Sharon A Jubrias

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 92:333-9. 2007
  2. ncbi request reprint Large energetic adaptations of elderly muscle to resistance and endurance training
    S A Jubrias
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Appl Physiol 90:1663-70. 2001
  3. pmc Contraction coupling efficiency of human first dorsal interosseous muscle
    Sharon A Jubrias
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Physiol 586:1993-2002. 2008
  4. pmc Acidosis inhibits oxidative phosphorylation in contracting human skeletal muscle in vivo
    Sharon A Jubrias
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    J Physiol 553:589-99. 2003
  5. doi request reprint Exercise efficiency is reduced by mitochondrial uncoupling in the elderly
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 98:768-77. 2013
  6. pmc Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo
    Catherine E Amara
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:1057-62. 2007
  7. doi request reprint Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 98:899-907. 2013
  8. ncbi request reprint Mitochondrial dysfunction: impact on exercise performance and cellular aging
    Kevin E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exerc Sport Sci Rev 35:43-9. 2007
  9. pmc Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects
    Kevin E Conley
    Department of Radiology, University of Washington Medical Center, Box 357115, Seattle, Washington 98195 7115, USA
    J Clin Endocrinol Metab 98:129-36. 2013
  10. pmc Oxidative capacity and ageing in human muscle
    K E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    J Physiol 526:203-10. 2000

Detail Information

Publications15

  1. ncbi request reprint Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 92:333-9. 2007
    ....
  2. ncbi request reprint Large energetic adaptations of elderly muscle to resistance and endurance training
    S A Jubrias
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Appl Physiol 90:1663-70. 2001
    ..Thus elderly muscle remains adaptable to chronic exercise, with large energetic changes accompanying both ET and RT...
  3. pmc Contraction coupling efficiency of human first dorsal interosseous muscle
    Sharon A Jubrias
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Physiol 586:1993-2002. 2008
    ....
  4. pmc Acidosis inhibits oxidative phosphorylation in contracting human skeletal muscle in vivo
    Sharon A Jubrias
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    J Physiol 553:589-99. 2003
    ..These results show that acidosis inhibits oxidative phosphorylation in vivo and can limit ATP supply in exercising muscle to below the mitochondrial capacity...
  5. doi request reprint Exercise efficiency is reduced by mitochondrial uncoupling in the elderly
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 98:768-77. 2013
    ..Thus, two independent methods revealed that reduced mitochondrial-coupling efficiency was a key part of the drop in exercise efficiency in these elderly subjects and may be an important part of the loss of exercise performance with age...
  6. pmc Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo
    Catherine E Amara
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 104:1057-62. 2007
    ..Instead, they support mild uncoupling as a mechanism protecting mitochondrial function and contributing to the paradoxical longevity of the most active muscle fibers...
  7. doi request reprint Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects
    Kevin E Conley
    Department of Radiology, Box 357115, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exp Physiol 98:899-907. 2013
    ..These results suggest that leg exercise performance benefits from elevations in energy coupling and oxidative phosphorylation capacity at both the whole-body and muscle levels that accompany endurance training in the elderly...
  8. ncbi request reprint Mitochondrial dysfunction: impact on exercise performance and cellular aging
    Kevin E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    Exerc Sport Sci Rev 35:43-9. 2007
    ..Exercise training can reverse age-related dysfunction, thereby providing an intervention to slow the pace of aging and disability in the elderly...
  9. pmc Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects
    Kevin E Conley
    Department of Radiology, University of Washington Medical Center, Box 357115, Seattle, Washington 98195 7115, USA
    J Clin Endocrinol Metab 98:129-36. 2013
    ..This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active individuals...
  10. pmc Oxidative capacity and ageing in human muscle
    K E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    J Physiol 526:203-10. 2000
    ..The cellular basis of this drop was a reduction in mitochondrial content, as well as a lower oxidative capacity of the mitochondria with age...
  11. pmc Glycolysis is independent of oxygenation state in stimulated human skeletal muscle in vivo
    K E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    J Physiol 511:935-45. 1998
    ..These results show a key role for muscle stimulation in the activation and maintenance of glycolysis. Further, this glycolytic control mechanism is independent of the feedback control mechanism that governs oxidative phosphorylation...
  12. ncbi request reprint A "functional biopsy" of muscle properties in sprinters and distance runners
    Gregory J Crowther
    Department of Radiology, University of Washington Medical Center, Seattle, 98195 7115, USA
    Med Sci Sports Exerc 34:1719-24. 2002
    ..We asked whether comparable flux differences are evident in the muscles of athletes specializing in extremely different (i.e., sprint and long-distance) running events...
  13. pmc High efficiency in human muscle: an anomaly and an opportunity?
    Frank E Nelson
    University of Washington, Seattle, WA 98195 7115, USA
    J Exp Biol 214:2649-53. 2011
    ....
  14. pmc Ageing, muscle properties and maximal O(2) uptake rate in humans
    K E Conley
    Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115
    J Physiol 526:211-7. 2000
    ....
  15. ncbi request reprint Altered energetic properties in skeletal muscle of men with well-controlled insulin-dependent (type 1) diabetes
    Gregory J Crowther
    Department of Physiology and Biophysics, University of Washington Medical Center, Seattle 98195, USA
    Am J Physiol Endocrinol Metab 284:E655-62. 2003
    ....