Alexander R Judkins

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Technical communication: rationale and technique for examination of nervous system in suspected infant victims of abuse
    Alexander R Judkins
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Forensic Med Pathol 25:29-32. 2004
  2. ncbi request reprint Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology
    Alexander R Judkins
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Adv Anat Pathol 14:335-9. 2007
  3. pmc Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors
    Eric M Jackson
    Department of Neurosurgery and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 15:1923-30. 2009
  4. pmc Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions
    Lisa M Sullivan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
    Mod Pathol 26:385-92. 2013
  5. pmc Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors
    Lisa M Sullivan
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Surg Pathol 36:73-80. 2012
  6. doi request reprint Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 35:1463-72. 2011
  7. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009
  8. doi request reprint Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases
    James H Stephen
    Divisions of Neurosurgery, Children s Hospital of Philadelphia, PA, USA
    J Neurosurg Pediatr 9:646-53. 2012
  9. ncbi request reprint Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors
    Andrew C Hoot
    Department of Pathology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:1485-91. 2004
  10. pmc Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors
    Katherine W Eaton
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 56:7-15. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Technical communication: rationale and technique for examination of nervous system in suspected infant victims of abuse
    Alexander R Judkins
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Forensic Med Pathol 25:29-32. 2004
    ..A standard series of histologic sections are also outlined to document the corresponding microscopic changes...
  2. ncbi request reprint Immunohistochemistry of INI1 expression: a new tool for old challenges in CNS and soft tissue pathology
    Alexander R Judkins
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Adv Anat Pathol 14:335-9. 2007
    ..Loss of INI1 expression may rarely be encountered in other tumor types. This article reviews the utility of immunohistochemical staining for INI1 expression...
  3. pmc Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors
    Eric M Jackson
    Department of Neurosurgery and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Cancer Res 15:1923-30. 2009
    ....
  4. pmc Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions
    Lisa M Sullivan
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA
    Mod Pathol 26:385-92. 2013
    ..Given the high percentage of SMARCB1 alterations in epithelioid sarcoma, these findings argue against using SMARCB1 gene deletion as a tool in distinguishing them from malignant rhabdoid tumors...
  5. pmc Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors
    Lisa M Sullivan
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Surg Pathol 36:73-80. 2012
    ..Although CLDN6 is expressed in both AT/RTs and MRTs, it is not a specific biomarker as it is expressed in a variety of other pediatric CNS and soft tissue tumors...
  6. doi request reprint Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 35:1463-72. 2011
    ..This study underscores similarities between MRTs and stem cells and may help elucidate common biologic pathways that could serve in advancing more effective therapeutic strategies to treat MRTs...
  7. pmc Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
    Portia A Kreiger
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mod Pathol 22:142-50. 2009
    ..Whether these undifferentiated sarcomas represent a clinicopathologic entity distinct from classic malignant rhabdoid tumor requires further investigation...
  8. doi request reprint Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases
    James H Stephen
    Divisions of Neurosurgery, Children s Hospital of Philadelphia, PA, USA
    J Neurosurg Pediatr 9:646-53. 2012
    ..The purpose of this study was to explore the tumor biology and outcomes in a consecutive series of pediatric patients treated at a single institution...
  9. ncbi request reprint Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors
    Andrew C Hoot
    Department of Pathology, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:1485-91. 2004
    ....
  10. pmc Spectrum of SMARCB1/INI1 mutations in familial and sporadic rhabdoid tumors
    Katherine W Eaton
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Blood Cancer 56:7-15. 2011
    ..However, these studies were limited by case selection and an inability to detect intragenic deletions and duplications...
  11. doi request reprint MiRNA-9 and MiRNA-200a distinguish hemangioblastomas from metastatic clear cell renal cell carcinomas in the CNS
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
    Brain Pathol 22:522-9. 2012
    ..Our data suggest that miR-9 and miR-200a can distinguish between hemangioblastomas and Met CCRCC. Further, these results may also provide insight in understanding the biology of hemangioblastomas...
  12. ncbi request reprint INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma
    Alexander R Judkins
    Department of Pathology, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Neuropathol Exp Neurol 64:391-7. 2005
    ..This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone...
  13. pmc p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors
    Sriram Venneti
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 70:596-609. 2011
    ..These results provide insights into cell cycle deregulation in the pathogenesis of human MRT and may aid in the design and evaluation of potential therapies for these tumors...
  14. pmc Surgical treatment of a clival-C2 atypical teratoid/rhabdoid tumor
    Gregory G Heuer
    Department of Neurosurgery, Children s Hospital of Philadelphia, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4399, USA
    J Neurosurg Pediatr 5:75-9. 2010
    ..The conus tumor was resected and found to be consistent with the primary tumor. Several months later the patient presented with disseminated intrathecal disease and ultimately died 42 months after the initial resection...
