R Juliano

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides
    Xin Ming
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 41:3673-87. 2013
  2. pmc Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
    Md Rowshon Alam
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill NC 27599, USA
    Nucleic Acids Res 36:2764-76. 2008
  3. pmc Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
    Xin Ming
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:6567-76. 2010
  4. pmc Integrin targeted delivery of gene therapeutics
    Rudy L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Theranostics 1:211-9. 2011
  5. pmc Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides
    R L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    J Drug Target 21:27-43. 2013
  6. pmc The chemistry and biology of oligonucleotide conjugates
    R L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, 27599, United States
    Acc Chem Res 45:1067-76. 2012
  7. pmc Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides
    Rudolph L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Bioconjug Chem 23:147-57. 2012
  8. pmc The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives
    Rudy L Juliano
    University of North Carolina, Chapel Hill, NC 27599, USA
    Nanomedicine (Lond) 6:19-24. 2011
  9. doi request reprint Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents
    Rudolph L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:324-35. 2009
  10. pmc Biological barriers to therapy with antisense and siRNA oligonucleotides
    R Juliano
    UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Pharm 6:686-95. 2009

Research Grants

  1. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1993
  2. Enhanced Delivery of Protein Biosensors: a Combinatorial Library Strategy
    Rudolph Juliano; Fiscal Year: 2007
  3. Conference on Signaling Via Cell-Cell Interactions
    Rudolph Juliano; Fiscal Year: 2003
  4. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2001
  5. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2004
  6. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1992
  7. Major Challenges in Clinical Medicine: An Overview for *
    Rudolph Juliano; Fiscal Year: 2006
  8. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1990
  9. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2007
  10. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2002

Collaborators

Detail Information

Publications29

  1. pmc The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides
    Xin Ming
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 41:3673-87. 2013
    ..These observations indicate that it is possible to enhance the pharmacological actions of oligonucleotides using non-toxic and non-lysosomotropic small molecule adjuncts...
  2. pmc Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis
    Md Rowshon Alam
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill NC 27599, USA
    Nucleic Acids Res 36:2764-76. 2008
    ..These observations suggest that the bivalent RGD peptide-oligonucleotide conjugate enters cells via a process of receptor-mediated endocytosis mediated by the alphavbeta3 integrin...
  3. pmc Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor
    Xin Ming
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 38:6567-76. 2010
    ..These observations suggest that the BBN-oligonucleotide conjugate enters cells via a process of GRPR mediated endocytosis followed by trafficking to deep endomembrane compartments...
  4. pmc Integrin targeted delivery of gene therapeutics
    Rudy L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Theranostics 1:211-9. 2011
    ..Thus a variety of useful strategies are available for using integrins to enhance the pharmacological efficacy of therapeutic oligonucleotides...
  5. pmc Receptors, endocytosis, and trafficking: the biological basis of targeted delivery of antisense and siRNA oligonucleotides
    R L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    J Drug Target 21:27-43. 2013
    ..Hopefully, the basic information presented in this review will be of value to investigators involved in designing delivery approaches for oligonucleotides...
  6. pmc The chemistry and biology of oligonucleotide conjugates
    R L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, 27599, United States
    Acc Chem Res 45:1067-76. 2012
    ..Although both of these strategies have had some success, further research is needed before oligonucleotide conjugates can find an important place in human therapeutics...
  7. pmc Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides
    Rudolph L Juliano
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Bioconjug Chem 23:147-57. 2012
    ..In this review, we examine the recent literature on oligonucleotide internalization and subcellular trafficking in the context of current insights into the basic machinery for endocytosis and intracellular vesicular traffic...
  8. pmc The Carolina Center of Cancer Nanotechnology Excellence: past accomplishments and future perspectives
    Rudy L Juliano
    University of North Carolina, Chapel Hill, NC 27599, USA
    Nanomedicine (Lond) 6:19-24. 2011
    ....
  9. doi request reprint Cell-targeting and cell-penetrating peptides for delivery of therapeutic and imaging agents
    Rudolph L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:324-35. 2009
    ..The article also briefly discusses several specific examples of the use of CTPs or CPPs to assist in the delivery of nanoparticles, liposomes, and other nanocarriers...
  10. pmc Biological barriers to therapy with antisense and siRNA oligonucleotides
    R Juliano
    UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Pharm 6:686-95. 2009
    ..An understanding of the biological processes underlying these barriers will aid in the design of more effective delivery systems...
  11. pmc Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
    Rudy Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Nucleic Acids Res 36:4158-71. 2008
    ..Thus, choice of an optimal delivery modality will likely depend on the therapeutic context...
  12. ncbi request reprint Challenges to macromolecular drug delivery
    R Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill NC 27599, USA
    Biochem Soc Trans 35:41-3. 2007
    ....
  13. ncbi request reprint Intracellular delivery of oligonucleotide conjugates and dendrimer complexes
    R L Juliano
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Ann N Y Acad Sci 1082:18-26. 2006
    ....
  14. pmc Epigenetic manipulation of gene expression: a toolkit for cell biologists
    Rudy L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 169:847-57. 2005
    ..However, we will restrict our comments primarily to the cell culture situation, only briefly alluding to fundamental differences between utilization in animals versus cells...
  15. ncbi request reprint Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA
    Rudolph L Juliano
    University of North Carolina, Department of Pharmacology, School of Medicine, Chapel Hill, NC 27599, USA
    Curr Opin Mol Ther 7:132-6. 2005
    ..This article will provide a perspective on issues in oligonucleotide delivery, and will examine recent literature on the preparation and use of several types of peptide-oligonucleotide conjugates...
  16. ncbi request reprint Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides
    R L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill 27599, USA
    Pharm Res 16:494-502. 1999
    ..The problems and advantages inherent in the use of delivery systems are discussed in the light of further enhancing in vivo pharmacological actions of oligonucleotides...
  17. ncbi request reprint Aspects of the transport and delivery of antisense oligonucleotides
    R L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Mol Ther 2:297-303. 2000
    ..It will also examine the merits of various delivery strategies for oligonucleotides. The use of conjugates of oligonucleotides with 'cell penetrating peptides' as a promising delivery technology will be emphasized...
  18. ncbi request reprint Critical issues in PhD training for biomedical scientists
    R L Juliano
    Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599 7365, USA
    Acad Med 76:1005-12. 2001
    ..They conclude that it is in the interest of faculty and institutions to make these and other drastic changes because the current system is both inherently unfair and self-destructive...
  19. ncbi request reprint Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members
    R L Juliano
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Annu Rev Pharmacol Toxicol 42:283-323. 2002
    ..These mechanisms often involve the ability of cell adhesion molecules to initiate the formation of organized structures or scaffolds that permit the efficient flow of information in signaling pathways...
  20. ncbi request reprint Macromolecular therapeutics: emerging strategies for drug discovery in the postgenome era
    R L Juliano
    Department of Pharmacology, School of Medicine and Program in Macromolecular Therapeutics, University of North Carolina, Chapel Hill 27599, USA
    Mol Interv 1:40-53. 2001
    ..Thus, the therapeutic use of macromolecules, including oligonucleotides, peptides, and proteins, may be an idea whose time has come...
  21. ncbi request reprint Integrins and GTPases in tumour cell growth, motility and invasion
    P Keely
    Dept of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill 27599, USA
    Trends Cell Biol 8:101-6. 1998
    ..In this review, the authors examine integrin signalling and integrin-GTPase interplay in the context of cancer cell growth and behaviour...
  22. ncbi request reprint Integrin regulation of cell signalling and motility
    R L Juliano
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Biochem Soc Trans 32:443-6. 2004
    ..These studies emphasize the intricate connection between integrins and Rho-family GTPases and their effectors in controlling both mitogenesis and migration...
  23. doi request reprint The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides
    Leaf Huang
    Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    J Drug Target 18:567-74. 2010
    ..We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery...
  24. ncbi request reprint Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways
    Jung Weon Lee
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cells 17:188-202. 2004
    ..2003)...
  25. ncbi request reprint Movin' on through with Cdc2
    Rudy Juliano
    Nat Cell Biol 5:589-90. 2003
  26. ncbi request reprint Increased uptake of antisense oligonucleotides by delivery as double stranded complexes
    Anna Astriab-Fisher
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Biochem Pharmacol 68:403-7. 2004
    ..The results obtained suggested that double stranded delivery could provide a simple and effective means for enhancing cell uptake of pharmacologically active oligonucleotides...
  27. ncbi request reprint In honour of Professor Rudy Juliano, winner of the 2004 Life-time Achievement Award from the Journal of Drug Targeting
    Saghir Akhtar
    J Drug Target 12:309-11. 2004
  28. ncbi request reprint Bugging tumors to put drugs on target
    Rudy Juliano
    Department of Pharmacology and the Carolina Center of Cancer Nanotechnology Excellence, School of Medicine, University of North Carolina, Chapel Hill, USA
    N Engl J Med 356:954-5. 2007

