Christopher J Kane

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Body mass index, prostate weight and transrectal ultrasound prostate volume accuracy
    Kamran P Sajadi
    Augusta Veterans Affairs Medical Center and Medical College of Georgia, Augusta, Georgia 30912, USA
    J Urol 178:990-5. 2007
  2. ncbi request reprint Changing nature of high risk patients undergoing radical prostatectomy
    Christopher J Kane
    Urology Section, Department of Surgery, Veterans Administration Medical Center San Francisco, San Francisco, USA
    J Urol 177:113-7. 2007
  3. ncbi request reprint Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE
    Christopher J Kane
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, USA
    J Urol 173:732-6. 2005
  4. ncbi request reprint Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:742-7. 2003
  5. ncbi request reprint Multigene methylation analysis for detection and staging of prostate cancer
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Clin Cancer Res 11:6582-8. 2005
  6. ncbi request reprint Improved clinical staging system combining biopsy laterality and TNM stage for men with T1c and T2 prostate cancer: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine and Department of Surgery, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    J Urol 169:2129-35. 2003
  7. ncbi request reprint Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer 106:79-86. 2006
  8. pmc What are the factors associated with short prostate specific antigen doubling time after radical prostatectomy? A report from the SEARCH database group
    Anna E Teeter
    Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Urol 180:1980-4; discussion 1985. 2008
  9. ncbi request reprint Ethnic group-related differences in CpG hypermethylation of the GSTP1 gene promoter among African-American, Caucasian and Asian patients with prostate cancer
    Hideki Enokida
    Department of Urology and Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Int J Cancer 116:174-81. 2005
  10. ncbi request reprint Do younger men have better biochemical outcomes after radical prostatectomy?
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 63:518-22. 2004

Detail Information

Publications92

  1. ncbi request reprint Body mass index, prostate weight and transrectal ultrasound prostate volume accuracy
    Kamran P Sajadi
    Augusta Veterans Affairs Medical Center and Medical College of Georgia, Augusta, Georgia 30912, USA
    J Urol 178:990-5. 2007
    ..We hypothesized that obesity may represent a technical challenge when performing transrectal ultrasound that decreases the accuracy of estimating prostate volume...
  2. ncbi request reprint Changing nature of high risk patients undergoing radical prostatectomy
    Christopher J Kane
    Urology Section, Department of Surgery, Veterans Administration Medical Center San Francisco, San Francisco, USA
    J Urol 177:113-7. 2007
    ..We examined the outcomes of radical prostatectomy alone in high risk patients with prostate cancer and evaluated changes in high risk prostate cancer outcomes with time...
  3. ncbi request reprint Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE
    Christopher J Kane
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, USA
    J Urol 173:732-6. 2005
    ..We investigated the association of obesity with prostate cancer case demographics and clinical disease features at presentation...
  4. ncbi request reprint Comparison of percentage of total prostate needle biopsy tissue with cancer to percentage of cores with cancer for predicting PSA recurrence after radical prostatectomy: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:742-7. 2003
    ..We compared the total percentage of biopsy tissue with cancer to the percentage of cores positive for their ability to predict adverse pathologic findings and biochemical failure after radical prostatectomy (RP)...
  5. ncbi request reprint Multigene methylation analysis for detection and staging of prostate cancer
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Clin Cancer Res 11:6582-8. 2005
    ..We hypothesize that a new method of multigene methylation analysis could be a good diagnostic and staging biomarker for prostate cancer...
  6. ncbi request reprint Improved clinical staging system combining biopsy laterality and TNM stage for men with T1c and T2 prostate cancer: results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine and Department of Surgery, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    J Urol 169:2129-35. 2003
    ..We determined whether we could improve the prognostic value of the TNM staging system in men with cT1c and cT2 cancers by including information on whether prostate needle biopsy was unilaterally or bilaterally positive...
  7. ncbi request reprint Smoking influences aberrant CpG hypermethylation of multiple genes in human prostate carcinoma
    Hideki Enokida
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, California 94121, USA
    Cancer 106:79-86. 2006
    ..The authors hypothesized that smoking influences both progression and prognosis of PC through CpG hypermethylation of related genes...
  8. pmc What are the factors associated with short prostate specific antigen doubling time after radical prostatectomy? A report from the SEARCH database group
    Anna E Teeter
    Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Urol 180:1980-4; discussion 1985. 2008
    ..We determined which demographic and clinicopathological variables were predictive of a short prostate specific antigen doubling time in a cohort of men with clinically localized prostate cancer treated with radical prostatectomy...
