V E Kagan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory
    Hulya Bayir
    Safar Center for Resuscitation Research, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, PA, USA
    Crit Care 12:206. 2008
  2. ncbi request reprint Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Chem Biol 1:223-32. 2005
  3. ncbi request reprint Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron
    V E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, United States
    Toxicol Lett 165:88-100. 2006
  4. ncbi request reprint The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes
    V E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA
    Chem Biol Interact 163:15-28. 2006
  5. ncbi request reprint Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Pharmacol 56:494-506. 1999
  6. ncbi request reprint Redox regulation of copper-metallothionein
    J P Fabisiak
    Department of Environmental and Occupational Health, School of Public Health, RIDC Park, 260 Kappa Drive, Pittsburgh, Pennsylvania 15238, USA
    Arch Biochem Biophys 363:171-81. 1999
  7. ncbi request reprint Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae
    B W Day
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Chem Res Toxicol 12:28-37. 1999
  8. ncbi request reprint Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Cancer Res 61:7777-84. 2001
  9. ncbi request reprint Mishandling of copper by albumin: role in redox-cycling and oxidative stress in preeclampsia plasma
    V E Kagan
    Department of Environmental and Occupational Health, and Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Hypertens Pregnancy 20:221-41. 2001
  10. ncbi request reprint Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238, USA
    FEBS Lett 477:1-7. 2000

Collaborators

Detail Information

Publications37

  1. pmc Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis--there is nothing more practical than a good theory
    Hulya Bayir
    Safar Center for Resuscitation Research, Department of Critical Care Medicine, School of Medicine, University of Pittsburgh, PA, USA
    Crit Care 12:206. 2008
    ....
  2. ncbi request reprint Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health and Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Chem Biol 1:223-32. 2005
    ..These results provide insight into the role of reactive oxygen species in triggering the cell-death pathway and describe an early role for cytochrome c before caspase activation...
  3. ncbi request reprint Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron
    V E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, United States
    Toxicol Lett 165:88-100. 2006
    ..Thus, the presence of iron in SWCNT may be important in determining redox-dependent responses of macrophages...
  4. ncbi request reprint The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes
    V E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219, USA
    Chem Biol Interact 163:15-28. 2006
    ....
  5. ncbi request reprint Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Mol Pharmacol 56:494-506. 1999
    ..thus minimizing the genotoxic effects of the radicals in bone marrow myelogenous progenitor cells, i.e., chemoprevention of etoposide-induced acute myelogenous leukemia...
  6. ncbi request reprint Redox regulation of copper-metallothionein
    J P Fabisiak
    Department of Environmental and Occupational Health, School of Public Health, RIDC Park, 260 Kappa Drive, Pittsburgh, Pennsylvania 15238, USA
    Arch Biochem Biophys 363:171-81. 1999
    ..Release of free Cu from MT during oxidative stress could enhance the formation of reactive oxygen species and potentiate cellular damage...
  7. ncbi request reprint Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae
    B W Day
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Chem Res Toxicol 12:28-37. 1999
    ....
  8. ncbi request reprint Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Cancer Res 61:7777-84. 2001
    ....
  9. ncbi request reprint Mishandling of copper by albumin: role in redox-cycling and oxidative stress in preeclampsia plasma
    V E Kagan
    Department of Environmental and Occupational Health, and Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Hypertens Pregnancy 20:221-41. 2001
    ....
  10. ncbi request reprint Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238, USA
    FEBS Lett 477:1-7. 2000
    ..Thus, cytochrome c-mediated phosphatidylserine oxidation may represent an important component of the apoptotic pathway...
  11. ncbi request reprint Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria
    H Bayir
    Center for Free Radical and Antioxidant Health, Pittsburgh, PA 15219, USA
    Biochim Biophys Acta 1757:648-59. 2006
    ..This review is focused on newly discovered redox mechanisms of complexes of cyt c with anionic phospholipids and their role in apoptotic pathways in health and disease...
  12. ncbi request reprint Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA
    Antioxid Redox Signal 3:189-202. 2001
    ..In the latter pathway, NO down-regulates expression of iron-containing proteins to prevent their catalytic prooxidant reactions...
