Research Topics
Species | Kamyar Kalantar-ZadehSummaryAffiliation: University of California Country: USA Publications
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Publications
Multicenter study of the validity and reliability of subjective global assessment in the hemodialysis populationAlison Steiber
Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 4954, USA
J Ren Nutr 17:336-42. 2007....
Management of mineral and bone disorder after kidney transplantationKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Curr Opin Nephrol Hypertens 21:389-403. 2012..We have reviewed the recent evidence about prevalence and consequences of MBD in kidney transplant recipients and examined diagnostic, preventive and therapeutic options to this end...
Estimated glomerular filtration rate at reinitiation of dialysis and mortality in failed kidney transplant recipientsMiklos Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA, USA
Nephrol Dial Transplant 27:2913-21. 2012..The role of estimated glomerular filtration rate (eGFR) in predicting outcome at reinitiation of dialysis in failed kidney transplant recipients is unclear...
Mineral and bone disorders and survival in hemodialysis patients with and without polycystic kidney diseaseLilia R Lukowsky
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Nephrol Dial Transplant 27:2899-907. 2012..It is unknown whether the different MBD mortality association between MHD populations with and without PKD can explain the survival differential...
A critical evaluation of glycated protein parameters in advanced nephropathy: a matter of life or death: A1C remains the gold standard outcome predictor in diabetic dialysis patients. CounterpointKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Diabetes Care 35:1625-8. 2012..In the counterpoint narrative below, Dr. Kalantar-Zadeh defends the use of A1C as the unquestioned gold standard for glycemic management in dialysis subjects...
Does AKI truly lead to CKD?Dena E Rifkin
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 23:979-84. 2012....
Examining associations of circulating endotoxin with nutritional status, inflammation, and mortality in hemodialysis patientsUsama Feroze
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
J Ren Nutr 22:317-26. 2012..Endotoxin level and clinical effect are determined by its soluble receptor sCD14 and high-density lipoprotein. We examine the hypothesis that endotoxin level correlates with mortality...
Mortality prediction by surrogates of body composition: an examination of the obesity paradox in hemodialysis patients using composite ranking score analysisKamyar Kalantar-Zadeh
David Geffen School of Medicine and UCLA School of Public Health, Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles, CA 90509 2910, USA
Am J Epidemiol 175:793-803. 2012..Assuming residual selection bias and confounding were not large, the present results suggest that a considerable proportion of the obesity paradox in dialysis patients might be explained by the amount of decline in muscle mass...
Glycemic control and cardiovascular mortality in hemodialysis patients with diabetes: a 6-year cohort studyJoni Ricks
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Diabetes 61:708-15. 2012..Hence, poor glycemic control (A1C ≥8% or serum glucose ≥200 mg/dL) appears to be associated with high all-cause and cardiovascular death in MHD patients. Very low glycemic levels are also associated with high mortality risk...
A1C and survival in maintenance hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
Diabetes Care 30:1049-55. 2007..The optimal target for glycemic control has not been established in diabetic dialysis patients...
Hepatitis C virus and death risk in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 18:1584-93. 2007..More diligent efforts to prevent and treat HCV infection may improve outcomes in MHD patients...
So, is leptin good or bad in chronic kidney disease?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1124 West Carson Street, Torrance, CA 90502, USA
Obesity (Silver Spring) 15:1343-4. 2007
Risk factor paradox in wasting diseasesKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Center at Harbor UCLA, Torrance, California 90509 2910, USA
Curr Opin Clin Nutr Metab Care 10:433-42. 2007..g. hypercholesterolemia and obesity) are paradoxically associated with better survival in distinct populations with wasting. We identify these populations and review survival paradoxes and common pathophysiologic mechanisms...
Racial and survival paradoxes in chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Nat Clin Pract Nephrol 3:493-506. 2007..Such movement away from the use of targets set on the basis of data gathered in general populations (e.g. the Framingham cohort) would be a major paradigm shift in clinical medicine and public health...
The fascinating but deceptive ferritin: to measure it or not to measure it in chronic kidney disease?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 1:S9-18. 2006..It may be time to revisit the utility of serum ferritin in CKD and ask ourselves whether its measurement has helped us or has caused more confusion and controversy...
