A C Kalil

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint Low-dose steroids for septic shock and severe sepsis: the use of Bayesian statistics to resolve clinical trial controversies
    Andre C Kalil
    Department of Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, 68198, USA
    Intensive Care Med 37:420-9. 2011
  2. doi request reprint Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: a systematic review and meta-analysis
    Andre C Kalil
    Divisions of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Liver Transpl 18:1440-7. 2012
  3. doi request reprint Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Lancet Infect Dis 12:678-86. 2012
  4. pmc Validation and comparison of clinical prediction rules for invasive candidiasis in intensive care unit patients: a matched case-control study
    Elizabeth D Hermsen
    Department of Pharmaceutical and Nutrition Care, The Nebraska Medical Center, 981090 Nebraska Medical Center, Omaha, NE 68198 1090, USA
    Crit Care 15:R198. 2011
  5. pmc Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis?
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA
    Crit Care 15:138. 2011
  6. doi request reprint How many patients with severe sepsis are needed to confirm the efficacy of drotrecogin alfa activated? A Bayesian design
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Intensive Care Med 34:1804-11. 2008
  7. pmc Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 3:e2291. 2008
  8. pmc IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxis
    A C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Transplant 11:18-21. 2011
  9. ncbi request reprint Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock
    Andre C Kalil
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 34:2719-28. 2006
  10. doi request reprint Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-analysis
    Andre C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Clin Infect Dis 52:313-21. 2011

Collaborators

Detail Information

Publications49

  1. doi request reprint Low-dose steroids for septic shock and severe sepsis: the use of Bayesian statistics to resolve clinical trial controversies
    Andre C Kalil
    Department of Medicine, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE, 68198, USA
    Intensive Care Med 37:420-9. 2011
    ..Low-dose steroids have shown contradictory results in trials and three recent meta-analyses. We aimed to assess the efficacy and safety of low-dose steroids for severe sepsis and septic shock by Bayesian methodology...
  2. doi request reprint Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: a systematic review and meta-analysis
    Andre C Kalil
    Divisions of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Liver Transpl 18:1440-7. 2012
    ..9-fold increase in the risk of leukopenia. Alternative CMV prophylaxis should be used for liver transplant recipients...
  3. doi request reprint Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Lancet Infect Dis 12:678-86. 2012
    ..We aimed to assess effectiveness and safety of use of this drug in the past 10 years and compare them with the original PROWESS results...
  4. pmc Validation and comparison of clinical prediction rules for invasive candidiasis in intensive care unit patients: a matched case-control study
    Elizabeth D Hermsen
    Department of Pharmaceutical and Nutrition Care, The Nebraska Medical Center, 981090 Nebraska Medical Center, Omaha, NE 68198 1090, USA
    Crit Care 15:R198. 2011
    ..The aims of this study were to validate and compare the Paphitou and Ostrosky-Zeichner clinical prediction rules in ICU patients in a 689-bed academic medical center...
  5. pmc Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis?
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA
    Crit Care 15:138. 2011
    ..Our updated meta-analysis with approximately 1,000 patients shows that active CMV infection continues to be associated with a significant 81% higher mortality rate than that in critically ill patients without active CMV infection...
  6. doi request reprint How many patients with severe sepsis are needed to confirm the efficacy of drotrecogin alfa activated? A Bayesian design
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Intensive Care Med 34:1804-11. 2008
    ..g. greater than 0.05, then (2) How many patients will be needed for the DAA confirmatory trial?..
  7. pmc Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 3:e2291. 2008
    ..Yet, the adoption of these therapies remains low among clinicians...
  8. pmc IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxis
    A C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Transplant 11:18-21. 2011
    ..Further, based on all available evidence, we consider that another clinical trial to test 200-day CMV prophylaxis is not necessary...
  9. ncbi request reprint Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock
    Andre C Kalil
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 34:2719-28. 2006
    ..L-arginine supplementation in sepsis is controversial. Septic shock has been alternatively viewed as an L-arginine-deficient state or as a syndrome caused by excess nitric oxide, an end-product of L-arginine metabolism...
