Research Topics
| H JyonouchiSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Evidence of dysregulated cytokine production by sinus lavage and peripheral blood mononuclear cells in patients with treatment-resistant chronic rhinosinusitisH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, MMC 610 FUMC, 420 Delaware St SE, Minneapolis, MN 55455, USA
Arch Otolaryngol Head Neck Surg 127:1488-94. 2001..Treatment-resistant chronic rhinosinusitis (CRS) imposes a clinical challenge. Its pathogenesis may be associated with dysregulated immune/inflammatory responses in the sinus...- Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regressionH Jyonouchi
Department of Pediatrics, University of Minnesota, MMC 610 FUMC, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Neuroimmunol 120:170-9. 2001..9% to 60% of ASD patients produced >2 SD above the CM values of TNF-alpha depending on stimulants. Our results indicate excessive innate immune responses in a number of ASD children that may be most evident in TNF-alpha production... - Polycyclic aromatic hydrocarbon diol epoxides increase cytosolic Ca(2+) of airway epithelial cellsH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
Am J Respir Cell Mol Biol 25:78-83. 2001..Short-term exposure to BPDE 36 to 48 h before the study rendered SAE cells less sensitive to BPDE, suggesting that BPDE may also induce persistent changes in Ca(2+) signaling pathways... - Dietary ribonucleotides modulate type 1 and type 2 T-helper cell responses against ovalbumin in young BALB/cJ miceH Jyonouchi
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
J Nutr 131:1165-70. 2001..Our findings thus indicate that in Th2-prone BALB/c J mice, dietary ribonucleotides modulated skewed Th2 responses against OVA toward Th1 as measured by production of IFN-gamma, a Th1 cytokine, and changes in anti-OVA Ab isotype levels... - Dietary nucleotides modulate antigen-specific type 1 and type 2 t-cell responses in young c57bl/6 miceH Jyonouchi
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Nutrition 16:442-6. 2000.... - Interferon gamma levels in the sinus, ear, and airway in a rabbit sinusitis model induced by Bacteroides inoculationH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis 55455, USA
Arch Otolaryngol Head Neck Surg 126:529-32. 2000..However, we observed an increase in anti-Bacteroides IgG antibodies in the contralateral sinus, lower airway, and middle ear, with an apparent increase in interferon gamma (IFN-gamma) messenger RNA expression in the ear and sinus mucosa... - Cytokine production by sinus lavage, bronchial lavage, and blood mononuclear cells in chronic rhinosinusitis with or without atopyH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis 55455, USA
Arch Otolaryngol Head Neck Surg 126:522-8. 2000..Chronic sinus inflammation may be determined partly by a balance of proinflammatory and counterregulatory cytokines and other mediators in the sinus. However, their mechanistic roles in chronic rhinosinusitis (CRS) are not well understood... - IgG antibody levels in the sinus, ear, and airway in a rabbit model of sinusitis with BacteroidesH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis 55455, USA
Arch Otolaryngol Head Neck Surg 124:767-72. 1998..To evaluate distribution of IgG antibodies (Ab) in the airway, ear, and sinuses in association with inflammatory changes in a rabbit sinusitis model... - Cell density and antioxidant vitamins determine the effects of hyperoxia on proliferation and death of MDCK epithelial cellsH Jyonouchi
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Nutr Cancer 28:115-24. 1997..These results indicate that cell density is a major determinant of the effects of hyperoxic injury and the profile of antioxidant vitamin protection... - Effects of various carotenoids on cloned, effector-stage T-helper cell activityH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis 55455, USA
Nutr Cancer 26:313-24. 1996..Carotenoid actions on Th cells may vary in each carotenoid and do not seem to be closely associated with carotenoid antioxidant activity or relative polarity... - Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositolH Jyonouchi
Department of Pediatrics, University of Minnesota, School of Medicine, UMHC, Minneapolis 55455, USA
Carcinogenesis 20:139-45. 1999.... - The effects of hyperoxic injury and antioxidant vitamins on death and proliferation of human small airway epithelial cellsH Jyonouchi
Departments of Pediatrics and Internal Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Am J Respir Cell Mol Biol 19:426-36. 1998..Although A549 cells underwent cell death mainly by necrosis, they also were influenced by cell density and hyperoxia. Cell density also determined specific antioxidant vitamin protection in SAE cells... - Antitumor activity of astaxanthin and its mode of actionH Jyonouchi
Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis 55455, USA
Nutr Cancer 36:59-65. 2000..Our results indicate that dietary astaxanthin suppressed Meth-A tumor cell growth and stimulated immunity against Meth-A tumor antigen...