Yuji Kaneko

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy
    Yuji Kaneko
    Center of Excellence for Aging and Brain, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Mol Neurobiol 53:1874-83. 2016
  2. pmc Dietary supplementations as neuroprotective therapies: focus on NT-020 diet benefits in a rat model of stroke
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA E Mails Y K L C S A P C B
    Int J Mol Sci 13:7424-44. 2012
  3. pmc Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
    Noriyuki Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    BMC Neurosci 10:126. 2009
  4. pmc Ischemic stroke brain sends indirect cell death signals to the heart
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M and Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D
    Stroke 44:3175-82. 2013
  5. pmc Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, K S, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M Medical Research Institute, Chung Ang University College of Medicine, Seoul, Korea H J L Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D and Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada S U K
    Stroke 44:3473-81. 2013
  6. pmc Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e53376. 2013
  7. pmc Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e74857. 2013
  8. doi request reprint Bone marrow-derived stem cell therapy for metastatic brain cancers
    Yuji Kaneko
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 24:625-30. 2015
  9. pmc Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair and School of Physical Therapy and Rehabilitation Sciences, University of South Florida Morsani College of Medicine, Tampa, Florida 33612, James A Haley Veterans Affairs Hospital, Research Service, Tampa, Florida 33612, and Departments of Molecular Pharmacology and Physiology and Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612
    J Neurosci 34:313-26. 2014
  10. pmc In vivo animal stroke models: a rationale for rodent and non-human primate models
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida USA
    Transl Stroke Res 4:308-21. 2013

