M Kaeberlein

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Longevity and aging
    Matt Kaeberlein
    Department of Pathology, University of Washington Seattle, WA 98195 USA Institute of Aging Research, Guangdong Medical College Dongguan 523808 China
    F1000Prime Rep 5:5. 2013
  2. pmc Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1
    Scott F Leiser
    Department of Pathology, University of Washington, Seattle, WA 98195
    J Gerontol A Biol Sci Med Sci 68:1135-44. 2013
  3. pmc Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
    Erica D Smith
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Dev Biol 8:49. 2008
  4. pmc YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast
    Brady Olsen
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Bioinformatics 11:141. 2010
  5. doi request reprint The ongoing saga of sirtuins and aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Cell Metab 8:4-5. 2008
  6. pmc Genome-wide approaches to understanding human ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hum Genomics 2:422-8. 2006
  7. pmc Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 166:1661-72. 2004
  8. pmc Molecular basis of ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    EMBO Rep 8:907-11. 2007
  9. ncbi request reprint Protein translation, 2007
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 6:731-4. 2007
  10. ncbi request reprint Sir2 and calorie restriction in yeast: a skeptical perspective
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Ageing Res Rev 6:128-40. 2007

Research Grants

Collaborators

Detail Information

Publications55

  1. pmc Longevity and aging
    Matt Kaeberlein
    Department of Pathology, University of Washington Seattle, WA 98195 USA Institute of Aging Research, Guangdong Medical College Dongguan 523808 China
    F1000Prime Rep 5:5. 2013
    ....
  2. pmc Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1
    Scott F Leiser
    Department of Pathology, University of Washington, Seattle, WA 98195
    J Gerontol A Biol Sci Med Sci 68:1135-44. 2013
    ..Collectively, our results show that hypoxia modulates longevity in a complex manner, likely involving components in addition to HIF-1. ..
  3. pmc Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
    Erica D Smith
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Dev Biol 8:49. 2008
    ..Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood...
  4. pmc YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast
    Brady Olsen
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    BMC Bioinformatics 11:141. 2010
    ....
  5. doi request reprint The ongoing saga of sirtuins and aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Cell Metab 8:4-5. 2008
    ..In this issue of Cell Metabolism, Li et al. (2008) provide evidence that SirT1 has properties consistent with both pro- and antiaging functions in mice...
  6. pmc Genome-wide approaches to understanding human ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Hum Genomics 2:422-8. 2006
    ....
  7. pmc Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genetics 166:1661-72. 2004
    ..We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains...
  8. pmc Molecular basis of ageing
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    EMBO Rep 8:907-11. 2007
  9. ncbi request reprint Protein translation, 2007
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 6:731-4. 2007
    ..This Hot Topic article discusses papers published in the last year related to the importance of translation and its regulation by signaling through the target of rapamycin kinase, in modulating aging and age-associated diseases...
  10. ncbi request reprint Sir2 and calorie restriction in yeast: a skeptical perspective
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Ageing Res Rev 6:128-40. 2007
    ..These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model...
  11. pmc Recent developments in yeast aging
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e84. 2007
    ..Here we briefly outline aging in yeast and describe recent findings that continue to keep this "simple" eukaryote at the forefront of aging research...
  12. ncbi request reprint Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 312:1312; author reply 1312. 2006
    ..Contradictory to this, we find that CR greatly increases life span in cells lacking Sir2, Hst1, and Hst2, which suggests that CR is not mediated by Sir2, Hst2, or Hst1...
  13. pmc Replicative aging in yeast: the means to the end
    K A Steinkraus
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Cell Dev Biol 24:29-54. 2008
    ..Although the question of what causes aging still cannot be answered definitively, that day may be rapidly approaching...
  14. pmc Increased life span due to calorie restriction in respiratory-deficient yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 1:e69. 2005
    ....
  15. ncbi request reprint Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
    Matt Kaeberlein
    Departments of Genome Sciences and Medicine, University of Washington, Seattle, WA 98195, USA
    Science 310:1193-6. 2005
    ..We propose that the TOR and Sch9 kinases define a primary conduit through which excess nutrient intake limits longevity in yeast...
  16. doi request reprint Protein translation, 2008
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Aging Cell 7:777-82. 2008
    ..Importantly, studies published this year also began to provide insights into specific mechanisms by which altered mRNA translation does (and in some cases does not) slow aging in invertebrate model organisms...
  17. ncbi request reprint Aging-related research in the "-omics" age
