DAVID KAETZEL

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma
    Stuart G Jarrett
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Clin Exp Metastasis 30:25-36. 2013
  2. pmc Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    Mol Cell Biochem 329:161-5. 2009
  3. ncbi request reprint Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Bioenerg Biomembr 38:163-7. 2006
  4. ncbi request reprint Transcription of the platelet-derived growth factor A-chain gene
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0084, USA
    Cytokine Growth Factor Rev 14:427-46. 2003
  5. ncbi request reprint The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    J Biol Chem 279:18073-84. 2004
  6. ncbi request reprint Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter
    Qingbei Zhang
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Gene 348:25-32. 2005
  7. ncbi request reprint Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival i
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0084, USA
    Cancer Res 65:5523-34. 2005
  8. pmc The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung
    Angela K Ormerod
    Department of Molecular and Biomedical Pharmacology, College of Medicine, 800 Rose Street, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Exp Lung Res 34:155-82. 2008
  9. ncbi request reprint NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Biol Chem 277:1560-7. 2002
  10. ncbi request reprint A 5'-distal element mediates vitamin D-inducibility of PDGF-A gene transcription
    Nancy Pedigo
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Growth Factors 21:151-60. 2003

Collaborators

  • Glenn Merlino
  • Rolf J Craven
  • Bin Liu
  • David Louis
  • Anjaneyulu Kowluru
  • Nicholas J Koszewski
  • E H Postel
  • Nancy G Pedigo
  • Deqin Ma
  • Qingbei Zhang
  • Stuart G Jarrett
  • Mengmeng Yang
  • Angela K Ormerod
  • Joseph R McCorkle
  • Zhenlan Xing
  • Hongxing Zhang
  • Marian Novak
  • Nancy Pedigo
  • Divyamani Srinivasan
  • Anjali Mishra
  • Piam Shanehsaz
  • Nathan Harris
  • Andrezj Slominski
  • Rina Plattner
  • Maria E C Bruno
  • Satyendra Shenoy
  • Robert F Hennigan
  • Catherine L Nutt
  • Amy R Dugan
  • Xuejun Peng
  • Charlotte S Kaetzel
  • Kamel Khalili
  • Zengliang Bai
  • Stephen G Zimmer

