D Julius

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms of nociception
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 413:203-10. 2001
  2. pmc Serotonin receptor knockouts: a moody subject
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 0450, USA
    Proc Natl Acad Sci U S A 95:15153-4. 1998
  3. ncbi request reprint The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998
  4. ncbi request reprint Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse
    W A Eckert
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA
    Pain 126:184-97. 2006
  5. ncbi request reprint The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  6. ncbi request reprint Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    H H Chuang
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 411:957-62. 2001
  7. ncbi request reprint Sense and specificity: a molecular identity for nociceptors
    M J Caterina
    Department of Cellular and Molecular Pharmacology University of California San Francisco, 94143 0450, USA
    Curr Opin Neurobiol 9:525-30. 1999
  8. ncbi request reprint Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  9. ncbi request reprint A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
  10. ncbi request reprint Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    L H Tecott
    Department of Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 374:542-6. 1995

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Molecular mechanisms of nociception
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 413:203-10. 2001
    ....
  2. pmc Serotonin receptor knockouts: a moody subject
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143 0450, USA
    Proc Natl Acad Sci U S A 95:15153-4. 1998
  3. ncbi request reprint The cloned capsaicin receptor integrates multiple pain-producing stimuli
    M Tominaga
    Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    Neuron 21:531-43. 1998
    ..A role for VR1 in injury-induced hypersensitivity at the level of the sensory neuron is presented...
  4. ncbi request reprint Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse
    W A Eckert
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA
    Pain 126:184-97. 2006
    ..Finally, our results suggest that the processing of noxious thermal messages by neurons in lamina I involves convergent inputs from a heterogeneous population of primary afferent thermal nociceptors...
  5. ncbi request reprint The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  6. ncbi request reprint Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    H H Chuang
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 411:957-62. 2001
    ..These studies delineate a biochemical mechanism through which bradykinin and NGF produce hypersensitivity and might explain how the activation of PLC signalling systems regulates other members of the TRP channel family...
  7. ncbi request reprint Sense and specificity: a molecular identity for nociceptors
    M J Caterina
    Department of Cellular and Molecular Pharmacology University of California San Francisco, 94143 0450, USA
    Curr Opin Neurobiol 9:525-30. 1999
    ..Pharmacological, electrophysiological and genetic studies are beginning to reveal how these signaling molecules specify roles for subsets of sensory neurons in the pain pathway...
  8. ncbi request reprint Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  9. ncbi request reprint A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
    ..We propose that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities...
  10. ncbi request reprint Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors
    L H Tecott
    Department of Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 374:542-6. 1995
    ..Mutant animals are also prone to spontaneous death from seizures, suggesting that 5-HT2C receptors mediate tonic inhibition of neuronal network excitability...
  11. pmc ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor
    N McNamara
    Departments of Anatomy and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0452, USA
    Proc Natl Acad Sci U S A 98:9086-91. 2001
    ..These results indicate that bacterial interaction with host cells can trigger autocrine nucleotide signaling and suggest that agents affecting nucleotide receptors may modulate host responses to bacteria...
  12. ncbi request reprint Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel
    A V Maricq
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Science 254:432-7. 1991
    ..Messenger RNA encoding this receptor is found in the brain, spinal cord, and heart. This receptor defines a new class of excitatory ligand-gated channels...
  13. ncbi request reprint Molecular characterization of a functional cDNA encoding the serotonin 1c receptor
    D Julius
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 241:558-64. 1988
    ....
  14. ncbi request reprint The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14
    C L Hsieh
    Howard Hughes Medical Institute, Stanford University Medical Center, California 94305
    Somat Cell Mol Genet 16:567-74. 1990
    ..Having mapped Htr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster...
  15. pmc The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors
    D Julius
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Proc Natl Acad Sci U S A 87:928-32. 1990
    ..However, RNA blotting shows that these two receptor subtypes are differentially expressed in the central nervous system. In this manner, structurally and functionally homologous receptor subtypes may elicit distinct physiologic actions...
  16. ncbi request reprint Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4)
    A Milatovich
    Department of Genetics, Stanford University Medical Center, CA 94305
    Hum Mol Genet 1:681-4. 1992
    ....