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Sci Aging Knowledge Environ 2004:pe39. 2004
    ..A meta-analysis of data derived from genome-wide studies of aging in simple eukaryotes will allow the identification of conserved determinants of longevity that can be tested in mammals...
  18. pmc Lessons on longevity from budding yeast
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Nature 464:513-9. 2010
    ..The first interventions to slow human ageing may spring from the humble yeast...
  19. ncbi request reprint Resveratrol and rapamycin: are they anti-aging drugs?
    Matt Kaeberlein
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Bioessays 32:96-9. 2010
    ..Compounds such as these, identified from longevity studies in model organisms, hold great promise as therapies to target multiple age-related diseases by modulating the molecular causes of aging...
  20. ncbi request reprint Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast
    Mitsuhiro Tsuchiya
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 5:505-14. 2006
    ..Thus, we propose that lifespan extension by CR is independent of sirtuins and that nicotinamide has sirtuin-independent effects on lifespan extension by CR...
  21. pmc Sir2-independent life span extension by calorie restriction in yeast
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington, USA
    PLoS Biol 2:E296. 2004
    ..These findings indicate that Sir2 and calorie restriction act in parallel pathways to promote longevity in yeast and, perhaps, higher eukaryotes...
  22. pmc Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genome Res 18:564-70. 2008
    ..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
  23. pmc Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
    Kristan K Steffen
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Cell 133:292-302. 2008
    ..Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms...
  24. ncbi request reprint The enigmatic role of Sir2 in aging
    Brian K Kennedy
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Cell 123:548-50. 2005
    ..In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction...
  25. ncbi request reprint Lifespan extension in Caenorhabditis elegans by complete removal of food
    Tammi L Kaeberlein
    Department of Microbiology, University of Washington, Seattle, WA, USA
    Aging Cell 5:487-94. 2006
    ..Removal of bacterial food also increases lifespan when initiated in postreproductive adults, suggesting that dietary restriction started during middle age can result in a substantial longevity benefit that is independent of reproduction...
  26. ncbi request reprint Substrate-specific activation of sirtuins by resveratrol
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:17038-45. 2005
    ..In light of these findings, the mechanism accounting for putative longevity effects of resveratrol should be reexamined...
  27. ncbi request reprint A method for high-throughput quantitative analysis of yeast chronological life span
    Christopher J Murakami
    Department of Pathology, University of Washington, Box 357470, Seattle, WA 98195 7470, USA
    J Gerontol A Biol Sci Med Sci 63:113-21. 2008
    ..We also report that life-span extension from dietary restriction does not require any of the five yeast sirtuins (Sir2, Hst1, Hst2, Hst3, or Hst4) either alone or in combination...
  28. pmc Extension of chronological life span in yeast by decreased TOR pathway signaling
    R Wilson Powers
    Department of Genome Sciences and Medicine, The Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    Genes Dev 20:174-84. 2006
    ..We propose that up-regulation of a highly conserved response to starvation-induced stress is important for life span extension by decreased TOR signaling in yeast and higher eukaryotes...
  29. ncbi request reprint Genes determining yeast replicative life span in a long-lived genetic background
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:491-504. 2005
    ..These results define a limited number of genes likely to regulate replicative life span in a strain-independent manner, and create a basis for future epistasis analysis to determine genetic pathways of aging...
  30. ncbi request reprint Ruminations on dietary restriction and aging
    B K Kennedy
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Cell Mol Life Sci 64:1323-8. 2007
    ..Here we discuss the links between nutrient reduction and enhanced longevity with emphasis on evolutionarily conserved nutrient response signaling...
  31. pmc Hot topics in aging research: protein translation, 2009
    Brian K Kennedy
    Departments of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Aging Cell 8:617-23. 2009
    ..Other significant findings have connected translation control with other known longevity pathways and provided fodder for mechanistic hypotheses. Here, we summarize advances in this emerging field and raise questions for future studies...
  32. ncbi request reprint Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes
    George L Sutphin
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Exp Gerontol 43:130-5. 2008
    ..remanei strains. Thus, we find no evidence that adaptation to laboratory conditions has significantly altered the aging process in C. elegans under either standard or food-restricted conditions...
  33. pmc A molecular mechanism of chronological aging in yeast
    Christopher R Burtner
    Department of Biochemistry, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cell Cycle 8:1256-70. 2009
    ..We conclude that acetic acid induced mortality is the primary mechanism of chronological aging in yeast under standard conditions...
  34. ncbi request reprint Large-scale identification in yeast of conserved ageing genes
