P A Kanetsky

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women
    P A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nutr Cancer 31:31-40. 1998
  2. ncbi request reprint Interaction of glutathione S-transferase M1 and T1 genotypes and malignant melanoma
    P A Kanetsky
    Departments of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 10:509-13. 2001
  3. pmc A polymorphism in the agouti signaling protein gene is associated with human pigmentation
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Am J Hum Genet 70:770-5. 2002
  4. ncbi request reprint Assessment of polymorphic variants in the melanocortin-1 receptor gene with cutaneous pigmentation using an evolutionary approach
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, Division of Hematology Oncology, Center for Clinical Epidemiology and Biostatistics and Epidemiology, University of Pennsylvania, 903 Blockley Hall, Philadelphia, PA 19104 6021
    Cancer Epidemiol Biomarkers Prev 13:808-19. 2004
  5. ncbi request reprint Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 66:9330-7. 2006
  6. ncbi request reprint Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism
    Charnita Zeigler-Johnson
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pigment Cell Res 17:185-7. 2004
  7. pmc Development of a novel location-based assessment of sensory symptoms in cancer patients: preliminary reliability and validity assessment
    Adam R Burkey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Pain Symptom Manage 37:848-62. 2009
  8. pmc Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?
    Peter A Kanetsky
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer 116:2416-28. 2010
  9. pmc The Y deletion gr/gr and susceptibility to testicular germ cell tumor
    Katherine L Nathanson
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 77:1034-43. 2005
  10. ncbi request reprint P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002