Collaborators

Detail Information

Publications42

  1. pmc Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy
    Yuji Kaneko
    Center of Excellence for Aging and Brain, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Mol Neurobiol 53:1874-83. 2016
    ....
  2. pmc Dietary supplementations as neuroprotective therapies: focus on NT-020 diet benefits in a rat model of stroke
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA E Mails Y K L C S A P C B
    Int J Mol Sci 13:7424-44. 2012
    ..We envision dietary supplementation as an adjunct therapy for stroke at acute, subacute, and even chronic periods...
  3. pmc Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
    Noriyuki Matsukawa
    Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    BMC Neurosci 10:126. 2009
    ..Assessment of the mechanism underlying minocycline neuroprotection should clarify the drug's clinical value in acute stroke setting...
  4. pmc Ischemic stroke brain sends indirect cell death signals to the heart
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M and Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D
    Stroke 44:3175-82. 2013
    ..However, it remains uncertain how an ischemic brain contributes to cardiac alternations. Here, we used experimental stroke models to reveal the pathological effects of the ischemic brain on the heart...
  5. pmc Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation
    Hiroto Ishikawa
    From the Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL H I, N T, K S, J V, Y K, C V B Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan H I, O M Medical Research Institute, Chung Ang University College of Medicine, Seoul, Korea H J L Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology, Tohoku University Graduate School of Medicine, Sendai, Japan M D and Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada S U K
    Stroke 44:3473-81. 2013
    ..Here, we examined the role of stem cell-mediated vascular repair in stroke...
  6. pmc Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e53376. 2013
    ..Therapeutic intervention at the chronic stage of TBI may confer abrogation of these deleterious cell death processes...
  7. pmc Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e74857. 2013
    ....
  8. doi request reprint Bone marrow-derived stem cell therapy for metastatic brain cancers
    Yuji Kaneko
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 24:625-30. 2015
    ..Abrogating this leaky BBB-mediated inflammation via stem cell therapy represents a paradigm-shifting approach to treating brain cancer. This review article discusses the pros and cons of cell therapy for melanoma brain metastases. ..
  9. pmc Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair and School of Physical Therapy and Rehabilitation Sciences, University of South Florida Morsani College of Medicine, Tampa, Florida 33612, James A Haley Veterans Affairs Hospital, Research Service, Tampa, Florida 33612, and Departments of Molecular Pharmacology and Physiology and Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612
    J Neurosci 34:313-26. 2014
    ..Furthermore, hADSCs showed reduced efficacy in aged rats, which may in part result from decreased homing of the cells to the spleen. ..
  10. pmc In vivo animal stroke models: a rationale for rodent and non-human primate models
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida USA
    Transl Stroke Res 4:308-21. 2013
    ..An emphasis in the present discussion of therapeutics development is given to stem cell therapy for stroke...
  11. pmc Advancing critical care medicine with stem cell therapy and hypothermia for cerebral palsy
    Travis Dailey
    Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, Florida, USA
    Neuroreport 24:1067-71. 2013
    ....
  12. pmc The battle of the sexes for stroke therapy: female- versus male-derived stem cells
    Yuji Kaneko
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair University of South Florida, College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    CNS Neurol Disord Drug Targets 12:405-12. 2013
    ..We highlight the practicality of experimental and clinical application of menstrual blood cells and Sertoli cells to treat stroke, from cell isolation and cryopreservation to administration...
  13. ncbi request reprint Cerebral aneurysm as an exacerbating factor in stroke pathology and a therapeutic target for neuroprotection
    Naoki Tajiri
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Curr Pharm Des 18:3663-9. 2012
    ..To this end, we discuss the laboratory and clinical evidence implicating aneurysm formation in stroke and also provide insights on how stem cell therapy may prove efficacious in combating aneurysm and stroke...
  14. pmc Cell therapy for stroke: emphasis on optimizing safety and efficacy profile of endothelial progenitor cells
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, Florida 33612, USA
    Curr Pharm Des 18:3731-4. 2012
    ..This review article discusses translational challenges associated in cell therapy, emphasizing the need for optimizing both safety and efficacy profiles for advancing the clinical applications of EPC transplantation for stroke patients...
  15. pmc Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e81585. 2013
    ....
  16. pmc Regeneration of neuronal cells following cerebral injury
    Travis Dailey
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Front Neurol Neurosci 32:54-61. 2013
    ..Furthermore, we outline specific mechanisms of action along with their clinical potential as therapeutic treatments for ischemic stroke. ..
  17. pmc Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats
    Naoki Tajiri
    Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e43779. 2012
    ..This study reports the therapeutic potential of AFS cell transplantation in stroke animals, possibly via enhancement of endogenous repair mechanisms...
  18. pmc Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation
    SeongJin Yu
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 8:e76329. 2013
    ..This study supports the use of stem cells for stroke therapy and implicates a key role of Hsp27 signaling pathway in neuroprotection. ..
  19. pmc Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e90953. 2014
    ..These results suggest that combined treatment rather than monotherapy appears optimal for abrogating histophalogical and motor impairments in chronic TBI. ..
  20. doi request reprint Stroke and cardiac cell death: Two peas in a pod
    Chiara Gonzales-Portillo
    University of South Florida, Department of Neurosurgery and Brain Repair, Tampa, FL, USA
    Clin Neurol Neurosurg 142:145-7. 2016
    ....
  21. doi request reprint A possible new focus for stroke treatment - migrating stem cells
    Robert Sullivan
    University of South Florida College of Medicine, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, 12901 Bruce B Downs Blvd, Tampa, FL, USA 1 813 974 3154 1 813 974 3078