  10. doi request reprint Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-analysis
    Andre C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Clin Infect Dis 52:313-21. 2011
    ..valganciclovir (VGC) 900 mg is approved for CMV prophylaxis, but it has been associated with 10%-40% leucopenia rate. We hypothesize that VGC 450 mg daily may be as effective as and safer than 900 mg daily...
  11. pmc Valganciclovir for cytomegalovirus prevention in solid organ transplant patients: an evidence-based reassessment of safety and efficacy
    Andre C Kalil
    Infectious Diseases Division, Internal Medicine Department, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 4:e5512. 2009
    ..The safety and efficacy data have been drawn from a single trial. We hypothesized that valganciclovir may not be as safe as nor more effective than other therapies for CMV prevention...
  12. doi request reprint Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit
    Andre C Kalil
    University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 37:2350-8. 2009
    ..Cytomegalovirus is the most common viral opportunistic infection in immunocompromised patients. However, recent studies have demonstrated active cytomegalovirus infection in nonimmunosuppressed intensive care unit patients...
  13. doi request reprint The importance of detecting cytomegalovirus infections in studies evaluating new therapies for severe sepsis
    Andre C Kalil
    Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 38:S663-7. 2010
    ..Even randomized trials could have a much higher probability of false-negative rates for a new therapy than designed. Future severe sepsis trials should consider including active cytomegalovirus infection as a prospective covariate...
  14. pmc Recommendations for the assessment and reporting of multivariable logistic regression in transplantation literature
    A C Kalil
    University of Nebraska Medical Center, Omaha, USA
    Am J Transplant 10:1686-94. 2010
    ....
  15. doi request reprint Is cefepime safe for clinical use? A Bayesian viewpoint
    Andre C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    J Antimicrob Chemother 66:1207-9. 2011
    ..In conclusion, cefepime should be avoided in patients with neutropenic fever or with skin structure infections...
  16. ncbi request reprint Sepsis and solid organ transplantation
    A C Kalil
    Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Curr Drug Targets 8:533-41. 2007
    ..The recent developments in severe sepsis are discussed in the context of the transplant recipient...
  17. ncbi request reprint Use of interferon-alpha in patients with West Nile encephalitis: report of 2 cases
    Andre C Kalil
    Section of Infectious Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Infect Dis 40:764-6. 2005
    ..To our knowledge, this is the first published report of the use of IFN-alpha to treat WNV encephalitis. Clinical trials are underway to further define the role of this therapy in persons with WNV encephalitis...
  18. doi request reprint Linezolid versus vancomycin or teicoplanin for nosocomial pneumonia: a systematic review and meta-analysis
    Andre C Kalil
    University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 38:1802-8. 2010
    ..However, clinical superiority has not been demonstrated...
  19. ncbi request reprint Meta-analysis: the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients
    Andre C Kalil
    University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Ann Intern Med 143:870-80. 2005
    ..Cytomegalovirus (CMV), the most common opportunistic viral infection in solid organ transplant recipients, is associated with substantial morbidity and mortality...
  20. ncbi request reprint L-Arginine supplementation in sepsis: beneficial or harmful?
    Andre C Kalil
    Infectious Diseases Division, Department of Internal Medicine, University of Nebraska, Omaha, Nebraska, USA
    Curr Opin Crit Care 12:303-8. 2006
    ..Recent results are reviewed on the effects of L-arginine supplements in excess of standard nutritional practices during severe sepsis and septic shock...
  21. doi request reprint Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis
    Andre C Kalil
    University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Shock 36:327-31. 2011
    ..These findings were used to design a phase 3 trial. Similar treatment by severity-of-illness interaction was found in most recent sepsis trials...
  22. doi request reprint Staphylococcus aureus infections after liver transplantation
    D F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, USA
    Infection 40:263-9. 2012
    ..More data on the risk factors and outcomes after Staphylococcus aureus infections in liver transplantation are needed...
