Stephen Kadlecek

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Regional alveolar partial pressure of oxygen measurement with parallel accelerated hyperpolarized gas MRI
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, 308C Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104 Electronic address
    Acad Radiol 20:1224-33. 2013
  2. doi request reprint A simple and low-cost device for generating hyperpolarized contrast agents using parahydrogen
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    NMR Biomed 24:933-42. 2011
  3. doi request reprint Regional determination of oxygen uptake in rodent lungs using hyperpolarized gas and an analytical treatment of intrapulmonary gas redistribution
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    NMR Biomed 24:1253-63. 2011
  4. pmc Optimal transfer of spin-order between a singlet nuclear pair and a heteronucleus
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, B 1 Stellar Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    J Magn Reson 205:9-13. 2010
  5. pmc Simultaneous measurement of pulmonary partial pressure of oxygen and apparent diffusion coefficient by hyperpolarized 3He MRI
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 61:1015-21. 2009
  6. doi request reprint Measurement of pulmonary partial pressure of oxygen and oxygen depletion rate with hyperpolarized helium-3 MRI: a preliminary reproducibility study on pig model
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, MMRRCC, B1 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Acad Radiol 15:702-12. 2008
  7. ncbi request reprint Optimization of scan parameters in pulmonary partial pressure oxygen measurement by hyperpolarized 3He MRI
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 59:124-31. 2008
  8. pmc Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics
    Kiarash Emami
    Department of Radiology, University of Pennsylvania, PA, USA
    J Appl Physiol (1985) 110:225-35. 2011
  9. ncbi request reprint Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI
    Martin C Fischer
    Department of Radiology, University of Pennsylvania School of Medicine, B1, Stellar Chance Labs, Philadelphia, PA19104 6100, USA
    Acad Radiol 12:1430-9. 2005
  10. pmc Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs
    Maurizio Cereda
    Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:527-35. 2013

