Edna S Kaneshiro

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. doi Highlights and summaries of the 11th International Workshops on Opportunistic Protists
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 58:1-6. 2011
  2. ncbi Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT
    D Nicole Worsham
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA
    J Eukaryot Microbiol 50:678-9. 2003
  3. pmc Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone
    Mireille Basselin
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Eukaryot Cell 4:1483-92. 2005
  4. ncbi Ubiquinone synthesis and its regulation in Pneumocystis carinii
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA
    J Eukaryot Microbiol 53:435-44. 2006
  5. ncbi Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Lipids 39:753-61. 2004
  6. ncbi Evidence that biosynthesis of individual ubiquinone homologs in Pneumocystis carinii is under homolog-specific negative feedback (product) control
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA
    J Eukaryot Microbiol 50:622-3. 2003
  7. ncbi Sterol biosynthesis in Pneumocystis: unique steps that define unique targets
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, OH 45221, USA
    Drug Resist Updat 5:259-68. 2002
  8. ncbi Is Pneumocystis a plant?
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Ohio 45221, USA
    J Eukaryot Microbiol 49:367-73. 2002
  9. ncbi The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Mol Microbiol 44:989-99. 2002
  10. ncbi The International Workshops on Opportunistic Protists
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 53:S1-7. 2006

Collaborators

Detail Information

Publications14

  1. doi Highlights and summaries of the 11th International Workshops on Opportunistic Protists
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 58:1-6. 2011
    ....
  2. ncbi Evidence for cholesterol scavenging by Pneumocystis and potential modifications of host-synthesized sterols by the P. carinii SAM:SMT
    D Nicole Worsham
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH, USA
    J Eukaryot Microbiol 50:678-9. 2003
  3. pmc Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone
    Mireille Basselin
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Eukaryot Cell 4:1483-92. 2005
    ..This is the first pathogenic eukaryotic microorganism in which biosynthesis of CoQ molecules from the initial PHBA:polyprenyl transferase reaction has been unambiguously shown to occur in two distinct compartments of the same cell...
  4. ncbi Ubiquinone synthesis and its regulation in Pneumocystis carinii
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA
    J Eukaryot Microbiol 53:435-44. 2006
    ..These studies on P. carinii suggest that cellular sites and the control of CoQ synthesis in different organisms and cell types might be more diverse than previously thought...
  5. ncbi Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USA
    Lipids 39:753-61. 2004
    ..The latter phenotype apparently represents organisms blocked at 14alpha-demethylation of the sterol nucleus. These studies suggest that SAM:SMT is an attractive drug target for developing new chemotherapy for PcP...
  6. ncbi Evidence that biosynthesis of individual ubiquinone homologs in Pneumocystis carinii is under homolog-specific negative feedback (product) control
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221, USA
    J Eukaryot Microbiol 50:622-3. 2003
  7. ncbi Sterol biosynthesis in Pneumocystis: unique steps that define unique targets
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, OH 45221, USA
    Drug Resist Updat 5:259-68. 2002
    ..carinii. The P. carinii S-adenosyl-L-methionine:sterol C-24 methyl transferase (SAM:SMT) has unique properties; it prefers lanosterol as its sterol substrate...
  8. ncbi Is Pneumocystis a plant?
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Ohio 45221, USA
    J Eukaryot Microbiol 49:367-73. 2002
    ..C31 24-Methylenelanosterol and C32 pneumocysterol, products of SAM:SMT activity on lanosterol, can accumulate in high amounts in some, but not all, human-derived Pneumocystis jiroveci populations...
  9. ncbi The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, OH 45221 0006, USA
    Mol Microbiol 44:989-99. 2002
    ..These observations, together with the absence of SAM:SMT among mammals, further support the identification of sterol C-24 alkylation reactions as excellent targets for the development of drugs specifically directed against this pathogen...
  10. ncbi The International Workshops on Opportunistic Protists
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 53:S1-7. 2006
  11. doi Identification of Naegleria fowleri in warm ground water aquifers
    Ian Laseke
    Dep of Civil and Environmental Engineering, Univ of Cincinnati, Cincinnati, OH, USA
    J Environ Qual 39:147-53. 2010
    ..Bacterial community analyses revealed a very diverse community structure in ground water samples testing positive for N. fowleri...
  12. doi Evidence for DNA synthesis in Pneumocystis carinii trophozoites treated with the beta-1,3-glucan synthesis inhibitor pneumocandin L-693,989
    Michael A Wyder
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 57:447-8. 2010
    ..Fluorescence intensities of trophozoite nuclei from drug-treated rats were greater than those of untreated controls, suggesting that DNA replication was not inhibited but that cytokinesis and perhaps karyokinesis were blocked...
  13. ncbi The sequence of the erg11 gene in form 1 and form 6 of Pneumocystis carinii are identical
    Stephenson W Nkinin
    Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221 0006, USA
    J Eukaryot Microbiol 53:S147-8. 2006
  14. ncbi Bacteriovorax stolpii proliferation and predation without sphingophosphonolipids
    Edna S Kaneshiro
    Department of Biological Sciences, University of Cincinnati, 720 Rieveschl Hall, ML 0006, Cincinnati, OH 45221 0006, USA
    Biochem Biophys Res Commun 367:21-5. 2008
    ..These observations open up the possibility for a role of sphingophosphonolipids in B. stolpii UKi2 complex behavior...