The kidney disease wasting: inflammation, oxidative stress, and diet-gene interactionKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, California 90502, USA
Hemodial Int 10:315-25. 2006....
Hepatitis C infection in dialysis patients: a link to poor clinical outcome?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Int Urol Nephrol 39:247-59. 2007..In this article, we review the link between the HCV infection and mortality in dialysis patients and compare HCV antibody to molecular methods to detect HCV infection in these individuals...
Fatal hyponatremia in a young woman after ecstasy ingestionKamyar Kalantar-Zadeh
Harbor UCLA Division of Nephrology and Hypertension, UCLA David Geffen School of Medicine, Torrance, CA 90502 2064, USA
Nat Clin Pract Nephrol 2:283-8, quiz 289. 2006..A 20-year old, otherwise healthy, female college student presented in an unresponsive state with respiratory distress after ingesting ecstasy (3,4-methylenedioxymethamphetamine). She had initial plasma sodium concentration of 117 mmol/l...
Obesity paradox in patients on maintenance dialysisKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Contrib Nephrol 151:57-69. 2006....
Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patientsK Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 70:771-80. 2006....
Serum myeloperoxidase and mortality in maintenance hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 48:59-68. 2006..We hypothesized that serum MPO levels are associated with adverse clinical outcomes in maintenance hemodialysis (MHD) patients...
HDL-inflammatory index correlates with poor outcome in hemodialysis patientsK Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Kidney Int 72:1149-56. 2007..Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome...
What is so bad about reverse epidemiology anyway?Kamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, Los Angeles Biomedical Research Center at Harbor UCLA, Torrance, USA
Semin Dial 20:593-601. 2007..Studying the survival paradoxes may lead to a paradigm shift by establishing targets beyond the Framingham guidelines for populations with chronic disease states...
Nutritional and anti-inflammatory interventions in chronic heart failureKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Center at Harbor UCLA, Torrance, California 90509 2910, USA
Am J Cardiol 101:89E-103E. 2008..Understanding the factors that modulate MIC and body wasting and their associations with clinical outcomes in CHF may lead to the development of nutritional strategies that alter the pathophysiology of CHF and improve outcomes...
Association of pretransplant glycemic control with posttransplant outcomes in diabetic kidney transplant recipientsMiklos Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Diabetes Care 34:2536-41. 2011..The association between pretransplant glycemic control and short- and long-term posttransplant outcomes in kidney transplant recipients is not clear...
Association of pretransplant serum phosphorus with posttransplant outcomesMarcelo S Sampaio
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
Clin J Am Soc Nephrol 6:2712-21. 2011..The association of pretransplant serum phosphorus levels with transplant outcomes is not clear...
Survival disparities within American and Israeli dialysis populations: learning from similarities and distinctions across race and ethnicityKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA, Harold Simmons Center for Chronic Disease Research and Epidemiology, Torrance, California 90509 2910, USA
Semin Dial 23:586-94. 2010..Better understanding the roots of racial/ethnic survival differences may help improve outcomes in both patients with chronic kidney disease and other individuals with chronic disease states...
The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysisKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Mayo Clin Proc 85:991-1001. 2010..To determine whether dry weight gain accompanied by an increase in muscle mass is associated with a survival benefit in patients receiving maintenance hemodialysis (HD)...
Design and development of a dialysis food frequency questionnaireKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Ren Nutr 21:257-62. 2011....
Impact of race on hyperparathyroidism, mineral disarrays, administered vitamin D mimetic, and survival in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA, USA
J Bone Miner Res 25:2724-34. 2010..Survival advantages of blacks appear restricted to those receiving higher doses of active vitamin D. Examining the effect of MBD modulation on racial survival disparities of hemodialysis patients is warranted...
Understanding sources of dietary phosphorus in the treatment of patients with chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 5:519-30. 2010..Provision of in-center and monitored meals during hemodialysis treatment sessions in the dialysis clinic may facilitate the achievement of these goals...
Clinical outcomes with active versus nutritional vitamin D compounds in chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 4:1529-39. 2009..Randomized controlled trials are needed to verify which agents offer superior survival advantages...