Research Grants30

  1. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1993
    ....
  2. Enhanced Delivery of Protein Biosensors: a Combinatorial Library Strategy
    Rudolph Juliano; Fiscal Year: 2007
    ..We anticipate that this approach will lead to a cohort of novel CPPs that will have an important impact on the entire field of intracellular delivery of proteins, especially biosensors. ..
  3. Conference on Signaling Via Cell-Cell Interactions
    Rudolph Juliano; Fiscal Year: 2003
    ..The proposed program will present a unique training opportunity for students and post-doctoral fellows, since it will provide a unifying thematic structure to converging, but still disparate, areas of research. ..
  4. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2001
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  5. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2004
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  6. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1992
    ....
  7. Major Challenges in Clinical Medicine: An Overview for *
    Rudolph Juliano; Fiscal Year: 2006
    ..As part of this component the trainee, with the mentor's guidance, will prepare the Abstract and Specific Aims of an NIH-type grant proposal dealing with a translational research topic. ..
  8. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1990
    ....
  9. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2007
    ....
  10. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2002
    ....
  11. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2005
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  12. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2003
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  13. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2002
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  14. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2001
    ....
  15. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2000
    ..We also believe that they will create opportunities for the development of novel approaches to cancer therapy. ..
  16. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2000
    ....
  17. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 1991
    ....
  18. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 1999
    ..We also believe that they will create opportunities for the development of novel approaches to cancer therapy. ..
  19. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2003
    ....
  20. Enhanced Delivery of Protein Biosensors: a Combinatorial Library Strategy
    Rudolph Juliano; Fiscal Year: 2009
    ..We anticipate that this approach will lead to a cohort of novel CPPs that will have an important impact on the entire field of intracellular delivery of proteins, especially biosensors. ..