Martin Kagnoff

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi Barriers impeding serologic screening for celiac disease in clinically high-prevalence populations
    Erika M Barbero
    Department of Medicine, Division of Gastroenterology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 MC 0623D, USA
    BMC Gastroenterol 14:42. 2014
  2. pmc Can consumers trust web-based information about celiac disease? Accuracy, comprehensiveness, transparency, and readability of information on the internet
    Shawna L McNally
    Wm K Warren Medical Research Center for Celiac Disease, Department of Medicine, University of California, San Diego, La Jolla, CA, United States
    Interact J Med Res 1:e1. 2012
  3. doi Introduction: celiac disease
    Martin F Kagnoff
    Laboratory of Mucosal Immunology and the Wm K Warren Medical Research Center for Celiac Disease, University of California San Diego, La Jolla, CA, USA
    Semin Immunopathol 34:471-2. 2012
  4. ncbi 2007 William K. Warren, Jr., prize for excellence in celiac disease research awarded to professor Ludvig M. Sollid of Oslo, Norway
    Martin F Kagnoff
    Medicine and Pediatrics, Wm K Warren Medical Research Center for Celiac Disease, University of California at San Diego, La Jolla, California, USA
    Gastroenterology 133:9-10. 2007
  5. pmc Celiac disease: pathogenesis of a model immunogenetic disease
    Martin F Kagnoff
    Department of Medicine, Laboratory of Mucosal Immunology, and Wm K Warren Medical Research Center for Celiac Disease, UCSD, La Jolla, California 92093 0623, USA
    J Clin Invest 117:41-9. 2007
  6. ncbi Microbial-epithelial cell crosstalk during inflammation: the host response
    Martin F Kagnoff
    Departments of Medicine and Pediatrics, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
    Ann N Y Acad Sci 1072:313-20. 2006
  7. ncbi Immunopathology of the gastrointestinal system. Introduction
    Martin F Kagnoff
    Department of Medicine and Pediatrics and The Laboratory of Mucosal Immunology, University of California, San Diego, La Jolla, CA, 92093, USA
    Springer Semin Immunopathol 27:129-31. 2005
  8. ncbi Overview and pathogenesis of celiac disease
    Martin F Kagnoff
    Department of Medicine, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, California 92093 0623, USA
    Gastroenterology 128:S10-8. 2005
  9. ncbi Mucosal immunology: new frontiers
    M F Kagnoff
    Dept of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Immunol Today 17:57-9. 1996
  10. ncbi Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription
    M F Kagnoff
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Infect Dis 179:S444-7. 1999

