M E Jung
Affiliation: University of California
- Jung M, Johnson T. First total synthesis of xestobergsterol A and active structural analogues of the xestobergsterols. Org Lett. 1999;1:1671-4 pubmed..The key steps of the synthesis are the Breslow remote functionalization of the polyoxygenated steroid derived from 25 and the base-catalyzed epimerization-aldol condensation of the dione derived from 27. ..
- Lee J, Shi Y, Vega M, Yang Y, Gera J, Jung M, et al. Structure-activity relationship study of small molecule inhibitors of the DEPTOR-mTOR interaction. Bioorg Med Chem Lett. 2017;27:4714-4724 pubmed publisher..Due to their targeting of DEPTOR, these compounds activate mTORC1 and selectively induce MM cell apoptosis and cell cycle arrest. ..