  13. ncbi request reprint Elevated levels of S-nitrosoalbumin in preeclampsia plasma
    V A Tyurin
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15238, USA
    Circ Res 88:1210-5. 2001
    ..We conclude that S-nitrosoalbumin and total S-nitrosothiol concentrations are significantly increased in preeclampsia plasma and may reflect insufficient release of NO groups in this condition...
  14. ncbi request reprint Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1-17. 2003
    ..The putative importance of this oxidative phosphatidylserine signaling in lung physiology and disease are also discussed...
  15. ncbi request reprint Selective oxidation and externalization of membrane phosphatidylserine: Bcl-2-induced potentiation of the final common pathway for apoptosis
    N F Schor
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Res 831:125-30. 1999
    ..The mechanism of potentiation of apoptosis by Bcl-2 is related to the enhanced reducing potential of bcl-2-overexpressing PC12 cells...
  16. ncbi request reprint Nitric oxide dissociates lipid oxidation from apoptosis and phosphatidylserine externalization during oxidative stress
    J P Fabisiak
    Department of Environmental Health, School of Public Health, University of Pittsburgh, Pennsylvania 15238, USA
    Biochemistry 39:127-38. 2000
    ..Thus, in the absence of significant peroxynitrite formation, NO's antioxidant effects are restricted to protection of lipids, while modification of protein substrates continues to occur...
  17. ncbi request reprint Recycling and redox cycling of phenolic antioxidants
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pennsylvania 15238, USA
    Ann N Y Acad Sci 854:425-34. 1998
    ..g., phenol) are capable of oxidizing both proteins and lipids. Hence, reactivity of phenoxyl radicals should be considered as a critical factor in the development of new antioxidant protectants...
  18. ncbi request reprint Interaction between 6-hydroxydopamine and transferrin: "Let my iron go"
    G G Borisenko
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, USA
    Biochemistry 39:3392-400. 2000
    ..These findings underscore the physiological and pharmacological relevance of 6-OHDA-mediated iron release from Fe-TF and suggest that iron chelators (DFO) may be used for prevention of 6-OHDA toxicity...
  19. ncbi request reprint Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical
    J P Fabisiak
    Department of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, PA 15238, USA
    Antioxid Redox Signal 2:73-82. 2000
    ..The hypersensitive SH-groups on RyR are shown to be targets for oxidation of VP-16 phenoxyl radical, and suggest that other phenolic compounds could similarly disrupt Ca2+ homeostasis...
  20. ncbi request reprint Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper-albumin complexes from antioxidants to prooxidants
    Y A Gryzunov
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, PA 15260, USA
    Arch Biochem Biophys 413:53-66. 2003
    ..We conclude that fatty acids regulate anti-/prooxidant properties of Cu-albumin via controlling redox status of Cys-34...
  21. ncbi request reprint Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells
    V E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Ave, PA 15260, USA
    Biochim Biophys Acta 1620:72-84. 2003
    ..The role of phenoxyl radical recycling in maintaining antioxidant defense and protecting against cytotoxic and genotoxic phenolics is discussed...
  22. ncbi request reprint Increased mutant frequencies in the HPRT gene locus of leukemia HL-60 cells treated with succinylacetone
    K C Zheng
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219 3130, USA
    Cell Biol Toxicol 22:361-70. 2006
    ..These data show a dose-response increase in HPRT-Mf in HL-60 cells treated with SA, suggesting that this chemical causes mutations in the HPRT locus in these cells either directly or indirectly through its inhibition of the MPO activity...
  23. ncbi request reprint Serum total antioxidant activity in relative hypo- and hypercholesterolemia
    M F Muldoon
    Center for Clinical Pharmacology, University of Pittsburg School of Medicine, PA 15260, USA
    Free Radic Res 25:239-45. 1996
    ..These data indicate that hypocholesterolemia may be associated with low serum antioxidant reserve, possibly increasing susceptibility to oxidative stress...