Research Grants

Collaborators

Detail Information

Publications37

  1. doi Barriers impeding serologic screening for celiac disease in clinically high-prevalence populations
    Erika M Barbero
    Department of Medicine, Division of Gastroenterology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 MC 0623D, USA
    BMC Gastroenterol 14:42. 2014
    ..This study aimed to assess if patient-centered barriers have a role in impeding serologic screening for celiac disease in individuals from populations that are clinically at an increased risk for celiac disease...
  2. pmc Can consumers trust web-based information about celiac disease? Accuracy, comprehensiveness, transparency, and readability of information on the internet
    Shawna L McNally
    Wm K Warren Medical Research Center for Celiac Disease, Department of Medicine, University of California, San Diego, La Jolla, CA, United States
    Interact J Med Res 1:e1. 2012
    ..Nonetheless, information about celiac disease that is available on various websites often is questioned by patients and other health care professionals regarding its reliability and content...
  3. doi Introduction: celiac disease
    Martin F Kagnoff
    Laboratory of Mucosal Immunology and the Wm K Warren Medical Research Center for Celiac Disease, University of California San Diego, La Jolla, CA, USA
    Semin Immunopathol 34:471-2. 2012
    ..This is the introduction for the Special Issue on Celiac Disease...
  4. ncbi 2007 William K. Warren, Jr., prize for excellence in celiac disease research awarded to professor Ludvig M. Sollid of Oslo, Norway
    Martin F Kagnoff
    Medicine and Pediatrics, Wm K Warren Medical Research Center for Celiac Disease, University of California at San Diego, La Jolla, California, USA
    Gastroenterology 133:9-10. 2007
  5. pmc Celiac disease: pathogenesis of a model immunogenetic disease
    Martin F Kagnoff
    Department of Medicine, Laboratory of Mucosal Immunology, and Wm K Warren Medical Research Center for Celiac Disease, UCSD, La Jolla, California 92093 0623, USA
    J Clin Invest 117:41-9. 2007
    ..This article focuses on the role of adaptive and innate immune mechanisms in the pathogenesis of celiac disease and how current concepts of immunopathogenesis might provide alternative approaches for treating celiac disease...
  6. ncbi Microbial-epithelial cell crosstalk during inflammation: the host response
    Martin F Kagnoff
    Departments of Medicine and Pediatrics, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
    Ann N Y Acad Sci 1072:313-20. 2006
    ..It further highlights the importance of intestinal epithelium in mediating host antimicrobial defense through the production of antimicrobial peptides of the defensin and cathelicidin families...
  7. ncbi Immunopathology of the gastrointestinal system. Introduction
    Martin F Kagnoff
    Department of Medicine and Pediatrics and The Laboratory of Mucosal Immunology, University of California, San Diego, La Jolla, CA, 92093, USA
    Springer Semin Immunopathol 27:129-31. 2005
  8. ncbi Overview and pathogenesis of celiac disease
    Martin F Kagnoff
    Department of Medicine, Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, California 92093 0623, USA
    Gastroenterology 128:S10-8. 2005
  9. ncbi Mucosal immunology: new frontiers
    M F Kagnoff
    Dept of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Immunol Today 17:57-9. 1996
    ..Mucosal immunology is one of the most rapidly developing and exciting fields of immunological research. A recent meeting discussed advances in the fundamental knowledge of this area, and reviewed possibilities for its clinical application...
  10. ncbi Human immunodeficiency virus type 1 (HIV-1) infection and expression in intestinal epithelial cells: role of protein kinase A and C pathways in HIV-1 transcription
    M F Kagnoff
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0623, USA
    J Infect Dis 179:S444-7. 1999
    ....
  11. ncbi Analysis of host responses to microbial infection using gene expression profiling
    M F Kagnoff
    University of California, San Diego, Laboratory of Mucosal Immunology, 9500 Gilman Drive, La Jolla, California 92093 0623, USA
    Curr Opin Microbiol 4:246-50. 2001
    ....
  12. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  13. pmc Opposing functions of IKKbeta during acute and chronic intestinal inflammation
    Lars Eckmann
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:15058-63. 2008
    ..Our findings caution against the therapeutic use of IKKbeta/NF-kappaB inhibitors in acute inflammatory settings dominated by cell loss and ulceration...
  14. pmc Central importance of immunoglobulin A in host defense against Giardia spp
    T Dianne Langford
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 70:11-8. 2002
    ..Moreover, B-cell-dependent but IgA-independent and B-cell-independent antigiardial host defenses exist but are less important for controlling infection...
  15. ncbi Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury
    Sungwon Chae
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Immunol 177:1214-20. 2006
    ..difficile toxin A exposure that is mediated, at least in part, through promoting epithelial cell survival by abrogating epithelial cell apoptosis...
  16. ncbi The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    Lee Wei Chen
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, California, USA
    Nat Med 9:575-81. 2003
    ..These results show the dual function of the NF-kappaB system, which is responsible for both tissue protection and systemic inflammation, and underscore the caution that should be exerted in using NF-kappaB and IKK inhibitors...
  17. pmc IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium
    Laurence J Egan
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 101:2452-7. 2004
    ..Selective preactivation of NF-kappaB through IKKbeta in intestinal epithelial cells could provide a therapeutic modality that allows higher doses of radiation to be tolerated during cancer radiotherapy...
  18. ncbi Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    Jongdae Lee
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0663, USA
    Nat Cell Biol 8:1327-36. 2006