  9. ncbi request reprint Ethnic group-related differences in CpG hypermethylation of the GSTP1 gene promoter among African-American, Caucasian and Asian patients with prostate cancer
    Hideki Enokida
    Department of Urology and Pathology, Veterans Affairs Medical Center and University of California, San Francisco, CA 94121, USA
    Int J Cancer 116:174-81. 2005
    ..Ours is the first study investigating GSTP1 methylation differences in PC among African-American, Caucasian and Asian...
  10. ncbi request reprint Do younger men have better biochemical outcomes after radical prostatectomy?
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Urology 63:518-22. 2004
    ..Prior studies have suggested that younger men have lower prostate-specific antigen recurrence rates after RP, although none of the prior studies had controlled for the year of surgery...
  11. pmc Postoperative prostate-specific antigen nadir improves accuracy for predicting biochemical recurrence after radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) and Duke Prostate Center databases
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center Department of Pathology, Duke University School of Medicine Urology Section, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Int J Urol 17:914-22. 2010
    ..Herein, we sought to explore the effect of including PSA nadir into commonly used models on their accuracy to predict BCR after RP...
  12. ncbi request reprint Multiinstitutional validation of the UCSF cancer of the prostate risk assessment for prediction of recurrence after radical prostatectomy
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Cancer 107:2384-91. 2006
    ..This study used a large external dataset to validate CAPRA...
  13. ncbi request reprint Percent of prostate needle biopsy cores with cancer is significant independent predictor of prostate specific antigen recurrence following radical prostatectomy: results from SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles, Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2136-41. 2003
    ..We evaluate whether either percent of cores with cancer or percent of cores positive from the most and least involved side of the prostate needle biopsy was associated with a worse outcome among men treated with radical prostatectomy...
  14. ncbi request reprint Time trends in biochemical recurrence after radical prostatectomy: results of the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, 90095 1738, USA
    Urology 61:736-41. 2003
    ..We also examined whether the biochemical recurrence rates after RP have changed with time...
  15. pmc Effect of race and socioeconomic status on surgical margins and biochemical outcomes in an equal-access health care setting: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    David I Chu
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Cancer 118:4999-5007. 2012
    ..The associations of race/SES with intermediate CaP outcomes, including positive surgical margin (PSM) and biochemical recurrence (BCR), were explored in an equal-access setting...
  16. ncbi request reprint Ability of 2 pretreatment risk assessment methods to predict prostate cancer recurrence after radical prostatectomy: data from CaPSURE
    Joseph A Mitchell
    Department of Urology, Urology Outcomes Research Group, University of California, San Francisco, USA
    J Urol 173:1126-31. 2005
    ..We tested the 2 instruments in the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database, a national registry of patients with prostate cancer, to assess their accuracy in a community based cohort...
  17. doi request reprint Validation of a nomogram to predict disease progression following salvage radiotherapy after radical prostatectomy: results from the SEARCH database
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 104:1452-6. 2009
    ..termed the 'Stephenson nomogram') to predict disease progression after salvage radiotherapy (SRT) among patients with prostate cancer from the Shared Equal Access Regional Cancer Hospital (SEARCH) database...
  18. ncbi request reprint Should a positive surgical margin following radical prostatectomy be pathological stage T2 or T3? Results from the SEARCH database
    Stephen J Freedland
    Department of Urology, University of California Los Angeles and Department of Surgery, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California 90095, USA
    J Urol 169:2142-6. 2003
    ..We examined the significance of the pathological features of positive surgical margin and extracapsular extension for predicting biochemical failure following radical prostatectomy...
  19. ncbi request reprint Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Clin Cancer Res 11:7735-42. 2005
    ..However, hormonal activity and diets vary between races. We examined whether height was significantly associated with biochemical progression following radical prostatectomy and whether there was an interaction between height and race...
  20. pmc Obesity, prostate-specific antigen nadir, and biochemical recurrence after radical prostatectomy: biology or technique? Results from the SEARCH database
    Tammy Ho
    Divison of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Eur Urol 62:910-6. 2012
    ..Obesity is associated with an increased risk of biochemical recurrence (BCR) after radical prostatectomy (RP). It is unclear whether this is due to technical challenges related to operating on obese men or other biologic factors...
  21. ncbi request reprint The impact of obesity on health related quality of life before and after radical prostatectomy (data from CaPSURE)
    Jason W Anast
    Department of Urology and UCSF Mt Zion Comprehensive Cancer Center, University of California, San Francisco, USA
    J Urol 173:1132-8. 2005
    ..We determined if there are differences in the HRQOL of obese men at diagnosis and after radical prostatectomy compared to the HRQOL of men with normal body mass index (BMI)...