Predictors of hyporesponsiveness to erythropoiesis-stimulating agents in hemodialysis patientsKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 53:823-34. 2009..Identification of predictors of hyporesponsiveness to erythropoietin-stimulating agents (ESAs) in hemodialysis (HD) patients may help improve anemia management and reduce hemoglobin level variability...
Intravenous iron versus erythropoiesis-stimulating agents: friends or foes in treating chronic kidney disease anemia?Kamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Adv Chronic Kidney Dis 16:143-51. 2009....
Hemoglobin variability in anemia of chronic kidney diseaseKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA, and UCLA David Geffen School of Medicine, Los Angeles, CA 90502, USA
J Am Soc Nephrol 20:479-87. 2009..Strategies that consider each of these factors and reduce hemoglobin variability may be associated with improved clinical outcomes...
Fluid retention is associated with cardiovascular mortality in patients undergoing long-term hemodialysisKamyar Kalantar-Zadeh
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 W Carson St, C1 Annex, Torrance, CA 90509 2910, USA
Circulation 119:671-9. 2009..Volume overload in heart failure is associated with worse outcomes. We hypothesized that in hemodialysis patients, greater interdialytic fluid gain is associated with poor all-cause and cardiovascular survival...
Epidemiology of dialysis patients and heart failure patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, David Geffen School of Medicine at UCLA, Los Angeles Biomedical Research Center at Harbor UCLA, Torrance, CA 90509 2910, USA
Semin Nephrol 26:118-33. 2006....
Associations of body fat and its changes over time with quality of life and prospective mortality in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Clin Nutr 83:202-10. 2006..In maintenance hemodialysis (MHD) patients, a larger body size is associated with better survival but a worse self-reported quality of life (QoL). It is not clear whether muscle mass or body fat confers the survival advantage...
Revisiting mortality predictability of serum albumin in the dialysis population: time dependency, longitudinal changes and population-attributable fractionKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 20:1880-8. 2005..However, serum albumin may change over time. Hence, its time-varying associations with outcome may be different...
Kidney insufficiency and nutrient-based modulation of inflammationKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Campus, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA
Curr Opin Clin Nutr Metab Care 8:388-96. 2005..We reviewed the pathophysiology of the malnutrition-inflammation complex syndrome and its potential modulation by dietary and other nutritional interventions in chronic kidney disease patients...
A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90509, USA
J Am Soc Nephrol 15:442-53. 2004..The lowest tHcy quartile confers a twofold increase in risk of death independent of hypoalbuminemia. The nutritional feature of tHcy in MHD patients may explain its reverse association with outcome...
Clinical characteristics and mortality in hepatitis C-positive haemodialysis patients: a population based studyKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 20:1662-9. 2005..The association between hepatitis C virus (HCV) infection and clinical and laboratory measures in maintenance haemodialysis (MHD) patients are poorly understood...
Relationship between dietary antioxidants and childhood asthma: more epidemiological studies are neededKamyar Kalantar-Zadeh
Department of Pharmacy, UCLA School of Medicine Harbor UCLA Medical Center, Harbor Mailbox 406, C1 Annex 1000 West Carson Street, Torrance, CA 90509, USA
Med Hypotheses 62:280-90. 2004..Risk set sampling may enable us to explore possible associations between the type and quantity of dietary antioxidants and the development and severity of asthma in such an epidemiological study...
Survival advantages of obesity in dialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Clin Nutr 81:543-54. 2005..Weight-gaining interventional studies in dialysis patients are urgently needed to ascertain whether they can improve survival and quality of life...
Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failureKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA
Semin Dial 17:455-65. 2004..Until then, all attempts should be made to adhere to the National Kidney Foundation Kidney Disease and Dialysis Outcome Quality Initiative guidelines to maintain a serum bicarbonate level in ESRD patients of at least 22 mEq/L...
A low serum iron level is a predictor of poor outcome in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor University of California at Los Angeles Medical Center, Torrance 90509 2910, USA
Am J Kidney Dis 43:671-84. 2004..Iron administration has been implicated as a cause of poor clinical outcome in maintenance hemodialysis (MHD) patients. However, the role of low iron levels in the clinical outcome of MHD patients is not clear...
