S S Kakar

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)
    S S Kakar
    Department of Physiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Gene 240:317-24. 1999
  2. ncbi request reprint Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cytogenet Cell Genet 84:211-6. 1999
  3. ncbi request reprint Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham AL USA
    Cytogenet Cell Genet 83:93-5. 1998
  4. ncbi request reprint Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization
    L Chen
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene 248:41-50. 2000
  5. ncbi request reprint Molecular structure of the human gonadotropin-releasing hormone receptor gene
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294 0005, USA
    Eur J Endocrinol 137:183-92. 1997
  6. ncbi request reprint Inhibition of growth and proliferation of EcRG293 cell line expressing high-affinity gonadotropin-releasing hormone (GnRH) receptor under the control of an inducible promoter by GnRH agonist (D-Lys6)GnRH and antagonist (Antide)
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294 0005, USA
    Cancer Res 58:4558-60. 1998
  7. ncbi request reprint Expression of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor mRNAs in various non-reproductive human tissues
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294, USA
    Cancer Lett 98:57-62. 1995
  8. ncbi request reprint Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama, Birmingham 35294
    Biochem Biophys Res Commun 189:289-95. 1992
  9. ncbi request reprint Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH)
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294
    Domest Anim Endocrinol 10:335-42. 1993
  10. ncbi request reprint The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294
    Mol Cell Endocrinol 106:145-9. 1994

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG)
    S S Kakar
    Department of Physiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Gene 240:317-24. 1999
    ....
  2. ncbi request reprint Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cytogenet Cell Genet 84:211-6. 1999
    ..These results suggest that TUTR1 is a novel and potent transforming gene, which may be involved in tumorigenesis in numerous different human tumors...
  3. ncbi request reprint Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham AL USA
    Cytogenet Cell Genet 83:93-5. 1998
  4. ncbi request reprint Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization
    L Chen
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene 248:41-50. 2000
    ....
  5. ncbi request reprint Molecular structure of the human gonadotropin-releasing hormone receptor gene
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294 0005, USA
    Eur J Endocrinol 137:183-92. 1997
    ..These findings indicate a multiplicity of regulation of expression of the GnRH receptor and provide the substrate for detailed investigation in the reproductive system...
  6. ncbi request reprint Inhibition of growth and proliferation of EcRG293 cell line expressing high-affinity gonadotropin-releasing hormone (GnRH) receptor under the control of an inducible promoter by GnRH agonist (D-Lys6)GnRH and antagonist (Antide)
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294 0005, USA
    Cancer Res 58:4558-60. 1998
    ..These data suggest strongly that the antitumor effect of GnRH agonists and antagonist is specific, direct, and mediated through high-affinity GnRH receptors present on the cell membranes of tumor cells...
  7. ncbi request reprint Expression of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor mRNAs in various non-reproductive human tissues
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294, USA
    Cancer Lett 98:57-62. 1995
    ....
  8. ncbi request reprint Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama, Birmingham 35294
    Biochem Biophys Res Commun 189:289-95. 1992
    ..Availability of a human GnRH receptor cDNA should permit the design of improved analogs for therapeutic applications...
  9. ncbi request reprint Molecular cloning, sequencing, and characterizing the bovine receptor for gonadotropin releasing hormone (GnRH)
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294
    Domest Anim Endocrinol 10:335-42. 1993
    ..Higher levels of GnRH receptor mRNA were found in the pituitaries of steers than in cohort bulls, suggesting regulation of GnRH receptor gene expression by testicular steroids...
  10. ncbi request reprint The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama at Birmingham 35294
    Mol Cell Endocrinol 106:145-9. 1994
    ....
  11. ncbi request reprint Pituitary tumor transforming gene: an important gene in normal cellular functions and tumorigenesis
    C Bradshaw
    James Graham Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Histol Histopathol 22:219-26. 2007
    ....
  12. ncbi request reprint Angiotensin II type-1 receptor subtype cDNAs: differential tissue expression and hormonal regulation
    S S Kakar
    Department of Physiology and Biophysics, University of Alabama, Birmingham 35294
    Biochem Biophys Res Commun 183:1090-6. 1992
    ..Thus, the unexpected existence of two putative AT1 receptor genes appears to be related to the differential regulation of their expression rather than to different functional properties of the encoded receptor proteins...
  13. ncbi request reprint PTTG and cancer
    T Hamid
    Department of Medicine, James Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Histol Histopathol 18:245-51. 2003
    ..Given the number of processes that are involved in the manifestation of cancer, it thus becomes mandatory to study the role of this potent oncogene in relation to the processes of cell survival, death and functioning...