  24. ncbi request reprint Mechanisms of nitric oxide protection against tert-butyl hydroperoxide-induced cytotoxicity in iNOS-transduced human erythroleukemia cells
    J C Yalowich
    Department of Pharmacology, University of Pittsburgh School of Medicine, Graduate School of Public Health, Pennsylvania 15238, USA
    Biochemistry 38:10691-8. 1999
    ..Second, nitric oxide can chemically reduce t-BuOOH-induced oxoferryl and t-BuO(*) alkoxyl radicals...
  25. doi request reprint Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid
    D A Stoyanovsky
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    Rapid Commun Mass Spectrom 28:403-12. 2014
    ..To circumvent some of these limitations of MALDI-MSI, we have developed improved matrices for lipid analysis based on structural modification of the commonly used matrix 2,5-dihydroxybenzoic acid (DHB)...
  26. ncbi request reprint Exploiting oxidative stress and signaling in chemotherapy of resistant neoplasms
    N F Schor
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, USA
    Biochemistry (Mosc) 69:38-44. 2004
    ....
  27. ncbi request reprint Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
    M W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Int J Cancer 96:221-31. 2001
    ..These studies provide further support for translation of MnSOD-PL treatment into human esophageal radiation protection...
  28. ncbi request reprint Phosphatidylserine peroxidation during apoptosis. A signaling pathway for phagocyte clearance
    Y Y Tyurina
    Department of Environmental and Occupational Health, University of Pittsburgh, Pennsylvania 15238, USA
    Subcell Biochem 36:79-96. 2002
  29. ncbi request reprint Cardiolipin activates cytochrome c peroxidase activity since it facilitates H(2)O(2) access to heme
    Yu A Vladimirov
    Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow 117192, Russia
    Biochemistry (Mosc) 71:998-1005. 2006
    ..These data suggest that cardiolipin activates specifically Cyt c peroxidase activity not only because it promotes Fe...S(Met80) bond breaking but also facilitates H2O2 penetration to the reaction center...
  30. ncbi request reprint Regulation of cytochrome C peroxidase activity by nitric oxide and laser irradiation
    A N Osipov
    Department of Biophysics, Russian State Medical University, Moscow, 117513, Russia
    Biochemistry (Mosc) 71:1128-32. 2006
    ..Finally, we conclude that nitric oxide and laser irradiation may serve as effective instruments for regulating the peroxidase activity of cytochrome c, and, probably, apoptosis...
  31. pmc Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
    A A Shvedova
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 295:L552-65. 2008
    ..SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice...
  32. doi request reprint Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA
    Toxicol Appl Pharmacol 231:235-40. 2008
    ..These results demonstrate a role for NADPH oxidase-derived reactive oxygen species in determining course of pulmonary response to SWCNT...
  33. ncbi request reprint Interactions of cardiolipin and lyso-cardiolipins with cytochrome c and tBid: conflict or assistance in apoptosis
    V A Tyurin
    Cell Death Differ 14:872-5. 2007
  34. ncbi request reprint Mechanism of activation of cytochrome C peroxidase activity by cardiolipin
    Yu A Vladimirov
    Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 117192, Russia
    Biochemistry (Mosc) 71:989-97. 2006
    ....
  35. ncbi request reprint Quantitative analysis of phospholipid peroxidation and antioxidant protection in live human epidermal keratinocytes
    A A Shvedova
    Health Effects Laboratory Division, NIOSH, Morgantown, WV 26505, USA
    Biosci Rep 21:33-43. 2001
    ....
  36. ncbi request reprint Apoptotic cells quench reactive oxygen and nitrogen species and modulate TNF-alpha/TGF-beta1 balance in activated macrophages: involvement of phosphatidylserine-dependent and -independent pathways
    B F Serinkan
    Cell Death Differ 12:1141-4. 2005
  37. ncbi request reprint Milk fat globule epidermal growth factor 8 (MFG-E8) binds to oxidized phosphatidylserine: implications for macrophage clearance of apoptotic cells
    G G Borisenko
    Cell Death Differ 11:943-5. 2004