P Kalinski

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000
  2. ncbi request reprint Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Blood 97:3466-9. 2001
  3. ncbi request reprint Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
  4. ncbi request reprint Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
  5. ncbi request reprint Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
  6. ncbi request reprint IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
  7. ncbi request reprint How to deal with polarized Th2 cells: exploring the Achilles' heel
    H H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:102-10. 2001
  8. ncbi request reprint Analysis of the CD4+ T cell responses to house dust mite allergoid
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 58:648-56. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells
    P Kalinski
    Department of Cell Biology and Histology and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 165:1877-81. 2000
    ....
  2. ncbi request reprint Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Blood 97:3466-9. 2001
    ..Selective induction of IL-12p40 and suppression of bioactive IL-12p70 may have negative impact on anticancer vaccination with PGE(2)-matured DCs. (Blood. 2001;97:3466-3469)..
  3. ncbi request reprint Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    P Kalinski
    Academic Medical Center, Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 161:2804-9. 1998
    ..These data imply that the character of pathogen-induced local inflammatory reaction can "instruct" local DC to initiate Th1 or Th2-biased responses...
  4. ncbi request reprint Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction
    P L Vieira
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 164:4507-12. 2000
    ..Type 1-polarized effector DC are resistant to further modulation, which may facilitate their potential use in immunotherapy...
  5. ncbi request reprint Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    P Kalinski
    Department of Cell Biology and Histology, University of Amsterdam, The Netherlands
    J Immunol 162:3231-6. 1999
    ....
  6. ncbi request reprint IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Immunol 159:28-35. 1997
    ..Since type 2 Th responses are protective in several Th1-related autoimmune disorders, PGE2-DC may be considered for use in immunotherapy...
  7. ncbi request reprint How to deal with polarized Th2 cells: exploring the Achilles' heel
    H H Smits
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:102-10. 2001
    ..The development of new therapies for atopic allergy now focuses on local IL-12-promoting substances to target both the development of new Th2 cells and the persistent population of established allergen-specific Th2 cells...
  8. ncbi request reprint Analysis of the CD4+ T cell responses to house dust mite allergoid
    P Kalinski
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 58:648-56. 2003
    ..Modified allergen extracts (allergoids) with reduced IgE-binding capacity are successfully used in immunotherapy of atopic allergy. Their reduced T-cell stimulatory capacity is less well studied and is a subject of the present study...