  23. doi request reprint Incidence, risk factors, and outcomes associated with cytomegalovirus disease in small bowel transplant recipients
    D F Florescu
    Infectious Diseases Division, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Transplant 16:294-301. 2012
    ..001). CMV disease in SBT recipients was associated with an 11-fold mortality increase and a fourfold faster time-to-death. Time-to-death was significantly shorter with CMV enteritis...
  24. doi request reprint Clostridium difficile and cytomegalovirus colitis co-infection: search for the hidden 'bug'
    D F Florescu
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Transpl Infect Dis 13:411-5. 2011
    ..We describe 2 cases of CMV and C. difficile colitis, and review 7 previously published reports. We aim to raise awareness of possible CMV-C. difficile co-infection, especially in refractory cases of C. difficile colitis...
  25. ncbi request reprint What is the impact of hypogammaglobulinemia on the rate of infections and survival in solid organ transplantation? A meta-analysis
    D F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE Transplant Surgery Division, University of Nebraska Medical Center, Omaha, NE
    Am J Transplant 13:2601-10. 2013
    ..55; p = 0.005; I(2) = 0%). Severe hypogammaglobulinemia during the first year posttransplantation significantly increased the risk of CMV, fungal and respiratory infections, and was associated with higher 1-year all-cause mortality...
  26. doi request reprint The effect of control group selection in the analysis of risk factors for extended spectrum beta-lactamase-producing Klebsiella pneumoniae infections. A prospective controlled study
    P R P Behar
    Department of Internal Medicine, Section of Infectious Diseases, Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre FFFCMPA, Porto Alegre, RS, Brazil
    J Hosp Infect 68:123-9. 2008
    ..A consistent underestimation of the magnitude of the risk factors is observed when the control group is defined by the non-ESBL-KP-infected patients...
  27. doi request reprint Seroprevalence of West Nile virus infection in solid organ transplant recipients
    A G Freifeld
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Transpl Infect Dis 12:120-6. 2010
    ..It has been suggested that solid organ transplant (SOT) recipients are also at higher risk for WNV NID, but definitive serologic and epidemiologic data are lacking...
  28. ncbi request reprint Adenovirus infections in pediatric small bowel transplant recipients
    Diana F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Transplantation 90:198-204. 2010
    ..Adenovirus is commonly isolated from pediatric small bowel transplant recipients, but its clinical consequences remain poorly understood...
  29. doi request reprint Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literature
    Diana F Florescu
    Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Transplant 23:116-20. 2009
    ..The utility of molecular analysis for the identification of unusual fungal pathogens is also described. The refractory nature of A. ustus to treatment is similar to other Aspergillus species and treatment options are reviewed...
  30. doi request reprint What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression
    Diana F Florescu
    Infectious Diseases Division, Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Infect Dis 54:670-80. 2012
    ..We aimed to assess the safety and efficacy of colistin for the treatment of VAP...
  31. ncbi request reprint West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review
    Kadiyala V Ravindra
    Department of Surgery, Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Clin Infect Dis 38:1257-60. 2004
    ..We also review the literature on West Nile fever in organ transplant recipients. In areas where West Nile virus is endemic, one must have a high index of suspicion for the illness when dealing with fever in transplant recipients...
  32. doi request reprint Incidence and outcome of fungal infections in pediatric small bowel transplant recipients
    D F Florescu
    Department of Internal Medicine, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Transpl Infect Dis 12:497-504. 2010
    ..Data on the incidence, timing, and outcome of fungal infections in pediatric small bowel transplantation (SBT) are lacking...
  33. doi request reprint Enterococcus pneumonia complicated with empyema and lung abscess in an HIV-positive patient. Case report and review of the literature
    T Vanschooneveld
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, NE, USA
    Int J STD AIDS 20:659-61. 2009
    ..Our case highlights the rarity of this entity and reviews the risk factors for Enterococcus pleuro-pulmonary infections...
  34. doi request reprint Effects of prolonged use of azithromycin in patients with cystic fibrosis: a meta-analysis
    D F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha 68198 5400, NE, USA
    Pulm Pharmacol Ther 22:467-72. 2009
    ..12, 95% CI 1.10, 4.08, p=0.02). Azithromycin improves lung function of CF patients, especially in the subgroup colonized with Pseudomonas. However, nausea and diarrhea are significantly more frequent with azythromycin...
