KYLE MATTHEW KAMPMAN

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence
    Kyle Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 28:437-48. 2003
  2. pmc The search for medications to treat stimulant dependence
    Kyle M Kampman
    University of Pennsylvania School of Medicine and Treatment Research Center, Philadelphia, Pennsylvania 19104, USA
    Addict Sci Clin Pract 4:28-35. 2008
  3. ncbi request reprint Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms
    K M Kampman
    Department of Psychiatry, University of Pennsylvannia School of Medicine, Philadelphia, 19104, USA
    Am J Psychiatry 157:2052-4. 2000
  4. doi request reprint What's new in the treatment of cocaine addiction?
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, University of Pennsylvania Treatment Research Center, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 12:441-7. 2010
  5. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
  6. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
  7. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
  8. ncbi request reprint A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 85:129-37. 2006
  9. ncbi request reprint Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned
    Kyle M Kampman
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Addiction 100:102-10. 2005
  10. ncbi request reprint A pilot trial of topiramate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 75:233-40. 2004

Research Grants

Detail Information

Publications35

  1. ncbi request reprint A pilot trial of piracetam and ginkgo biloba for the treatment of cocaine dependence
    Kyle Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 28:437-48. 2003
    ..Nootropic agents, such as piracetam and ginkgo biloba, may improve cognitive function and reduce the incidence of relapse in these patients...
  2. pmc The search for medications to treat stimulant dependence
    Kyle M Kampman
    University of Pennsylvania School of Medicine and Treatment Research Center, Philadelphia, Pennsylvania 19104, USA
    Addict Sci Clin Pract 4:28-35. 2008
    ..Treatment approaches that combine efficacious medications and empirically proven behavioral interventions, such as voucher-based reinforcement therapy, will almost certainly produce the best results...
  3. ncbi request reprint Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms
    K M Kampman
    Department of Psychiatry, University of Pennsylvannia School of Medicine, Philadelphia, 19104, USA
    Am J Psychiatry 157:2052-4. 2000
    ..The study examined the effectiveness of amantadine in reducing cocaine withdrawal symptoms and improving treatment outcome among cocaine-dependent patients in outpatient treatment...
  4. doi request reprint What's new in the treatment of cocaine addiction?
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, University of Pennsylvania Treatment Research Center, Philadelphia, PA 19104, USA
    Curr Psychiatry Rep 12:441-7. 2010
    ..New medications and new psychosocial techniques are leading to significant improvements in the treatment of cocaine dependence...
  5. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  6. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  7. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
    ..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
  8. ncbi request reprint A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 85:129-37. 2006
    ..This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms...
  9. ncbi request reprint Cocaine Rapid Efficacy Screening Trials (CREST): lessons learned
    Kyle M Kampman
    Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA
    Addiction 100:102-10. 2005
    ....
  10. ncbi request reprint A pilot trial of topiramate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 75:233-40. 2004
    ..Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence...
  11. ncbi request reprint Cocaine dependence severity predicts outcome in outpatient detoxification from cocaine and alcohol
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Am J Addict 13:74-82. 2004
    ..Among cocaine- and alcohol-dependent subjects, cocaine dependence severity appears to be a more important predictor of detoxification success than alcohol dependence severity...
  12. ncbi request reprint Effectiveness of propranolol for cocaine dependence treatment may depend on cocaine withdrawal symptom severity
    K M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 63:69-78. 2001
    ..Propranolol may be useful only for the treatment of cocaine dependent patients with severe cocaine withdrawal symptoms...
  13. ncbi request reprint Concurrent cocaine withdrawal alters alcohol withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine and the Department of Veterans Affairs Medical Center, Philadelphia, USA
    J Addict Dis 21:13-26. 2002
    ..Both subject and clinician factors may explain the difference in oxazepam use...
  14. ncbi request reprint Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Addict Behav 27:251-60. 2002
    ..Urine toxicology results and CSSA scores obtained at treatment entry are useful predictors of outcome in outpatient cocaine dependence treatment...
  15. ncbi request reprint A pilot trial of olanzapine for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, School of Medicine, Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:265-73. 2003
    ....