  22. ncbi request reprint Methylation of the gamma-catenin gene is associated with poor prognosis of renal cell carcinoma
    Julia E Breault
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Clin Cancer Res 11:557-64. 2005
    ..To test these hypotheses, we analyzed the CpG methylation status of the gamma-catenin gene and its correlation with clinical outcome in RCC...
  23. doi request reprint Re-calibration and external validation of an existing nomogram to predict aggressive recurrences after radical prostatectomy
    Florian R Schroeck
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 105:1654-9. 2010
    ..e. a BCR with a postoperative PSA doubling time (PSADT) of <9 months)...
  24. ncbi request reprint Impact of obesity on biochemical control after radical prostatectomy for clinically localized prostate cancer: a report by the Shared Equal Access Regional Cancer Hospital database study group
    Stephen J Freedland
    Department of Urology, The Johns Hopkins School of Medicine, 600 N Wolfe Street, Baltimore, MD 21287 2101, USA
    J Clin Oncol 22:446-53. 2004
    ..Given the limited information regarding the impact of obesity on treatment outcomes for prostate cancer, we sought to examine the relationship between body mass index (BMI) and cancer control after radical prostatectomy (RP)...
  25. pmc Are repeat prostate biopsies safe? A cohort analysis from the SEARCH database
    Ryan P Kopp
    Division of Urology, University of California, San Diego, San Diego, California 92103 8897, USA
    J Urol 187:2056-60. 2012
    ..Therefore, we investigated whether there is an association between the number of prior biopsy sessions and biochemical recurrence after radical prostatectomy...
  26. doi request reprint Obesity and oncological outcome after radical prostatectomy: impact of prostate-specific antigen-based prostate cancer screening: results from the Shared Equal Access Regional Cancer Hospital and Duke Prostate Center databases
    Stephen J Freedland
    Urology Section, Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 102:969-74. 2008
    ....
  27. ncbi request reprint The percentage of prostate needle biopsy cores with carcinoma from the more involved side of the biopsy as a predictor of prostate specific antigen recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEAR
    Stephen J Freedland
    Department of Urology, University of California Los Angeles, Los Angeles, California, USA
    Cancer 98:2344-50. 2003
    ....
  28. doi request reprint Changes in specific domains of sexual function and sexual bother after radical prostatectomy
    Jesse D Le
    University of California San Francisco, San Francisco, CA, USA
    BJU Int 106:1022-9. 2010
    ....
  29. pmc Upgrading and downgrading of prostate needle biopsy specimens: risk factors and clinical implications
    Stephen J Freedland
    Department of Surgery, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Urology 69:495-9. 2007
    ..Given the critical role that needle biopsy plays in treatment decisions, we sought to determine the risk factors for upgrading and downgrading the prostate biopsy specimen...
  30. pmc Statin medication use and the risk of biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) Database
    Robert J Hamilton
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Cancer 116:3389-98. 2010
    ..The authors sought to examine the association between statin use and PSA recurrence after radical prostatectomy (RP)...
  31. pmc Diabetes and outcomes after radical prostatectomy: are results affected by obesity and race? Results from the shared equal-access regional cancer hospital database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University School of Medicine, Durham, NC 27710, USA
    Cancer Epidemiol Biomarkers Prev 19:9-17. 2010
    ..The association of diabetes with prostate cancer outcomes is less clear. We examined the association between diabetes and outcomes after radical prostatectomy and tested whether associations varied by race and/or obesity...
  32. doi request reprint Definition and preoperative predictors of persistently elevated prostate-specific antigen after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Durham, NC, USA
    BJU Int 105:1541-7. 2010
    ....
  33. ncbi request reprint Impact of obesity on prostate cancer recurrence after radical prostatectomy: data from CaPSURE
    William W Bassett
    Department of Urology, Urologic Outcomes Research Group, University of California, School of Medicine, Comprehensive Cancer Center, San Francisco, California, USA
    Urology 66:1060-5. 2005
    ..To determine the association between obesity and prostate cancer recurrence after primary treatment with radical prostatectomy...
  34. ncbi request reprint Obesity and biochemical outcome following radical prostatectomy for organ confined disease with negative surgical margins
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287 2101, USA
    J Urol 172:520-4. 2004
    ....
