Gabor Juhasz

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body
    G Juhasz
    Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
    Cell Death Differ 14:1181-90. 2007
  2. ncbi request reprint Hid can induce, but is not required for autophagy in polyploid larval Drosophila tissues
    Gabor Juhasz
    Department of General Zoology, Eotvos Lorand University, H 1117 Pázmány sétány 1 C, Budapest, Hungary
    Eur J Cell Biol 84:491-502. 2005
  3. pmc Autophagy: a forty-year search for a missing membrane source
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS Biol 4:e36. 2006
  4. ncbi request reprint A novel role for the Drosophila epsin (lqf): involvement in autophagy
    György Csikós
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 5:636-48. 2009
  5. pmc Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila
    Karolina Pircs
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e44214. 2012
  6. pmc The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Biol 181:655-66. 2008
  7. pmc Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest H 1117, Hungary
    FEBS Lett 588:408-13. 2014
  8. pmc Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila
    Szabolcs Takáts
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, H 1117 Budapest, Hungary
    J Cell Biol 201:531-9. 2013
  9. pmc Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
    Balázs Erdi
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 8:1124-35. 2012
  10. pmc Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila
    Peter Low
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Pázmány P s 1 C, H 1117, Budapest, Hungary
    BMC Cell Biol 14:29. 2013

Collaborators

Detail Information

Publications34

  1. pmc Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body
    G Juhasz
    Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
    Cell Death Differ 14:1181-90. 2007
    ..Accordingly, we found that Foxo mutants cannot properly undergo autophagy in response to starvation, and that overexpression of Foxo induces autophagy...
  2. ncbi request reprint Hid can induce, but is not required for autophagy in polyploid larval Drosophila tissues
    Gabor Juhasz
    Department of General Zoology, Eotvos Lorand University, H 1117 Pázmány sétány 1 C, Budapest, Hungary
    Eur J Cell Biol 84:491-502. 2005
    ..Our results show that the large, post-mitotic larval cells do not react or activate autophagy in response to the same strong apoptotic stimuli that trigger apoptosis in small, mitotically active imaginal disc cells...
  3. pmc Autophagy: a forty-year search for a missing membrane source
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS Biol 4:e36. 2006
  4. ncbi request reprint A novel role for the Drosophila epsin (lqf): involvement in autophagy
    György Csikós
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 5:636-48. 2009
    ....
  5. pmc Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila
    Karolina Pircs
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e44214. 2012
    ....
  6. pmc The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Biol 181:655-66. 2008
    ..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation...
  7. pmc Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest H 1117, Hungary
    FEBS Lett 588:408-13. 2014
    ..The simultaneous interaction of Atg18 with both Atg9 and Ref(2)P raises the possibility that Atg18 may facilitate selective degradation of ubiquitinated protein aggregates by autophagy. ..
  8. pmc Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila
    Szabolcs Takáts
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, H 1117 Budapest, Hungary
    J Cell Biol 201:531-9. 2013
    ..Our findings reveal the molecular mechanism underlying autophagosomal fusion events and show that lysosomal degradation and recycling of sequestered autophagosome content is crucial to maintain proper functioning of the nervous system...
  9. pmc Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila
    Balázs Erdi
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 8:1124-35. 2012
    ..Our results, for the first time, demonstrated the fundamental role of Rack1 in autophagy and glycogen synthesis...
  10. pmc Impaired proteasomal degradation enhances autophagy via hypoxia signaling in Drosophila
    Peter Low
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Pázmány P s 1 C, H 1117, Budapest, Hungary
    BMC Cell Biol 14:29. 2013
    ....
  11. doi request reprint Matrix metalloproteinase-9 activity increased by two different types of epileptic seizures that do not induce neuronal death: a possible role in homeostatic synaptic plasticity
    Eszter Takács
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    Neurochem Int 56:799-809. 2010
    ..In these epilepsy models MMP-9 induction may therefore be associated with functions such as homeostatic synaptic plasticity rather than neuronal death...
  12. pmc Status epilepticus affects the gigantocellular network of the pontine reticular formation
    Péter Baracskay
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, H 1117 Budapest, Hungary
    BMC Neurosci 10:133. 2009
    ..The behavioral signs of the developing epileptic seizures were scored in all rats. The EEG activity was recorded in eight rats...
  13. ncbi request reprint Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis
    Gabor Juhasz
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Autophagy 4:357-8. 2008
    ..These results suggest that in Drosophila, normal levels of autophagy may play a more important role in the homeostasis of certain terminally differentiated cells and stress survival than during development...
  14. doi request reprint Brain protein expression changes in WAG/Rij rats, a genetic rat model of absence epilepsy after peripheral lipopolysaccharide treatment
    Balazs Gyorffy
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Pazmany P stny 1 C, Budapest H 1117, Hungary
    Brain Behav Immun 35:86-95. 2014
    ..Our physiological findings support the phenomenon that high dose of peripheral LPS injection increases SWD-number, modifies its duration as well as the sleep-wake stages and decreases body temperature. ..
  15. ncbi request reprint SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy
    Mónika Lippai
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    Autophagy 4:476-86. 2008
    ..Our results demonstrate that SNF4Agamma has an essential role in the regulation of autophagy in Drosophila larval fat body cells...
  16. pmc Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Genes Dev 21:3061-6. 2007
    ..Thus, normal levels of autophagy are crucial for stress survival and continuous cellular renewal, but not metamorphosis...
