Sandra L Kane-Gill

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint A comparison of voluntarily reported medication errors in intensive care and general care units
    S L Kane-Gill
    Center for Pharmacoinformatics and Outcomes Research, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Qual Saf Health Care 19:55-9. 2010
  2. doi request reprint Comparison of three pharmacovigilance algorithms in the ICU setting: a retrospective and prospective evaluation of ADRs
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Saf 35:645-53. 2012
  3. pmc Analysis of risk factors for adverse drug events in critically ill patients*
    Sandra L Kane-Gill
    Department of Pharmacy and Clinical Translational Sciences, University of Pittsburgh, School of Pharmacy, Center for Pharmacoinformatics and Outcomes Research, Pittsburgh, PA, USA
    Crit Care Med 40:823-8. 2012
  4. pmc Transitioning knowledge gained from simulation to pharmacy practice
    Sandra L Kane-Gill
    School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Pharm Educ 75:210. 2011
  5. pmc Computerized detection of adverse drug reactions in the medical intensive care unit
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, School of Pharmacy, University Pittsburgh, Pittsburgh, PA 15261, United States
    Int J Med Inform 80:570-8. 2011
  6. doi request reprint Evaluating the positive predictive values of antidote signals to detect potential adverse drug reactions (ADRs) in the medical intensive care unit (ICU)
    Sandra L Kane-Gill
    School of Pharmacy, Center for Pharmacoinformatics and Outcomes Research, University of Pittsburgh, Pittsburgh, PA, USA
    Pharmacoepidemiol Drug Saf 18:1185-91. 2009
  7. doi request reprint Adverse drug reactions in hospital and ambulatory care settings identified using a large administrative database
    Sandra L Kane-Gill
    School of Pharmacy and Clinical Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Pharmacother 44:983-93. 2010
  8. ncbi request reprint Adverse drug events in intensive care units: risk factors, impact, and the role of team care
    Sandra L Kane-Gill
    School of Pharmacy, Center for Pharmacoinformactics and Outcomes Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:S83-9. 2010
  9. doi request reprint Medication errors during medical emergencies in a large, tertiary care, academic medical center
    Roman Gokhman
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, 15213, USA
    Resuscitation 83:482-7. 2012
  10. doi request reprint Drug-drug interactions contributing to QT prolongation in cardiac intensive care units
    Michael J Armahizer
    Cardiothoracic Intensive Care Unit, UPMC, Pittsburgh, PA, USA
    J Crit Care 28:243-9. 2013

Collaborators

Detail Information

Publications42

  1. doi request reprint A comparison of voluntarily reported medication errors in intensive care and general care units
    S L Kane-Gill
    Center for Pharmacoinformatics and Outcomes Research, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Qual Saf Health Care 19:55-9. 2010
    ..Few institutions currently track intensive care unit (ICU)-specific medication safety data. A comparison of medication error data for intensive care and general care units may determine if ICU-specific surveillance is needed...
  2. doi request reprint Comparison of three pharmacovigilance algorithms in the ICU setting: a retrospective and prospective evaluation of ADRs
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Saf 35:645-53. 2012
    ..Pharmacovigilance algorithms are used to assess the likelihood of adverse drug reaction (ADR) occurrence. The preferred instrument for use in the intensive care unit (ICU) is not established...
  3. pmc Analysis of risk factors for adverse drug events in critically ill patients*
    Sandra L Kane-Gill
    Department of Pharmacy and Clinical Translational Sciences, University of Pittsburgh, School of Pharmacy, Center for Pharmacoinformatics and Outcomes Research, Pittsburgh, PA, USA
    Crit Care Med 40:823-8. 2012
    ..An evaluation of risk factors for adverse drug events in critically ill patients has not been previously studied. The purpose of this original study was to determine risk factors for adverse drug events in critically ill adult patients...
  4. pmc Transitioning knowledge gained from simulation to pharmacy practice
    Sandra L Kane-Gill
    School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Pharm Educ 75:210. 2011
    ..Educators should continue to be creative in the incorporation of simulation into pharmacy education and conduct more studies on the impact of simulation education on patient care to demonstrate the efficacy of this teaching modality...
  5. pmc Computerized detection of adverse drug reactions in the medical intensive care unit
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, School of Pharmacy, University Pittsburgh, Pittsburgh, PA 15261, United States
    Int J Med Inform 80:570-8. 2011
    ..The primary goal was to evaluate the positive predictive values of select signals used to automate the detection of ADRs in the medical intensive care unit...
  6. doi request reprint Evaluating the positive predictive values of antidote signals to detect potential adverse drug reactions (ADRs) in the medical intensive care unit (ICU)
    Sandra L Kane-Gill
    School of Pharmacy, Center for Pharmacoinformatics and Outcomes Research, University of Pittsburgh, Pittsburgh, PA, USA
    Pharmacoepidemiol Drug Saf 18:1185-91. 2009
    ....
