Pradeep Kachroo

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Acyl CoA Binding Proteins are Required for Cuticle Formation and Plant Responses to Microbes
    Ye Xia
    Department of Plant Pathology, University of Kentucky Lexington, KY, USA
    Front Plant Sci 3:224. 2012
  2. doi Systemic signaling during plant defense
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, United States
    Curr Opin Plant Biol 16:527-33. 2013
  3. doi Virus-induced gene silencing in soybean
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 894:287-97. 2012
  4. ncbi The Arabidopsis stearoyl-acyl carrier protein-desaturase family and the contribution of leaf isoforms to oleic acid synthesis
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Plant Mol Biol 63:257-71. 2007
  5. doi An oleic acid-mediated pathway induces constitutive defense signaling and enhanced resistance to multiple pathogens in soybean
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Mol Plant Microbe Interact 21:564-75. 2008
  6. ncbi Fatty Acid-derived signals in plant defense
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Annu Rev Phytopathol 47:153-76. 2009
  7. pmc Plastidial fatty acid levels regulate resistance gene-dependent defense signaling in Arabidopsis
    A C Chandra-Shekara
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 104:7277-82. 2007
  8. pmc Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase
    Rae Dong Jeong
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 107:13538-43. 2010
  9. pmc SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus
    Shifeng Zhu
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Pathog 7:e1002318. 2011
  10. pmc Glycerol-3-phosphate and systemic immunity
    Mihir K Mandal
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    Plant Signal Behav 6:1871-4. 2011

Collaborators

  • M B Shine
  • Ramesh Raina
  • Said A Ghabrial
  • J Shanklin
  • Jyoti Shah
  • Keiko Yoshioka
  • Aardra Kachroo
  • DuRoy Navarre
  • Keshun Yu
  • Rae Dong Jeong
  • A C Chandra-Shekara
  • Ye Xia
  • Bidisha Chanda
  • Srivathsa C Venugopal
  • Qing Ming Gao
  • Shifeng Zhu
  • Daniel F Klessig
  • Caixia Wang
  • Mihir Kumar Mandal
  • Ludmila Lapchyk
  • David Hildebrand
  • Mihir K Mandal
  • Ashis Nandi
  • Hong Gu Kang
  • Daniel Klessig
  • Devarshi Selote
  • Ken Taro Sekine
  • Lisa Vaillancourt
  • Subhankar Roy Barman
  • Hirotada Fukushige
  • Yumiko Shirano
  • Mohamed El-Shetehy
  • David Wendehenne
  • Andrew N Gifford
  • Joanna S Fowler
  • Juliana Moreira Soares
  • Guillaume P Robin
  • Gah Hyun Lim
  • Ella V Wilson
  • Arnold Stromberg
  • Yanling Hu
  • Kenneth Seebold
  • Matthew Hersh
  • Arnold J Stromberg
  • Saurabh Kulshrestha
  • Bruce Downie
  • Wendy Havens
  • Duroy A Navarre
  • Da Qi Fu
  • Joseph C Kuhl
  • Edward Whittle
  • Surabhi Raina
  • Manisha Gupte
  • Wolfgang Moeder
  • Deane Falcone
  • David F Hildebrand

