STEVEN EMANUEL KAHN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Interactions between genetic background, insulin resistance and β-cell function
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Obes Metab 14:46-56. 2012
  2. pmc Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function
    Anna L Marina
    Division of Metabolism, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes Care 35:1119-25. 2012
  3. pmc Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women
    Anna Gradmark
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    BMC Pregnancy Childbirth 11:44. 2011
  4. doi request reprint Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT)
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 31:845-51. 2008
  5. doi request reprint An examination of beta-cell function measures and their potential use for estimating beta-cell mass
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Diabetes Obes Metab 10:63-76. 2008
  6. ncbi request reprint Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes
    S E Kahn
    Department of Medicine, University of Washington, and Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Diabetes 48:241-53. 1999
  7. pmc Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT)
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes Care 33:177-83. 2010
  8. pmc The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
    S E Kahn
    Department of Medicine, Division of Metabolism, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1003-12. 2009
  9. pmc Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT
    Steven E Kahn
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes 60:1552-60. 2011
  10. ncbi request reprint Mechanisms linking obesity to insulin resistance and type 2 diabetes
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Nature 444:840-6. 2006

Research Grants

  1. Mechanisms of Islet Amyloidogenesis
    STEVEN EMANUEL KAHN; Fiscal Year: 2010
  2. Study of Health Outcomes of Weight loss: Look AHEAD-Action for Health in Diabetes
    Steven Kahn; Fiscal Year: 2007
  3. Mechanisms of Islet Amyloidogenesis
    Steven Kahn; Fiscal Year: 2009
  4. Mechanisms of Islet Amyloidogenesis
    STEVEN EMANUEL KAHN; Fiscal Year: 2010
  5. ISLET FUNCTION IN TYPE 2 DIABETES
    Steven Kahn; Fiscal Year: 2003
  6. Post-DDP Follow-up Study
    Steven Kahn; Fiscal Year: 2007

Detail Information

Publications88

  1. pmc Interactions between genetic background, insulin resistance and β-cell function
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Obes Metab 14:46-56. 2012
    ....
  2. pmc Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and β-cell function
    Anna L Marina
    Division of Metabolism, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes Care 35:1119-25. 2012
    ..To determine the mechanism by which the bile acid sequestrant colesevelam improves glycemic control...
  3. pmc Physical activity, sedentary behaviors, and estimated insulin sensitivity and secretion in pregnant and non-pregnant women
    Anna Gradmark
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    BMC Pregnancy Childbirth 11:44. 2011
    ..Here we examined physical activity patterns and their relationships with measures of glucose homeostasis in late pregnancy compared to non-pregnant women...
  4. doi request reprint Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT)
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 31:845-51. 2008
    ..The purpose of this study was to examine possible factors associated with the increased risk of fractures observed with rosiglitazone in A Diabetes Outcome Progression Trial (ADOPT)...
  5. doi request reprint An examination of beta-cell function measures and their potential use for estimating beta-cell mass
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Diabetes Obes Metab 10:63-76. 2008
    ..However, until beta-cell volume can be quantified reliably and non-invasively, we will need to rely on the ability of glucose to potentiate insulin release as the best surrogate estimate of the number of beta-cells...
  6. ncbi request reprint Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes
    S E Kahn
    Department of Medicine, University of Washington, and Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Diabetes 48:241-53. 1999
    ....
  7. pmc Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT)
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes Care 33:177-83. 2010
    ..In the short term, commonly prescribed antidiabetic agents have different effects on CRP; however, the long-term effects of those agents are unknown...
  8. pmc The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality
    S E Kahn
    Department of Medicine, Division of Metabolism, VA Puget Sound Health Care System 151, Seattle, WA 98108, USA
    Diabetologia 52:1003-12. 2009
    ..Based on human and animal studies, it appears that neither alone is sufficient. Rather, for glucose to rise to the level at which diabetes would be diagnosed, defects in beta cell mass and in beta cell function are required...
  9. pmc Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT
    Steven E Kahn
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Diabetes 60:1552-60. 2011
    ..Herein, we examine measures of β-cell function and insulin sensitivity from an oral glucose tolerance test (OGTT) over a 4-year period among the three treatments...
  10. ncbi request reprint Mechanisms linking obesity to insulin resistance and type 2 diabetes
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 South Columbian Way, Seattle, Washington 98108, USA
    Nature 444:840-6. 2006
    ..This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention...
