Research Topics
Species | A M KanayaSummaryAffiliation: University of California Country: USA Publications
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Publications
Glycemic associations with endothelial function and biomarkers among 5 ethnic groups: the multi-ethnic study of atherosclerosis and the mediators of atherosclerosis in South Asians living in America studiesAlka M Kanaya
University of California, San Francisco, CA 94143 0320, USA
J Am Heart Assoc 2:e004283. 2013..We examined data from 5 ethnic groups to determine the association between glucose categories and FMD or endothelial biomarkers. We determined whether these associations vary by ethnic group or body mass index...- The Live Well, Be Well study: a community-based, translational lifestyle program to lower diabetes risk factors in ethnic minority and lower-socioeconomic status adultsAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94115, USA
Am J Public Health 102:1551-8. 2012..We evaluated a community-based, translational lifestyle program to reduce diabetes risk in lower-socioeconomic status (SES) and ethnic minority adults... - Asian Americans and obesity in California: a protective effect of biculturalismSophia Wang
School of Medicine, University of California, San Francisco, San Francisco, CA, USA
J Immigr Minor Health 13:276-83. 2011..Biculturalism in Asian Americans as measured by Asian language retention appears protective against obesity. Further research is needed to understand the mechanisms underlying this association... - Heterogeneity of diabetes outcomes among asians and pacific islanders in the US: the diabetes study of northern california (DISTANCE)Alka M Kanaya
Division of General Internal Medicine, Women s Health Clinical Research Center, University of California, San Francisco, California, USA
Diabetes Care 34:930-7. 2011..Diabetes outcomes among Asian and Pacific Islander subgroups have not been disaggregated... 
Serum adiponectin and coronary heart disease risk in older Black and White AmericansAlka M Kanaya
Univerisity of California, San Francisco, California 94115, USA
J Clin Endocrinol Metab 91:5044-50. 2006..Adiponectin may influence the risk of coronary heart disease (CHD) independently of traditional cardiovascular risk factors...- Endothelin-1 and prevalent coronary heart disease in older men and women (the Rancho Bernardo Study)Alka M Kanaya
Division of General Internal Medicine, University of California San Francisco, San Francisco, California, USA
Am J Cardiol 99:486-90. 2007..Further adjustment for ankle-brachial index and carotid intima media thickness did not alter these results. In conclusion, higher endothelin-1 levels are independently associated with CHD in women of all ages and among older men only... - F2-isoprostanes and adiposity in older adultsAlka M Kanaya
University of California, San Francisco, California, USA
Obesity (Silver Spring) 19:861-7. 2011..05). In conclusion, F(2)-IPs were associated with measures of total and regional adiposity in women alone and these associations were partially explained by adipocytokines. F(2)-IPs predicted loss of total adiposity over time among women... - Prevalence and correlates of diabetes in South asian indians in the United States: findings from the metabolic syndrome and atherosclerosis in South asians living in america study and the multi-ethnic study of atherosclerosisA M Kanaya
Division of General Internal Medicine, University of California, San Francisco, San Francisco, California 94115, USA
Metab Syndr Relat Disord 8:157-64. 2010..Individuals from South Asia have high diabetes prevalence despite low body weight. We compared the prevalence of diabetes among South Asian Indians with other U.S. ethnic groups and explored correlates of diabetes... - Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) studyAlka M Kanaya
Department of Medicine, University of California San Francisco, 94115, USA
Arch Neurol 66:329-35. 2009.... - Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1Alka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
Arch Intern Med 166:350-6. 2006..Adipose tissue produces "adipocytokines" of uncertain clinical significance... - PPAR-gamma Pro12Ala genotype and risk of cognitive decline in eldersK Yaffe
Department of Psychiatry and Neurology, University of California, San Francisco, CA 94121, United States
Neurobiol Aging 29:78-83. 2008..We tested whether this polymorphism is associated with cognition... - Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition StudyOmer T Njajou
University of California, San Francisco, CA 94143 0794, USA
Diabetes Metab Res Rev 25:733-9. 2009..We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up... - Urinary incontinence in elderly women: findings from the Health, Aging, and Body Composition StudyR A Jackson
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA
Obstet Gynecol 104:301-7. 2004..To estimate the prevalence of and risk factors for stress and urge incontinence in a biracial sample of well-functioning older women... - Diabetes, impaired fasting glucose, and development of cognitive impairment in older womenK Yaffe
Department of Psychiatry, University of California, San Francisco, Box 181 4150 Clement St, San Francisco, CA 94121, USA
