Karl Kandler

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Activity-dependent organization of inhibitory circuits: lessons from the auditory system
    Karl Kandler
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 14:96-104. 2004
  2. pmc NMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory Synapses
    Abigail Kalmbach
    Department of Neurobiology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA
    Front Synaptic Neurosci 2:27. 2010
  3. pmc Tonotopic reorganization of developing auditory brainstem circuits
    Karl Kandler
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 12:711-7. 2009
  4. ncbi request reprint Developmental refinement of inhibitory sound-localization circuits
    Karl Kandler
    Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Trends Neurosci 28:290-6. 2005
  5. pmc Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map
    Jihyun Noh
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 13:232-8. 2010
  6. ncbi request reprint Inhibitory synapses in the developing auditory system are glutamatergic
    Deda C Gillespie
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:332-8. 2005
  7. ncbi request reprint Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation
    Gunsoo Kim
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 6:282-90. 2003
  8. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
  9. pmc Metabotropic glutamate receptors in the lateral superior olive activate TRP-like channels: age- and experience-dependent regulation
    F Aura Ene
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurophysiol 97:3365-75. 2007
  10. ncbi request reprint Glutamatergic calcium responses in the developing lateral superior olive: receptor types and their specific activation by synaptic activity patterns
    F Aura Ene
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 90:2581-91. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Activity-dependent organization of inhibitory circuits: lessons from the auditory system
    Karl Kandler
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 14:96-104. 2004
    ..These studies importantly shed some new light on the general rules and cellular mechanisms that manage the organization of precise inhibitory circuits in the developing brain...
  2. pmc NMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory Synapses
    Abigail Kalmbach
    Department of Neurobiology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA
    Front Synaptic Neurosci 2:27. 2010
    ....
  3. pmc Tonotopic reorganization of developing auditory brainstem circuits
    Karl Kandler
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 12:711-7. 2009
    ..Accumulating evidence from several brainstem nuclei, however, is now changing this view by demonstrating that developing auditory brainstem circuits undergo a marked degree of refinement on both a subcellular and circuit level...
  4. ncbi request reprint Developmental refinement of inhibitory sound-localization circuits
    Karl Kandler
    Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Trends Neurosci 28:290-6. 2005
    ..Lessons from auditory brainstem circuits thus could provide insight into inhibitory development in other brain areas, where inhibitory networks are less experimentally accessible...
  5. pmc Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map
    Jihyun Noh
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 13:232-8. 2010
    ..These results indicate that glutamate co-transmission is crucial for the synaptic reorganization and topographic specification of a developing inhibitory circuit...
  6. ncbi request reprint Inhibitory synapses in the developing auditory system are glutamatergic
    Deda C Gillespie
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:332-8. 2005
    ..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits...
  7. ncbi request reprint Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation
    Gunsoo Kim
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 6:282-90. 2003
    ..These results provide new insights into the mechanisms by which precisely organized inhibitory circuits are established during development...
  8. pmc Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3
    Rebecca P Seal
    Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 57:263-75. 2008
    ..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
  9. pmc Metabotropic glutamate receptors in the lateral superior olive activate TRP-like channels: age- and experience-dependent regulation
    F Aura Ene
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurophysiol 97:3365-75. 2007
    ....
  10. ncbi request reprint Glutamatergic calcium responses in the developing lateral superior olive: receptor types and their specific activation by synaptic activity patterns
    F Aura Ene
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 90:2581-91. 2003
    ..Together, these results indicate that before hearing onset, distinct patterns of afferent activity generate qualitatively distinct types of calcium responses, which likely serve in guiding different aspects of LSO development...
  11. ncbi request reprint Excitatory action of an immature glycinergic/GABAergic sound localization pathway
    Karl Kandler
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, W1457 BST, 15261, Pittsburgh, PA, USA
    Physiol Behav 77:583-7. 2002
    ..These results provide support for the notion that the influence of glycinergic/GABAergic synaptic activity on development of the LSO involves calcium-dependent signaling mechanisms...
  12. ncbi request reprint Glycinergic and GABAergic calcium responses in the developing lateral superior olive