  11. ncbi request reprint Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    Steven E Kahn
    Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    N Engl J Med 355:2427-43. 2006
    ..The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known...
  12. ncbi request reprint Insulin resistance and beta cell dysfunction: a dual therapeutic approach
    S E Kahn
    Department of Medicine, VA Puget Sound Health Care System, and University of Washington, Sattle 98108, USA
    Eur J Clin Invest 32:1-2. 2002
  13. ncbi request reprint Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes
    Steven E Kahn
    Department of Internal Medicine, Division of Metbolism, Endocrinology and Nurtrition, VA Puget Sound Health Care System, 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:2357-64. 2006
    ..Further, for CRP and fibrinogen this relationship is determined by body adiposity and not by insulin sensitivity or glucose control...
  14. ncbi request reprint The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitus
    S E Kahn
    University of Washington, Seattle VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Med 108:2S-8S. 2000
    ..Furthermore, the recently completed landmark United Kingdom Prospective Diabetes Study demonstrated that type 2 diabetes is a progressive disease and that this progression is due to declining beta-cell function...
  15. ncbi request reprint Obesity, body fat distribution, insulin sensitivity and Islet beta-cell function as explanations for metabolic diversity
    S E Kahn
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and Department of Veterans Affairs, Puget Sound Health Care, Seattle, WA 98108, USA
    J Nutr 131:354S-60S. 2001
    ..Furthermore, the progression from normal glucose tolerance to impaired glucose tolerance and type 2 diabetes is associated with declining insulin secretion...
  16. ncbi request reprint Importance of early phase insulin secretion to intravenous glucose tolerance in subjects with type 2 diabetes mellitus
    S E Kahn
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 86:5824-9. 2001
    ....
  17. ncbi request reprint Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide
    Sofianos Andrikopoulos
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington, USA
    Am J Physiol Endocrinol Metab 286:E418-24. 2004
    ..However, hIAPPxRIP-Tag mice did have an increase in life span that was associated with insulin resistance, suggesting that hIAPP has extrapancreatic effects, possibly on peripheral glucose metabolism...
  18. ncbi request reprint Insulin and amylin release are both diminished in first-degree relatives of subjects with type 2 diabetes
    Negar G Knowles
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 19808, USA
    Diabetes Care 25:292-7. 2002
    ....
  19. ncbi request reprint Minimum waist and visceral fat values for identifying Japanese Americans at risk for the metabolic syndrome
    Tomoshige Hayashi
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Diabetes Care 30:120-7. 2007
    ..Central adiposity is considered to play a key role in the metabolic syndrome. Not known are the optimal cut point values for central and visceral adiposity to identify Japanese Americans at risk for the metabolic syndrome...
  20. ncbi request reprint Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes
    Miriam Cnop
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 30:677-82. 2007
    ..First-degree relatives of individuals with type 2 diabetes are at increased risk of developing hyperglycemia...
  21. ncbi request reprint Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans
    Tomoshige Hayashi
    Veterans Affairs Puget Sound Health Care System and the University of Washington, Seattle, Washington 98108, USA
    Ann Intern Med 140:992-1000. 2004
    ..Visceral adiposity is generally considered to play a key role in the metabolic syndrome...
  22. pmc Regression from pre-diabetes to normal glucose regulation in the diabetes prevention program
    Leigh Perreault
    Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver School of Medicine, Aurora, Colorado, USA
    Diabetes Care 32:1583-8. 2009
    ..We explored the effect of baseline characteristics, weight change, ILS, and metformin on regression from pre-diabetes to the lowest-risk state of normal glucose regulation (NGR) defined by American Diabetes Association criteria...
  23. ncbi request reprint Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance
    David Liao
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195, USA
    Diabetes Care 25:1504-10. 2002
    ..To determine whether diet and endurance exercise improved adiposity-related measurements in Japanese Americans with impaired glucose tolerance (IGT)...
  24. doi request reprint Visceral adiposity, not abdominal subcutaneous fat area, is associated with an increase in future insulin resistance in Japanese Americans
    Tomoshige Hayashi
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System S 152E, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 57:1269-75. 2008
    ..We sought to determine whether greater visceral adiposity directly measured by computed tomography (CT) is associated with increased future insulin resistance independent of other adipose depots...
