Joonsoo Kang

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Randall H Friedline
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 206:421-34. 2009
  2. pmc Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
    Kavitha Narayan
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 13:511-8. 2012
  3. pmc IL-7: the global builder of the innate lymphoid network and beyond, one niche at a time
    Joonsoo Kang
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Immunol 24:190-7. 2012
  4. ncbi request reprint Cytokine functions in the formative stages of a lymphocyte's life
    Joonsoo Kang
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, S2 240, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Opin Immunol 16:180-90. 2004
  5. ncbi request reprint STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
  6. pmc A network of high-mobility group box transcription factors programs innate interleukin-17 production
    Nidhi Malhotra
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 38:681-93. 2013
  7. ncbi request reprint Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
    Heather J Melichar
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Science 315:230-3. 2007
  8. pmc Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function
    Nitya Jain
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:4192-6. 2009
  9. pmc The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells
    Catherine C Yin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 190:2659-69. 2013
  10. pmc Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo
    Martin Felices
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:8308-13. 2009

Research Grants

  1. ITK: an emerging target for treatment of T cell-mediated autoimmune disease
    Leslie J Berg; Fiscal Year: 2011
  2. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2007
  3. 'Mechanisms of CTLA-4 Function'
    Joonsoo Kang; Fiscal Year: 2006
  4. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2006
  5. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2003
  6. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
  7. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
  8. 'Mechanisms of CTLA-4 Function'
    Joonsoo Kang; Fiscal Year: 2005
  9. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
  10. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005