Detail Information

Publications16

  1. pmc NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma
    Stuart G Jarrett
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Clin Exp Metastasis 30:25-36. 2013
    ..These studies demonstrate for the first time in vivo a potent metastasis suppressor activity of NM23 in UVR-induced melanoma, and have provided new tools for identifying molecular mechanisms that underlie melanoma metastasis...
  2. pmc Potential contributions of antimutator activity to the metastasis suppressor function of NM23-H1
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536 0298, USA
    Mol Cell Biochem 329:161-5. 2009
    ..These results and their implications for understanding the molecular mechanisms underlying NM23-H1 functions in cancer are discussed...
  3. ncbi request reprint Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Bioenerg Biomembr 38:163-7. 2006
    ....
  4. ncbi request reprint Transcription of the platelet-derived growth factor A-chain gene
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0084, USA
    Cytokine Growth Factor Rev 14:427-46. 2003
    ....
  5. ncbi request reprint The metastasis suppressor NM23-H1 possesses 3'-5' exonuclease activity
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0084, USA
    J Biol Chem 279:18073-84. 2004
    ..3'-5' Exonucleases are believed to play an important role in DNA repair, a logical candidate function underlying the putative antimetastatic and oncogenic activities of NM23-H1...
  6. ncbi request reprint Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter
    Qingbei Zhang
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Gene 348:25-32. 2005
    ..These results indicate Puralpha enhances transcription of the PDGF-A gene through its interactions with single-stranded, G-rich strands in the promoter, perhaps by stabilizing non-B-form DNA conformations...
  7. ncbi request reprint Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival i
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0084, USA
    Cancer Res 65:5523-34. 2005
    ..This study identifies genes associated with oncogenic activity of PDGF and provides important insights into biomarkers and therapeutic targets in malignant gliomas...
  8. pmc The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung
    Angela K Ormerod
    Department of Molecular and Biomedical Pharmacology, College of Medicine, 800 Rose Street, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Exp Lung Res 34:155-82. 2008
    ..These studies demonstrate that 1,25-(OH)2D3 disrupts the overall alveolarization process in the neonatal lung, although it stimulates expression of some proteins associated with lung morphogenesis...
  9. ncbi request reprint NM23-H1 and NM23-H2 repress transcriptional activities of nuclease-hypersensitive elements in the platelet-derived growth factor-A promoter
    Deqin Ma
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Biol Chem 277:1560-7. 2002
    ..They also indicate a role for NM23 proteins in repressing transcription of a growth factor oncogene, providing a possible molecular mechanism to explain their metastasis-suppressing effects...
  10. ncbi request reprint A 5'-distal element mediates vitamin D-inducibility of PDGF-A gene transcription
    Nancy Pedigo
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Growth Factors 21:151-60. 2003
    ..Thus, PDGF-A represents a novel mitogenic target of 1,25-(OH)2D3 whose expression is induced via binding of hormone-activated VDR to a response element located far upstream of the transcription start site...
  11. pmc YNK1, the yeast homolog of human metastasis suppressor NM23, is required for repair of UV radiation- and etoposide-induced DNA damage
    Mengmeng Yang
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536 0298, USA
    Mutat Res 660:74-8. 2009
    ..This study indicates a novel role for YNK1 in DNA repair in yeast, and suggests an anti-mutator function that may contribute to the metastasis suppressor function of NM23-H1 in humans...
  12. pmc Metastasis suppressor function of NM23-H1 requires its 3'-5' exonuclease activity
    Qingbei Zhang
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Int J Cancer 128:40-50. 2011
    ....
  13. pmc Reciprocal regulation of Abl and receptor tyrosine kinases
    Divyamani Srinivasan
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, 800 Rose Street, Lexington, KY 40346, USA
    Cell Signal 21:1143-50. 2009
    ..These data are exciting as they indicate that Abl kinases not only are activated by PDGFR and promote PDGFR-mediated proliferation and migration,but also act in an intricate negative feedback loop to turn-off PDGFR-mediated chemotaxis...
  14. ncbi request reprint A 5'-distal enhanceosome in the PDGF-A gene is activated in choriocarcinoma cells via ligand-independent binding of vitamin D receptor and constitutive jun kinase signaling
    Nancy G Pedigo
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Oncogene 24:2654-66. 2005
    ....
  15. ncbi request reprint Retinoic acid inducibility of the human PDGF-a gene is mediated by 5'-distal DNA motifs that overlap with basal enhancer and vitamin D response elements
    Nancy G Pedigo
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Gene Expr 14:1-12. 2007
    ..The addition of RARE activity to previously described functions of the 5'-distal enhanceosome underscores the importance of this region as a key integration point for regulatory control of PDGF-A expression...
  16. ncbi request reprint Regulatory roles for nm23/nucleoside diphosphate kinase-like enzymes in insulin secretion from the pancreatic islet beta cell
    Anjaneyulu Kowluru
    Department of Pharmaceutical Sciences, Wayne State University and beta Cell Biochemistry Laboratory, John D Dingell VA Medical Center, Detroit, MI, 48201, USA
    J Bioenerg Biomembr 38:227-32. 2006
    ..Potential significance of these findings in relation to contributory roles for nm23/NDPK-like enzymes in the stimulus-secretion coupling of GSIS is discussed...

Research Grants10

  1. Molecular Mechanisms of Metastasis Suppression by NM23
    DAVID KAETZEL; Fiscal Year: 2009
    ....
  2. Molecular Mechanisms of Metastasis Suppression by NM23
    DAVID KAETZEL; Fiscal Year: 2007
    ....
  3. NM23 PROTEINS AND MECHANISMS OF PDGF A CHAIN SILENCING
    DAVID KAETZEL; Fiscal Year: 2003
    ..Together, the proposed studies should provide important new insights into the mechanisms through which precise control of GF gene transcription is compromised in cancer. ..
  4. PDGF GENE REGULATION BY VITAMINS A & D IN ALVEOLIZATION
    DAVID KAETZEL; Fiscal Year: 2003
    ....
  5. Molecular Mechanisms of Metastasis Suppression by NM23
    David M Kaetzel; Fiscal Year: 2010
    ....