  25. ncbi request reprint Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S
    Christine C Jensen
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 51:2170-8. 2002
    ..Both insulin resistance and impaired beta-cell function are associated with impaired glucose metabolism in all ethnic groups, with beta-cell function seeming to be more important in determining glucose disposal...
  26. ncbi request reprint Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans
    Tomoshige Hayashi
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 26:650-5. 2003
    ..Whether visceral adiposity increases risk of impaired glucose tolerance (IGT) independent of other adipose depots, insulin resistance, and insulin secretion is not known...
  27. ncbi request reprint The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments
    Miriam Cnop
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System, and Harborview Medical Center, Seattle, Washington 98108, USA
    Diabetes 51:1005-15. 2002
    ....
  28. pmc Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans
    Fernando Gerchman
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Diabetes Res Clin Pract 77:320-6. 2007
    ....
  29. ncbi request reprint Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects
    Lisa R Tannock
    Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6426, USA
    Circulation 111:3058-62. 2005
    ..Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known...
  30. pmc Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation
    Sakeneh Zraika
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Biol Chem 285:18177-83. 2010
    ..These findings suggest that targeting the role of neprilysin in IAPP fibril assembly, in addition to IAPP cleavage by other peptidases, may provide a novel approach to reduce and/or prevent islet amyloid deposition in type 2 diabetes...
  31. ncbi request reprint Effects of sex and hormone replacement therapy use on the prevalence of isolated impaired fasting glucose and isolated impaired glucose tolerance in subjects with a family history of type 2 diabetes
    Renate E van Genugten
    VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:3529-35. 2006
    ..Based on the influence of sex and HRT on the prevalence of isolated IFG and isolated IGT, we conclude that female sex hormones may play an important role in the pathogenesis of IFG and IGT...
  32. pmc Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution
    Fernando Gerchman
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 94:3781-8. 2009
    ..Although obesity has been, in general, associated with glomerular hyperfiltration, visceral adiposity has been suggested to be associated with reduced glomerular filtration...
  33. ncbi request reprint Visceral adiposity and the prevalence of hypertension in Japanese Americans
    Tomoshige Hayashi
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
    Circulation 108:1718-23. 2003
    ..The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin...
  34. ncbi request reprint Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat
    Tara M Wallace
    Department of Medicine, VA Puget Sound Health Care System, and University of Washington, Seattle, WA 98108, USA
    Diabetes Care 30:2673-8. 2007
    ..The purpose of this study was to determine the relationship between plasma liver enzyme concentrations, insulin sensitivity, and intra-abdominal fat (IAF) distribution...
  35. pmc Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    Am J Physiol Cell Physiol 293:C1586-93. 2007
    ....
  36. pmc Glucose- and time-dependence of islet amyloid formation in vitro
    Sakeneh Zraika
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA 98108, USA
    Biochem Biophys Res Commun 354:234-9. 2007
    ..It thus enables studies investigating the mechanism(s) underlying the amyloid-associated loss of beta-cell mass in type 2 diabetes...
  37. ncbi request reprint Identification of the amyloid-degrading enzyme neprilysin in mouse islets and potential role in islet amyloidogenesis
    Sakeneh Zraika
    Division of Metabolism, Endocrinology anmd Nutrition, Department of Medicine, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 56:304-10. 2007
    ..Together, these findings demonstrate that neprilysin is a factor associated with islet amyloid accumulation and subsequent deterioration of beta-cell function in hIAPP transgenic male mice...
  38. ncbi request reprint The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat
    Delma J Nieves
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    Diabetes 52:172-9. 2003
    ..Thus an atherogenic lipoprotein profile appears to be the result primarily of an increase in IAF, perhaps via insulin resistance...
  39. pmc Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia
    Andrew N Hoofnagle
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Arterioscler Thromb Vasc Biol 30:2528-34. 2010
    ..To determine whether obesity and insulin resistance associate with changes in the protein content of high-density lipoprotein (HDL) in 2 different groups of men by using targeted proteomics...
  40. ncbi request reprint The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington and VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Diabetes Care 31:108-13. 2008
    ..To evaluate the effect of treatment with the dipeptidyl peptidase (DPP)-4 inhibitor vildagliptin on insulin sensitivity and beta-cell function in subjects with impaired fasting glucose (IFG)...
  41. doi request reprint Modestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes Care 31:1037-9. 2008
    ..To determine whether 1-h oral glucose challenge test (OGCT) or 3-h oral glucose tolerance test (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes...
