciences, Room 43 091, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    J Dent Res 90:810-6. 2011
    ..Analysis of these data indicates that premature senescence of oral mucosal cells and subsequent defective soft-tissue wound healing might be partly responsible for the development of BRONJ in individuals receiving PAM or other BPs...
  8. ncbi request reprint Conversion of normal to malignant phenotype: telomere shortening, telomerase activation, and genomic instability during immortalization of human oral keratinocytes
    M K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles 90095, USA
    Crit Rev Oral Biol Med 12:38-54. 2001
    ..Our in vitro model may be useful for investigators with interest in furthering our understanding of oral carcinogenesis...
  9. ncbi request reprint c-Myc and Sp1/3 are required for transactivation of hamster telomerase catalytic subunit gene promoter
    N H Park
    Dental and Craniofacial Research Institute, University of California, Los Angeles 90095 1668, USA
    Int J Oncol 19:755-61. 2001
    ..These results indicate that c-Myc and Sp1/3 are the major regulatory determinants of the hamTERT transcriptional activation. The mechanism of TERT gene activation during immortalization and carcinogenesis may be conserved among species...
  10. pmc Hypermethylation of the hTERT promoter inhibits the expression of telomerase activity in normal oral fibroblasts and senescent normal oral keratinocytes
    K H Shin
    School of Dentistry, University of California, Los Angeles, CA 90095, USA
    Br J Cancer 89:1473-8. 2003
    ..Our results suggest that hypermethylation of the hTERT promoter plays a critical role in the negative regulation of telomerase activity in normal human oral cells...
  11. ncbi request reprint Anticancer effect of a lentiviral vector capable of expressing HIV-1 Vpr
    S Pang
    School of Dentistry, Dental Research Institute, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA
    Clin Cancer Res 7:3567-73. 2001
    ..The Vpr lentiviral vector offers a powerful new strategy for cancer gene therapy and may be useful for the control of solid tumors, such as human oral squamous cell carcinomas...
  12. ncbi request reprint Extension of cell life span using exogenous telomerase
    Mo K Kang
    School of Dentistry, David Geffen School of Medicine, and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
    Methods Mol Biol 371:151-65. 2007
    ..In this article, we discuss the detailed methods to extend the in vitro replicative life span of primary human cells by ectopic expression of hTERT...
  13. ncbi request reprint Microarray analysis of Bmi-1 downstream genes in normal human oral keratinocytes
    Felix K Yip
    University of California, School of Dentistry, Los Angeles 90095, USA
    J Calif Dent Assoc 35:858-64. 2007
    ..The authors report here several potential target genes of Bmi-1...
  14. doi request reprint Heterogeneous nuclear ribonucleoprotein G, nitric oxide, and oral carcinogenesis
    Ki Hyuk Shin
    School of Dentistry, Dental Research Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
    Nitric Oxide 19:125-32. 2008
    ..In this article, we review the role of hnRNP G in tumor suppression and maintenance of genetic integrity, with focus on its potential association with NO in the context of oral carcinogenesis...
  15. pmc hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip
    Ki Hyuk Shin
    School of Dentistry, University of California, CHS 43 033, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 372:880-5. 2008
    ..These studies indicate that hnRNP G promotes the expression of Txnip and mediates its tumor-suppressive effect...
  16. pmc A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion
    Jean Philippe Coppe
    California Pacific Medical Center, Research Institute, San Francisco, CA 94107, USA
    Mol Cancer Res 6:1085-98. 2008
    ..Thus, tobacco may not only initiate mutagenic changes in epithelial cells but also promote the growth and invasion of mutant cells by creating a procarcinogenic stromal environment...
  17. ncbi request reprint HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome
    Reuben H Kim
    UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Int J Oncol 33:777-82. 2008
    ..Our results indicate that HIV could play a role in the HPV-associated pathogenesis by exerting oncogenic stimulus via Tat protein...