  35. ncbi request reprint Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center
    A G Freifeld
    Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Transpl Infect Dis 7:109-15. 2005
    ..9%. Histoplasmosis can present as a prolonged febrile illness with subacute pulmonary symptoms in a cohort of SOT patients, despite the absence of a regional outbreak...
  36. doi request reprint Cytomegalovirus viremia in solid organ transplantation: does the initial viral load correlate with risk factors and outcomes?
    Josh Levitsky
    Division of Hepatology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Clin Transplant 22:222-8. 2008
    ..Alternatively, late asymptomatic viremia and recurrent CMV are associated with lower PCR levels and a low likelihood to progress and result in clinical disease...
  37. doi request reprint Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America
    NAOMI P O'GRADY
    National Institutes of Health, Bethesda, MD, USA
    Crit Care Med 36:1330-49. 2008
    ..To update the practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit, for the purpose of guiding clinical practice...
  38. ncbi request reprint Chicken pox after pediatric liver transplantation
    Josh Levitsky
    Department of Medicine, Division of Hepatology, Northwestern Memorial Hospital, Feinberg School of Medicine, Chicago, IL, USA
    Liver Transpl 11:1563-6. 2005
    ..No risk factors were identified. Some cases required prolonged hospitalizations. Close monitoring for the development of late bacterial infections is warranted...
  39. ncbi request reprint Controlling the troll
    Andre C Kalil
    Ann Intern Med 144:457-8; author reply 458. 2006
  40. ncbi request reprint An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 40:1756-61. 2005
    ..We describe an immune reconstitution syndrome (IRS)-like entity in the course of evolution of Cryptococcus neoformans infection in organ transplant recipients...
  41. ncbi request reprint New drugs for rheumatoid arthritis
    Andre C Kalil
    N Engl J Med 351:2659-61; author reply 2659-61. 2004
  42. ncbi request reprint Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    Transplantation 80:1033-9. 2005
    ..The risk of relapse and time to recurrence is not known. We assessed antifungal treatment practices for cryptococcosis in a cohort of prospectively followed organ transplant recipients...
  43. ncbi request reprint Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis
    Phil Barton
    Department of Pediatrics, Division of Pediatric Critical Care, Children s Hospital at Saint Francis, Tulsa, Oklahoma, USA
    Pediatrics 113:7-17. 2004
    ..We have now performed a preliminary analysis of the safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in pediatric patients with severe sepsis...
  44. pmc Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality
    Nina Singh
    University of Pittsburgh Medical Center, Pittsburgh, PA 15240, USA
    J Infect Dis 195:756-64. 2007
    ..Additionally, discerning the basis for transplant type-specific differences in disease severity has implications relevant for yielding further insights into the pathogenesis of C. neoformans infection in transplant recipients...
  45. pmc Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis
    Dimitrios P Kontoyiannis
    M D Anderson Cancer Center, University of Texas, Houston, Texas 77030 3930, USA
    Antimicrob Agents Chemother 52:735-8. 2008
    ....
  46. pmc Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen
    Nina Singh
    University of Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 46:e12-8. 2008
    ..The role of serum cryptococcal antigen in the diagnosis and determinants of antigen positivity in solid organ transplant (SOT) recipients with pulmonary cryptococcosis has not been fully defined...
  47. pmc Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 86:647-51. 2008
    ..Prognostic implications of cryptococcal antigen and outcomes associated with central nervous system (CNS) cryptococcal lesions in solid organ transplant recipients have not been fully defined...
  48. ncbi request reprint Effects of drotrecogin alfa (activated) in human endotoxemia
    Andre C Kalil
    UMDNJ Robert Wood Johnson Medical School, Department of Surgery, New Brunswick, New Jersey 08903, USA
    Shock 21:222-9. 2004
    ..These results suggest a novel role for drotrecogin alfa (activated) in the human endotoxin model...