TIMOTHY KAMP

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi request reprint Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology
    Jia Qiang He
    Cellular Dynamics International, Inc, 525 Science Drive, Suite 200, Madison, WI 53711, USA 1 608 263 4856 1 608 263 0405
    Expert Opin Drug Discov 2:739-53. 2007
  2. pmc Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
    Jianhua Zhang
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Circ Res 111:1125-36. 2012
  3. pmc Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
    Christine L Mummery
    Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands
    Circ Res 111:344-58. 2012
  4. ncbi request reprint Voltage-dependent facilitation of cardiac L-type Ca channels expressed in HEK-293 cells requires beta-subunit
    T J Kamp
    Departments of Medicine and Physiology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Am J Physiol Heart Circ Physiol 278:H126-36. 2000
  5. ncbi request reprint Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C
    T J Kamp
    Department of Medicine, University of Wisconsin, Madison, WI 53792 3248, USA
    Circ Res 87:1095-102. 2000
  6. ncbi request reprint Cardiomyocyte transverse tubule loss leads the way to heart failure
    Ravi C Balijepalli
    Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Future Cardiol 7:39-42. 2011
  7. pmc Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels
    Jabe M Best
    University of Wisconsin School of Medicine and Public Health, H6 370 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3248, USA
    Am J Physiol Cell Physiol 300:C1023-33. 2011

Collaborators

  • JOSE JALIFE
  • Jianhua Zhang
  • Ravi C Balijepalli
  • Christine L Mummery
  • Jabe M Best
  • James A Thomson
  • Craig T January
  • Jia Qiang He
  • Andrew G Soerens
  • Todd J Herron
  • Kunil K Raval
  • Elizabeth S Ng
  • Amanda M Herman
  • Junying Yu
  • Luqia Hou
  • Gary E Lyons
  • David A Elliott
  • Xiaojun Lian
  • Andrew G Elefanty
  • Matthew R Barron
  • Sean P Palecek
  • Matthew Klos
  • Gisela F Wilson
  • Jason D Foell
  • Brian P Delisle
  • Courtney R Buss

Detail Information

Publications7

  1. doi request reprint Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology
    Jia Qiang He
    Cellular Dynamics International, Inc, 525 Science Drive, Suite 200, Madison, WI 53711, USA 1 608 263 4856 1 608 263 0405
    Expert Opin Drug Discov 2:739-53. 2007
    ..Furthermore, cardiac safety pharmacology assays evaluating the risk of proarrhythmic side effects associated with QT prolongation may be enhanced in their predictive value with the use of hESC-CMs...
  2. pmc Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
    Jianhua Zhang
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Circ Res 111:1125-36. 2012
    ..However, extracellular matrix is also fundamentally involved in cardiac development from the earliest morphogenetic events, such as gastrulation...
  3. pmc Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview
    Christine L Mummery
    Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands
    Circ Res 111:344-58. 2012
    ....
  4. ncbi request reprint Voltage-dependent facilitation of cardiac L-type Ca channels expressed in HEK-293 cells requires beta-subunit
    T J Kamp
    Departments of Medicine and Physiology, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Am J Physiol Heart Circ Physiol 278:H126-36. 2000
    ....
  5. ncbi request reprint Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C
    T J Kamp
    Department of Medicine, University of Wisconsin, Madison, WI 53792 3248, USA
    Circ Res 87:1095-102. 2000
    ..Crosstalk between PKA and PKC pathways occurs in the modulation of I:(Ca). Ultimately, precise regulation of I:(Ca) is needed for normal cardiac function, and alterations in these regulatory pathways may prove important in heart disease...
  6. ncbi request reprint Cardiomyocyte transverse tubule loss leads the way to heart failure
    Ravi C Balijepalli
    Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Future Cardiol 7:39-42. 2011
    ..These findings provide a new insight into the critical transition from compensated hypertrophy to heart failure and suggests important future areas for investigation...
  7. pmc Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels
    Jabe M Best
    University of Wisconsin School of Medicine and Public Health, H6 370 Clinical Science Center, 600 Highland Ave, Madison, WI 53792 3248, USA
    Am J Physiol Cell Physiol 300:C1023-33. 2011
    ..This suggests Rab11b differentially regulates the trafficking of distinct cargo and extends our understanding of how endosomal transport impacts the functional expression of LTCCs...

Research Grants16

  1. Embryonic Stem Cell-based Therapies for Myocardial Infarction
    Timothy J Kamp; Fiscal Year: 2010
    ..Overall, these studies will provide new insights into cell-based therapies in the post-MI setting and bring approaches using human ESCs closer to clinical application. ..
  2. Caveolae and L-type Calcium Channels in Cardiomyocytes
    TIMOTHY KAMP; Fiscal Year: 2009
    ..Ultimately, a molecular understanding of caveolae and L-type Ca2+ channels has the potential to inspire new therapies for these prevalent cardiovascular diseases. ..
  3. Embryonic Stem Cell-based Therapies for Myocardial Infarction
    TIMOTHY KAMP; Fiscal Year: 2009
    ..Overall, these studies will provide new insights into cell-based therapies in the post-MI setting and bring approaches using human ESCs closer to clinical application. ..
  4. Caveolae and L-type Calcium Channels in Cardiomyocytes
    TIMOTHY KAMP; Fiscal Year: 2007
    ..Ultimately, a molecular understanding of caveolae and L-type Ca2+ channels has the potential to inspire new therapies for these prevalent cardiovascular diseases. ..
  5. Embryonic Stem Cell-based Therapies for Myocardial Infarction
    TIMOTHY KAMP; Fiscal Year: 2007
    ..Overall, these studies will provide new insights into cell-based therapies in the post-MI setting and bring approaches using human ESCs closer to clinical application. ..
  6. Rhesus Heart Regeneration With Embryonic Stem Cells
    TIMOTHY KAMP; Fiscal Year: 2004
    ..Overall, these developmental approaches have the potential to dramatically advance the field of myocardial regeneration and bring cardiac cell transplantation much closer to clinical reality. ..
  7. T-TUBULES AND L-TYPE CALCIUM CHANNELS IN HEART FAILURE
    TIMOTHY KAMP; Fiscal Year: 2002
    ....
  8. VOLTAGE DEPENDENT ACTIVATION OF CARDIAC CALCIUM CHANNELS
    TIMOTHY KAMP; Fiscal Year: 2001
    ..5) To quantitate the difference in the number of elementary charges per channel comparing a1C+a2-d vs. a1C+a2-d+b channels in order to detect Qf. ..
  9. Caveolae and L-type Calcium Channels in Cardiomyocytes
    Timothy J Kamp; Fiscal Year: 2010
    ..Ultimately, a molecular understanding of caveolae and L-type Ca2+ channels has the potential to inspire new therapies for these prevalent cardiovascular diseases. ..