    Expert Opin Biol Ther 15:949-58. 2015
    ..More so, its infliction often leaves patients with lasting morbidity and deficits. Ischemic stroke comprises nearly 90% of incidents and the majority of medical treatment aims at reestablishing perfusion and preventing recurrence...
  22. pmc DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, USA
    Neurobiol Dis 62:56-61. 2014
    ..DJ-1 was detected immediately after stroke and efficiently translocated into the mitochondria offering a new venue for developing treatment strategies against ischemic stroke. ..
  23. pmc Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease
    Sandra A Acosta
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida
    J Cell Physiol 230:1024-32. 2015
    ....
  24. doi request reprint No pain, no gain: lack of exercise obstructs neurogenesis
    Nate Watson
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    Cell Transplant 24:591-7. 2015
    ..Studies designed to reveal how in vivo stimulation, or lack thereof, alters the stem cell microenvironment are needed to begin to develop treatment strategies for enhancing neurogenesis in bedridden patients. ..
  25. pmc Epidemiological survey-based formulae to approximate incidence and prevalence of neurological disorders in the United States: a meta-analysis
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida, United States of America
    PLoS ONE 8:e78490. 2013
    ..We report here the incidence and prevalence of the major adult-onset brain disorders in the United States using a meta-analysis approach...
  26. doi request reprint Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells
    Paula C Bickford
    Research Service, James A Haley Veterans Affairs Hospital, Tampa, FL, 33620, USA
    Age (Dordr) 37:103. 2015
    ..Serum from aged rats treated with NT-020 was not different from serum from young rats. Therefore, NT-020 rescued the effect of serum from aged rats to reduce stem cell proliferation...
  27. doi request reprint Brain Region-Specific Histopathological Effects of Varying Trajectories of Controlled Cortical Impact Injury Model of Traumatic Brain Injury
    Mibel M Pabon
    Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida College of Medicine, Tampa, FL, USA
    CNS Neurosci Ther 22:200-11. 2016
    ..The aim of this study was to examine the histopathological effects of different angles of mechanical injury by manipulating the trajectory of the controlled cortical impact injury (CCI) model in adult Sprague-Dawley rats...
  28. doi request reprint Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy
    Kelsey Duncan
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, United States
    Brain Res 1623:160-5. 2015
    ..This article is part of a Special Issue entitled SI: Cell Interactions In Stroke. ..
  29. pmc Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e47583. 2012
    ....
  30. pmc Autologous stem cell transplant with gene therapy for Friedreich ataxia
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Med Hypotheses 83:296-8. 2014
    ....
  31. pmc Delta opioid receptor and its peptide: a receptor-ligand neuroprotection
    Meaghan Staples
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Int J Mol Sci 14:17410-9. 2013
    ..In its entirety, the delta opioid system represents a promising target for neural therapies. ..
  32. doi request reprint Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke
    Sandra A Acosta
    From the Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa
    Stroke 46:2616-27. 2015
    ..Adult stem cell therapy is an experimental stroke treatment. Here, we assessed homing and anti-inflammatory effects of bone marrow stromal cells (hBMSCs) in chronic stroke...
  33. pmc Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis
    Ike C Dela Peña
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, Florida, USA
    J Cereb Blood Flow Metab 35:338-46. 2015
    ..The use of G-CSF to protect the vasculature may improve the clinical outcome of tPA even outside the currently indicated therapeutic window for ischemic stroke. ..
  34. pmc Toward personalized cell therapies: autologous menstrual blood cells for stroke
    Maria Carolina O Rodrigues
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Biomed Biotechnol 2011:194720. 2011
    ..Practical aspects of clinical application of menstrual blood cells for stroke will be discussed, from cell harvesting and cryopreservation to administration to the patient...
  35. pmc Adult stem cell transplantation: is gender a factor in stemness?
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Int J Mol Sci 15:15225-43. 2014
    ....
  36. pmc Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Brain Res 1559:65-71. 2014
    ..These results suggest a robust, immediate anti-inflammatory response mounted by the contralateral hemisphere of the young brain. ..
  37. pmc Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: a potent stroke therapeutic target
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA
    CNS Neurosci Ther 20:275-81. 2014
    ..In particular, we examined DJ-1 secretion from primary rat neural cells (PRNCs) exposed to experimental stroke...
  38. pmc The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders
    Cesar V Borlongan
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Prog Neurobiol 95:213-28. 2011
    ..When possible, we also discuss the relevance of this therapeutic regimen in other central nervous system (CNS) disorders...
  39. pmc Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model
    Loren E Glover
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 7:e33646. 2012
    ..That immediate, but not delayed, skull reconstruction may exacerbate TBI-induced cortical tissue damage warrants a careful consideration of aesthetic repair of the skull in TBI...
  40. pmc Stroke in the eye of the beholder
    Hiroto Ishikawa
    Department of Neurosurgery and Brain Repair, 12901 Bruce B Downs Blvd, University of South Florida, Tampa, FL 33612, USA
    Med Hypotheses 80:411-5. 2013
    ..That retinal damage is closely associated with ischemic stroke, yet remains neglected in stroke treatment regimen, provides the impetus for recognizing the treatment of retinal damage as a critical component of stroke therapy...
  41. doi request reprint Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection
    Yuji Kaneko
    Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA
    J Pineal Res 50:272-80. 2011
    ....
  42. pmc Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines
    Naoki Tajiri
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, Florida, United States of America
    PLoS ONE 9:e91408. 2014
    ..Despite absence of reduction in infarct volume, NSI-566RSC transplantation produced behavioral improvements possibly via robust engraftment and neuronal differentiation, supporting the use of this NSC line for stroke therapy. ..