  35. ncbi request reprint Preoperative model for predicting prostate specific antigen recurrence after radical prostatectomy using percent of biopsy tissue with cancer, biopsy Gleason grade and serum prostate specific antigen
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Urol 171:2215-20. 2004
    ..We developed a preoperative model to risk stratify patients for prostate specific antigen (PSA) failure following radical prostatectomy (RP) and identify those at high risk who would be potential candidates for neoadjuvant clinical trials...
  36. ncbi request reprint Impact of patient educational level on treatment for patients with prostate cancer: data from CaPSURE
    Christopher J Kane
    Department of Urology, Program in Urologic Oncology, Urology Outcomes Research Group, and UCSF Mount Zion Comprehensive Cancer Center, University of California, San Francisco, School of Medicine, 94143 1695, USA
    Urology 62:1035-9. 2003
    ..A patient's educational level may impact a patient's understanding and perception of the risks and benefits of the treatment options for prostate cancer...
  37. ncbi request reprint Biochemical outcome after radical prostatectomy among men with normal preoperative serum prostate-specific antigen levels
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 2101, USA
    Cancer 101:748-53. 2004
    ..Whether malignancies in such men are associated with better outcomes is unclear. The authors compared the risk of biochemical failure after radical prostatectomy (RP) between men with normal PSA levels and men with elevated PSA levels...
  38. pmc Does salvage radiation therapy change the biology of recurrent prostate cancer based on PSA doubling times? Results from the SEARCH database
    Roberto L Muller
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
    Urology 79:1105-10. 2012
    ..PSA doubling time (PSADT) was used as a surrogate endpoint for cancer aggressiveness. We compared PSADT calculated before start of SRT and after SRT failure...
  39. pmc Outcomes after radical prostatectomy among men who are candidates for active surveillance: results from the SEARCH database
    Christopher J Kane
    Division of Urology, Department of Surgery, University of California San Diego, San Diego, CA 92103 8897, USA
    Urology 76:695-700. 2010
    ..We sought to evaluate outcomes after radical prostatectomy among men with low-risk prostate cancer who would be candidates for active surveillance...
  40. ncbi request reprint Predictors of prostate-specific antigen progression among men with seminal vesicle invasion at the time of radical prostatectomy
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 100:1633-8. 2004
    ..The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival...
  41. doi request reprint Predictors of secondary treatment following biochemical recurrence after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    Daniel M Moreira
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC, USA
    BJU Int 105:28-33. 2010
    ..To investigate the predictors of secondary treatment for recurrent prostate cancer after radical prostatectomy (RP) among subjects from the Shared Equal Access Regional Cancer Hospital (SEARCH) database...
  42. doi request reprint Freedom from a detectable ultrasensitive prostate-specific antigen at two years after radical prostatectomy predicts a favorable clinical outcome: analysis of the SEARCH database
    Steven L Chang
    Department of Urology, Stanford University Medical Center, Stanford, California 94305, USA
    Urology 75:439-44. 2010
    ..Previous studies demonstrate that a PSADT < 9 months after radical prostatectomy is associated with prostate cancer-specific mortality. Conventionally, PSADT has been calculated after biochemical failure (PSA > or = 2 0.2 ng/mL)...
  43. ncbi request reprint Promoter CpG hypomethylation and transcription factor EGR1 hyperactivate heparanase expression in bladder cancer
    Tatsuya Ogishima
    Department of Urology, Veterans Affairs Medical Center, San Francisco and University of California, San Francisco, 4150 Clement Street, CA 94121, USA
    Oncogene 24:6765-72. 2005
    ..To our knowledge, this is the first study demonstrating that increased heparanase expression during the pathogenesis of bladder cancer is due to promoter hypomethylation and transcription factor EGR1...
  44. pmc Do nomograms predict aggressive recurrence after radical prostatectomy more accurately than biochemical recurrence alone?
    Florian R Schroeck
    Division of Urologic Surgery, Department of Surgery, and Duke Prostate Center, Duke University Medical Center, Durham, NC 27710, USA
    BJU Int 103:603-8. 2009
    ..To compare the predictive accuracy (PA) of existing models in estimating risk of biochemical recurrence (BCR) vs aggressive recurrence (BCR with a prostate-specific antigen, PSA, doubling time, DT, of <9 months)...
  45. pmc Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    Jayakrishnan Jayachandran
    Urology Section, Veterans Affairs Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    BJU Int 102:964-8. 2008
    ....
