M Kamboh

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
  2. pmc Genome-wide association study of antiphospholipid antibodies
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Autoimmune Dis 2013:761046. 2013
  3. pmc A multiethnic replication study of plasma lipoprotein levels-associated SNPs identified in recent GWAS
    Emily K Bryant
    Human Genetics, GSPH, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e63469. 2013
  4. pmc Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
    Samantha L Rosenthal
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95152. 2014
  5. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
  6. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012
  7. pmc Association of CLU and PICALM variants with Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurobiol Aging 33:518-21. 2012
  8. pmc Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
    Sudeshna Dasgupta
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Med Genet 12:7. 2011
  9. pmc Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus
    F Yesim K Demirci
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Rheumatol 38:652-7. 2011

Research Grants

Collaborators

Detail Information

Publications9

  1. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
    ..43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples...
  2. pmc Genome-wide association study of antiphospholipid antibodies
    M Ilyas Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Autoimmune Dis 2013:761046. 2013
    ..Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings...
  3. pmc A multiethnic replication study of plasma lipoprotein levels-associated SNPs identified in recent GWAS
    Emily K Bryant
    Human Genetics, GSPH, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e63469. 2013
    ..However, the associations were not consistently present in all ethnic groups. This observation was consistent with mixed results obtained in other studies that also examined various ethnic groups...
  4. pmc Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings
    Samantha L Rosenthal
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95152. 2014
    ..This study further supports the assumption that some of the non-coding GWAS SNPs are true associations rather than tagged associations and demonstrates the application of RegulomeDB to GWAS data. ..
  5. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
    ..The E4 allele of the apolipoprotein E (APOE) gene is a well-documented risk factor for the development of AD. However, genetic association studies of the APOE 4 allele and BPS in AD have produced conflicting findings...
  6. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012
    ..These findings need to be confirmed in additional well-powered samples...
  7. pmc Association of CLU and PICALM variants with Alzheimer's disease
    M Ilyas Kamboh
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States
    Neurobiol Aging 33:518-21. 2012
    ..Our data from an independent and large case-control sample suggest that these gene regions should be followed up by comprehensive resequencing to find functional variants...
  8. pmc Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
    Sudeshna Dasgupta
    Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Med Genet 12:7. 2011
    ....
  9. pmc Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus
    F Yesim K Demirci
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Rheumatol 38:652-7. 2011
    ....

