MARIANNA JUNG

Summary

Affiliation: University of North Texas
Country: USA

Publications

  1. ncbi request reprint Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal
    M E Jung
    Department of Pharmacology and Substance Abuse Institute of North Texas, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
    J Pharmacol Exp Ther 291:576-82. 1999
  2. doi request reprint Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase
    Marianna E Jung
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s disease, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurobiol Aging 32:2266-78. 2011
  3. pmc Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Pharmacol Exp Ther 328:692-8. 2009
  4. doi request reprint Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner
    Marianna E Jung
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Bioenerg Biomembr 40:35-44. 2008
  5. pmc Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 416:160-4. 2007
  6. ncbi request reprint A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 319:543-50. 2006
  7. ncbi request reprint Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 95:745-55. 2005
  8. ncbi request reprint Estradiol protects against alteration of protein kinase C(epsilon) in a binge model of ethanol dependence and withdrawal
    Marianna Eunsun Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Eur J Pharmacol 515:62-72. 2005
  9. ncbi request reprint Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanisms
    M E Jung
    Department of Pharmacology and Neuroscience, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 230:8-22. 2005
  10. ncbi request reprint The discriminative stimulus effects of pentylenetetrazol as a model of anxiety: recent developments
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Neurosci Biobehav Rev 26:429-39. 2002