  46. doi request reprint Does early prostate-specific antigen doubling time (ePSADT) after radical prostatectomy, calculated using PSA values from the first detectable until the first recurrence value, correlate with standard PSADT? A report from the Shared Equal Access Regional
    Anna E Teeter
    Department of Surgery, Division of Urologic Surgery, Duke Prostate Center, Durham, NC 27710, USA
    BJU Int 104:1604-9. 2009
    ..2 ng/mL, as a short PSADT following biochemical recurrence (BCR) after RP portends a poor prognosis and poor response to salvage treatment but this is based upon PSADT calculated using PSA values of >or=0.2 ng/mL...
  47. pmc Risk stratification for biochemical recurrence in men with positive surgical margins or extracapsular disease after radical prostatectomy: results from the SEARCH database
    Jayakrishnan Jayachandran
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 179:1791-6; discussion 1796. 2008
    ..We further stratified these men into a low risk group in which watchful waiting after surgery may be preferred and a high risk cohort in which adjuvant therapy may be preferred...
  48. ncbi request reprint Comparison of preoperative prostate specific antigen density and prostate specific antigen for predicting recurrence after radical prostatectomy: results from the search data base
    Stephen J Freedland
    Department of Urology, University of California Los Angeles School of Medicine, USA
    J Urol 169:969-73. 2003
    ..We determined whether preoperative PSA density calculated using transrectal ultrasound prostate volume was a better predictor of advanced pathological findings or biochemical recurrence after radical prostatectomy relative to PSA...
  49. doi request reprint Estimated blood loss as a predictor of PSA recurrence after radical prostatectomy: results from the SEARCH database
    Jessica C Lloyd
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
    BJU Int 105:347-51. 2010
    ..Study Type - Diagnosis (exploratory cohort) Level of Evidence 2b...
  50. ncbi request reprint PSA in the new millennium: a powerful predictor of prostate cancer prognosis and radical prostatectomy outcomes--results from the SEARCH database
    Stephen J Freedland
    Urology Section, Veterans Affairs Medical Center, Durham, NC, USA
    Eur Urol 53:758-64; discussion 765-6. 2008
    ..We examined the prognostic significance of preoperative PSA to predict pathologic stage and biochemical progression among men undergoing radical prostatectomy in the new millennium (2000-2006)...
  51. ncbi request reprint Prostate size and risk of high-grade, advanced prostate cancer and biochemical progression after radical prostatectomy: a search database study
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287 2101, USA
    J Clin Oncol 23:7546-54. 2005
    ..We examined whether prostate weight was associated with tumor grade, advanced disease, or risk of biochemical progression after radical prostatectomy (RP)...
  52. pmc Glycemic control and prostate cancer progression: results from the SEARCH database
    Howard S Kim
    Division of Urologic Surgery, Department of Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    Prostate 70:1540-6. 2010
    ..We sought to investigate the role of glycemic control, as measured by HbA1c, on PCa aggressiveness and prognosis in men with DM and PCa from the Shared Equal Access Regional Cancer Hospital (SEARCH) database...
  53. ncbi request reprint Prostate biopsy tumor extent but not location predicts recurrence after radical prostatectomy: results from CaPSURE
    Kirsten L Greene
    Department of Urology, University of California, San Francisco Comprehensive Cancer Center, University of California, San Francisco, USA
    J Urol 175:125-9; discussion 129. 2006
    ..We compared the ability of positive prostate biopsy location and pattern with number and percent positive biopsies to predict recurrence after RP...
  54. doi request reprint Does timing of cytoreductive nephrectomy impact patient survival with metastatic renal cell carcinoma in the tyrosine kinase inhibitor era? A multi-institutional study
    Sean P Stroup
    Division of Urology, Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 92093 0987, USA
    Urology 81:805-11. 2013
    ..To compare outcomes of metastatic renal cell carcinoma (mRCC) patients who underwent primary cytoreductive nephrectomy (CRN), followed by adjuvant sunitinib therapy, vs those who underwent primary sunitinib therapy before planned CRN...
  55. ncbi request reprint Inactivation of the hMSH3 mismatch repair gene in bladder cancer
    Toshifumi Kawakami
    Department of Urology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, CA, USA
    Biochem Biophys Res Commun 325:934-42. 2004
    ..This is the first report suggesting that genetic and epigenetic alterations in the human MSH3 gene might play a significant role in the progression of bladder tumors...
  56. ncbi request reprint Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:500-4; discussion 504. 2006
    ..We examined the association between BMI, and PSA and prostate weight in a cohort of men undergoing RP...