Collaborators

Detail Information

Publications43

  1. pmc CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
    Randall H Friedline
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Exp Med 206:421-34. 2009
    ..These results demonstrate that CTLA-4 is absolutely required for FOXP3(+) regulatory T cell function in vivo...
  2. pmc Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
    Kavitha Narayan
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 13:511-8. 2012
    ..The immature γδ subsets were distinguished by unique transcription-factor modules that program effector function...
  3. pmc IL-7: the global builder of the innate lymphoid network and beyond, one niche at a time
    Joonsoo Kang
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Semin Immunol 24:190-7. 2012
    ....
  4. ncbi request reprint Cytokine functions in the formative stages of a lymphocyte's life
    Joonsoo Kang
    Department of Pathology, Immunology and Virology Program, University of Massachusetts Medical School, S2 240, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Opin Immunol 16:180-90. 2004
    ..The influences of these core cytokines on precursor lymphocyte subsets overlap during development and are often synergistic. Recent studies are beginning to uncover the molecular mechanisms of these interrelated core cytokine functions...
  5. ncbi request reprint STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  6. pmc A network of high-mobility group box transcription factors programs innate interleukin-17 production
    Nidhi Malhotra
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 38:681-93. 2013
    ..These results indicate that similar gene network architecture programs innate sources of IL-17, independent of anatomical origins...
  7. ncbi request reprint Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
    Heather J Melichar
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Science 315:230-3. 2007
    ..Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes...
  8. pmc Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function
    Nitya Jain
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:4192-6. 2009
    ..However, not all aspects of Treg cell function are perturbed, and DAB2 appears to be dispensable for Treg cell function in maintaining naive T cell homeostasis...
  9. pmc The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells
    Catherine C Yin
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 190:2659-69. 2013
    ..These data indicate that Itk signaling is required to prevent the expansion of γδ NKT cells in the adult thymus, to block their emigration, and to promote terminal NKT cell maturation...
  10. pmc Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo
    Martin Felices
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 106:8308-13. 2009
    ..Together, these data indicate that Itk signaling regulates gammadelta T cell lineage development and effector function and is required to control IgE production in vivo...
  11. pmc SMAD2 is essential for TGF beta-mediated Th17 cell generation
    Nidhi Malhotra
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 285:29044-8. 2010
    ..These results demonstrate that SMAD2 is uniquely essential for TGFβ signaling in CD4(+) T effector cell differentiation...
  12. pmc Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity
    Nitya Jain
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 107:1524-8. 2010
    ....
  13. pmc CD28 and ITK signals regulate autoreactive T cell trafficking
    Nitya Jain
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Med 19:1632-7. 2013
    ....
  14. pmc Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes
    Hang Zhao
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nat Immunol 6:1263-71. 2005
    ..This cytokine-directed tissue-specific TCR repertoire formation probably reflects distinct TCR repertoire selection criteria for gammadelta and alphabeta T cell lineages adopted for different antigen-recognition strategies...
  15. pmc Noncanonical Wnt signaling promotes apoptosis in thymocyte development
    Huiling Liang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01545, USA
    J Exp Med 204:3077-84. 2007
    ..These results indicate that Wnt5a induction of the noncanonical Wnt-Ca(2+) pathway alters canonical Wnt signaling and is critical for normal T cell development...
  16. pmc Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:90-9. 2013
    ..Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes...
  17. ncbi request reprint Molecular events that regulate alphabeta versus gammadelta T cell lineage commitment: old suspects, new players and different game plans
    Kavitha Narayan
    University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Opin Immunol 19:169-75. 2007
    ..Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment...
  18. ncbi request reprint Integrated morphogen signal inputs in gammadelta versus alphabeta T-cell differentiation
    Heather Melichar
    Department of Pathology University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 215:32-45. 2007
    ..In this review, we summarize functions of morphogens in the thymus and provide a highly speculative model of integrated morphogen signals, potentially directing the gammadelta versus alphabeta T-cell fate determination process...
  19. pmc The transcriptional landscape of αβ T cell differentiation
    Michael Mingueneau
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:619-32. 2013
    ..The transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation...
  20. ncbi request reprint The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor
    Cynthia A Chambers
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    Blood 99:4509-16. 2002
    ..These results demonstrate the importance of inhibitory signals in T-cell homeostasis and suggest the common biochemical basis of inhibitory signaling pathways in T lymphocytes...
  21. pmc SMAD regulatory networks construct a balanced immune system
    Nidhi Malhotra
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunology 139:1-10. 2013
    ..This review highlights recent advances in unravelling the molecular basis for the multi-faceted functions of TGF-β in the gut that are dictacted by fluid orchestrations of SMADs and their myriad partners...
  22. ncbi request reprint Strength of T cell receptor signaling strikes again
    Leslie J Berg
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 31:529-31. 2009
    ..2009) demonstrate that signaling via the Itk kinase, a component of the T cell receptor signaling pathway, is required for interleukin-17A but not interleukin-17F expression in T helper 17 cells...
  23. ncbi request reprint Tec family kinases in T lymphocyte development and function
    Leslie J Berg
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Annu Rev Immunol 23:549-600. 2005
    ..Although they quantitatively reduce proximal signaling, mutations that eliminate Tec family kinases in T cells nonetheless qualitatively alter T cell development and differentiation...
  24. ncbi request reprint Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development
    Leslie J Berg
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Nat Rev Immunol 7:479-85. 2007
    ..These findings lead to the hypothesis that altered TCR signalling, together with distinct co-stimulatory signals, is the basis for the development of non-conventional T-cell lineages...