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Sex differences in the pentylenetetrazol-like stimulus induced by ethanol withdrawal
    M E Jung
    Department of Pharmacology and Substance Abuse Institute of North Texas, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA
    J Pharmacol Exp Ther 291:576-82. 1999
    ....
  2. doi request reprint Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase
    Marianna E Jung
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s disease, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurobiol Aging 32:2266-78. 2011
    ..E2 treatment mitigated each of the EW effects to a different extent. Collectively, pP38 may mediate the brain-aging changes associated with pro-oxidant EW at vulnerable ages and in vulnerable neurons in a manner protected by estrogen...
  3. pmc Ethanol withdrawal provokes opening of the mitochondrial membrane permeability transition pore in an estrogen-preventable manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Pharmacol Exp Ther 328:692-8. 2009
    ..These findings suggest that EW provokes PTP opening partly but not entirely through the pro-oxidant nature and that E2 counteracts EW-associated factors to protect against the PTP opening...
  4. doi request reprint Ethanol withdrawal provokes mitochondrial injury in an estrogen preventable manner
    Marianna E Jung
    Department of Pharmacology, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Bioenerg Biomembr 40:35-44. 2008
    ..These findings demonstrate that EW provokes oxidative injury to mitochondrial membranes in a manner that is exacerbated by estrogen deprivation...
  5. pmc Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 416:160-4. 2007
    ..Neither EW nor E2 altered the protein levels of the subunits. These findings suggest that a counteracting relationship exists between the effects of EW and E2 on the activity of COX in a subunit specific manner...
  6. ncbi request reprint A nonfeminizing estrogen analog protects against ethanol withdrawal toxicity in immortalized hippocampal cells
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    J Pharmacol Exp Ther 319:543-50. 2006
    ..Therefore, ZYC26 can be a potential alternative estrogen therapy for a cellular and oxidative imbalance associated with ethanol withdrawal...
  7. ncbi request reprint Suppression of protein kinase Cepsilon mediates 17beta-estradiol-induced neuroprotection in an immortalized hippocampal cell line
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Neurochem 95:745-55. 2005
    ..These data suggest that the neuroprotective effects of estrogens are mediated in part by inhibition of PKCepsilon activity and membrane translocation...
  8. ncbi request reprint Estradiol protects against alteration of protein kinase C(epsilon) in a binge model of ethanol dependence and withdrawal
    Marianna Eunsun Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Eur J Pharmacol 515:62-72. 2005
    ..PKC(epsilon) appears more vulnerable during ethanol withdrawal than during ethanol exposure...
  9. ncbi request reprint Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanisms
    M E Jung
    Department of Pharmacology and Neuroscience, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA
    Exp Biol Med (Maywood) 230:8-22. 2005
    ..These studies serve as a guide for continuing research into the mechanisms of the neuroprotective effects of estrogen during EW and for the development of potential estrogen-based treatments for male and female alcoholics...
  10. ncbi request reprint The discriminative stimulus effects of pentylenetetrazol as a model of anxiety: recent developments
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Neurosci Biobehav Rev 26:429-39. 2002
    ..Further work with the PTZ drug discrimination is warranted for characterization of anxiety during withdrawal, and the hormonal mechanisms of anxiety...
  11. ncbi request reprint Estrogen protects against brain lipid peroxidation in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Pharmacol Biochem Behav 79:573-86. 2004
    ..These data suggest that EW rather than ethanol enhances brain lipid peroxidation that is transient and brain-region specific. Estrogens protect against the brain lipid peroxidation in a manner independent of blood ethanol concentrations...
  12. ncbi request reprint Sex differences in the discriminative stimulus effects of m-chlorophenylpiperazine and ethanol withdrawal
    M E Jung
    Department of Pharmacology and Substance Abuse Institute of North Texas, University of North Texas Health Science Center at Fort Worth, 76107 2699, USA
    Psychopharmacology (Berl) 149:170-5. 2000
    ..The serotonergic system plays a role in regulation of anxiety and ethanol withdrawal (EW). Nevertheless, few studies have assessed sex differences in serotonergic effects on EW...
  13. ncbi request reprint Sex differences in nicotine substitution to a pentylenetetrazol discriminative stimulus during ethanol withdrawal in rats
    M E Jung
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Psychopharmacology (Berl) 149:235-40. 2000
    ..Nicotine and ethanol are frequently co-abused in men and women, but few studies compare common stimulus effects produced by these substances between males and females...
  14. ncbi request reprint Role of protein kinase C in estrogen protection against apoptotic cerebellar cell death in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:39-48. 2003
    ....
  15. ncbi request reprint Estradiol protects against cerebellar damage and motor deficit in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Alcohol 26:83-93. 2002
    ..These findings support the suggestion that E(2) exerts protective effects against withdrawal signs, cerebellar neuronal damage, and motoric impairment in subjects exposed to, and withdrawn from, chronic ethanol exposure...
  16. pmc Intermittent hypoxia conditioning prevents behavioral deficit and brain oxidative stress in ethanol-withdrawn rats
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    J Appl Physiol (1985) 105:510-7. 2008
    ..We conclude that IH conditioning during chronic ethanol consumption attenuates oxidative damage to the brain and mitigates behavioral abnormalities during subsequent EW. IH-induced ROS may evoke this powerful protection...
  17. pmc The role of p38 in mitochondrial respiration in male and female mice
    Xiaohua Ju
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 544:152-6. 2013
    ..These data suggest that p38 is required for the mitochondrial respiration of male mice. When p38 is below a normal level, females may maintain mitochondrial respiration through COX up-regulation...
  18. ncbi request reprint Effects of GABA(A) compounds on mCPP drug discrimination in rats
    Michael B Gatch
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth 76107 2699, USA
    Life Sci 71:2657-65. 2002
    ..These findings provide evidence that GABA(A) antagonists modulate the discriminative stimulus effects of mCPP, but that these effects are not mediated by activity at the benzodiazepine site...
  19. ncbi request reprint Role of parvalbumin in estrogen protection from ethanol withdrawal syndrome
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas 76107 2699, USA
    Alcohol Clin Exp Res 29:1837-44. 2005
    ..This study examined whether ethanol exposure and/or ethanol withdrawal (EW) alter the levels of PA in a manner that is protected by 17beta-estradiol (E2)...
  20. ncbi request reprint Role of the GABAA system in behavioral, motoric, and cerebellar protection by estrogen during ethanol withdrawal
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas HSC at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol 31:49-61. 2003
    ..Also, results of the current study provide indirect evidence that the GABAergic system is involved in protective effects of E(2) against the EW syndrome...
  21. pmc Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress
    Katalin Prokai-Tatrai
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA
    Int J Mol Sci 10:1773-87. 2009
    ....
  22. ncbi request reprint Ethanol withdrawal reduces cerebellar parvalbumin expression in a manner reversed by estrogens
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Neurosci Lett 377:44-8. 2005
    ..These data suggest that E2 treatment protects against the PA-suppression associated with EW toxicity...
  23. ncbi request reprint Role of the GABA-A system in estrogen-induced protection against brain lipid peroxidation in ethanol-withdrawn rats
    Mridula Rewal
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107 2699, USA
    Alcohol Clin Exp Res 28:1907-15. 2004
    ..In this study, we examined the effect of the GABA-A antagonist bicuculline on the neuroprotective effect of E2 by assessing the oxidative marker thiobarbituric acid reactive substances (TBARS) during ethanol withdrawal (EW)...
  24. doi request reprint Alcohol withdrawal and brain injuries: beyond classical mechanisms
    Marianna E Jung
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107 2699, USA
    Molecules 15:4984-5011. 2010
    ..The current review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which EW provokes brain injuries and E2 protects against it...

Research Grants5

  1. Effects of Age on Ethanol Withdrawal Toxicity: Mechanisms and Therapy
    MARIANNA JUNG; Fiscal Year: 2009
    ..These studies may ultimately contribute to a better understanding of and strategy for female alcoholics undergoing EW during brain aging. ..
  2. Effects of Age on Ethanol Withdrawal Toxicity: Mechanisms and Therapy
    MARIANNA JUNG; Fiscal Year: 2009
    ..These studies may ultimately contribute to a better understanding of and strategy for female alcoholics undergoing EW during brain aging. ..