  57. doi request reprint Decreasing size at diagnosis of stage 1 renal cell carcinoma: analysis from the National Cancer Data Base, 1993 to 2004
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
    J Urol 179:2131-5. 2008
    ..The proportion of renal cell carcinoma cases diagnosed at stage I is known to be increasing significantly. We characterized stage I tumors further in terms of tumor size at diagnosis using a large national cancer registry...
  58. doi request reprint Active surveillance for the management of prostate cancer in a contemporary cohort
    Marc A Dall'Era
    Department of Urology and the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143 1695, USA
    Cancer 112:2664-70. 2008
    ..In this article, the authors report their experience in a contemporary cohort of men with prostate cancer who were managed with active surveillance...
  59. pmc Limitations of prostate specific antigen doubling time following biochemical recurrence after radical prostatectomy: results from the SEARCH database
    Robert J Hamilton
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 179:1785-9; discussion 1789-90. 2008
    ..Hence, those with calculable prostate specific antigen doubling time may represent a select lower risk group relative to all men with biochemical recurrence...
  60. ncbi request reprint Health related quality of life patterns in patients treated with interstitial prostate brachytherapy for localized prostate cancer--data from CaPSURE
    Tracy M Downs
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, UCSF Mt Zion Comprehensive Cancer Center, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143, USA
    J Urol 170:1822-7. 2003
    ..We measured the impact brachytherapy monotherapy (BMT) has on general and disease specific health related quality of life (HRQOL) compared to patients treated with radical prostatectomy (RP)...
  61. ncbi request reprint Race, biochemical disease recurrence, and prostate-specific antigen doubling time after radical prostatectomy: results from the SEARCH database
    Robert J Hamilton
    Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Cancer 110:2202-9. 2007
    ..To address this issue, the authors examined racial differences in pathologic features, time to disease recurrence, and prostate-specific antigen (PSA) doubling time (PSADT) among a cohort of patients treated with RP...
  62. ncbi request reprint CpG methylation at promoter site -140 inactivates TGFbeta2 receptor gene in prostate cancer
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center and University of California San Francisco, San Francisco, California 94121, USA
    Cancer 104:44-52. 2005
    ..The authors of the current study hypothesized that CpG methylation of the TbetaRII promoter at the Sp1 binding site -140 mediates this loss of TbetaRII expression in prostate cancer...
  63. pmc A natural history of weight change in men with prostate cancer on androgen-deprivation therapy (ADT): results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Howard S Kim
    Division of Urologic Surgery, Department of Surgery, and the Duke Prostate Center, Duke University School of Medicine, Durham, NC, USA
    BJU Int 107:924-8. 2011
    ..Men undergoing ADT lose lean muscle but gain fat mass, contributing to an overall gain in weight...
  64. ncbi request reprint Education predicts quality of life among men with prostate cancer cared for in the Department of Veterans Affairs: a longitudinal quality of life analysis from CaPSURE
    Sara J Knight
    San Francisco VA Medical Center, Department of Psychiatry, University of California, San Francisco, California 94121, USA
    Cancer 109:1769-76. 2007
    ..Patient education level and quality of life were examined among men diagnosed with prostate cancer and cared for within an equal-access health care system, the Department of Veterans Affairs Veterans Health Administration (VA)...
  65. doi request reprint Renal cell cancer stage migration: analysis of the National Cancer Data Base
    Christopher J Kane
    Division of Urology, Department of Surgery, University of California at San Diego Medical Center, San Diego, CA 92103 8897, USA
    Cancer 113:78-83. 2008
    ..The aim of the study was to analyze patterns of disease presentation and outcome of RCC by AJCC stage using data from the National Cancer Data Base (NCDB) over a 12-year period...
  66. ncbi request reprint Delay of radical prostatectomy and risk of biochemical progression in men with low risk prostate cancer
    Stephen J Freedland
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 175:1298-302; discussion 1302-3. 2006
    ..Whether delays and especially prolonged delays, eg greater than 180 days, before RP negatively impact the disease outcome is unclear...
  67. doi request reprint Adequacy of lymphadenectomy among men undergoing robot-assisted laparoscopic radical prostatectomy
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urologic Outcomes Research Group, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA
    BJU Int 105:88-92. 2010
    ..To compare rates of lymph node dissection (LND) and nodal yields between patients treated with open radical retropubic prostatectomy (ORRP) and robot-assisted RRP (RARP) in a contemporary single-institution series...