  42. pmc Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults
    Christine G Lee
    Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Diabetes Res Clin Pract 89:58-64. 2010
    ..We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender...
  43. pmc Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Diabetes Care 32:335-41. 2009
    ..First, we assessed the validity of the DI(O) by demonstrating that a hyperbolic relationship exists between oral indexes of insulin sensitivity and beta-cell function...
  44. doi request reprint Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes
    Kristina M Utzschneider
    VA Puget Sound Health Care System, Seattle, Washington, USA
    Obesity (Silver Spring) 18:1781-7. 2010
    ..Further, as many lean individuals with a first-degree relative with type 2 diabetes are IR and metabolically unhealthy, they may all benefit from metabolic testing...
  45. pmc Latent class analysis of the metabolic syndrome
    Edward J Boyko
    VA Puget Sound Health Care System, Seattle, WA, USA
    Diabetes Res Clin Pract 89:88-93. 2010
    ..One class of this factor was associated with hypertension and hyperglycemia but not central adiposity or FI, suggesting another pathway for observed MetS features...
  46. ncbi request reprint Review: The role of insulin resistance in nonalcoholic fatty liver disease
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 South Columbian Way, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 91:4753-61. 2006
    ..This review outlines the evidence linking insulin resistance and NAFLD, explores whether liver fat is a cause or consequence of insulin resistance, and reviews the current evidence for treatment of NAFLD...
  47. ncbi request reprint Is central obesity associated with cirrhosis-related death or hospitalization? A population-based, cohort study
    George N Ioannou
    Health Services Research and Development and Northwest Hepatitis C Resource Centers, Veterans Affairs Puget Sound System, Seattle, Washington, USA
    Clin Gastroenterol Hepatol 3:67-74. 2005
    ..We aimed to determine the interaction between body fat distribution (central versus peripheral) and increased body mass index (BMI) with regards to the risk of cirrhosis-related death or hospitalization...
  48. ncbi request reprint PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity
    Susan J Murdoch
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Lipid Res 44:1705-12. 2003
    ..71, P < 0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance...
  49. ncbi request reprint Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice
    Rebecca L Hull
    Division of Metabolism, Endocrinology, and Nutrition, Veterans Affairs Puget Sound Health Care System, University of Washington, Seattle, WA 98108, USA
    Am J Physiol Endocrinol Metab 289:E703-9. 2005
    ..These findings underscore the importance of genetic and environmental factors in studying metabolic disease...
  50. ncbi request reprint Contribution of metabolic factors to alanine aminotransferase activity in persons with other causes of liver disease
    George N Ioannou
    Gastroenterology, Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington USA
    Gastroenterology 128:627-35. 2005
    ....
  51. ncbi request reprint Diet-induced weight loss is associated with an improvement in beta-cell function in older men
    Kristina M Utzschneider
    Department of Medicine, Veterans Affairs Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:2704-10. 2004
    ..05). Thus, the weight loss-associated improvements in both insulin sensitivity and beta-cell function may explain the beneficial effects of a lifestyle intervention on delaying the development of diabetes in older subjects...
  52. ncbi request reprint Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l...
  53. ncbi request reprint Insulin, C-peptide, and leptin concentrations predict increased visceral adiposity at 5- and 10-year follow-ups in nondiabetic Japanese Americans
    Jenny Tong
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98108, USA
    Diabetes 54:985-90. 2005
    ....
  54. ncbi request reprint Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function
    Kristina M Utzschneider
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 53:2867-72. 2004
    ....
  55. ncbi request reprint A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function
    Darcy B Carr
    Department of ObstetricsGynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes 54:340-7. 2005
    ..However, such changes did not improve beta-cell function, suggesting that this degree of lifestyle modifications may be limited in preventing type 2 diabetes over the long term...
  56. ncbi request reprint Effects of insulin resistance and obesity on lipoproteins and sensitivity to egg feeding
    Robert H Knopp
    University of Washington, Northwest Lipid Research Clinic, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 23:1437-43. 2003
    ..This study was undertaken to determine if insulin resistance without and with obesity influences LDL response to dietary cholesterol and saturated fat...
  57. ncbi request reprint Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 54:2235-44. 2005
    ....
  58. ncbi request reprint Suppression of Beta-cell secretion by somatostatin does not fully reverse the disproportionate proinsulinemia of type 2 diabetes
    Michael E Røder
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, Veteran Affairs, Puget Sound Health Care System, University of Washington, Seattle, USA
    Diabetes 53:S22-5. 2004
    ....