Research Grants39

  1. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2006
    ....
  2. Search for the Alzheimer's Gene on Chromosome 10
    M Kamboh; Fiscal Year: 2009
    ..This study is focused on identifying the AD gene on chromosome 10 by using a large case-control sample in the discovery sample and a family-based sample in the replication sample. ..
  3. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2003
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  4. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2003
    ..S. whites and blacks. The proposed immunochemical, functional, molecular and genetic epidemiological studies will enable us to delineate the role of the apoD in the etiology of AD. ..
  5. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2004
    ....
  6. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2004
    ..S. whites and blacks. The proposed immunochemical, functional, molecular and genetic epidemiological studies will enable us to delineate the role of the apoD in the etiology of AD. ..
  7. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2006
    ..We will systematically screen the three PON genes for new mutations (Aim 1) and, in conjunction with known PON potymorphisms, we will evaluate their genetic and functional significances (Aims 2-4). ..
  8. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2006
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  9. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2002
    ..S. whites and blacks. The proposed immunochemical, functional, molecular and genetic epidemiological studies will enable us to delineate the role of the apoD in the etiology of AD. ..
  10. Genetic Determinants of HDL-Cholesterol
    M Ilyas Kamboh; Fiscal Year: 2010
    ..As a result of these analyses, we should be able to definitively determine both rare and common variants that contribute to high and low HDL-C levels. ..
  11. MOLECULAR GENETICS ANALYSIS OF APOLIPOPROTEIN H IN SLE
    M Kamboh; Fiscal Year: 2001
    ..The investigators state that the proposed studies will facilitate the identification and characterization of the role of APOH genetic polymorphisms in the prediction of the antiphospholipid antibodies in SLE patients. ..
  12. RISK GENES IN ALZHEIMERS DISEASE
    M Kamboh; Fiscal Year: 2000
    ..The proposed focused genetic and epidemiological studies will enable us to delineate the role of several candidate genes in further refining and defining the role of genes in determining the risk and natural history of AD. ..
  13. MOLECULAR GENETICS ANALYSIS OF APOLIPOPROTEIN H IN SLE
    M Kamboh; Fiscal Year: 2000
    ..The investigators state that the proposed studies will facilitate the identification and characterization of the role of APOH genetic polymorphisms in the prediction of the antiphospholipid antibodies in SLE patients. ..
  14. Search for the Alzheimer's Gene on Chromosome 10
    M Ilyas Kamboh; Fiscal Year: 2010
    ..This study is focused on identifying the AD gene on chromosome 10 by using a large case-control sample in the discovery sample and a family-based sample in the replication sample. ..
  15. Immune/Inflammation Genomics and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2011
    ....
  16. Prothrombin Gene Variation and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2010
    ....
  17. Risk Genes in Alzheimer's Disease
    M Kamboh; Fiscal Year: 2006
    ..S. whites and blacks. The proposed immunochemical, functional, molecular and genetic epidemiological studies will enable us to delineate the role of the apoD in the etiology of AD. ..
  18. Immune/Inflammation Genomics and the Risk of SLE and CHD
    M Kamboh; Fiscal Year: 2009
    ....
  19. Immune/Inflammation Genomics and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2010
    ....
  20. Genetic Determinants of HDL-Cholesterol
    M Kamboh; Fiscal Year: 2009
    ..As a result of these analyses, we should be able to definitively determine both rare and common variants that contribute to high and low HDL-C levels. ..
  21. Prothrombin Gene Variation and the Risk of SLE and CHD
    M Kamboh; Fiscal Year: 2009
    ....
  22. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2005
    ..We will systematically screen the three PON genes for new mutations (Aim 1) and, in conjunction with known PON potymorphisms, we will evaluate their genetic and functional significances (Aims 2-4). ..
  23. MOLECULAR GENETICS ANALYSIS OF APOLIPOPROTEIN H IN SLE
    M Kamboh; Fiscal Year: 1999
    ..The investigators state that the proposed studies will facilitate the identification and characterization of the role of APOH genetic polymorphisms in the prediction of the antiphospholipid antibodies in SLE patients. ..
  24. RISK GENES IN ALZHEIMERS DISEASE
    M Kamboh; Fiscal Year: 1999
    ..The proposed focused genetic and epidemiological studies will enable us to delineate the role of several candidate genes in further refining and defining the role of genes in determining the risk and natural history of AD. ..
  25. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2002
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  26. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2003
    ....
  27. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2003
    ..We will systematically screen the three PON genes for new mutations (Aim 1) and, in conjunction with known PON potymorphisms, we will evaluate their genetic and functional significances (Aims 2-4). ..
  28. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2004
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  29. Genetic & Structure-Function Studies: Paraoxonase In SLE
    M Kamboh; Fiscal Year: 2004
    ..We will systematically screen the three PON genes for new mutations (Aim 1) and, in conjunction with known PON potymorphisms, we will evaluate their genetic and functional significances (Aims 2-4). ..
  30. Functional Characterization-Lipoprotein Lipase Mutations
    M Kamboh; Fiscal Year: 2005
    ....
  31. Analysis of Apolipoprotein H in Lupus
    M Kamboh; Fiscal Year: 2005
    ..Aim 5) perform in vitro mutagenesis and expression studies to express different apoH allelic-isoforms to evaluate isoform-specific inhibition of LDL oxidation. ..
  32. Immune/Inflammation Genomics and the Risk of SLE and CHD
    M Ilyas Kamboh; Fiscal Year: 2010
    ..abstract_text> ..