Research Grants

  1. MELANOMA AND ALLELIC VARIATION IN THE MCIR GENE
    Peter Kanetsky; Fiscal Year: 2005

Detail Information

Publications23

  1. ncbi request reprint Dietary intake and blood levels of lycopene: association with cervical dysplasia among non-Hispanic, black women
    P A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nutr Cancer 31:31-40. 1998
    ..Overall, correlations between estimates from the FFQ and serum levels were poor. This study indicates that, among black women, lycopene and perhaps vitamin A may play a protective role in the early stages of cervical carcinogenesis...
  2. ncbi request reprint Interaction of glutathione S-transferase M1 and T1 genotypes and malignant melanoma
    P A Kanetsky
    Departments of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 10:509-13. 2001
    ..5; 95% CI, 1.2-73) compared with those without CMM. These data suggest that among persons with hair colors traditionally associated with increased risk for melanoma, absence of both GSTM1 and GSTT1 may act to further elevate CMM risk...
  3. pmc A polymorphism in the agouti signaling protein gene is associated with human pigmentation
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Am J Hum Genet 70:770-5. 2002
    ..This is the first report of an association of ASIP with specific human pigmentation characteristics. It remains to be investigated whether the interaction of MC1R and ASIP can enhance prediction of human pigmentation and melanoma risk...
  4. ncbi request reprint Assessment of polymorphic variants in the melanocortin-1 receptor gene with cutaneous pigmentation using an evolutionary approach
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, Division of Hematology Oncology, Center for Clinical Epidemiology and Biostatistics and Epidemiology, University of Pennsylvania, 903 Blockley Hall, Philadelphia, PA 19104 6021
    Cancer Epidemiol Biomarkers Prev 13:808-19. 2004
    ..S. Caucasians. Risk variants defined by either the published literature or by evolutionary criteria are strongly and significantly associated with all fair pigmentation phenotypes that were measured...
  5. ncbi request reprint Population-based study of natural variation in the melanocortin-1 receptor gene and melanoma
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer Res 66:9330-7. 2006
    ....
  6. ncbi request reprint Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism
    Charnita Zeigler-Johnson
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pigment Cell Res 17:185-7. 2004
    ....
  7. pmc Development of a novel location-based assessment of sensory symptoms in cancer patients: preliminary reliability and validity assessment
    Adam R Burkey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Pain Symptom Manage 37:848-62. 2009
    ....
  8. pmc Does MC1R genotype convey information about melanoma risk beyond risk phenotypes?
    Peter A Kanetsky
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cancer 116:2416-28. 2010
    ..A study was carried out to describe associations of MC1R variants and melanoma in a US population and to investigate whether genetic risk is modified by pigmentation characteristics and sun exposure measures...
  9. pmc The Y deletion gr/gr and susceptibility to testicular germ cell tumor
    Katherine L Nathanson
    Department of Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Hum Genet 77:1034-43. 2005
    ..0; 95% CI 1.6-5.4; P = .0004) than with nonseminoma TGCT (aOR 1.5; 95% CI 0.72-3.0; P = .29). These data indicate that the Y microdeletion gr/gr is a rare, low-penetrance allele that confers susceptibility to TGCT...
  10. ncbi request reprint P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002
    ..001), or the combination of both variants (P = 0.003). These results suggest that P gene, in part, determines normal phenotypic variation in human eye color and may therefore represent an inherited biomarker of cutaneous cancer risk...
  11. pmc Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
    Peter A Kanetsky
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Nat Genet 41:811-5. 2009
    ..All of the genotypes were associated with both seminoma and nonseminoma TGCT subtypes. These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility...
  12. ncbi request reprint Allelic variants in HOX genes in cryptorchidism
    Yanping Wang
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Birth Defects Res A Clin Mol Teratol 79:269-75. 2007
    ..Findings from animal models and small clinical studies suggest that the posterior HOX genes (paralogs 9-13) could be potential candidate genes for cryptorchidism and that the HOX genes are functionally redundant within paralogous groups...
  13. pmc Collapse of the CD27+ B-cell compartment associated with systemic plasmacytosis in patients with advanced melanoma and other cancers
    Erica L Carpenter
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 15:4277-87. 2009
    ..This study aimed to investigate whether B-cell physiology was altered in the presence of melanoma and other cancers...
  14. ncbi request reprint p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
    Emad Kaabipour
    Department of Pathology, Pennsylvania Hospital, Philadelphia, PA 19107, USA
    Arch Pathol Lab Med 130:69-73. 2006
    ..Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma...
  15. pmc A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)
    Mark Harland
    Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
    Eur J Cancer 44:1269-74. 2008
    ..The relatively low rate of CDKN2A mutation detection is not due to failure to detect mutations and implies the existence of other high penetrance melanoma susceptibility genes...
  16. ncbi request reprint CDKN2A germline mutations in individuals with cutaneous malignant melanoma
    Irene Orlow
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Invest Dermatol 127:1234-43. 2007
    ..With the exception of the variant in position -34 of CDKN2A of known functional consequence, the remaining rare variants in the non-coding region have no apparent impact on risk...
  17. ncbi request reprint Ambient UV, personal sun exposure and risk of multiple primary melanomas
    Anne Kricker
    School of Public Health, University of Sydney, Edward Ford Building A27, NSW, 2006, Australia, and Women s College Hospital, Toronto, ON, Canada
    Cancer Causes Control 18:295-304. 2007
    ..Sun exposure is the main cause of melanoma in populations of European origin. No previous study has examined the effect of sun exposure on risk of multiple primary melanomas compared with people who have one melanoma...
  18. ncbi request reprint High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    Cancer Res 66:9818-28. 2006
    ..This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available...
  19. ncbi request reprint MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 97:998-1007. 2005
    ..We examined MC1R and ASIP genotypes in relation to phenotypic characteristics, sporadic and familial melanoma risk, and melanoma thickness as an indicator of disease progression in a Mediterranean population...
  20. ncbi request reprint The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study
    Marianne Berwick
    University of New Mexico, Department of Internal Medicine, New Mexico Cancer Research Facility, MSC08 4630, Room 103A, 1 University of New Mexico, Albuquerque, NM 87131, USA
    Cancer Epidemiol Biomarkers Prev 15:1520-5. 2006
    ..The results suggest that the relative risk of mutation carriers in the population may be lower than currently believed and that different mutations on the CDKN2A gene may confer substantially different risks of melanoma...
  21. ncbi request reprint MC1R germline variants confer risk for BRAF-mutant melanoma
    Maria Teresa Landi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Science 313:521-2. 2006
    ..In this tumor subtype, the risk for melanoma associated with MC1R is due to an increase in risk of developing melanomas with BRAF mutations...
  22. ncbi request reprint Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer
    Jiyoung Ahn
    Division of Cancer Prevention and Population Science, Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 12:7063-70. 2006
    ....
  23. pmc Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    J Med Genet 44:99-106. 2007
    ....

Research Grants1

  1. MELANOMA AND ALLELIC VARIATION IN THE MCIR GENE
    Peter Kanetsky; Fiscal Year: 2005
    ..Result from this project may provide valuable insight into the genetic predisposition to melanoma seen in some families, and may lead to more efficient mechanisms of primary prevention and clinical follow-up within these families. ..