  18. pmc p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    DNA Repair (Amst) 6:830-40. 2007
    ..Our results suggest that wt p53 modulates DNA DSB repair by, in part, inducing hnRNP G, and the ability of hnRNP G to bind and protect DNA ends may contribute its ability to promote the fidelity of DNA EJ...
  19. ncbi request reprint The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes
    Mo K Kang
    Dental Research Institute, University of California, 73 017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Mech Ageing Dev 123:585-92. 2002
    ..The short telomere length and decreased telomeric length heterogeneity in immortalized cells suggested that there is a critical minimum for cell survival...
  20. ncbi request reprint Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity
    Ki Hyuk Shin
    School of Dentistry, University of California, Los Angeles, California 90095, USA
    Clin Cancer Res 10:2551-60. 2004
    ..We investigated this possibility in normal human oral fibroblasts (NHOF) with and without ectopic expression of hTERT/telomerase...
  21. ncbi request reprint Telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts
    Mo K Kang
    UCLA School of Dentistry, University of California, CHS 53 038, 10833 Le Conte Ave, Los Angeles, CA 90095 1668, USA
    Mech Ageing Dev 124:873-6. 2003
    ..8 bp per year of age, which was not statistically significant (r=0.11; P>0.1). These data indicate that telomere shortening does not occur during donor aging in situ, and therefore, is not physiologically relevant for NHOF...
  22. ncbi request reprint Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence
    Mo K Kang
    School of Dentistry, University of California, Los Angeles, UCLA, CHS 53 038, 10833 Le Conte Avenue, Los Angeles, CA 90095 1668, USA
    Mech Ageing Dev 126:475-9. 2005
    ..However, the frequency of end joining errors was significantly elevated in NHOK during replicative senescence. Senescing NHOK could thus accumulate abnormal end joining products, which might contribute to cellular aging and cancer...
  23. ncbi request reprint Senescence-associated genes in normal human oral keratinocytes
    Mo K Kang
    School of Dentistry and Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Exp Cell Res 287:272-81. 2003
    ..These results indicate that the onset of senescence in NHOK is associated with altered expression of the SA genes, which represent discrete gene groups, independently of the donor variation or culture conditions...
  24. ncbi request reprint Absence of hamTERT gene expression is associated with promoter hypermethylation in immortal hamster buccal pouch epithelial cells
    Ayako Kameta
    Dental Research Institute, University of California, Los Angeles, CA, USA
    Int J Oncol 22:1351-6. 2003
    ..These results indicated that HBPE-SI cells maintained their telomere length in the absence of telomerase activity, and that hamTERT gene expression in these cells was silenced by hypermethylation of the promoter...
  25. ncbi request reprint Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells
    Ki Hyuk Shin
    School of Dentistry, University of California, Los Angeles, California 90095 1668, USA
    Clin Cancer Res 12:3222-8. 2006
    ..The current study was designed to test the hypothesis that hnRNP G is a tumor suppressor...
  26. ncbi request reprint Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes
    Reuben H Kim
    School of Dentistry at UCLA, Los Angeles, CA 90095, USA
    Exp Cell Res 313:462-72. 2007
    ..Our results provide new information on the roles of Bmi-1 and HPV-16 E6 in the multi-step process of oral epithelial carcinogenesis...
  27. ncbi request reprint Abnormal DNA end-joining activity in human head and neck cancer
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095 1668, USA
    Int J Mol Med 17:917-24. 2006
    ..These data indicated that aberrant DNA EJ activity may be partly responsible for genetic instability and oncogenic transformation...
  28. ncbi request reprint HPV-16 E6 oncoprotein impairs the fidelity of DNA end-joining via p53-dependent and -independent pathways
    Ki Hyuk Shin
    UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Int J Oncol 28:209-15. 2006
    ..These findings suggest that E6 can disrupt the fidelity of DSB repair via both p53-dependent and -independent pathways and the impaired fidelity might contribute to the development of genetic instability found in HPV-associated cancer...