Neurology 63:658-63. 2004..To investigate the association between diabetes and impaired fasting glucose (IFG) and cognition and risk of developing both dementia and mild cognitive impairment (MCI) in older women... - Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: action for health in diabetes (look ahead) studySuzanne Phelan
Kinesiology Department, California Polytechnic State University, San Luis Obispo, California, USA
Diabetes Care 32:1391-7. 2009..Increasing obesity (BMI > or =35 kg/m(2)) was the strongest modifiable risk factor for overall incontinence and stress incontinence in this diverse cohort... - Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) studyA Shah
Veterans Affairs Medical Center, University of California San Francisco, CA 94115, USA
Int J Obes (Lond) 36:810-6. 2012..To investigate whether leptin and adiponectin are associated with body fat composition in a South Asian population independent of metabolic variables... - Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC StudyA J Fiocco
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA, USA
Prostaglandins Leukot Essent Fatty Acids 84:57-61. 2011..No association was found between F2-IsoP tertile and baseline or change (slope) in cognitive function over eight years. Plasma F2-IsoP is not a valuable biomarker in predicting cognitive change over years in non-demented older adults... - Quality-of-life impact and treatment of urinary incontinence in ethnically diverse older womenAlison J Huang
General Internal Medicine Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Arch Intern Med 166:2000-6. 2006..To identify the factors associated with greater quality-of-life impact, treatment seeking, and use of treatments for urinary incontinence in ethnically diverse older women... - Urinary incontinence and pelvic floor dysfunction in Asian-American womenA J Huang
Division of General Medicine, San Francisco Veterans Affairs Medical Center, 4150 Clement Street, VAMC 111A1, San Francisco, CA 94121, USA
Am J Obstet Gynecol 195:1331-7. 2006..The objective of the study was to describe the prevalence, risk factors, and impact of urinary incontinence and other pelvic floor disorders among Asian-American women... - Differences in medical care and disease outcomes among black and white women with heart diseaseAshish K Jha
Division of General Medicine, San Francisco VA Medical Center, San Francisco, USA
Circulation 108:1089-94. 2003..We sought to evaluate differences in medical care and clinical outcomes among black and white women with established coronary artery disease... - Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factorsJ S Brown
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California 94115, USA
Obstet Gynecol 98:1045-52. 2001..To assess the effects of hormone therapy on urinary tract infection frequency and to examine potential risk factors... - Identifying pulmonary tuberculosis in patients with negative sputum smear resultsA M Kanaya
Divisions of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Chest 120:349-55. 2001..Study objective: To identify the clinical, demographic, and radiographic characteristics that identify smear-negative patients who have TB, and to create a TB prediction rule... 
Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trialBeth E Cohen
Department of General Internal Medicine, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
Metab Syndr Relat Disord 6:223-9. 2008..We conducted a randomized controlled pilot trial to determine whether a restorative yoga intervention was feasible and acceptable in underactive, overweight adults with metabolic syndrome...- Fetuin-A and incident diabetes mellitus in older personsJoachim H Ix
Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, and San Diego Veterans Affairs Healthcare System, 3350 La Jolla Village Dr, Mail Code 111 H, San Diego, CA 92161, USA
JAMA 300:182-8. 2008..In prior cross-sectional studies in humans, higher fetuin-A levels were associated with insulin resistance. However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown... - Association of total and central obesity with mortality in postmenopausal women with coronary heart diseaseAlka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 64115, USA
Am J Epidemiol 158:1161-70. 2003.... - Fat infiltration of muscle, diabetes, and clinical fracture risk in older adultsAnne L Schafer
Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 95:E368-72. 2010..Older adults with type 2 diabetes are at higher risk for fracture compared with nondiabetic adults after adjustment for their higher bone mineral density. Infiltration of muscle by fat predicts increased risk of hip fracture... - Higher protein intake is associated with diabetes risk in South Asian Indians: the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) studyErica T Wang
University of California, San Francisco, 4150 Clement Street, Section 111A1, San Francisco, CA 94121, USA
J Am Coll Nutr 29:130-5. 2010..The association of macronutrient intake and diabetes in South Asian Indians was examined in this cross-sectional study... - Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernardo study cohortAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, USA