Comparing outcome predictability of markers of malnutrition-inflammation complex syndrome in haemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 19:1507-19. 2004..However, it is not clear which one is a more sensitive and stronger predictor of outcome...
Diets and enteral supplements for improving outcomes in chronic kidney diseaseKamyar Kalantar-Zadeh
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Nat Rev Nephrol 7:369-84. 2011..Controlled trials are needed to better assess the effectiveness of in-center meals and oral supplements...
Reverse epidemiology of hypertension and cardiovascular death in the hemodialysis population: the 58th annual fall conference and scientific sessionsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, Calif 90509 2910, USA
Hypertension 45:811-7. 2005..Although these associations may not be causal, they call into question whether treatment goals for the general population can be applied to dialysis patients or other similar populations...
Reverse epidemiology: a spurious hypothesis or a hardcore reality?Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, UCLA David Geffen School of Medicine, Torrance, CA 90509 2910, USA
Blood Purif 23:57-63. 2005....
An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility studyKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Ren Nutr 15:318-31. 2005..8 g/dL, a marker of malnutrition-inflammation complex syndrome, is observed in approximately half of all maintenance hemodialysis (MHD) patients in the United States and is strongly associated with increased mortality...
Trace elements and vitamins in maintenance dialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
Adv Ren Replace Ther 10:170-82. 2003..Dietary requirements for vitamins and trace elements in maintenance dialysis patients are reviewed and the recommended daily intakes are discussed...
Time-dependent associations between iron and mortality in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90502, USA
J Am Soc Nephrol 16:3070-80. 2005..For ascertaining whether the observed associations between moderate doses of administered intravenous iron and improved survival are causal or due to selection bias by indication, clinical trials are warranted...
Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor University of California, Los Angeles Medical Center, Harbor Mailbox 406, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Am J Clin Nutr 80:299-307. 2004..Malnutrition-inflammation complex syndrome, an outcome predictor in maintenance hemodialysis (MHD) patients, may be related to anorexia...
Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
Kidney Int 63:793-808. 2003..It is possible that new standards or goals for such traditional risk factors as body mass, serum cholesterol, and blood pressure should be considered for these individuals...
Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Harbor Mailbox 406, 1000 West Carson St, Torrance, CA 90509 2910, USA
Am J Kidney Dis 42:761-73. 2003..Elements of malnutrition-inflammation complex syndrome (MICS) may blunt the responsiveness of anemia of end-stage renal disease (ESRD) to recombinant human erythropoietin (EPO)...
The latest addition to the inflammatory homeboys in chronic kidney disease: interleukin-8Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor-UCLA Medical Center, Torrance, California 90502, USA
Nephron Clin Pract 102:c59-60. 2006
Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequencesKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 42:864-81. 2003..Clinical trials focusing on MICS and its possible causes and consequences are urgently required to improve poor clinical outcome in dialysis patients...
A matched comparison of serum lipids between hemodialysis patients and nondialysis morbid controlsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomiedical Research Institute, Los Angeles, California 90509 2910, USA
Hemodial Int 9:314-24. 2005....
Causes and consequences of the reverse epidemiology of body mass index in dialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, Torrance, USA
J Ren Nutr 15:142-7. 2005....
Health related quality of life in patients with chronic kidney diseaseKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA 90509 2910, USA
Int Urol Nephrol 37:367-78. 2005..These recent findings underline the critical need to measure HRQOL and to expand the boundaries of our multidimensional tools with technology and a more patient centered concept of quality of life...
Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, University of California Los Angeles, 1000 West Carson Street, Torrance, CA 90509 2910, USA
Nephrol Dial Transplant 19:141-9. 2004..We hypothesized that such non-iron-related factors as elements of the malnutrition-inflammation complex syndrome (MICS) may increase serum ferritin concentration independently of iron status...
Inflammation and nutrition in renal insufficiencyKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, and David Geffen School of Medicine, University of California Los Angeles, Torrance, CA 90509 2910, USA
Adv Ren Replace Ther 10:155-69. 2003....
Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis populationKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 46:489-500. 2005..However, the association between changes in weight over time and prospective mortality is not known...
