Darnell Kaigler

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA
    Cell Transplant 22:767-77. 2013
  2. pmc Guided bone regeneration using injectable vascular endothelial growth factor delivery gel
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Periodontol 84:230-8. 2013
  3. pmc Angiogenic and osteogenic potential of bone repair cells for craniofacial regeneration
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Tissue Eng Part A 16:2809-20. 2010
  4. ncbi request reprint Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration
    Yen Chen Huang
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    J Bone Miner Res 20:848-57. 2005
  5. ncbi request reprint Endothelial cell modulation of bone marrow stromal cell osteogenic potential
    Darnell Kaigler
    Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 19:665-7. 2005
  6. ncbi request reprint VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, 48109, USA
    J Bone Miner Res 21:735-44. 2006
  7. pmc Growth factor delivery for oral and periodontal tissue engineering
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Expert Opin Drug Deliv 3:647-62. 2006
  8. ncbi request reprint Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells
    Darnell Kaigler
    Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Tissue Eng 9:95-103. 2003
  9. pmc Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration
    Darnell Kaigler
    University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI 48109 1078, USA
    Expert Opin Biol Ther 11:375-85. 2011
  10. pmc Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor
    Bita Carrion
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States
    Exp Cell Res 319:2964-76. 2013

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Stem cell therapy for craniofacial bone regeneration: a randomized, controlled feasibility trial
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA
    Cell Transplant 22:767-77. 2013
    ..The results from this trial support expanded studies of TRC therapy in the treatment of craniofacial deformities (ClinicalTrials.gov number CT00755911)...
  2. pmc Guided bone regeneration using injectable vascular endothelial growth factor delivery gel
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Periodontol 84:230-8. 2013
    ..This study evaluates the regenerative potential of GBR in combination with vascular endothelial growth factor (VEGF) delivery via an injectable hydrogel system...
  3. pmc Angiogenic and osteogenic potential of bone repair cells for craniofacial regeneration
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Tissue Eng Part A 16:2809-20. 2010
    ..Taken together, these data provide evidence for the multilineage and clinical potential of BRCs for craniofacial regeneration...
  4. ncbi request reprint Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration
    Yen Chen Huang
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    J Bone Miner Res 20:848-57. 2005
    ..Combined delivery of these factors significantly enhanced bone formation compared with other conditions...
  5. ncbi request reprint Endothelial cell modulation of bone marrow stromal cell osteogenic potential
    Darnell Kaigler
    Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 19:665-7. 2005
    ..These data suggest that ECs function not only to form the microvasculature that delivers nutrients to developing bone but also to modulate the differentiation of osteoprogenitor cells in vitro and in vivo...
  6. ncbi request reprint VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, 48109, USA
    J Bone Miner Res 21:735-44. 2006
    ..VEGF-releasing polymers significantly increased blood vessel density and vascular perfusion in irradiated defects and increased bone formation relative to control conditions...
  7. pmc Growth factor delivery for oral and periodontal tissue engineering
    Darnell Kaigler
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
    Expert Opin Drug Deliv 3:647-62. 2006
    ..In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral- and tooth-supporting structures, namely the periodontium and alveolar bone...
  8. ncbi request reprint Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells
    Darnell Kaigler
    Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Tissue Eng 9:95-103. 2003
    ..These data demonstrate that human BMSCs secrete sufficient quantities of VEGF to enhance survival and differentiation of endothelial cells in vitro, and suggest they may be capable of directly orchestrating angiogenesis in vivo...
  9. pmc Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration
    Darnell Kaigler
    University of Michigan School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI 48109 1078, USA
    Expert Opin Biol Ther 11:375-85. 2011
    ....
  10. pmc Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor
    Bita Carrion
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, United States
    Exp Cell Res 319:2964-76. 2013
    ..This conclusion may have important implications in the optimization of cell-based strategies to promote angiogenesis...
  11. ncbi request reprint Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution
    Hyun Joon Kong
    Department of Biologic and Materials Science, University of Michigan, Ann Arbor 48109 2136, USA
    Biomacromolecules 5:1720-7. 2004
    ..The results of these studies will be useful for controlling the physical properties of a broad array of hydrogel-forming polymers...