P Kalinski

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000
  2. ncbi Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Blood 97:3466-9. 2001
  3. ncbi Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
  4. ncbi Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
  5. ncbi Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
  6. ncbi IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
  7. ncbi How to deal with polarized Th2 cells: exploring the Achilles' heel
    H H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:102-10. 2001
  8. ncbi Analysis of the CD4+ T cell responses to house dust mite allergoid
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 58:648-56. 2003

Collaborators

Detail Information

Publications8

  1. ncbi IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000
    ....
  2. ncbi Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Blood 97:3466-9. 2001
    ..Selective induction of IL-12p40 and suppression of bioactive IL-12p70 may have negative impact on anticancer vaccination with PGE(2)-matured DCs. (Blood. 2001;97:3466-3469)..
  3. ncbi Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
    ..These data imply that the character of pathogen-induced local inflammatory reaction can "instruct" local DC to initiate Th1 or Th2-biased responses...
  4. ncbi Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
    ..Type 1-polarized effector DC are resistant to further modulation, which may facilitate their potential use in immunotherapy...
  5. ncbi Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
    ....
  6. ncbi IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
    ..Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherapy...
  7. ncbi How to deal with polarized Th2 cells: exploring the Achilles' heel
    H H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:102-10. 2001
    ..The development of new therapies for atopic allergy now focuses on local IL-12-promoting substances to target both the development of new Th2 cells and the persistent population of established allergen-specific Th2 cells...
  8. ncbi Analysis of the CD4+ T cell responses to house dust mite allergoid
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 58:648-56. 2003
    ..Varying frequencies of allergoid-nonreactive HDM-specific Th cells may result in differential responses of individual patients to immunotherapy...