  7. doi request reprint Adverse drug reactions in hospital and ambulatory care settings identified using a large administrative database
    Sandra L Kane-Gill
    School of Pharmacy and Clinical Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Pharmacother 44:983-93. 2010
    ..Previous studies are limited in sample size and number of sites for the detection and characterization of adverse drug reactions (ADRs) in ambulatory care and hospital settings...
  8. ncbi request reprint Adverse drug events in intensive care units: risk factors, impact, and the role of team care
    Sandra L Kane-Gill
    School of Pharmacy, Center for Pharmacoinformactics and Outcomes Research, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 38:S83-9. 2010
    ..The costs of an adverse drug event can be substantial to healthcare systems with an additional $6,000-$9,000 for each event. The multiprofessional patient care team is one approach to promoting patient safety in the ICU...
  9. doi request reprint Medication errors during medical emergencies in a large, tertiary care, academic medical center
    Roman Gokhman
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, 15213, USA
    Resuscitation 83:482-7. 2012
    ..Evaluate the rate, type and severity of medication errors occurring during Medical Emergency Team (MET) care at a large, tertiary-care, academic medical center...
  10. doi request reprint Drug-drug interactions contributing to QT prolongation in cardiac intensive care units
    Michael J Armahizer
    Cardiothoracic Intensive Care Unit, UPMC, Pittsburgh, PA, USA
    J Crit Care 28:243-9. 2013
    ..To determine the most common drug-drug interaction (DDI) pairs contributing to QTc prolongation in cardiac intensive care units (ICUs)...
  11. doi request reprint Simulation-based learning versus problem-based learning in an acute care pharmacotherapy course
    Amy L Seybert
    Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Simul Healthc 7:162-5. 2012
    ..The objective of the study was to determine whether high-fidelity simulation is superior to problem-based learning (PBL) for training pharmacy students in an acute care elective...
  12. doi request reprint Impact of simulation-based learning on medication error rates in critically ill patients
    Daniel G Ford
    Department of Pharmacy, Northbay Medical Center, Fairfield, 1200 B Gale Wilson Blvd, Fairfield, CA 94533, USA
    Intensive Care Med 36:1526-31. 2010
    ..To compare medication administration error rates before and after the provision of educational sessions using either traditional didactic lecture or simulation-based training...
  13. doi request reprint Improving adverse drug event detection in critically ill patients through screening intensive care unit transfer summaries
    Ananth M Anthes
    Surgical Intensive Care Unit, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pharmacoepidemiol Drug Saf 22:510-6. 2013
    ....
  14. doi request reprint Drug-drug interactions in the medical intensive care unit: an assessment of frequency, severity and the medications involved
    Pamela L Smithburger
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    Int J Pharm Pract 20:402-8. 2012
    ..Currently, there is a lack of literature describing DDIs in the intensive care unit (ICU). The purpose of this study is to evaluate frequency, severity and drug combinations involved in DDIs occurring in a medical ICU (MICU)...
  15. doi request reprint Analgosedation: a paradigm shift in intensive care unit sedation practice
    Sandeep Devabhakthuni
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Pharmacother 46:530-40. 2012
    ..To critically evaluate the use of analgosedation in the management of agitation in critically ill mechanically ventilated patients...
  16. doi request reprint QT prolongation in the intensive care unit: commonly used medications and the impact of drug-drug interactions
    Pamela L Smithburger
    University of Pittsburgh School of Pharmacy, Critical Care Pharmacist, Medical Intensive Care Unit, University of Pittsburgh Medical Center, 200 Lothrop Street, PFG 01 01 01, Pittsburgh, PA 15213, USA
    Expert Opin Drug Saf 9:699-712. 2010
    ..Additional DDI education and a review of management strategies could assist with prevention of future adverse outcomes...
  17. doi request reprint Grading the severity of drug-drug interactions in the intensive care unit: a comparison between clinician assessment and proprietary database severity rankings
    Pamela L Smithburger
    University of Pittsburgh Medical Center, PA, USA
    Ann Pharmacother 44:1718-24. 2010
    ..A DDI alert system based on severity rankings has been shown to reduce alert fatigue; however, the best method to populate this type of database is unclear...
  18. ncbi request reprint Medication error analysis: a systematic approach
    G Patel Patel
    Division of Pulmonary and Critical Care, Department of Pharmacy, Rush University Medical Center, Jelke 299, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Curr Drug Saf 5:2-5. 2010
    ..Further research efforts are currently taking place in this challenging aspect of patient care to further provide more strategies for medication error detection, analysis, and prevention...
