Paul J Kammermeier

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA
    Mol Pharmacol 82:438-47. 2012
  2. pmc The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Pharmacol 12:6. 2012
  3. doi request reprint C-terminal deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Box 711, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Eur J Pharmacol 627:63-8. 2010
  4. doi request reprint Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:8560-7. 2008
  5. pmc Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
  6. pmc The interaction between mGluR1 and the calcium channel Cav₂.₁ preserves coupling in the presence of long Homer proteins
    Donald Beqollari
    University of Rochester Medical Center, Department of Pharmacology and Physiology, Rochester, NY 14642, USA
    Neuropharmacology 66:302-10. 2013
  7. doi request reprint The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Pharmacol 589:49-52. 2008
  8. doi request reprint Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Pharmacol 76:992-7. 2009
  9. doi request reprint Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurophysiol 104:439-48. 2010
  10. ncbi request reprint G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells
    Liantian Tian
    Department of Biomedical Sciences, Kent State University, Rootstown, Ohio, USA
    Vis Neurosci 23:909-16. 2006

Collaborators

  • Paul F Worley
  • Donald Beqollari
  • Liantian Tian
  • Stephen R Ikeda
  • Matthew J Betzenhauser

Detail Information

Publications16

  1. pmc Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA
    Mol Pharmacol 82:438-47. 2012
    ....
  2. pmc The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    BMC Pharmacol 12:6. 2012
    ..SCG neurons offer a null mGluR-background in which specific mGluR subtypes can be made to express via intranuclear cDNA injection...
  3. doi request reprint C-terminal deletion of metabotropic glutamate receptor 1 selectively abolishes coupling to Galphaq
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Box 711, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Eur J Pharmacol 627:63-8. 2010
    ..These data indicate that C-terminal deletion of mGlu(1) receptor selectively abolishes Galpha(q/11) coupling...
  4. doi request reprint Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:8560-7. 2008
    ..In both cases, RNA silencing of Homer 1a but not control RNA interference treatment prevented the PACAP effect, suggesting that it resulted specifically from native Homer 1a expression...
  5. pmc Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
    ..Thus, alteration of mGluR signaling by changes in Homer protein expression may represent a viable mechanism for fine-tuning synaptic strength in neurons...
  6. pmc The interaction between mGluR1 and the calcium channel Cav₂.₁ preserves coupling in the presence of long Homer proteins
    Donald Beqollari
    University of Rochester Medical Center, Department of Pharmacology and Physiology, Rochester, NY 14642, USA
    Neuropharmacology 66:302-10. 2013
    ..1) into the mGluR1/Homer signaling complex, thereby preserving modulation in the presence of scaffolding Homer proteins. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'...
  7. doi request reprint The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Eur J Pharmacol 589:49-52. 2008
    ..Conversely, PHCCC directly activates the mGlu(6) receptor and does not enhance activity of glutamate. Therefore, PHCCC is a direct mGlu(6) receptor agonist, but lacks allosteric modulatory properties...
  8. doi request reprint Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mol Pharmacol 76:992-7. 2009
    ..Most importantly, our results indicate a switch in G-protein coupling, in which E775K loses G(o) coupling but retains coupling to G(i), which may explain the phenotype...
  9. doi request reprint Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling
    Donald Beqollari
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurophysiol 104:439-48. 2010
    ....
  10. ncbi request reprint G protein coupling profile of mGluR6 and expression of G alpha proteins in retinal ON bipolar cells
    Liantian Tian
    Department of Biomedical Sciences, Kent State University, Rootstown, Ohio, USA
    Vis Neurosci 23:909-16. 2006
    ..Together, these data indicate that signaling through mGluR6 in mammalian ON bipolar cells is highly focused, apparently acting through a single G alpha protein subtype...
  11. pmc Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    BMC Neurosci 7:1. 2006
    ..Further, an exhaustive study of the effects of each long Homer isoform on mGluR distribution has not been published...
  12. ncbi request reprint Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits
    Paul J Kammermeier
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P O Box 95, Rootstown, OH 44272, USA
    J Pharmacol Exp Ther 312:502-8. 2005
    ..These data suggest that mutant/wild-type heterodimeric receptors are inactive at ligand concentrations favoring glutamate association with receptor dimers at only one subunit...
  13. ncbi request reprint Specificity of metabotropic glutamate receptor 2 coupling to G proteins
    Paul J Kammermeier
    Laboratory of Molecular Physiology, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland, USA
    Mol Pharmacol 63:183-91. 2003
    ..Strong bands were detected for all members of the G(i/o) family (Galphao, Galphai1, Galphai2, Galphai3, Galphaz) as well as for Galpha11 and Galphas. A weak signal was detected for Galphaq and no Galpha15 mRNA was detected...
  14. ncbi request reprint Metabotropic glutamate receptor expression in the rat superior cervical ganglion
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, PA 18840, USA
    Neurosci Lett 330:260-4. 2002
    ....
  15. ncbi request reprint Desensitization of group I metabotropic glutamate receptors in rat sympathetic neurons
    Paul J Kammermeier
    Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Neurophysiol 87:1669-76. 2002
    ..These data indicate a role for nonconventional protein kinase C isoforms as a mediator of mGluR5 desensitization and that the phosphorylation of mGluR5a that competes with calmodulin binding does not mediate desensitization...
  16. ncbi request reprint M current mystery messenger revealed?
    Stephen R Ikeda
    Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Neuron 35:411-2. 2002
    ..These data suggest that breakdown of phosphotidylinositol 4,5-bisphosphate (PIP(2)) is a crucial determinant of M channel modulation...