Research Topics
| D JuliusSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Serotonin receptor knockouts: a moody subjectD Julius
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA
Proc Natl Acad Sci U S A 95:15153-4. 1998
Molecular mechanisms of nociceptionD Julius
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
Nature 413:203-10. 2001....- The cloned capsaicin receptor integrates multiple pain-producing stimuliM Tominaga
Department of Cellular and Molecular Pharmacology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
Neuron 21:531-43. 1998..A role for VR1 in injury-induced hypersensitivity at the level of the sensory neuron is presented... - Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouseW A Eckert
Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94143, USA
Pain 126:184-97. 2006..Finally, our results suggest that the processing of noxious thermal messages by neurons in lamina I involves convergent inputs from a heterogeneous population of primary afferent thermal nociceptors... - The capsaicin receptor: a heat-activated ion channel in the pain pathwayM J Caterina
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
Nature 389:816-24. 1997..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo... - Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibitionH H Chuang
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
Nature 411:957-62. 2001..These studies delineate a biochemical mechanism through which bradykinin and NGF produce hypersensitivity and might explain how the activation of PLC signalling systems regulates other members of the TRP channel family... - Sense and specificity: a molecular identity for nociceptorsM J Caterina
Department of Cellular and Molecular Pharmacology University of California San Francisco, 94143 0450, USA
Curr Opin Neurobiol 9:525-30. 1999..Pharmacological, electrophysiological and genetic studies are beginning to reveal how these signaling molecules specify roles for subsets of sensory neurons in the pain pathway... - Impaired nociception and pain sensation in mice lacking the capsaicin receptorM J Caterina
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
Science 288:306-13. 2000..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia... - A capsaicin-receptor homologue with a high threshold for noxious heatM J Caterina
Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
Nature 398:436-41. 1999..We propose that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities... - Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptorsL H Tecott
Department of Pharmacology, University of California, San Francisco 94143 0450, USA
Nature 374:542-6. 1995..Mutant animals are also prone to spontaneous death from seizures, suggesting that 5-HT2C receptors mediate tonic inhibition of neuronal network excitability... - ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptorN McNamara
Departments of Anatomy and Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0452, USA
Proc Natl Acad Sci U S A 98:9086-91. 2001..These results indicate that bacterial interaction with host cells can trigger autocrine nucleotide signaling and suggest that agents affecting nucleotide receptors may modulate host responses to bacteria... - Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channelA V Maricq
Department of Pharmacology, University of California, San Francisco 94143 0450
Science 254:432-7. 1991..Messenger RNA encoding this receptor is found in the brain, spinal cord, and heart. This receptor defines a new class of excitatory ligand-gated channels... - Molecular characterization of a functional cDNA encoding the serotonin 1c receptorD Julius
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Science 241:558-64. 1988.... - The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14C L Hsieh
Howard Hughes Medical Institute, Stanford University Medical Center, California 94305
Somat Cell Mol Genet 16:567-74. 1990..Having mapped Htr-2 to mouse chromosome 14, we predict that it falls into this known conserved gene cluster... - The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptorsD Julius
Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032
Proc Natl Acad Sci U S A 87:928-32. 1990..However, RNA blotting shows that these two receptor subtypes are differentially expressed in the central nervous system. In this manner, structurally and functionally homologous receptor subtypes may elicit distinct physiologic actions... - Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4)A Milatovich
Department of Genetics, Stanford University Medical Center, CA 94305
Hum Mol Genet 1:681-4. 1992....