    Paul H M Kullmann
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Eur J Neurosci 15:1093-104. 2002
    ..The direct link of glycinergic/GABAergic synaptic activity to intracellular calcium signalling during the period of inhibitory synaptic plasticity could be one of the mechanisms by which tonotopic MNTB-LSO connections become established...
  13. pmc Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning
    Mandar A Aras
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 110:106-17. 2009
    ..These results indicate that neuronal Zn(2+) serves as an important, highly regulated signaling component responsible for the initiation of a neuroprotective pathway...
  14. pmc KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses
    Hanmi Lee
    Department Neurobiology, University of Pittsburgh School of Medicine, W1447 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Eur J Neurosci 21:2593-9. 2005
    ..We conclude that KCC2 expression is not only necessary but is also sufficient for ending the depolarizing period of GABA in developing cortical neurons...
  15. pmc Paired recordings from distant inhibitory neuron pairs by a sequential scanning approach
    Gunsoo Kim
    Department of Neurobiology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
    J Neurosci Methods 200:185-9. 2011
    ..In general, this method should provide a valuable tool to find connected neurons in other brain areas in which recording from candidate pairs has a low success rate...
  16. pmc Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing
    Tuan D Nguyen
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 209:367-70. 2012
    ..Here we report on a method that can initially infect a single neuron-of-choice, allowing for greater precision and specificity of labeled circuits...
  17. pmc Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge
    Megan E Knoch
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Glia 56:89-96. 2008
    ..These results establish a direct link between microglial-generated oxygen and nitrogen reactive products and neuronal cell death mediated by intracellular Zn(2+) release and a surge in K(+) currents...
  18. ncbi request reprint Somatotopic organization of rat thalamocortical slices
    Peter W Land
    Department of Neurobiology and Center for Neuroscience, W1458 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 119:15-21. 2002
    ..We found that barrels associated with the large mobile whiskers occupy a particular location in TC slices, but that there are certain constraints to studying this portion of the barrelfield in vitro...
  19. ncbi request reprint The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement
    Amanda Clause
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Neuron 82:822-35. 2014
    ..These results provide evidence that the precise temporal pattern of spontaneous activity before hearing onset is crucial for the establishment of precise tonotopy, the major organizing principle of central auditory pathways. ..
  20. pmc Cannabinoid receptor expression at the MNTB-LSO synapse in developing rats
    David H Chi
    Department of Otolaryngology, 10027 Biomedical Science Tower 3, 3501 Fifth Ave, Pittsburgh, PA 15261, United States
    Neurosci Lett 509:96-100. 2012
    ..These results suggest that endocannabinoid signaling can modulate the strength of the developing MNTB-LSO synapse...
  21. pmc An acoustic startle-based method of assessing frequency discrimination in mice
    Amanda Clause
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Neurosci Methods 200:63-7. 2011
    ..This approach can be used to investigate the neuronal mechanisms underlying frequency discrimination, its maturation during development, and its relationship to tonotopic organization...
  22. ncbi request reprint Synthesis, photophysical, photochemical and biological properties of caged GABA, 4-[[(2H-1-benzopyran-2-one-7-amino-4-methoxy) carbonyl] amino] butanoic acid
    Beate Cürten
    Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Photochem Photobiol 81:641-8. 2005
    ..BC204 is chemically stable and shows no intrinsic activity after many hours under physiological dark conditions. These properties suggest that BC204 is an excellent form of caged GABA that is well suited for long-term biological studies...
  23. ncbi request reprint Flipping the switch from electrical to chemical communication
    Karl Kandler
    Nat Neurosci 8:1633-4. 2005

Research Grants19

  1. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2009
    ..abstract_text> ..
  2. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2009
    ..abstract_text> ..
  3. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2006
    ....
  4. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2007
    ....
  5. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2005
    ....
  6. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2003
    ....
  7. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2000
    ....
  8. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2000
    ....
  9. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2010
    ..abstract_text> ..
  10. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2002
    ....
  11. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2001
    ....
  12. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2006
    ....
  13. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2001
    ....
  14. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2003
    ....
  15. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 2004
    ....
  16. DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEM
    Karl Kandler; Fiscal Year: 1999
    ....