  15. doi request reprint Ependymoblastoma: dear, damned, distracting diagnosis, farewell!*
    Alexander R Judkins
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Brain Pathol 20:133-9. 2010
    ..We believe that ependymoblastoma as a diagnosis is neither precise nor specific and that it is time once and for all to retire this diagnosis from the lexicon of neuropathology...
  16. ncbi request reprint Immunohistochemical analysis of hSNF5/INI1 in pediatric CNS neoplasms
    Alexander R Judkins
    Department of Pathology, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:644-50. 2004
    ..INI1 immunostaining may have particular utility in the analysis of tumors with indeterminate histologic features or atypical immunophenotypic profiles...
  17. ncbi request reprint Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding
    Sydney M Evans
    School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 64:1886-92. 2004
    ..The proportion of moderately to severely hypoxic cells is relatively low, even in the high-grade tumors. Human brain tumors are dominated by oxic to moderately hypoxic cells...
  18. ncbi request reprint Testicular seminoma 16 years after treatment for CNS germinoma
    Amit Maity
    Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Neurooncol 70:83-5. 2004
    ..These patients require lifelong medical follow-up and should be encouraged to perform testicular self-examination at the appropriate age...
  19. ncbi request reprint Differential cellular gene expression in ganglioglioma
    Uzma Samadani
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 48:646-53. 2007
    ....
  20. pmc Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene
    Angela J Sievert
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Brain Pathol 19:449-58. 2009
    ..Further studies are required to determine the role of this fusion gene in downstream MAPK signaling and its role in development of pediatric low-grade astrocytomas...
  21. ncbi request reprint Gliomatosis cerebri: 20 years of experience at the Children's Hospital of Philadelphia
    Gregory T Armstrong
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 107:1597-606. 2006
    ..In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival...
  22. ncbi request reprint Intracranial capillary hemangioma: case report and review of the literature
    Scott L Simon
    Department of Neurosurgery, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Surg Neurol 64:154-9. 2005
    ..The authors present an exceedingly rare case of an intracranial capillary hemangioma arising in an adult. Only 4 biopsy-proven cases have been reported in the pediatric population previous to this case report...
  23. pmc The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study
    Sydney M Evans
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Transl Oncol 3:160-9. 2010
    ..0291). In summary, patients had a worse prognosis if the [EF5/Ki-67(Binding)]/[Tumor(binding)] ratio was high. A hypothesis for the mechanisms and translational significance of these findings is discussed...
  24. ncbi request reprint Intramedullary cervical spine germinoma: case report
    Jason H Huang
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurgery 55:1432. 2004
    ..We report an extremely rare case of primary intramedullary germinoma in the cervical spinal cord arising in an 18-year-old man who had not undergone previous surgery or irradiation...
  25. pmc Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: case study
    Jeffrey C Allen
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Neuro Oncol 8:79-82. 2006
    ..This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor...
  26. ncbi request reprint INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
    ..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor...
  27. ncbi request reprint Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma
    Geeta Chacko
    Division of Neuropathology, Department of Neurological Sciences, Christian Medical College, Vellore, India
    J Neurooncol 84:217-22. 2007
    ..We speculate that the PXA was a quiescent tumor and that the secondary genetic alterations, including inactivation of the INI1 gene led to clinical progression...
  28. ncbi request reprint Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation
    Kristin Janson
    Department of Radiation Oncology, Tulane University, New Orleans, Los Angeles, USA
    Pediatr Blood Cancer 47:279-84. 2006
    ..Germline mutations of the INI1 gene predispose children to the development of rhabdoid tumors. Reports of familial cases, however, are extremely rare...
  29. ncbi request reprint Germinoma: unusual imaging and pathological characteristics. Report of two cases
    Elisabeth J Rushing
    Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Neurosurg 104:143-8. 2006
    ..The diagnosis of diffuse germinoma was confirmed, and the patient was treated with adjunctive chemotherapy. Although uncommon, germ cell tumors can present outside the midline and exhibit a multifocal growth pattern...
  30. ncbi request reprint Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma
    Pang Hsien Tu
    Division of Neuropathology and Section of Hematopathology, Campus Box 8118, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Clin Oncol 23:5718-27. 2005
    ..Although rare overall, marginal zone B-cell lymphoma (MZBCL) is the most common primary low-grade CNS lymphoma reported in the literature. The aim of this study is to elucidate the biology and genetic features of this unusual tumor...