  59. ncbi request reprint Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes Care 29:2078-83. 2006
    ..We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes...
  60. ncbi request reprint Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses
    Kristina M Utzschneider
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes Care 29:356-62. 2006
    ..To determine whether the hyperbolic relationship between insulin sensitivity and the acute insulin response to glucose (AIRg) exists in subjects with impaired fasting glucose (IFG) or decreased glucose tolerance...
  61. ncbi request reprint Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose tolerance
    G Stennis Watson
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington 98108, USA
    Diabetes Care 29:135-6. 2006
  62. ncbi request reprint Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 13:950-8. 2005
    ..Authors evaluated the effects of the PPAR-gamma agonist rosiglitazone on cognition and plasma levels of the APP derivative beta-amyloid (Abeta) in humans...
  63. ncbi request reprint Continuous measurement of oxygen consumption by pancreatic islets
    Ian R Sweet
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Diabetes Technol Ther 4:661-72. 2002
    ..The system has particular application to the field of human islet transplantation, where assessment and the study of islet viability have been hampered by a lack of experimental methods...
  64. ncbi request reprint Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Diabetes 52:372-9. 2003
    ....
  65. ncbi request reprint Comparison of a clinical model, the oral glucose tolerance test, and fasting glucose for prediction of type 2 diabetes risk in Japanese Americans
    Marguerite J McNeely
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 26:758-63. 2003
    ..To test the validity of a published clinical model for predicting incident diabetes in Japanese Americans...
  66. ncbi request reprint Management of patients with diabetic hyperlipidemia
    Robert H Knopp
    Northwest Lipid Research Clinic and Department of Medicine, University of Washington School of Medicine, Seattle 98104, USA
    Am J Cardiol 91:24E-28E. 2003
    ..We also present a case study of a diabetic woman with hyperlipidemia and coronary artery disease...
  67. ncbi request reprint Proteoglycans synthesized and secreted by pancreatic islet beta-cells bind amylin
    Susan Potter-Perigo
    The Hope Heart Institute, Seattle, WA 98104, USA
    Arch Biochem Biophys 413:182-90. 2003
    ..Medium and cell layer proteoglycans bound exclusively to fibrillogenic amylin, as determined by gel mobility shift assays, indicating a possible role for beta-cell-derived proteoglycans in islet amyloid formation...
  68. pmc Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy
    Mario Kratz
    Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Clin Endocrinol Metab 93:959-66. 2008
    ..The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy...
  69. pmc Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the diabetes prevention program
    Richard R Rubin
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes Care 31:420-6. 2008
    ..To assess the association between elevated depression symptoms or antidepressant medicine use on entry to the Diabetes Prevention Program (DPP) and during the study and the risk of developing diabetes during the study...
  70. ncbi request reprint Population approaches to estimate minimal model indexes of insulin sensitivity and glucose effectiveness using full and reduced sampling schedules
    Kevin M Krudys
    Resource Facility for Population Kinetics, Department of Bioengineering, Box 352255, University of Washington, Seattle, WA 98195 2255, USA
    Am J Physiol Endocrinol Metab 291:E716-23. 2006
    ....
  71. pmc Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
    Allan F Moore
    Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Diabetes 57:2503-10. 2008
    ....
  72. ncbi request reprint Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes
    Rebecca L Hull
    Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 89:3629-43. 2004
    ..These agents could thus lead to a preservation of beta-cell mass and amelioration of the islet lesion in type 2 diabetes...
  73. ncbi request reprint Engineering a new beta-cell: a critical venture requiring special attention to constantly changing physiological needs
    Steven E Kahn
    Division of Metabolism, Endocrinology and Nutrition, VA Puget Sound Health Care System 151, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Semin Cell Dev Biol 15:359-70. 2004
    ..The new cell should have a low risk for recurrence of the primary disease and ensuring its survival should not be worse than diabetes itself...
  74. pmc Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin
    Abbas E Kitabchi
    Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, Rockville, MD 20852, USA
    Diabetes 54:2404-14. 2005
    ..The better preventive effectiveness of intensive lifestyle may be due to improved insulin sensitivity concomitant with preservation of beta-cell function...