Arch Intern Med 164:1327-33. 2004..A few studies have examined change in cognitive performance by diabetes status with disparate results. We examined the 4-year change in cognitive performance among older adults according to glucose tolerance status... - Food insecurity is associated with diabetes mellitus: results from the National Health Examination and Nutrition Examination Survey (NHANES) 1999-2002Hilary K Seligman
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
J Gen Intern Med 22:1018-23. 2007..There is a clear association between food insecurity and obesity among women, but little is known about the relationship between food insecurity and type 2 diabetes... - Adipocytokines attenuate the association between visceral adiposity and diabetes in older adultsAlka M Kanaya
University of California San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
Diabetes Care 27:1375-80. 2004..To examine whether adiponectin is independently associated with diabetes and whether adiponectin and other adipocytokines account for the relationship between fat and diabetes... - Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyChristina L Wassel Fyr
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
Hum Genet 121:615-24. 2007..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin... - Association of glucose measures with total and coronary heart disease mortality: does the effect change with time? The Rancho Bernardo StudyBeth E Cohen
General Internal Medicine Section, Department of Veterans Affairs Medical Center, San Francisco, CA 94121 1598, USA
Diabetes Res Clin Pract 86:67-73. 2009..To compare the associations of three glucose measures with coronary heart disease (CHD) and total mortality and to examine how these associations changed over time... - Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition studyAlka M Kanaya
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, 1701 Divisadero St, Suite 554, San Francisco, CA 94143 1732, USA
Arch Intern Med 162:773-9. 2002..Thyroid dysfunction increases with age. Less is known about the prevalence of thyroid disease in older black adults and whether an association between thyroid function and serum cholesterol level exists, as in older white adults... - Explaining the sex difference in coronary heart disease mortality among patients with type 2 diabetes mellitus: a meta-analysisAlka M Kanaya
Department of Medicine, Division of General Internal Medicine, University of California, San Diego, USA
Arch Intern Med 162:1737-45. 2002..Most studies suggest that diabetes is a stronger coronary heart disease (CHD) risk factor for women than men, but few have adjusted their results for classic CHD risk factors: age, hypertension, total cholesterol level, and smoking... - Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trialAlka M Kanaya
Division of General Internal Medicine, University of California, San Francisco, 1701 Divisadero Street, Suite 536, San Francisco, CA 94143 1732, USA
Ann Intern Med 138:1-9. 2003..Randomized trials of postmenopausal hormone therapy have found differing effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on diabetes incidence... - Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001-2002Jeanette S Brown
Department of Obstetrics, Gynecology and Reproductive Sciences, UCSF Women s Health Clinical Research Center, University of California San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
Diabetes Care 29:1307-12. 2006..It is unknown whether women with pre-diabetes, or impaired fasting glucose (IFG), have increased prevalence of incontinence. We determined the prevalence of, and risk factors for, incontinence among U.S. women with diabetes and IFG... - Feasibility and acceptability of restorative yoga for treatment of hot flushes: a pilot trialBeth E Cohen
General Internal Medicine Section, San Francisco Veterans Affairs Medical Center, CA 94121 1598, USA
Maturitas 56:198-204. 2007..To determine the feasibility and acceptability of a restorative yoga intervention for the treatment of hot flushes in postmenopausal women... - Impaired fasting glucose and cardiovascular outcomes in postmenopausal women with coronary artery diseaseAlka M Kanaya
University of California, San Francisco, San Francisco, California, USA
Ann Intern Med 142:813-20. 2005..Type 2 diabetes increases risk for cardiovascular disease. Persons with impaired fasting glucose levels may also have increased risk... - Predicting the development of diabetes in older adults: the derivation and validation of a prediction ruleAlka M Kanaya
Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
Diabetes Care 28:404-8. 2005..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort... - Prevalence and correlates of cardiovascular risk factors in South Asians: population-based data from two California surveysSusan L Ivey
School of Public Health, University of California, Berkeley 94720 7360, USA
Ethn Dis 16:886-93. 2006..Few population-based studies report cardiovascular disease (CVD) risk factor prevalence for South Asians in the United States. We examined CVD risk for South Asians in California... - Prevention of type 2 diabetes: data from recent trialsA M Kanaya