  16. ncbi request reprint Adding a nicotine blocking agent to cigarette tapering
    Peter Gariti
    Treatment Research Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Subst Abuse Treat 27:17-25. 2004
    ..Biochemically confirmed abstinence rates at followups did not differ between treatment groups (AD&C = 10%, 13%, 10% vs. PD&C = 3%, 10%, 13%). There is not enough evidence to suggest a Stage II trial...
  17. ncbi request reprint Limbic activation to cigarette smoking cues independent of nicotine withdrawal: a perfusion fMRI study
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:2301-9. 2007
    ....
  18. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  19. pmc The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia School of Medicine, PA 19104, USA
    Drug Alcohol Depend 103:30-6. 2009
    ..These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation...
  20. doi request reprint Cocaine withdrawal symptoms identify "Type B" cocaine-dependent patients
    Jamshid Ahmadi
    Center for the Study of Addictions, Treatment Research Center, University of Pennsylvania, Philadelphia, PA, USA
    Am J Addict 17:60-4. 2008
    ..Identifying Type B cocaine-dependent patients may help to develop targeted psychosocial or pharmacological treatments for these difficult-to-treat patients...
  21. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  22. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  23. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
    ..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
  24. pmc Why do those who request smoking treatment fail to attend the first appointment?
    Peter Gariti
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 35:62-7. 2008
    ..Those who kept the initial appointment were more likely to report smoking abstinence at 12 weeks. The study has implications for increasing the utilization of potentially effective treatments for smokers...
  25. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  26. ncbi request reprint A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychopharmacology 30:205-11. 2005
    ..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
  27. ncbi request reprint An evaluation of anabolic-androgenic steroid abusers over a period of 1 year: seven case studies
    Paul J Fudala
    Department of Psychiatry, University of Pennsylvania School of Medicine Philadelphia, Pennsylvania, USA
    Ann Clin Psychiatry 15:121-30. 2003
    ..The results provide the first long-term, prospective evaluation of the effects of AASs, when these drugs are administered in a naturalistic pattern of abuse...
  28. ncbi request reprint Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  29. ncbi request reprint Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  30. ncbi request reprint The status of disulfiram: a half of a century later
    Jesse J Suh
    Treatment Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 26:290-302. 2006
    ..Preliminary evidence also suggests that disulfiram treatment could be a viable treatment for cocaine dependence because it was shown to reduce cocaine use among nonalcoholic, cocaine-dependent patients...
  31. ncbi request reprint Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study
    Charles A Dackis
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:29-37. 2003
    ..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
  32. ncbi request reprint No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  33. ncbi request reprint The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6178, USA
    J Clin Psychopharmacol 26:610-25. 2006
    ..Clinical trial results in this article are evaluated by the type of outcome measure used to determine naltrexone's treatment advantage, that is, measures related to reducing heavy drinking versus those related to increasing abstinence...
  34. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  35. pmc Atomoxetine for treatment of marijuana dependence: a report on the efficacy and high incidence of gastrointestinal adverse events in a pilot study
    Carlos F Tirado
    University of Texas Southwestern Medical Center Division on Addictions, 5323 Harry Hines Boulevard, Dallas, TX 75390 8564, USA
    Drug Alcohol Depend 94:254-7. 2008
    ..Atomoxetine is of limited utility in the treatment of cannabis dependence and is associated with clinically significant GI adverse events...

Research Grants10

  1. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2004
    ..abstract_text> ..
  2. Quetiapine for the treatment of Type A and Type B alcoholism
    Kyle Kampman; Fiscal Year: 2009
    ..Exploratory analyses will be conducted to further investigate other possible quetiapine / alcohol subtype interactions ..
  3. Quetiapine for the treatment of Type A and Type B alcoholism
    Kyle Kampman; Fiscal Year: 2007
    ..Exploratory analyses will be conducted to further investigate other possible quetiapine / alcohol subtype interactions ..
  4. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2007
    ..abstract_text> ..
  5. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2006
    ..abstract_text> ..
  6. Topiramate for alcohol and cocaine dependence
    Kyle Kampman; Fiscal Year: 2005
    ..abstract_text> ..
  7. Quetiapine for the treatment of Type A and Type B alcoholism
    KYLE MATTHEW KAMPMAN; Fiscal Year: 2010
    ..Exploratory analyses will be conducted to further investigate other possible quetiapine / alcohol subtype interactions ..