Research Grants

  1. Molecular imaging using hyperpolarized carbon-13
    Stephen Kadlecek; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. pmc Regional alveolar partial pressure of oxygen measurement with parallel accelerated hyperpolarized gas MRI
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, 308C Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA 19104 Electronic address
    Acad Radiol 20:1224-33. 2013
    ..We present a new Pao2 imaging scheme, using parallel accelerated MRI, which significantly reduces measurement error...
  2. doi request reprint A simple and low-cost device for generating hyperpolarized contrast agents using parahydrogen
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    NMR Biomed 24:933-42. 2011
    ..The resulting degree of hyperpolarization is shown to be substantial, ranging from a few to over 50%, depending on the choice of target molecule. Finally, the use of the hyperpolarized agent is demonstrated in a series of in vivo images...
  3. doi request reprint Regional determination of oxygen uptake in rodent lungs using hyperpolarized gas and an analytical treatment of intrapulmonary gas redistribution
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    NMR Biomed 24:1253-63. 2011
    ..Limitations of the technique with respect to spatial resolution and robustness are also discussed...
  4. pmc Optimal transfer of spin-order between a singlet nuclear pair and a heteronucleus
    Stephen Kadlecek
    Department of Radiology, University of Pennsylvania, B 1 Stellar Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104, USA
    J Magn Reson 205:9-13. 2010
    ....
  5. pmc Simultaneous measurement of pulmonary partial pressure of oxygen and apparent diffusion coefficient by hyperpolarized 3He MRI
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 61:1015-21. 2009
    ..A case study was performed on a COPD patient, which showed that in a region of interest ADC was 29% higher while oxygen depletion rate was 61% lower than the corresponding global average values...
  6. doi request reprint Measurement of pulmonary partial pressure of oxygen and oxygen depletion rate with hyperpolarized helium-3 MRI: a preliminary reproducibility study on pig model
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, MMRRCC, B1 Stellar Chance Building, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Acad Radiol 15:702-12. 2008
    ..This work presents a preliminary reproducibility study on a pig model. In this study, important scan parameters, such as measurement timing and flip angle, are optimized to minimize the noise-induced measurement uncertainty...
  7. ncbi request reprint Optimization of scan parameters in pulmonary partial pressure oxygen measurement by hyperpolarized 3He MRI
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 59:124-31. 2008
    ..2% for pO(2) and 12.0% for R, and that the average variation of percentiles (10th, 25th, 50th, 75th, and 90th) is 8.7% for pO(2) and 19.0% for R...
  8. pmc Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics
    Kiarash Emami
    Department of Radiology, University of Pennsylvania, PA, USA
    J Appl Physiol (1985) 110:225-35. 2011
    ..Correlation of imaging and PFT metrics revealed that r and ADC divide the rats into two separate clusters in the sample space...
  9. ncbi request reprint Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI
    Martin C Fischer
    Department of Radiology, University of Pennsylvania School of Medicine, B1, Stellar Chance Labs, Philadelphia, PA19104 6100, USA
    Acad Radiol 12:1430-9. 2005
    ..We point out limitations of the methods and suggest improvements to increase their accuracy...
  10. pmc Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs
    Maurizio Cereda
    Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, PA, USA
    Crit Care Med 41:527-35. 2013
    ..We tested the hypothesis that during mechanical ventilation, surfactant depletion increases the dimensions of aerated airspaces and that lung recruitment reverses these changes...
  11. pmc Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation
    Maurizio Cereda
    Department of Radiology, Univ of Pennsylvania, 1 Silverstein Bldg, 3400 Spruce St, Philadelphia, PA 19104, USA
    J Appl Physiol (1985) 110:499-511. 2011
    ....
  12. pmc A robust method for estimating regional pulmonary parameters in presence of noise
    Richard A Guyer
    Department of Radiology, University of Pennsylvania School of Medicine, 422 Curie Blvd, B1 Stellar Chance Labs, Philadelphia, PA 19104 6100, USA
    Acad Radiol 15:740-52. 2008
    ..The application to this technique is demonstrated in measurements of regional lung oxygen tension using hyperpolarized (3)He magnetic resonance imaging (MRI)...
  13. pmc Multislice fractional ventilation imaging in large animals with hyperpolarized gas MRI
    Kiarash Emami
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    NMR Biomed 25:1015-25. 2012
    ....
  14. pmc Quantitative assessment of lung ventilation and microstructure in an animal model of idiopathic pulmonary fibrosis using hyperpolarized gas MRI
    Michael J Stephen
    Department of Pulmonary and Critical Care, 834 W Gates Building, University of Pennsylvania, Philadelphia, PA 19104, USA
    Acad Radiol 17:1433-43. 2010
    ..In this study, the regional measurements of structure and function were applied to a bleomycin rat model of interstitial lung disease...
  15. ncbi request reprint Multiple regression method for pulmonary apparent diffusion coefficient measurement by hyperpolarized 3He MRI
    Jiangsheng Yu
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Magn Reson Imaging 25:982-91. 2007
    ..To develop and validate a new multiple regression technique for the separation of flip angle effect in pulmonary apparent diffusion coefficient (ADC) measurement...
  16. doi request reprint Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces
    Maurizio Cereda
    Assistant Professor, Department of Anesthesiology and Critical Care, Research Specialist, Project Manager, Student, Research Assistant Professor, Technical Director, Professor, Department of Radiology, Professor, Department of Anesthesiology and Critical Care and Stavropoulos Sepsis Research Program, University of Pennsylvania, Philadelphia, Pennsylvania Professor, Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 119:1402-9. 2013
    ..newly opening) peripheral airspaces contribute to increased lung volume is unknown...
  17. pmc Accelerated fractional ventilation imaging with hyperpolarized Gas MRI
    Kiarash Emami
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 70:1353-9. 2013
    ..Additionally, it may improve r estimation accuracy by reducing radiofrequency destruction of hyperpolarized gas...
  18. pmc Quantitative assessment of lung using hyperpolarized magnetic resonance imaging
    Kiarash Emami
    University of Pennsylvania, Department of Radiology, 1 Silverstein Bldg, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Proc Am Thorac Soc 6:431-8. 2009
    ..Finally, it discusses the challenges currently faced by researchers in this field to translate this rich body of methodology into wider-scale clinical applications...
  19. ncbi request reprint Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results
    Angela Haczku
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 6100, USA
    Acad Radiol 12:1362-70. 2005
    ..The objective of this study was to investigate regional ventilation changes in the mouse lung following allergen sensitization and challenge...
  20. pmc Improved technique for measurement of regional fractional ventilation by hyperpolarized 3He MRI
    Kiarash Emami
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6100, USA
    Magn Reson Med 63:137-50. 2010
    ..Finally, sensitivity of the new technique to model parameters, noise, and number of included images were assessed numerically. As a prelude to application in humans, the technique was implemented in a large animal study successfully...
  21. ncbi request reprint Early changes of lung function and structure in an elastase model of emphysema--a hyperpolarized 3He MRI study
    Kiarash Emami
    Dept of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd, Philadelphia, PA 19104 6100, USA
    J Appl Physiol (1985) 104:773-86. 2008
    ....
  22. doi request reprint An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology
    Robert H Brown
    Proc Am Thorac Soc 5:591-600. 2008
  23. ncbi request reprint Hyperpolarized helium-3 MR imaging of pulmonary function
    Masaru Ishii
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 4940 Eastern Avenue, A5W 595A, Baltimore, MD 21224, USA
    Radiol Clin North Am 43:235-46. 2005
    ..Recent advances in HP MR imaging contrast agents have led to novel tests of pulmonary function. Many of these tests show promise in the clinical arena...

Research Grants1

  1. Molecular imaging using hyperpolarized carbon-13
    Stephen Kadlecek; Fiscal Year: 2007
    ..This effort also lays the ground work for planned in vivo studies by measuring magnetic interactions with blood and tissue components. Key Words: Polarized Carbon-13 MRI; Metabolic imaging; Molecular imaging. ..