    Matt Kaeberlein
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 126:17-21. 2005
    ....
  35. pmc Proteasomal regulation of the hypoxic response modulates aging in C. elegans
    Ranjana Mehta
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Science 324:1196-8. 2009
    ..VHL-1 and HIF-1 control longevity by a mechanism distinct from both dietary restriction and insulin-like signaling. These findings define VHL-1 and the hypoxic response as an alternative longevity and protein homeostasis pathway...
  36. pmc Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    Katherine A Steinkraus
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Aging Cell 7:394-404. 2008
    ..These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1...
  37. ncbi request reprint The TOR pathway comes of age
    Monique N Stanfel
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Biochim Biophys Acta 1790:1067-74. 2009
    ..Longevity studies in mammals are not published to date. Instead, we highlight studies in mouse models, which indicate that dampening the TOR pathway leads to widespread protection from an array of age-related diseases...
  38. doi request reprint A genomic approach to yeast chronological aging
    Christopher R Burtner
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Methods Mol Biol 548:101-14. 2009
    ..This method has accuracy comparable to traditional assays, while allowing for higher throughput and decreased variability in measurement...
  39. ncbi request reprint Single-gene deletions that restore mating competence to diploid yeast
    Tom Schmidlin
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    FEMS Yeast Res 8:276-86. 2008
    ..In summary, this study underscores and elaborates upon predicted pathways by which mutations restore mating function to yeast diploids and identifies new mutants warranting further study...
  40. ncbi request reprint Genome-wide identification of conserved longevity genes in yeast and worms
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
    Mech Ageing Dev 128:106-11. 2007
    ..Here we compare and contrast the results from genome-wide aging screens and assess the likelihood that there are "public" aging mechanisms...
  41. ncbi request reprint Regulation of mRNA translation as a conserved mechanism of longevity control
    Ranjana Mehta
    Department of Pathology, University of Washington, Seattle, Washington, USA
    Adv Exp Med Biol 694:14-29. 2010
    ....
  42. pmc The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function
    Daniel Lockshon
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genetics 175:77-91. 2007
    ..We propose that yeast deficient in peroxisomal and other functions are sensitive to oleate perhaps because of an inability to effectively control the fatty acid composition of membrane phospholipids...
  43. ncbi request reprint Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
    ..We discuss how this metabolic strategy may apply to CR in animals...
  44. pmc Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity
    Christopher M Armstrong
    Department of Biology, Massachussetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 13:1427-38. 2002
    ..We also show that the histone deacetylase activity of Sir2p is necessary for the proper localiztion of the SIR complex to the telomeres...
  45. pmc High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction
    Matt Kaeberlein
    Longenity, Inc, Waltham, Massachusetts 02451, USA
    Mol Cell Biol 22:8056-66. 2002
    ..This metabolic shift likely increases NAD levels, thereby activating Sir2p and promoting longevity...
  46. ncbi request reprint Does resveratrol activate yeast Sir2 in vivo?
    Matt Kaeberlein
    Aging Cell 6:415-6. 2007
  47. pmc Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity
    Matt Kaeberlein
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genetics 160:83-95. 2002
    ..This work also provides evidence that post-transcriptional regulation is likely to be important both for maintaining cell integrity and for promoting longevity...
  48. doi request reprint Cell biology: A molecular age barrier
    Matt Kaeberlein
    Nature 454:709-10. 2008
  49. ncbi request reprint Rookie rising
    Ingfei Chen
    Sci Aging Knowledge Environ 2002:nf16. 2002
  50. ncbi request reprint The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America
    Rita B Effros
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1732, USA
    J Gerontol A Biol Sci Med Sci 63:331-7. 2008
    ..Novel animal models, including those showing no evidence of aging, as well as ethical and political implications of embryonic stem cells and alternative medicine are also discussed...
  51. ncbi request reprint AGEID: a database of aging genes and interventions
    Matt Kaeberlein
    Longenity Inc, Medford, MA 02153, USA
    Mech Ageing Dev 123:1115-9. 2002
    ..The use of this database by researchers who study aging should facilitate easy comparison of the genes and interventions that affect life span in different organisms...
  52. ncbi request reprint Medicine: grapes versus gluttony
    Matt Kaeberlein
    Nature 444:280-1. 2006

Research Grants4

  1. Mechanisms of Life Span Extension By Dietary Deprivation
    Matt Kaeberlein; Fiscal Year: 2009
    ..These studies will identify candidate therapeutic targets for several age-associated human diseases, including cancer, heart disease, diabetes, and Alzheimer's disease. ..
  2. Mechanisms of Life Span Extension By Dietary Deprivation
    Matt Kaeberlein; Fiscal Year: 2010
    ..These studies will identify candidate therapeutic targets for several age-associated human diseases, including cancer, heart disease, diabetes, and Alzheimer's disease. ..