  19. ncbi request reprint Alteplase treatment of acute pulmonary embolism in the intensive care unit
    Pamela L Smithburger
    University of Pittsburgh School of Pharmacy, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh PA 15213, USA
    Crit Care Nurse 33:17-27. 2013
    ..Clinical pearls for the administration, monitoring, and care of a patient receiving alteplase in an intensive care unit also are discussed...
  20. doi request reprint Comparing effectiveness of 3 learning strategies: simulation-based learning, problem-based learning, and standardized patients
    Pamela L Smithburger
    Department of Pharmacy and Therapeutics, UPMC Presbyterian Shadyside, Pittsburgh, PA 15213, USA
    Simul Healthc 7:141-6. 2012
    ..Several learning strategies, including problem-based learning (PBL), standardized patients, and high-fidelity human simulation, have been incorporated into courses; however, it is currently unknown which technique is the most effective...
  21. doi request reprint Drug-drug interactions in cardiac and cardiothoracic intensive care units: an analysis of patients in an academic medical centre in the US
    Pamela L Smithburger
    University of Pittsburgh School of Pharmacy, and Medical Intensive Care Unit, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Drug Saf 33:879-88. 2010
    ..Knowing the clinically significant drug-drug interactions allows the opportunity for prevention through knowledge and computer-assisted programmes...
  22. ncbi request reprint Resource use in decompensated heart failure by disease progression categories
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, PA 15261, USA
    Congest Heart Fail 13:22-8. 2007
    ..05): echocardiography, electrophysiology, neurodiagnostic, nuclear cardiology, and pharmacy. Careful analysis of hospital resource use by services for heart failure patients provides opportunities for institutional cost containment...
  23. ncbi request reprint Comparison of patient outcomes with bivalirudin versus unfractionated heparin in percutaneous coronary intervention
    Kristin Watson
    Department of Pharmacy Practice and Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
    Pharmacotherapy 27:647-56. 2007
    ..To compare clinical outcomes and glycoprotein IIb-IIIa inhibitor use in patients undergoing percutaneous coronary intervention (PCI) who received bivalirudin or unfractionated heparin (UFH) in a real-world setting...
  24. ncbi request reprint Outcomes and costs of abciximab versus eptifibatide for percutaneous coronary intervention
    James C Coons
    Cardiology Specialty Resident, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Pharmacother 39:1621-6. 2005
    ..However, drug selection is often based on clinicians' preference and cost because few studies have directly compared abciximab and eptifibatide...
  25. doi request reprint A critical evaluation of clinical decision support for the detection of drug-drug interactions
    Pamela L Smithburger
    University of Pittsburgh School of Pharmacy, Department of Pharmacy and Therapeutics, Critical Care Pharmacist, Medical Intensive Care Unit, UPMC, Pittsburgh, PA, USA
    Expert Opin Drug Saf 10:871-82. 2011
    ..The generation of DDI alerts is one aspect of CDSS that may improve patient safety and reduce adverse drug events...
  26. pmc A real-world, multicenter assessment of drugs requiring weight-based calculations in overweight, adult critically ill patients
    Sandra L Kane-Gill
    Department of Pharmacy, Translational Science Institute and Critical Care Medicine, Schools for Pharmacy and Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    ScientificWorldJournal 2013:909135. 2013
    ..Given the medications' increased propensity to cause harm, institutions should aggressively monitor these medications in overweight patients...
  27. doi request reprint Use of an abnormal laboratory value-drug combination alert to detect drug-induced thrombocytopenia in critically Ill patients
    Lisa M Harinstein
    Department of Pharmacy, Cleveland Clinic, Cleveland, OH 44195, USA
    J Crit Care 27:242-9. 2012
    ..The aim of this study was to assess the performance of a commercially available clinical decision support system (CDSS) drug-laboratory result alert in detecting drug-induced thrombocytopenia in critically ill patients...
  28. ncbi request reprint Multicenter treatment and outcome evaluation of aspiration syndromes in critically ill patients
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Center for Pharmacoinformatics and Outcomes Research, Pittsburgh, PA 15261, USA
    Ann Pharmacother 41:549-55. 2007
    ..Aspiration syndromes (pneumonia and pneumonitis) have significantly different processes. An evaluation of treatment and outcomes for these different syndromes has not been reported previously...
  29. ncbi request reprint Adverse drug event reporting in intensive care units: a survey of current practices
    Sandra L Kane-Gill
    University of Pittsburgh, Center for Pharmacoinformatics and Outcomes Research, PA 15261, USA
    Ann Pharmacother 40:1267-73. 2006
    ..Understanding the frequency with which institutions incorporate standardized operational ADE/ADR definitions, triggers, and evaluation tools in this population will facilitate benchmarking between hospitals...