Division of General Internal Medicine, University of California San Francisco, 1701 Divisadero Street, Suite 500, San Francisco, CA 94143 1732, USA
Prim Care 30:511-26. 2003..New strategies that identify those with pre-diabetes and that overcome the limitations of the current tests, particularly the 2-hour post-challenge glucose test, are needed... - Adiponectin and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul studyMary H Zhang
University of California, San Francisco, CA 94121, USA
Atherosclerosis 205:233-8. 2009..We sought to determine whether higher adiponectin levels are associated with exercise-induced ischemia in patients with stable CHD... - Serum leptin concentrations and body adipose measures in older black and white adultsConstance E Ruhl
Social and Scientific Systems, Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
Am J Clin Nutr 80:576-83. 2004..Among US adults, serum leptin concentrations are higher in women than in men and are higher in blacks than in whites independent of anthropometric measures of body fatness... - Abdominal obesity is an independent risk factor for chronic heart failure in older peopleBarbara J Nicklas
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Am Geriatr Soc 54:413-20. 2006..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women... - Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition StudyBarbara J Nicklas
Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Epidemiol 160:741-9. 2004..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women... - Body mass index and serum leptin concentration independently estimate percentage body fat in older adultsConstance E Ruhl
Social and Scientific Systems Inc, Silver Spring, MD, USA
Am J Clin Nutr 85:1121-6. 2007.... - Joint effects of adiposity and physical activity on incident mobility limitation in older adultsAnnemarie Koster
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA
J Am Geriatr Soc 56:636-43. 2008..To examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation... - Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adultsNadine R Sahyoun
Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USA
Am J Clin Nutr 82:547-52. 2005..Recent evidence suggests that the rate of carbohydrate digestion and absorption may influence the development of type 2 diabetes... - Polymorphisms in the peroxisome proliferator activated receptor alpha gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not CaucasiansMin Jeong Shin
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Atherosclerosis 198:313-9. 2008.... - Relationship of ankle blood pressures to cardiovascular events in older adultsKim Sutton-Tyrrell
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, GSPH 505A Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA
Stroke 39:863-9. 2008..We focus on the extent to which low and high ankle-arm index values as well as noncompressible arteries are associated with mortality and cardiovascular events, including stroke in older adults... - Insulin-like growth factor-1Lisa H Colbert
J Am Geriatr Soc 52:1962-3. 2004 - Lifestyle intervention for the prevention of type 2 diabetes mellitus: putting theory to practiceK M Venkat Narayan
Division of Diabetes Translation, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, Georgia 30341, USA
Treat Endocrinol 2:315-20. 2003..Delivery of lifestyle interventions in practice is fraught with challenges, but there are several tools and practical strategies available for the implementation of trial findings... - Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention ProgramJeanette S Brown
Diabetes Prevention Program Research Group, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
Diabetes Care 29:385-90. 2006..We examined whether an intensive lifestyle intervention or metformin therapy among overweight pre-diabetic women was associated with a lower prevalence of incontinence...
Research Grants
- Obesity, Oxidative Stress, and Diabetes in Older AdultsAlka Kanaya; Fiscal Year: 2007..If these markers are implicated in causing diabetes, then this would lead to testing whether vitamins or other supplements that target these markers may decrease the risk of diabetes in obese individuals. ..
- Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) studyAlka Kanaya; Fiscal Year: 2009..If yoga is associated with improved metabolic risk factors, this would offer an inexpensive and safe alternative to diet and exercise to delay or prevent diabetes or cardiovascular disease. ..
- Metabolic Syndrome and Atherosclerosis in South AsiansAlka Kanaya; Fiscal Year: 2007..End of Abstract) ..
- Mediators of Atherosclerosis in South Asians Living in AmericaAlka M Kanaya; Fiscal Year: 2010..These will provide targets for future therapies to prevent or cure the leading cause of death worldwide, cardiovascular disease. ..
- Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) studyAlka M Kanaya; Fiscal Year: 2010..If yoga is associated with improved metabolic risk factors, this would offer an inexpensive and safe alternative to diet and exercise to delay or prevent diabetes or cardiovascular disease. ..