Detail Information

Publications36

  1. pmc Acyl CoA Binding Proteins are Required for Cuticle Formation and Plant Responses to Microbes
    Ye Xia
    Department of Plant Pathology, University of Kentucky Lexington, KY, USA
    Front Plant Sci 3:224. 2012
    ..Together, these data show that ACBP3, ACBP4, and ACBP6 are required for cuticle development as well as defense against microbial pathogens...
  2. doi Systemic signaling during plant defense
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, United States
    Curr Opin Plant Biol 16:527-33. 2013
    ..This review summarizes recent findings related to SAR signal generation, movement, and perception. ..
  3. doi Virus-induced gene silencing in soybean
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 894:287-97. 2012
    ..Using this strategy, we have identified genes participating in basal, resistance gene-mediated, and systemic immunity in soybean...
  4. ncbi The Arabidopsis stearoyl-acyl carrier protein-desaturase family and the contribution of leaf isoforms to oleic acid synthesis
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Plant Mol Biol 63:257-71. 2007
    ..Enzyme activities of the desaturase isoforms in a 5-fold excess of 18:1-ACP show product inhibition of up to 73%. Together these data indicate that 18:1 levels are regulated at both transcriptional and post-translational levels...
  5. doi An oleic acid-mediated pathway induces constitutive defense signaling and enhanced resistance to multiple pathogens in soybean
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Mol Plant Microbe Interact 21:564-75. 2008
    ..We also demonstrate the efficacy of BPMV-induced gene silencing as a tool for functional studies in soybean...
  6. ncbi Fatty Acid-derived signals in plant defense
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Annu Rev Phytopathol 47:153-76. 2009
    ..This review summarizes the current knowledge of the involvement of FAs, FA-derived oxylipins, and enzymes catalyzing FA metabolism in plant defense...
  7. pmc Plastidial fatty acid levels regulate resistance gene-dependent defense signaling in Arabidopsis
    A C Chandra-Shekara
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 104:7277-82. 2007
    ..These results suggest that the 18:1-regulated pathway may be specifically targeted during pathogen infection and that altering 18:1 levels may serve as a unique strategy for promoting disease resistance...
  8. pmc Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase
    Rae Dong Jeong
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 107:13538-43. 2010
    ..We propose that CRY2/PHOT2 negatively regulate the proteasome-mediated degradation of HRT, likely via COP1, and blue-light relieves this repression resulting in HRT degradation...
  9. pmc SAG101 forms a ternary complex with EDS1 and PAD4 and is required for resistance signaling against turnip crinkle virus
    Shifeng Zhu
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS Pathog 7:e1002318. 2011
    ..Together, these results suggest that EDS1, PAD4 and SAG101 also perform independent functions in HRT-mediated resistance...
  10. pmc Glycerol-3-phosphate and systemic immunity
    Mihir K Mandal
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    Plant Signal Behav 6:1871-4. 2011
    ..Conversely, G3P is required for the translocation of DIR1 to distal tissues. Together, these observations suggest that the cooperative interaction of DIR1 and G3P mediates the induction of SAR in plants...
  11. ncbi Light-dependent hypersensitive response and resistance signaling against Turnip Crinkle Virus in Arabidopsis
    A C Chandra-Shekara
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Plant J 45:320-34. 2006
    ..Light was also required for N gene-mediated HR and resistance to Tobacco Mosaic Virus, suggesting that it is an important factor which may be generally required during defense signaling...
  12. pmc Plastidial fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Cell 15:2952-65. 2003
    ....
  13. pmc Oleic acid-dependent modulation of NITRIC OXIDE ASSOCIATED1 protein levels regulates nitric oxide-mediated defense signaling in Arabidopsis
    Mihir Kumar Mandal
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Cell 24:1654-74. 2012
    ..Together, these data suggest that 18:1 levels regulate NO synthesis, and, thereby, NO-mediated signaling, by regulating NOA1 levels...
  14. ncbi Double-stranded RNA-binding protein 4 is required for resistance signaling against viral and bacterial pathogens
    Shifeng Zhu
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Cell Rep 4:1168-84. 2013
    ..The requirement of DRB4 in resistance to bacterial infection suggests a universal role in R-mediated defense signaling. ..
  15. pmc Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling
    Srivathsa C Venugopal
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    PLoS Genet 5:e1000545. 2009
    ..The functional redundancy with SA was specific to EDS1. Results presented here redefine our understanding of the roles of EDS1 and SA in plant defense...
  16. pmc Role of salicylic acid and fatty acid desaturation pathways in ssi2-mediated signaling
    Pradeep Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Physiol 139:1717-35. 2005
    ....
  17. ncbi Signaling requirements and role of salicylic acid in HRT- and rrt-mediated resistance to turnip crinkle virus in Arabidopsis
    A C Chandra-Shekara
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Plant J 40:647-59. 2004
    ..These data suggest that the HRT-TCV interaction is unable to generate sufficient amounts of SA required for a stable resistance phenotype, and the presence of rrt possibly corrects this deficiency...
  18. doi An intact cuticle in distal tissues is essential for the induction of systemic acquired resistance in plants
    Ye Xia
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Cell Host Microbe 5:151-65. 2009
    ..This cuticular requirement was relevant only during mobile signal generation and its translocation to distal tissues. Collectively, these data suggest an active role for the plant cuticle in SAR-related molecular signaling...
  19. doi A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity
    Keshun Yu
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Cell Rep 3:1266-78. 2013
    ..Conversely, reduced G3P resulted in decreased AZI1 and DIR1 transcription. Our results demonstrate that an intricate feedback regulatory loop among G3P, DIR1, and AZI1 regulates SAR and that AA functions upstream of G3P in this pathway...
  20. doi HRT-mediated hypersensitive response and resistance to Turnip crinkle virus in Arabidopsis does not require the function of TIP, the presumed guardee protein