Novel lipoprotein subfraction and size measurements in prediction of mortality in maintenance hemodialysis patientsNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Clin J Am Soc Nephrol 6:2861-70. 2011..We hypothesized that novel lipoprotein subfraction concentrations and LDL particle size measurements better predict mortality in maintenance hemodialysis (MHD) patients...
High platelet count as a link between renal cachexia and cardiovascular mortality in end-stage renal disease patientsMiklos Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, CA, USA
Am J Clin Nutr 94:945-54. 2011..Platelet reactivity predisposes to thromboembolic events in the setting of atherosclerotic cardiovascular disease, which is often present in patients with end-stage renal disease (ESRD)...
Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort studyMehdi Rambod
Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
Am J Kidney Dis 53:298-309. 2009..We hypothesized that MIS risk stratification of hemodialysis (HD) patients in predicting outcomes is better than its components or laboratory markers of inflammation...
Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patientsDeborah L Regidor
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
J Am Soc Nephrol 19:2193-203. 2008..Prospective controlled trials will be necessary to test whether serum AlkPhos measurements could be used to improve the management of renal osteodystrophy...
Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomesMiklos Z Molnar
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 59:841-8. 2012..Recent studies show a survival advantage with kidney transplant in elderly patients compared with those on dialysis therapy...
Erythropoietin, iron depletion, and relative thrombocytosis: a possible explanation for hemoglobin-survival paradox in hemodialysisElani Streja
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Kidney Dis 52:727-36. 2008..High doses of human recombinant erythropoietin (rHuEPO) to achieve hemoglobin levels greater than 13 g/dL in patients with chronic kidney disease appear to be associated with increased mortality...
Diagnostic discordance for hepatitis C virus infection in hemodialysis patientsKamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Kidney Dis 46:290-300. 2005....
The Nutritional and Inflammatory Evaluation in Dialysis patients (NIED) study: overview of the NIED study and the role of dietitiansSara Colman
DaVita, Norwalk, CA, USA
J Ren Nutr 15:231-43. 2005..This article reviews the design and infrastructure of the NIED study and reports preliminary findings of the first 12 to 30 months of the study...
Racial and ethnic differences in mortality of hemodialysis patients: role of dietary and nutritional status and inflammationNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Torrance, Calif, USA
Am J Nephrol 33:157-67. 2011..We hypothesized that significant differences exist between Black and non-Hispanic and Hispanic White hemodialysis patients in nutritional status, dietary intake and inflammation, and that they account for racial survival disparities...
Associations of pretransplant weight and muscle mass with mortality in renal transplant recipientsElani Streja
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 6:1463-73. 2011....
Is controlling phosphorus by decreasing dietary protein intake beneficial or harmful in persons with chronic kidney disease?Christian S Shinaberger
Harold Simmons Center for Kidney Disease Research and Epidemiology, Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Am J Clin Nutr 88:1511-8. 2008..Dietary restrictions to control serum phosphorus, which are routinely recommended to persons with chronic kidney disease, are usually associated with a reduction in protein intake. This may lead to protein-energy wasting and poor survival...
Combined high serum ferritin and low iron saturation in hemodialysis patients: the role of inflammationMehdi Rambod
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
Clin J Am Soc Nephrol 3:1691-701. 2008....
Associations between changes in hemoglobin and administered erythropoiesis-stimulating agent and survival in hemodialysis patientsDeborah L Regidor
Division of Nephrology and Hypertension, Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910, USA
J Am Soc Nephrol 17:1181-91. 2006..Falling hemoglobin and requiring higher ESA doses were associated with decreased survival. Randomized clinical trials are required to examine these associations...
Association of serum prealbumin and its changes over time with clinical outcomes and survival in patients receiving hemodialysisMehdi Rambod
Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, General Clinical Research Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Clin Nutr 88:1485-94. 2008..In patients receiving maintenance hemodialysis (MHD), a low serum prealbumin is an indicator of protein-energy wasting...
Should we limit the ferritin upper threshold to 500 ng/ml in CKD patients?Ram Dukkipati
Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Nephrol News Issues 21:34-8. 2007..Given the lack of support from the literature, any attempt to contemplate an upper limit for serum ferritin would be arbitrary, and would not serve to improve the quality of treatment in the CKD population...
