Affiliation: University of Washington
Kaeberlein M, Andalis A, Liszt G, Fink G, Guarente L. Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. Genetics. 2004;166:1661-72 pubmed
..We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains. ..
Kaeberlein M, Powers R. Sir2 and calorie restriction in yeast: a skeptical perspective. Ageing Res Rev. 2007;6:128-40 pubmed
..These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model. ..
Steinkraus K, Kaeberlein M, Kennedy B. Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol. 2008;24:29-54 pubmed publisher
..Although the question of what causes aging still cannot be answered definitively, that day may be rapidly approaching. ..
Kaeberlein M, Kapahi P. The hypoxic response and aging. Cell Cycle. 2009;8:2324 pubmed
Kaeberlein M, Kapahi P. Cell signaling. Aging is RSKy business. Science. 2009;326:55-6 pubmed publisher
Kaeberlein M. Resveratrol and rapamycin: are they anti-aging drugs?. Bioessays. 2010;32:96-9 pubmed publisher
..Compounds such as these, identified from longevity studies in model organisms, hold great promise as therapies to target multiple age-related diseases by modulating the molecular causes of aging. ..
Kaeberlein M. Lessons on longevity from budding yeast. Nature. 2010;464:513-9 pubmed publisher
..The first interventions to slow human ageing may spring from the humble yeast. ..
Olsen B, Murakami C, Kaeberlein M. YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast. BMC Bioinformatics. 2010;11:141 pubmed publisher
..We estimate that use of YODA as described here reduces the effort and resources required to measure chronological life span and analyze the resulting data by at least 15-fold. ..
Leiser S, Fletcher M, Begun A, Kaeberlein M. Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1. J Gerontol A Biol Sci Med Sci. 2013;68:1135-44 pubmed publisher
..Collectively, our results show that hypoxia modulates longevity in a complex manner, likely involving components in addition to HIF-1. ..