M E Jung

Summary

Affiliation: University of California
Country: USA

Publications

  1. request reprint
    Jung M, Johnson T. First total synthesis of xestobergsterol A and active structural analogues of the xestobergsterols. Org Lett. 1999;1:1671-4 pubmed
    ..The key steps of the synthesis are the Breslow remote functionalization of the polyoxygenated steroid derived from 25 and the base-catalyzed epimerization-aldol condensation of the dione derived from 27. ..
  2. Lee J, Shi Y, Vega M, Yang Y, Gera J, Jung M, et al. Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction. Bioorg Med Chem Lett. 2017;27:4714-4724 pubmed publisher
    ..Due to their targeting of DEPTOR, these compounds activate mTORC1 and selectively induce MM cell apoptosis and cell cycle arrest. ..

Collaborators

Detail Information

Publications2

  1. request reprint
    Jung M, Johnson T. First total synthesis of xestobergsterol A and active structural analogues of the xestobergsterols. Org Lett. 1999;1:1671-4 pubmed
    ..The key steps of the synthesis are the Breslow remote functionalization of the polyoxygenated steroid derived from 25 and the base-catalyzed epimerization-aldol condensation of the dione derived from 27. ..
  2. Lee J, Shi Y, Vega M, Yang Y, Gera J, Jung M, et al. Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction. Bioorg Med Chem Lett. 2017;27:4714-4724 pubmed publisher
    ..Due to their targeting of DEPTOR, these compounds activate mTORC1 and selectively induce MM cell apoptosis and cell cycle arrest. ..