  30. ncbi request reprint Monitoring abnormal laboratory values as antecedents to drug-induced injury
    Sandra L Kane-Gill
    Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania 15101, USA
    J Trauma 59:1457-62. 2005
    ..Detection of preceding drug-related hazardous conditions (DRHCs) may provide the opportunity to prevent injury. This study evaluated the frequency of abnormal laboratory values attributed to the effect of drugs...
  31. doi request reprint Neuroleptic malignant syndrome in traumatic brain injury patients treated with haloperidol
    Cassandra J Bellamy
    Department of Pharmacy, Medical Intensive Care Unit, Hospital of University of Pennsylvania, USA
    J Trauma 66:954-8. 2009
    ..The purpose of this manuscript was to review the literature describing NMS and haloperidol use in patients sustaining a traumatic brain injury (TBI) since these patients may be at greater risk for NMS...
  32. doi request reprint Clinical and economic evaluation of an evidence-based institutional epoetin-utilization management program
    Mitchell S Buckley
    Department of Pharmacy, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Clin Ther 35:294-302. 2013
    ....
  33. ncbi request reprint An evidence based systematic review of remifentanil associated opioid-induced hyperalgesia
    Ryan M Rivosecchi
    University of Pittsburgh Medical Center Presbyterian Campus, Pittsburgh, PA, USA
    Expert Opin Drug Saf 13:587-603. 2014
    ..Opioids are known for their side-effect profile, including bradycardia and respiratory depression; questions remain, however, regarding lesser known side effects such as opioid-induced hyperalgesia (OIH)...
  34. doi request reprint Coronary vasospasm and atrial fibrillation associated with ondansetron therapy
    Pamela L Havrilla
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Pharmacother 43:532-6. 2009
    ....
  35. doi request reprint Pharmacologic and pharmacokinetic rationale for combination therapy in pulmonary arterial hypertension
    Roman Gokhman
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Cardiovasc Pharmacol 56:686-95. 2010
    ....
  36. ncbi request reprint Implementing an intravenous insulin infusion protocol in the intensive care unit
    Rhonda S Rea
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, PA 15213, USA
    Am J Health Syst Pharm 64:385-95. 2007
    ..The implementation of three different insulin protocols in intensive care unit (ICU) settings in two community hospitals and one academic hospital is described...
  37. doi request reprint Interpatient variability in dexmedetomidine response: a survey of the literature
    Samantha F Holliday
    University of Pittsburgh School of Pharmacy, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    ScientificWorldJournal 2014:805013. 2014
    ..To fully understand the role of dexmedetomidine, it is vital to further evaluate what prompts such marked interpatient variability in critically ill patients. ..
  38. ncbi request reprint Sedation assessment in critically ill adults: 2001-2004 update
    Brian D Watson
    Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Pharmacother 38:1898-906. 2004
    ..To review recently published literature on the validity and reliability of sedation assessment tools in critically ill adults and evaluate the potential advantages and disadvantages of each...
  39. pmc Development of a dosage strategy in patients receiving enoxaparin by continuous intravenous infusion using modelling and simulation
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA
    Br J Clin Pharmacol 62:165-76. 2006
    ..To develop an appropriate dosing strategy for continuous intravenous infusions (CII) of enoxaparin by minimizing the percentage of steady-state anti-Xa concentration (C(ss)) outside the therapeutic range of 0.5-1.2 IU ml(-1)...
  40. doi request reprint Recent advances in the treatment of hypertensive emergencies
    Pamela L Smithburger
    University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15213, USA
    Crit Care Nurse 30:24-30; quiz 31. 2010
    ..The application of knowledge of treatment goals, hemodynamic monitoring, and pharmacological therapy for hypertensive emergencies can lead to the safe recovery of these critically ill patients...
  41. ncbi request reprint Comparing intravenous amiodarone or lidocaine, or both, outcomes for inpatients with pulseless ventricular arrhythmias
    Rhonda S Rea
    University of Pittsburgh School of Pharmacy, Center for Pharmacoinformatics and Outcomes Research, Department of Pharmaceutical Sciences, PA, and Saint Mary s Hospital Mayo Foundation, Rochester, MN, USA
    Crit Care Med 34:1617-23. 2006
    ..To compare survival rates of patients with in-hospital cardiac arrest due to pulseless ventricular tachycardia/ventricular fibrillation treated with lidocaine, amiodarone, or amiodarone plus lidocaine...
  42. ncbi request reprint Use of acetylcysteine for non-acetaminophen-induced acute liver failure
    Ibrahim Sales
    University of Pittsburgh Medical Center, USA
    Ann Hepatol 12:6-10. 2013
    ..It may be considered in non-transplant centers while awaiting referral or when transplantation is not an option. Further studies are necessary to determine optimal dosing, duration, and criteria for patient selection...