Research Topics
| Karl KandlerSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Activity-dependent organization of inhibitory circuits: lessons from the auditory systemKarl Kandler
Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
Curr Opin Neurobiol 14:96-104. 2004..These studies importantly shed some new light on the general rules and cellular mechanisms that manage the organization of precise inhibitory circuits in the developing brain...
Tonotopic reorganization of developing auditory brainstem circuitsKarl Kandler
Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
Nat Neurosci 12:711-7. 2009..Accumulating evidence from several brainstem nuclei, however, is now changing this view by demonstrating that developing auditory brainstem circuits undergo a marked degree of refinement on both a subcellular and circuit level...- Developmental refinement of inhibitory sound-localization circuitsKarl Kandler
Department of Neurobiology and Center for the Neuronal Basis of Cognition, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
Trends Neurosci 28:290-6. 2005..Lessons from auditory brainstem circuits thus could provide insight into inhibitory development in other brain areas, where inhibitory networks are less experimentally accessible... - Inhibitory synapses in the developing auditory system are glutamatergicDeda C Gillespie
Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
Nat Neurosci 8:332-8. 2005..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits... - Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formationGunsoo Kim
Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
Nat Neurosci 6:282-90. 2003..These results provide new insights into the mechanisms by which precisely organized inhibitory circuits are established during development... - Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory mapJihyun Noh
Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
Nat Neurosci 13:232-8. 2010..These results indicate that glutamate co-transmission is crucial for the synaptic reorganization and topographic specification of a developing inhibitory circuit... - Excitatory action of an immature glycinergic/GABAergic sound localization pathwayKarl Kandler
Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, W1457 BST, 15261, Pittsburgh, PA, USA
Physiol Behav 77:583-7. 2002..These results provide support for the notion that the influence of glycinergic/GABAergic synaptic activity on development of the LSO involves calcium-dependent signaling mechanisms... - Glutamatergic calcium responses in the developing lateral superior olive: receptor types and their specific activation by synaptic activity patternsF Aura Ene
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurophysiol 90:2581-91. 2003..Together, these results indicate that before hearing onset, distinct patterns of afferent activity generate qualitatively distinct types of calcium responses, which likely serve in guiding different aspects of LSO development... - Metabotropic glutamate receptors in the lateral superior olive activate TRP-like channels: age- and experience-dependent regulationF Aura Ene
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurophysiol 97:3365-75. 2007.... - Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioningMandar A Aras
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurochem 110:106-17. 2009..These results indicate that neuronal Zn(2+) serves as an important, highly regulated signaling component responsible for the initiation of a neuroprotective pathway... - Paired recordings from distant inhibitory neuron pairs by a sequential scanning approachGunsoo Kim
Department of Neurobiology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA
J Neurosci Methods 200:185-9. 2011..In general, this method should provide a valuable tool to find connected neurons in other brain areas in which recording from candidate pairs has a low success rate... - Glycinergic and GABAergic calcium responses in the developing lateral superior olivePaul H M Kullmann
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Eur J Neurosci 15:1093-104. 2002..The direct link of glycinergic/GABAergic synaptic activity to intracellular calcium signalling during the period of inhibitory synaptic plasticity could be one of the mechanisms by which tonotopic MNTB-LSO connections become established... - KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responsesHanmi Lee
Department Neurobiology, University of Pittsburgh School of Medicine, W1447 Biomedical Science Tower, 3500 Terrace Street, Pittsburgh, PA 15261, USA
Eur J Neurosci 21:2593-9. 2005..We conclude that KCC2 expression is not only necessary but is also sufficient for ending the depolarizing period of GABA in developing cortical neurons... - Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracingTuan D Nguyen
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurosci Methods 209:367-70. 2012..Here we report on a method that can initially infect a single neuron-of-choice, allowing for greater precision and specificity of labeled circuits... - Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surgeMegan E Knoch
Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Glia 56:89-96. 2008..These results establish a direct link between microglial-generated oxygen and nitrogen reactive products and neuronal cell death mediated by intracellular Zn(2+) release and a surge in K(+) currents... - Somatotopic organization of rat thalamocortical slicesPeter W Land
Department of Neurobiology and Center for Neuroscience, W1458 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurosci Methods 119:15-21. 2002..We found that barrels associated with the large mobile whiskers occupy a particular location in TC slices, but that there are certain constraints to studying this portion of the barrelfield in vitro... - Cannabinoid receptor expression at the MNTB-LSO synapse in developing ratsDavid H Chi
Department of Otolaryngology, 10027 Biomedical Science Tower 3, 3501 Fifth Ave, Pittsburgh, PA 15261, United States
Neurosci Lett 509:96-100. 2012..These results suggest that endocannabinoid signaling can modulate the strength of the developing MNTB-LSO synapse... - An acoustic startle-based method of assessing frequency discrimination in miceAmanda Clause
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Neurosci Methods 200:63-7. 2011..This approach can be used to investigate the neuronal mechanisms underlying frequency discrimination, its maturation during development, and its relationship to tonotopic organization... - Synthesis, photophysical, photochemical and biological properties of caged GABA, 4-[[(2H-1-benzopyran-2-one-7-amino-4-methoxy) carbonyl] amino] butanoic acidBeate Cürten
Molecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA
Photochem Photobiol 81:641-8. 2005..BC204 is chemically stable and shows no intrinsic activity after many hours under physiological dark conditions. These properties suggest that BC204 is an excellent form of caged GABA that is well suited for long-term biological studies... - NMDAR-Mediated Calcium Transients Elicited by Glutamate Co-Release at Developing Inhibitory SynapsesAbigail Kalmbach
Department of Neurobiology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA
Front Synaptic Neurosci 2:27. 2010.... - Flipping the switch from electrical to chemical communicationKarl Kandler
Nat Neurosci 8:1633-4. 2005 - Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3Rebecca P Seal
Department of Physiology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 57:263-75. 2008..The glutamate release conferred by expression of VGLUT3 thus has an essential role in both function and development of the auditory pathway, as well as in the control of cortical excitability...
Research Grants
- Development of Neuronal Circuits in the Auditory SystemsKarl Kandler; Fiscal Year: 2010..abstract_text> ..
- Development of Neuronal Circuits in the Auditory SystemsKarl Kandler; Fiscal Year: 2007....
- DEVELOPMENT OF NEURONAL CIRCUITS IN THE AUDITORY SYSTEMKarl Kandler; Fiscal Year: 2005....