  17. pmc Myc-driven overgrowth requires unfolded protein response-mediated induction of autophagy and antioxidant responses in Drosophila melanogaster
    Peter Nagy
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest, Hungary
    PLoS Genet 9:e1003664. 2013
    ..These novel results give additional support for finding future approaches to specifically inhibit the growth of cancer cells addicted to oncogenic Myc...
  18. pmc Redistribution of CB1 cannabinoid receptors in the acute and chronic phases of pilocarpine-induced epilepsy
    Mária R Karlócai
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e27196. 2011
    ....
  19. doi request reprint Experimental control and characterization of autophagy in Drosophila
    Gabor Juhasz
    Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
    Methods Mol Biol 445:125-33. 2008
    ..We also describe methods for experimentally activating and inhibiting autophagy in this system and discuss the potential for genetic analysis in Drosophila to identify novel genes involved in autophagy...
  20. doi request reprint Nutrient-dependent regulation of autophagy through the target of rapamycin pathway
    Yu Yun Chang
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem Soc Trans 37:232-6. 2009
    ..Further insight into these TOR-dependent control mechanisms may support development of autophagy-based therapies for a number of pathological conditions...
  21. doi request reprint Different electrophysiological actions of 24- and 72-hour aggregated amyloid-beta oligomers on hippocampal field population spike in both anesthetized and awake rats
    Gergely Orbán
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    Brain Res 1354:227-35. 2010
    ..These results demonstrate that oligomeric Abeta aggregates elicit opposite electrophysiological effects on neuronal excitability which depend on their degree of oligomerization...
  22. ncbi request reprint Preconditioning-specific reduction of c-fos expression in hippocampal granule and pyramidal but not other forebrain neurons of ischemic brain: a quantitative immunohistochemical study
    Gabriella Nyitrai
    Department of Neurochemistry, Chemical Research Center, HAS, Budapest, Hungary
    Neurosci Lett 381:344-9. 2005
    ..In fact stress-response and induction of ischemic tolerance in different forebrain areas can be distinguished...
  23. ncbi request reprint The Drosophila homolog of Aut1 is essential for autophagy and development
    Gabor Juhasz
    Department of General Zoology, Eotvos Lorand University, H 1117 Pázmány sétány 1 C, Budapest, Hungary
    FEBS Lett 543:154-8. 2003
    ..To our knowledge, this is the first report of a multicellular animal lacking the function of a gene participating in the protein conjugation systems of autophagy...
  24. pmc Altered functional protein networks in the prefrontal cortex and amygdala of victims of suicide
    Katalin Adrienna Kékesi
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e50532. 2012
    ..The opposite changes of ACTB, CTSD and GFAP in the two brain structures were validated by western blot analysis...
  25. ncbi request reprint Systems biology of Alzheimer's disease: how diverse molecular changes result in memory impairment in AD
    Gabor Juhasz
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Pazmany P stny 1 C, H 1117 Budapest, Hungary
    Neurochem Int 58:739-50. 2011
    ..Finally, we give a systems biology model of AD explaining how AD can develop in an individual manner in each particular subject but always results in a rapidly developing dementia and memory impairment...
  26. doi request reprint Drosophila basement membrane collagen col4a1 mutations cause severe myopathy
    Ildikó Kelemen-Valkony
    Department of Genetics, University of Szeged, Kozepfasor 52, H 6726 Szeged, Hungary
    Matrix Biol 31:29-37. 2012
    ..In conclusion, our Drosophila mutant series may serve as an effective model to uncover the mechanisms by which COL4A1 mutations result in compromised myofiber-basement membrane interactions and aberrant muscle function...
  27. pmc Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death
    Ryan C Scott
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Biol 17:1-11. 2007
    ..Here, we circumvent this difficulty by directly manipulating autophagy rates in Drosophila through the autophagy-specific protein kinase Atg1...
  28. pmc The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila
    Krisztina Hegedus
    Department of Anatomy, Cell and Developmental Biology, Eotvos Lorand University, Budapest 1117, Hungary
    Biomed Res Int 2014:470482. 2014
    ....
  29. ncbi request reprint Concentration of nucleosides and related compounds in cerebral and cerebellar cortical areas and white matter of the human brain
    Katalin A Kekesi
    Department of Physiology and Neurobiology, Eotvos Lorand University, Budapest, Hungary
    Cell Mol Neurobiol 26:833-44. 2006
    ..The methods presented here allow to creation of a nucleoside map of the human brain by measuring the concentration of nucleosides in microdissected tissue samples. Our data support a functional role for nucleosides in the brain...
  30. ncbi request reprint Generalization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat
    Péter Baracskay
    Institute of Biology, Faculty of Natural Sciences, Eotvos Lorand University, H 1117 Budapest, Hungary
    Brain Res 1228:217-28. 2008
    ..The EEG analysis revealed the generalization of the epileptic seizures. We found that the formation of "dark" neurons in the hippocampus and the pontine reticular formation paralleled the generalization of the seizures...
  31. doi request reprint Functional consequences of retinopetal fibers originating in the dorsal raphe nucleus
    Magor L Lorincz
    Neurobiology Research Group, Hungarian Academy of Sciences, Eotvos Lorand University, Budapest, Hungary
    Int J Neurosci 118:1374-83. 2008
    ....
  32. pmc Cleavage of kininogen and subsequent bradykinin release by the complement component: mannose-binding lectin-associated serine protease (MASP)-1
    József Dobó
    Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary
    PLoS ONE 6:e20036. 2011
    ....
  33. ncbi request reprint Visible light induces matrix metalloproteinase-9 expression in rat eye
    Andrea M Papp
    Laboratory of Proteomics, Institute of Biology, Eotvos Lorand University, Budapest, Hungary
    J Neurochem 103:2224-33. 2007
    ..This is the first demonstration of MMP-9 induction by a sensory stimulus...
  34. ncbi request reprint Autophagy occurs upstream or parallel to the apoptosome during histolytic cell death
    Fatih Akdemir
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:1457-65. 2006
    ....