  75. ncbi request reprint Effects of short-term experimental insulin resistance and family history of diabetes on pancreatic beta-cell function in nondiabetic individuals
    Neda Rasouli
    Medicine and Research Services, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas 72205, USA
    J Clin Endocrinol Metab 90:5825-33. 2005
    ..This ability to compensate for reduced insulin sensitivity is highly heritable, but the mechanisms for this compensation or its failure in type 2 diabetes (T2DM) are unknown...
  76. pmc Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone
    Jose C Florez
    Center for Human Genetic Research and Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    J Clin Endocrinol Metab 92:1502-9. 2007
    ..The common P12A polymorphism in PPARG (a target for thiazolidinedione medications) has been consistently associated with type 2 diabetes...
  77. ncbi request reprint Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
    Sofianos Andrikopoulos
    University of Melbourne, Department of Medicine, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australia
    J Endocrinol 187:45-53. 2005
    ..Understanding these differences will provide researchers with the information to choose the appropriate genetic background on which to express their particular genetic alteration...
  78. ncbi request reprint A diabetes outcome progression trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2 diabetes
    Giancarlo Viberti
    Guy s, King s, and St Thomas School of Medicine, King s College, London, U K
    Diabetes Care 25:1737-43. 2002
    ....
  79. pmc Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program
    Jose C Florez
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:531-6. 2007
    ..We further hypothesize that the diabetes-preventive effect of metformin may interact with the impact of these variants on insulin regulation...
  80. pmc Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program
    John M Lachin
    d, Diabetes Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    Diabetes 56:1153-9. 2007
    ....
  81. pmc Differences in A1C by race and ethnicity among patients with impaired glucose tolerance in the Diabetes Prevention Program
    William H Herman
    Department of Internal Medicine and Epidemiology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Diabetes Care 30:2453-7. 2007
    ..We sought to examine racial and ethnic differences in A1C in individuals with impaired glucose tolerance (IGT)...
  82. ncbi request reprint Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes
    Donna H Ryan
    Pennington Biomedical Research Center
    Control Clin Trials 24:610-28. 2003
    ..Other outcomes include components of CVD risk, cost and cost-effectiveness, diabetes control and complications, hospitalizations, intervention processes, and quality of life...
  83. ncbi request reprint Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    Utpal B Pajvani
    Department of Cell Biology, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Biol Chem 279:12152-62. 2004
    ..These observations suggest that the HMW adiponectin complex is the active form of this protein, which we directly demonstrate in vivo by its ability to depress serum glucose levels in a dose-dependent manner...
  84. pmc Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program
    William C Knowler
    George Washington University Biostatistics Center, Rockville, Maryland, USA
    Diabetes 54:1150-6. 2005
    ..Whether other thiazolidinedione drugs used for longer periods can safely prevent diabetes remains to be determined...
  85. pmc Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program
    Kieren J Mather
    Division of Endocrinology and Metabolism, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Diabetes 57:980-6. 2008
    ..To determine whether baseline adiponectin levels or intervention-associated change in adiponectin levels were independently associated with progression to diabetes in the Diabetes Prevention Program (DPP)...
  86. ncbi request reprint Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Diabetes 53:3193-200. 2004
    ..1 vs. 83.7%, P = 0.0009). These phenotypic differences may underlie a potential difference in the natural history of hyperglycemia and its clinical outcomes...

Research Grants9

  1. Mechanisms of Islet Amyloidogenesis
    STEVEN EMANUEL KAHN; Fiscal Year: 2010
    ..This proposal will examine mechanisms by which these deposits form in order to try and prevent their formation and the loss of insulin producing cells. ..
  2. Study of Health Outcomes of Weight loss: Look AHEAD-Action for Health in Diabetes
    Steven Kahn; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..
  3. Mechanisms of Islet Amyloidogenesis
    Steven Kahn; Fiscal Year: 2009
    ..This proposal will examine mechanisms by which these deposits form in order to try and prevent their formation and the loss of insulin producing cells. ..
  4. Mechanisms of Islet Amyloidogenesis
    STEVEN EMANUEL KAHN; Fiscal Year: 2010
    ..This proposal will examine mechanisms by which these deposits form in order to try and prevent their formation and the loss of insulin producing cells. ..
  5. ISLET FUNCTION IN TYPE 2 DIABETES
    Steven Kahn; Fiscal Year: 2003
    ..The applicant has successfully trained a number of young investigators in the areas of patient-oriented and basic research and a plan to continue doing so is presented. ..
  6. Post-DDP Follow-up Study
    Steven Kahn; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..