    Rae Dong Jeong
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40514, USA
    Mol Plant Microbe Interact 21:1316-24. 2008
    ..Strikingly, the mutation in TIP resulted in increased replication of TCV and Cucumber mosaic virus, suggesting that TIP may play a role in basal resistance but is not required for HRT-mediated signaling...
  21. pmc The glabra1 mutation affects cuticle formation and plant responses to microbes
    Ye Xia
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Physiol 154:833-46. 2010
    ..Our findings question the prudence of using mutant backgrounds for genetic screens and underscore a need to reevaluate phenotypes previously studied in the gl1 background...
  22. pmc Glycerol-3-phosphate levels are associated with basal resistance to the hemibiotrophic fungus Colletotrichum higginsianum in Arabidopsis
    Bidisha Chanda
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky 40546, USA
    Plant Physiol 147:2017-29. 2008
    ..These data suggest that G3P-associated resistance to C. higginsianum occurs independently or downstream of the camalexin pathway. Together, these results suggest a novel and specific link between G3P metabolism and plant defense...
  23. doi Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants
    Bidisha Chanda
    Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, USA
    Nat Genet 43:421-7. 2011
    ..These observations, along with the fact that dir1 plants accumulate reduced levels of G3P in their petiole exudates, suggest that the cooperative interaction of DIR1 and G3P orchestrates the induction of SAR in plants...
  24. ncbi Restoration of defective cross talk in ssi2 mutants: role of salicylic acid, jasmonic acid, and fatty acids in SSI2-mediated signaling
    Pradeep Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington 40546, USA
    Mol Plant Microbe Interact 16:1022-9. 2003
    ..Together, these results show that defective cross talk in ssi2 can be restored by second site mutations and is independent of morphological size of the plants, cell death, and elevated levels of 18:0...
  25. pmc Blue light photoreceptors are required for the stability and function of a resistance protein mediating viral defense in Arabidopsis
    Rae Dong Jeong
    Department of Plant Pathology, University of Kentucky, Lexington, KY, USA
    Plant Signal Behav 5:1504-9. 2010
    ..These and the fact that PHOT2 interacts directly with the R protein RPS2 suggest that blue-light photoreceptors might be involved in regulation and/or signaling mediated by several R proteins...
  26. ncbi Salicylic acid-, jasmonic acid- and ethylene-mediated regulation of plant defense signaling
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Genet Eng (N Y) 28:55-83. 2007
  27. ncbi Plant signal transduction and defense against viral pathogens
    Pradeep Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, 40546, USA
    Adv Virus Res 66:161-91. 2006
    ..This review aims to document the advances that have improved our understanding of plant resistance to viruses...
  28. ncbi Free radicals mediate systemic acquired resistance
    Caixia Wang
    College of Agronomy and Plant Protection, Qingdao Agricultural University, Qingdao 266109, P R China Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Cell Rep 7:348-55. 2014
    ..We propose that the parallel operation of NO/ROS and SA pathways facilitates coordinated regulation in order to ensure optimal induction of SAR...
  29. pmc The common metabolite glycerol-3-phosphate is a novel regulator of plant defense signaling
    Srivathsa C Venugopal
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Plant Signal Behav 4:746-9. 2009
    ..higginsianum...
  30. pmc Oleic acid levels regulated by glycerolipid metabolism modulate defense gene expression in Arabidopsis
    Aardra Kachroo
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    Proc Natl Acad Sci U S A 101:5152-7. 2004
    ..Our results show that 18:1 levels in plastids are regulated by means of acylation with G3P, and a balance between G3P and 18:1 is critical for the regulation of salicylic acid- and jasmonic acid-mediated signaling pathways...
  31. ncbi Chemical inducers of systemic immunity in plants
    Qing Ming Gao
    Department of Plant Pathology, University of Kentucky, Lexington, KY 40546, USA
    J Exp Bot 65:1849-55. 2014
    ..This review mainly discusses organized signalling by two such chemicals, glycerol-3-phoshphate and azelaic acid, and the role of basal salicylic acid levels in G3P-conferred SAR...
  32. doi CRT1, an Arabidopsis ATPase that interacts with diverse resistance proteins and modulates disease resistance to turnip crinkle virus
    Hong Gu Kang
    Boyce Thompson Institute for Plant Research, Ithaca, NY 14853, USA
    Cell Host Microbe 3:48-57. 2008
    ..Furthermore, CRT1 interacts with HRT, SSI4, and two other R proteins, RPS2 and Rx. These data identify CRT1 as an important mediator of defense signaling triggered by distinct classes of R proteins...
  33. pmc The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses
    Keiko Yoshioka
    Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA
    Plant Cell 18:747-63. 2006
    ..Moreover, the requirement for both NDR1-dependent and EDS1/PAD4-dependent pathways for cpr22-mediated resistance suggests that these pathways are cross-regulated...
  34. ncbi Arabidopsis ssi2-conferred susceptibility to Botrytis cinerea is dependent on EDS5 and PAD4
    Ashis Nandi
    Division of Biology, Cellular and Developmental Biology Program, Kansas State University, Manhattan 66506, USA
    Mol Plant Microbe Interact 18:363-70. 2005
    ..cinerea. Our results suggest that interaction between an SSI2-dependent factor or factors and an EDS5- and PAD4-dependent mechanism or mechanisms modulates defense to B. cinerea...
  35. ncbi Ethylene and jasmonic acid signaling affect the NPR1-independent expression of defense genes without impacting resistance to Pseudomonas syringae and Peronospora parasitica in the Arabidopsis ssi1 mutant
    Ashis Nandi
    Division of Biology, Kansas State University, Manhattan 66506, USA
    Mol Plant Microbe Interact 16:588-99. 2003
    ..Taken together, our results indicate that although cross talk in ssi1 renders expression of ethylene- or JA-responsive defense genes sensitive to SA and vice versa, it does not affect downstream signaling leading to resistance...
  36. pmc A gain-of-function mutation in an Arabidopsis Toll Interleukin1 receptor-nucleotide binding site-leucine-rich repeat type R gene triggers defense responses and results in enhanced disease resistance
    Yumiko Shirano
    Boyce Thompson Institute for Plant Research, Ithaca, New York 14853, USA
    Plant Cell 14:3149-62. 2002
    ....