Association between serum lipids and survival in hemodialysis patients and impact of raceRyan D Kilpatrick
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Institute at Harbor UCLA Medical Center, CA 90509 2910, USA
J Am Soc Nephrol 18:293-303. 2007..Although these associations may not be causal, they call into question whether specific subgroups of dialysis patients are better targets for cholesterol-lowering therapy...
Association of serum total iron-binding capacity and its changes over time with nutritional and clinical outcomes in hemodialysis patientsRachelle Bross
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Nephrol 29:571-81. 2009..03) compared to the stable TIBC group. Hence, low baseline serum TIBC is associated with iron deficiency, PEW, inflammation, poor QoL and mortality, and its decline over time is independently associated with increased death risk...
Association of dietary phosphorus intake and phosphorus to protein ratio with mortality in hemodialysis patientsNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 5:683-92. 2010..The hypothesis that higher dietary phosphorus intake and higher phosphorus content per gram of dietary protein intake are each associated with increased mortality in MHD patients was examined...
Outcome research, nutrition, and reverse epidemiology in maintenance dialysis patientsKamyar Kalantar-Zadeh
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Ren Nutr 14:64-71. 2004....
Effects of sevelamer and calcium-based phosphate binders on lipid and inflammatory markers in hemodialysis patientsRonney Shantouf
Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, Calif 90502, USA
Am J Nephrol 28:275-9. 2008..A combination of lipid-lowering and anti-inflammatory effects along with avoidance of hypercalcemia should be taken into account when choosing phosphorus binders for maintenance hemodialysis (MHD) patients...
Comparing body composition assessment tests in long-term hemodialysis patientsRachelle Bross
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
Am J Kidney Dis 55:885-96. 2010..The accuracy and reliability of field methods to measure body composition is unknown in this population...
The outcomes of continuous ambulatory and automated peritoneal dialysis are similarRajnish Mehrotra
Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
Kidney Int 76:97-107. 2009..Thus, the improved chronic peritoneal dialysis outcomes cannot be attributed to a greater use of automated peritoneal dialysis...
Longitudinal associations between dietary protein intake and survival in hemodialysis patientsChristian S Shinaberger
Division of Nephrology and Hypertension, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
Am J Kidney Dis 48:37-49. 2006..Whether the association between time-varying protein intake and survival is causal or a consequence of anorexia secondary to MICS or other factors needs to be explored further in interventional trials...
Ratio of paricalcitol dosage to serum parathyroid hormone level and survival in maintenance hemodialysis patientsChristian S Shinaberger
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Clin J Am Soc Nephrol 3:1769-76. 2008..It was hypothesized that the ratio of the administered paricalcitol dosage to serum PTH level discloses better the underlying dosage-survival association...
Association of relatively low serum parathyroid hormone with malnutrition-inflammation complex and survival in maintenance hemodialysis patientsRamanath Dukkipati
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
J Ren Nutr 20:243-54. 2010..We hypothesized that the malnutrition-inflammation complex is associated with low PTH levels in these patients and confounds the PTH-survival association...
Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failureKamyar Kalantar-Zadeh
Harbor-UCLA Medical Center, Torrance, CA, USA
J Am Coll Cardiol 43:1439-44. 2004..Reverse epidemiology of conventional cardiovascular risk factors is observed in CHF and may have a bearing on the management of these patients; thus, it deserves further investigation...
Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patientsNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 5:2258-68. 2010..We hypothesized that mid-arm muscle circumference (MAMC), a conveniently measured surrogate of lean body mass (LBM), has stronger association with clinical outcomes than triceps skinfold (TSF), a surrogate of fat mass...
Survival predictability of lean and fat mass in men and women undergoing maintenance hemodialysisNazanin Noori
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
Am J Clin Nutr 92:1060-70. 2010..Larger body size is associated with greater survival in maintenance hemodialysis (MHD) patients. It is not clear how lean body mass (LBM) and fat mass (FM) compare in their associations with survival across sex in these patients...