    ..Our data provide a case for organ-specific innate immunity in which TLR expression in polarized IECs has uniquely evolved to maintain colonic homeostasis and regulate tolerance and inflammation...
  19. pmc Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium
    Koji Hase
    Laboratory of Mucosal Immunology Histology Shared Resources, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 70:953-63. 2002
    ....
  20. ncbi Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Gastroenterology 122:667-80. 2002
    ..MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators important for regulating mucosal immune and inflammatory responses, we sought to determine if these cells produce MIF...
  21. ncbi Regulated production of the chemokine CCL28 in human colon epithelium
    Hiroyuki Ogawa
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1062-9. 2004
    ..These findings indicate that CCL28 functions as an "inflammatory" chemokine in human colon epithelium and suggest the notion that CCL28 may act to counterregulate colonic inflammation...
  22. ncbi IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Cell 118:285-96. 2004
    ..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer...
  23. pmc Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors
    Jae Gyu Kim
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, California 92093 0623, USA
    Infect Immun 72:1487-95. 2004
    ..Signaling through Nod1 provides the intestinal epithelium with a backup mechanism for rapidly activating innate immunity during infection with a group of highly invasive pathogenic gram-negative bacteria...
  24. ncbi Role of EHEC O157:H7 virulence factors in the activation of intestinal epithelial cell NF-kappaB and MAP kinase pathways and the upregulated expression of interleukin 8
    M Cecilia Berin
    Laboratory of Mucosal Immunology, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Cell Microbiol 4:635-48. 2002
    ..The activation of proinflammatory signals in human colon epithelial cells in response to this non-invasive pathogen appears to depend to a significant extent on H7 flagellin...
  25. ncbi Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens
    Mitsutoshi Iimura
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0623, USA
    J Immunol 174:4901-7. 2005
    ..Moreover, Cnlp+/+ mice were protected from oral infections with C. rodentium inocula that infected the majority of Cnlp-/- mice. These results establish cathelicidin as an important component of innate antimicrobial defense in the colon...
  26. pmc GM-CSF-facilitated dendritic cell recruitment and survival govern the intestinal mucosal response to a mouse enteric bacterial pathogen
    Yoshihiro Hirata
    Department of Medicine, University of California, San Diego, La Jolla, 92093 0623, USA
    Cell Host Microbe 7:151-63. 2010
    ..Thus, GM-CSF produced in the intestinal mucosa acts to enhance host protection against an enteric bacterial pathogen through regulating recruitment and survival of DCs...
  27. ncbi Nuclear factor-kappa B activation promotes restitution of wounded intestinal epithelial monolayers
    Laurence J Egan
    Laboratory of Mucosal Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0623, USA
    Am J Physiol Cell Physiol 285:C1028-35. 2003
    ....
  28. ncbi Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells
    Yoshihiro Hirata
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 179:5425-32. 2007
    ..Virus replication and virus-induced cell death increased in IECs in which RIG-I was silenced, consistent with the importance of the RIG-I signaling pathway in IEC antiviral innate immune defense mechanisms...
  29. ncbi Role of Shiga toxin versus H7 flagellin in enterohaemorrhagic Escherichia coli signalling of human colon epithelium in vivo
    Yukiko Miyamoto
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA, USA
    Cell Microbiol 8:869-79. 2006
    ..We conclude that EHEC H7 flagellin and not Stx is the major EHEC factor that directly upregulates proinflammatory chemokine production by human colon epithelium in vivo...
  30. pmc Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium
    Christian Maaser
    Laboratory of Mucosal Immunology, Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Immunology 112:437-45. 2004
    ....
  31. ncbi Intestinal mucosal responses to microbial infection
    Lars Eckmann
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Springer Semin Immunopathol 27:181-96. 2005
    ....
  32. ncbi Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells
    Günther Paesold
    Department of Medicine 0623D, University of California at San Diego, La Jolla, CA 92093 0623, USA
    Cell Microbiol 4:771-81. 2002
    ..In addition to their influence on intracellular proliferation of Salmonella, genes in those loci determine the ultimate fate of infected epithelial cells with respect to caspase 3 activation and undergoing death by apoptosis...
  33. ncbi Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells
    Charles C Yang
    Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0623, USA
    Am J Physiol Cell Physiol 288:C321-8. 2005
    ....
  34. ncbi Mucosal inflammation in celiac disease: interleukin-15 meets transforming growth factor beta-1
    Martin F Kagnoff
    Gastroenterology 132:1174-6. 2007
  35. ncbi Celiac disease pathogenesis: the plot thickens
    Martin F Kagnoff
    Gastroenterology 123:939-43. 2002
  36. ncbi SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4
    Michael B Dwinell
    Dept of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Gastrointest Liver Physiol 286:G844-50. 2004
    ..Taken together, these data indicate that epithelial CXCR4 can transduce functional signals in human intestinal epithelial cells that modulate important cAMP-mediated cellular functions...
  37. ncbi American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease
    Alaa Rostom
    Division of Gastroenterology, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 131:1981-2002. 2006

Research Grants5

  1. INTESTINAL EPITHELIAL RESPONSES TO FOOD BORNE PATHOGENS
    Martin Kagnoff; Fiscal Year: 2004
    ..Our experimental approaches will draw on in vitro and in vivo model systems established in this laboratory and a duality of hypothesis and discovery based experimental approaches. ..