  25. pmc Innate PLZF+CD4+ αβ T Cells Develop and Expand in the Absence of Itk
    Amanda L Prince
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655 and
    J Immunol 193:673-87. 2014
    ..These data support the conclusion that itk(-/-) innate PLZF(+)CD4(+) T cells are a novel subset of innate T cells. ..
  26. pmc Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis
    Andrew H Coles
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Cancer Res 67:2054-61. 2007
    ..Furthermore, these data reveal that p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner...
  27. pmc Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment
    Kavitha Narayan
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, S3 137, Worcester, MA 01655, USA
    Semin Immunol 22:222-7. 2010
    ..A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal...
  28. ncbi request reprint The role of Tec family kinases in T cell development and function
    Julie A Lucas
    University of Massachussets Medical School Department of Pathology, Worcester, MA 01655, USA
    Immunol Rev 191:119-38. 2003
    ....
  29. ncbi request reprint The absence of Itk inhibits positive selection without changing lineage commitment
    Julie A Lucas
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 168:6142-51. 2002
    ....
  30. ncbi request reprint Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet
    Andrew T Miller
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester 01655, USA
    Immunity 21:67-80. 2004
    ..Together, these findings provide a molecular explanation for the essential role of Itk in Th2 differentiation...
  31. ncbi request reprint New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
    Andrew T Miller
    Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Curr Opin Immunol 14:331-40. 2002
    ..Genetic studies of kinase-knockout mice have emphasized the importance of Tec kinases in lymphocyte development, differentiation and apoptosis...
  32. ncbi request reprint Itk is not essential for CD28 signaling in naive T cells
    Cheng Rui Li
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:4475-9. 2005
    ..These findings indicate that Itk is not essential for CD28 signaling in primary naive CD4+ T cells...
  33. ncbi request reprint The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells
    Luana O Atherly
    Department of Pathology, University of Massachusetts Medical School, Worcester, 01655, USA
    Immunity 25:79-91. 2006
    ..These data indicate a critical role for Itk and Rlk in conventional CD8(+) T cell development in the thymus...
  34. ncbi request reprint Tec kinases in T cell and mast cell signaling
    Martin Felices
    Department of Pathology, University of Massachusetts Medical School, Massachusetts, USA
    Adv Immunol 93:145-84. 2007
    ..The known functions of Tec kinases in T cell and mast cell signaling will then be described, with a particular focus on T cell receptor and mast cell Fc epsilon RI signaling pathways...
  35. ncbi request reprint Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals
    Shane R Mayack
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 176:2059-63. 2006
    ..We conclude that Jak3 is a critical component of signaling pathways that regulate T cell differentiation into effector vs regulatory lineages...
  36. pmc Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation
    Min Shi
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunity 28:763-73. 2008
    ..These data indicate that Jak3 regulates epigenetic modification and chromatin remodeling of the Ifng locus during Th1 cell differentiation...
  37. ncbi request reprint Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help
    Luana O Atherly
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 176:1571-81. 2006
    ..These defects cannot be rescued by providing virus-specific CD4(+) T cell help, thereby substantiating the important role of Tec kinases in CD8(+) T cell signaling...
  38. pmc The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development
    Amanda L Prince
    Department of Pathology, University of Massachussets Medical School, Worcester, MA 01655, USA
    Immunol Rev 228:115-31. 2009
    ..Here we discuss these two signaling pathways that each contribute to conventional versus innate T-cell lineage commitment...
  39. pmc IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions
    Heather D Marshall
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 185:1419-28. 2010
    ....
  40. ncbi request reprint The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival
    Martin Felices
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 180:3007-18. 2008
    ..These data indicate that the Tec kinases Itk and Rlk provide important signals for terminal maturation, efficient cytokine production, and peripheral survival of NKT cells...
  41. pmc Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals
    Min Shi
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 183:4493-501. 2009
    ..Because CD28 signaling has been found to be dispensable for autoreactive T cell responses, these data suggest the potential for interfering with autoimmune T cell responses by inhibition of Jak3 signaling...
  42. ncbi request reprint Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase
    Andrew T Miller
    Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Immunol 168:2163-72. 2002
    ..Together these studies define an important role for Itk in TCR signaling, leading to cytokine gene expression and activation-induced cell death...
  43. ncbi request reprint Itk and Th2 responses: action but no reaction
    Yoko Kosaka
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Immunol 27:453-60. 2006
    ..In this review, we discuss the pathways by which Itk might impact the differentiation of Th cells...

Research Grants14

  1. ITK: an emerging target for treatment of T cell-mediated autoimmune disease
    Leslie J Berg; Fiscal Year: 2011
    ..A better understanding of this mechanism may provide opportunities to prevent the onset of autoimmune processes in susceptible individuals and to treat and cure patients with these diseases. ..
  2. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2007
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  3. 'Mechanisms of CTLA-4 Function'
    Joonsoo Kang; Fiscal Year: 2006
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  4. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2006
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  5. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2003
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  6. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  7. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  8. 'Mechanisms of CTLA-4 Function'
    Joonsoo Kang; Fiscal Year: 2005
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  9. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  10. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  11. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2005
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  12. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2002
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  13. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2004
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..