  68. ncbi request reprint Laparoscopic versus open cytoreductive nephrectomy in advanced renal-cell carcinoma
    Manuel S Eisenberg
    Department of Urology, University of California San Francisco, San Francisco, California 94143 1695, USA
    J Endourol 20:504-8. 2006
    ..We compared the outcomes of patients with metastatic RCC undergoing laparoscopic and open cytoreductive nephrectomy prior to systemic therapy...
  69. ncbi request reprint Update of staging and risk assessment for prostate cancer patients
    Adam B Hittelman
    Department of Urology, University of California San Francisco, 94143, USA
    Curr Opin Urol 14:163-70. 2004
    ....
  70. ncbi request reprint Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database
    Stephen J Freedland
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 60:670-4. 2002
    ....
  71. ncbi request reprint Sociodemographic and clinical risk characteristics of patients with prostate cancer within the Veterans Affairs health care system: data from CaPSURE
    Matthew R Cooperberg
    Department of Urology, Program in Urologic Oncology, Urology Outcomes Research Group, University of California San Francisco, 400 Parnassus Avenue, San Francisco, CA 94143, USA
    J Urol 170:905-8. 2003
    ..Veterans Affairs (VA) health care system investigators perform large clinical trials in prostate cancer treatment but potential differences between VA and other patient cohorts have not been explored systematically...
  72. doi request reprint Effect of BMI on primary treatment of prostate cancer
    Benjamin J Davies
    Department of Urology, Urology Outcomes Research Group, University of California San Francisco Comprehensive Cancer Center, University of California, San Francisco 94143 1695, USA
    Urology 72:406-11. 2008
    ..This study was designed to assess the relationship between body mass index (BMI) and treatment patterns of prostate cancer patients...
  73. pmc Incidence of bladder neck contracture after robot-assisted laparoscopic and open radical prostatectomy
    Benjamin N Breyer
    Department of Urology, University of California San Francisco, San Francisco, CA, USA
    BJU Int 106:1734-8. 2010
    ....
  74. ncbi request reprint Prostate cancer outcomes among older men: insurance status comparisons results from CaPSURE database
    N Sadetsky
    Department of Urology, UCSF Comprehensive Cancer Center, University of California San Francisco, CA 94115, USA
    Prostate Cancer Prostatic Dis 11:280-7. 2008
    ..Future explorations of associations between health care delivery system, cancer care and outcomes are needed...
  75. ncbi request reprint Surgery for prostate cancer: rationale, technique and outcomes
    Tracy M Downs
    Department of Urology and UCSF Mt Zion Comprehensive Cancer Center, University of California, San Francisco 94143 0738, USA
    Cancer Metastasis Rev 21:29-44. 2002
    ..It can be performed with limited risk of complications and is likely to be curative in patients with organ-confined disease and those with limited extracapsular extension...
  76. ncbi request reprint Quality of life in young men after radical prostatectomy
    J L Wright
    Department of Urology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Prostate Cancer Prostatic Dis 11:67-73. 2008
    ..Baseline scores are strongly associated with post-RP scores and severity of declines. Current relationships and use of sexual aids have significant roles in post-RP bother...
  77. ncbi request reprint Effects of hospital procedure volume and resident training on clinical outcomes and resource use in radical retropubic prostatectomy surgery in the Department of Veterans Affairs
    Tse Sun Ku
    Anesthesiology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Urol 179:272-8; discussion 278-9. 2008
    ....
  78. ncbi request reprint Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy
    Christopher J Kane
    Department of Urology, Naval Medical Center San Diego, San Diego, California, USA
    Urology 61:607-11. 2003
    ..To define the utility of bone scan and computed tomography (CT) in the evaluation of patients with biochemical recurrence after radical prostatectomy...
  79. ncbi request reprint Effect of race on biochemical disease-free outcome in patients with prostate cancer treated with definitive radiation therapy in an equal-access health care system: radiation oncology report of the Department of Defense Center for Prostate Disease Researc
    Peter A S Johnstone
    Naval Medical Ctr, San Diego, Calif 92134 1014, USA
    Radiology 225:420-6. 2002
    ..To report on the first collaboration of the Department of Defense Center for Prostate Disease Research concerned with the relationship between African American race and biochemical disease-free outcomes after definitive radiation therapy...
  80. ncbi request reprint Effect of age on biochemical disease-free outcome in patients with T1-T3 prostate cancer treated with definitive radiotherapy in an equal-access health care system: a radiation oncology report of the Department of Defense Center for Prostate Disease Resea
    Peter A S Johnstone
    Investigation Department, Naval Medical Center, San Diego, CA 92134, USA
    Int J Radiat Oncol Biol Phys 55:964-9. 2003
    ..The records of the Department of Defense Center for Prostate Disease Research were queried for the biochemical disease-free results of patients after definitive RT and analyzed by age...