Albumin levels predict survival in patients with systolic heart failureTamara B Horwich
Ahmanson University of California Los Angeles Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
Am Heart J 155:883-9. 2008..This study investigated the effect of serum albumin level on survival in patients with advanced HF...
Normalized protein nitrogen appearance is correlated with hospitalization and mortality in hemodialysis patients with Kt/V greater than 1.20Kamyar Kalantar-Zadeh
Division of Nephrology and Hypertension, David Geffen UCLA School of Medicine, Los Angeles, CA, USA
J Ren Nutr 13:15-25. 2003..We therefore investigated whether nPNA is associated with outcome in patients who have adequate or high Kt/V...
Glycemic control and survival in peritoneal dialysis patients with diabetes mellitusUyen Duong
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
Clin J Am Soc Nephrol 6:1041-8. 2011..The optimal target for glycemic control has not been established for diabetic peritoneal dialysis (PD) patients...
Quality-of-life and mortality in hemodialysis patients: roles of race and nutritional statusUsama Feroze
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, 1124 West Carson Street, C1 Annex, Torrance, CA 90502, USA
Clin J Am Soc Nephrol 6:1100-11. 2011..We hypothesized that poor QoL scores and their nutritional correlates have a bearing on racial survival disparities of MHD patients...
Organic and inorganic dietary phosphorus and its management in chronic kidney diseaseNazanin Noori
Harold Simmons Center for Chronic Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center and Departments of Epidemiology or Community Health Sciences, UCLA School of Public Health, Los Angeles, USA
Iran J Kidney Dis 4:89-100. 2010..Fresh (nonprocessed) egg white (phosphorus-protein ratio less than 2 mg/g) is a good example of desirable food, which contains a high proportion of essential amino acids with low amounts of fat, cholesterol, and phosphorus...
Megestrol acetate in a moderate dose for the treatment of malnutrition-inflammation complex in maintenance dialysis patientsMeenakshi Rammohan
General Clinical Research Center, Division of Nephrology, Hypertension, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
J Ren Nutr 15:345-55. 2005..Megestrol acetate, 800 mg/day, has been shown to increase appetite and food intake and to mitigate inflammation in cachectic AIDS and cancer patients, leading to weight gain, but it is also associated with side effects at this dose...
Inverse association between lipid levels and mortality in men with chronic kidney disease who are not yet on dialysis: effects of case mix and the malnutrition-inflammation-cachexia syndromeCsaba P Kovesdy
Division of Nephrology, Salem VA Medical Center, 1970 Roanoke Boulevard, Salem, VA 24153, USA
J Am Soc Nephrol 18:304-11. 2007..This inverse association is explained in part by case-mix characteristics and the presence of surrogates for MICS...
Recent advances in understanding the malnutrition-inflammation-cachexia syndrome in chronic kidney disease patients: What is next?Kamyar Kalantar-Zadeh
Semin Dial 18:365-9. 2005..Clinical trials focusing on the causes and consequences of MICS and its modulation using nutritional interventions may be the key to improving survival in these individuals...
Association of low blood pressure with increased mortality in patients with moderate to severe chronic kidney diseaseCsaba P Kovesdy
Division of Nephrology, Salem VA Medical Center, 1970 Roanoke Blvd, Salem, VA 24153, USA
Nephrol Dial Transplant 21:1257-62. 2006..Blood pressure shows an inverse association with mortality in patients with chronic kidney disease (CKD) on dialysis. It is unclear if the same phenomenon exists in patients with CKD not yet on dialysis...
Research Grants
- Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseKamyar Kalantar Zadeh; Fiscal Year: 2010..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
- Nutritional/Inflammatory Evaluation of Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2005....
- Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis PatientsKamyar Kalantar Zadeh; Fiscal Year: 2007....
- Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseKamyar Kalantar Zadeh; Fiscal Year: 2009..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
- Examining Racial and Cardiovascular Paradoxes in Chronic Kidney DiseaseKamyar Kalantar Zadeh; Fiscal Year: 2009..to developing new treatment targets beyond traditional (Framingham) CV risk factors to improve poor outcomes in these 2 patient populations and maybe in geriatric populations or those with chronic disease states and similar paradoxes ..
