Paul J Kammermeier
Affiliation: University of Rochester
Kammermeier P. The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency. BMC Pharmacol. 2012;12:6 pubmed publisher
..While some weak biased agonism was observed with CHPG acting on mGluR1, but not mGluR5, favoring Gi/o signaling over Gq/11, this effect does not appear sufficient to fully explain the discrepancies in the literature. ..
Hu J, Worley P, Kammermeier P. Dynamic Regulation of Homer Binding to Group I Metabotropic Glutamate Receptors by Preso1 and Converging Kinase Cascades. J Pharmacol Exp Ther. 2017;361:122-129 pubmed publisher
..These data suggest that the BDNF/tyrosine receptor kinase B and Cdk5 pathways converge at the level of mGluR to similarly induce Homer ligand phosphorylation, recruit Homer binding, and uncouple mGluRs from channel regulation. ..
Kammermeier P. Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. J Neurosci. 2008;28:8560-7 pubmed publisher
..In both cases, RNA silencing of Homer 1a but not control RNA interference treatment prevented the PACAP effect, suggesting that it resulted specifically from native Homer 1a expression. ..
Sevastyanova T, Kammermeier P. Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5. Mol Pharmacol. 2014;86:492-504 pubmed publisher
..Together, these data demonstrate cooperative signaling between mGluR1 and mGluR5 in a manner inconsistent with heterodimerization, and thus suggest an interaction between homodimers. ..
Kammermeier P. Constitutive activity of metabotropic glutamate receptor 7. BMC Neurosci. 2015;16:17 pubmed publisher
..Constitutive activity of mGluR7 may be eliminated or reduced by the presence of other group III mGluRs, perhaps due to heterodimer formation. In addition, both MMPIP and PPG acted as inverse agonists at mGluR7, and agonists at mGluR8. ..
Kammermeier P, Worley P. Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Proc Natl Acad Sci U S A. 2007;104:6055-60 pubmed
..Thus, alteration of mGluR signaling by changes in Homer protein expression may represent a viable mechanism for fine-tuning synaptic strength in neurons. ..
Kammermeier P. C-terminal deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq. Eur J Pharmacol. 2010;627:63-8 pubmed publisher
..These data indicate that C-terminal deletion of mGlu(1) receptor selectively abolishes Galpha(q/11) coupling. ..
Kammermeier P. Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers. Mol Pharmacol. 2012;82:438-47 pubmed publisher