Won Kyu Ju
Affiliation: University of California
Ju W, Kim K, Angert M, Duong Polk K, Lindsey J, Ellisman M, et al
. Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina. Invest Ophthalmol Vis Sci. 2009;50:707-16 pubmed publisher
Ju W, Lindsey J, Angert M, Patel A, Weinreb R. Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina. Mol Vis. 2008;14:2629-38 pubmed
..These results support further studies to determine whether ischemia-induced OPA1 release may be an important component of the biochemical cascade leading to pressure-related ischemic damage in glaucomatous retina. ..
Ju W, Kim K, Lindsey J, Angert M, Patel A, Scott R, et al
. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol Vis. 2009;15:120-34 pubmed
..These results suggest that sustained moderate pressure elevation may directly damage RGC integrity by injuring mitochondria. ..
Ju W, Kim K, Duong Polk K, Lindsey J, Ellisman M, Weinreb R. Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma. Mol Vis. 2010;16:1331-42 pubmed
..OPA1 can directly modulate RGC survival, and increasing OPA1 expression may protect against RGC death in glaucomatous optic neuropathy. ..
Ju W, Liu Q, Kim K, Crowston J, Lindsey J, Agarwal N, et al
. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Invest Ophthalmol Vis Sci. 2007;48:2145-51 pubmed
..Increased understanding of the molecular mechanisms that regulate the cellular response to elevated pressure including mitochondrial fission may provide new therapeutic targets for protecting RGCs from elevated hydrostatic pressure. ..