  81. doi request reprint The effect of race/ethnicity on the accuracy of the 2001 Partin Tables for predicting pathologic stage of localized prostate cancer
    Elisabeth I Heath
    Barbara Ann Karmanos Cancer Institute, Department of Hematology and Oncology, Wayne State University, 4100 John R, 4 HWCRC, Detroit, MI 48201, USA
    Urology 71:151-5. 2008
    ..To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States...
  82. ncbi request reprint Clinical and pathologic outcome after radical prostatectomy for prostate cancer patients with a preoperative Gleason sum of 8 to 10
    Patrick J Bastian
    James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer 107:1265-72. 2006
    ....
  83. ncbi request reprint Is biopsy Gleason score independently associated with biochemical progression following radical prostatectomy after adjusting for pathological Gleason score?
    Nicholas J Fitzsimons
    Division of Urologic Surgery, Duke Prostate Center, University Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    J Urol 176:2453-8; discussion 2458. 2006
    ..However, it is unclear whether it remains associated with outcome after surgery when the pathological Gleason score is known...
  84. ncbi request reprint Health-related quality of life for men with prostate cancer and diabetes: a longitudinal analysis from CaPSURE
    David M Latini
    Scott Department of Urology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA
    Urology 68:1242-7. 2006
    ....
  85. ncbi request reprint Small transrectal ultrasound volume predicts clinically significant Gleason score upgrading after radical prostatectomy: results from the SEARCH database
    Ryan S Turley
    Division of Urological Surgery, Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    J Urol 179:523-7; discussion 527-8. 2008
    ..We examined the likelihood of clinically relevant upgrading after radical prostatectomy as a function of transrectal ultrasound volume...
  86. ncbi request reprint Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer
    Lionel L Banez
    Division of Urologic Surgery and the Duke Prostate Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 298:2275-80. 2007
    ..Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among obese men may be due to hemodilution...
  87. ncbi request reprint Impact of obesity on the utility of preoperative prostate-specific antigen velocity to predict for relapse after prostatectomy: a report from the SEARCH database
    Christopher R King
    Division of Urologic Oncology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:921-6. 2007
    ....
  88. ncbi request reprint Optimal timing, cutoff, and method of calculation of preoperative prostate-specific antigen velocity to predict relapse after prostatectomy: a report from SEARCH
    Christopher R King
    Department of Radiation Oncology, Division of Urologic Oncology, Stanford University School of Medicine, Stanford, California 94305 5847, USA
    Urology 69:732-7. 2007
    ..We studied the timing, cutoff levels, and method of calculation to better define its usefulness...
  89. ncbi request reprint Is a positive bladder neck margin truly a T4 lesion in the prostate specific antigen era? Results from the SEARCH Database
    W Cooper Buschemeyer
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine and Urology Section, Surgical Service, Veterans Affairs Medical Center Durham, Durham, North Carolina 27710, USA
    J Urol 179:124-9; discussion 129. 2008
    ..We examined the association between positive bladder neck margins and prostate specific antigen recurrence relative to other pathological findings...
  90. ncbi request reprint Fear of recurrence, treatment satisfaction, and quality of life after radical prostatectomy for prostate cancer
    Stacey L Hart
    Department of Psychology, Ryerson University, Toronto, ON, Canada
    Support Care Cancer 16:161-9. 2008
    ..The objective of this study was to examine treatment satisfaction (TS) as a moderator of the relationship between FOR and QOL...
  91. ncbi request reprint Predicting unilateral prostate cancer based on biopsy features: implications for focal ablative therapy--results from the SEARCH database
    Charles D Scales
    Department of Surgery Division of Urologic Surgery, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Urol 178:1249-52. 2007
    ..However, few studies have assessed the correlation between biopsy parameters and pathological outcome (unilateral vs bilateral disease)...
  92. pmc Risk stratification of men with Gleason score 7 to 10 tumors by primary and secondary Gleason score: results from the SEARCH database
    David E Kang
    Division of Urologic Surgery, Department of Surgery and Duke Prostate Center, Duke University School of Medicine, Durham, North Carolina, USA
    Urology 70:277-82. 2007
    ..Whether the increased risk associated with Gleason score 4+3 disease is equivalent to that of Gleason score 4+4 or greater is unclear...