Won Kyu Ju

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina
    Won Kyu Ju
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 50:707-16. 2009
  2. pmc Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina
    Won Kyu Ju
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, CA 92037 0946, USA
    Mol Vis 14:2629-38. 2008
  3. pmc Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells
    Won Kyu Ju
    The Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA 92037 0946, USA
    Mol Vis 15:120-34. 2009
  4. pmc Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma
    Won Kyu Ju
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA 92037, USA
    Mol Vis 16:1331-42. 2010
  5. pmc Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes
    Y H Noh
    Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA
    Cell Death Dis 4:e820. 2013
  6. pmc A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
    D Nguyen
    The Sophie and Arthur Brody Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Cell Death Dis 2:e240. 2011
  7. pmc Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
    S Y Kim
    Laboratory for Optic Nerve Biology, Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA, USA
    Cell Death Dis 5:e1105. 2014
  8. pmc Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA, USA
    Methods Mol Biol 740:149-56. 2011
  9. ncbi request reprint Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells
    Won Kyu Ju
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 48:2145-51. 2007
  10. pmc Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, School of Medicine, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:4903-11. 2008

Collaborators

Detail Information

Publications25

  1. pmc Memantine blocks mitochondrial OPA1 and cytochrome c release and subsequent apoptotic cell death in glaucomatous retina
    Won Kyu Ju
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 50:707-16. 2009
    ....
  2. pmc Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina
    Won Kyu Ju
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, CA 92037 0946, USA
    Mol Vis 14:2629-38. 2008
    ....
  3. pmc Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells
    Won Kyu Ju
    The Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA 92037 0946, USA
    Mol Vis 15:120-34. 2009
    ....
  4. pmc Increased optic atrophy type 1 expression protects retinal ganglion cells in a mouse model of glaucoma
    Won Kyu Ju
    Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA 92037, USA
    Mol Vis 16:1331-42. 2010
    ..The goal of this study is to determine whether increased optic atrophy type 1 (OPA1) expression protects against retinal ganglion cell (RGC) death in glaucomatous DBA/2J mice...
  5. pmc Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes
    Y H Noh
    Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA
    Cell Death Dis 4:e820. 2013
    ..CoQ10 may provide new therapeutic potentials and strategies for protecting ONH astrocytes against oxidative stress-mediated mitochondrial dysfunction or alteration in glaucoma and other optic neuropathies...
  6. pmc A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics
    D Nguyen
    The Sophie and Arthur Brody Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Cell Death Dis 2:e240. 2011
    ..Therefore, we propose a new vicious cycle involved in neurodegeneration that includes glutamate excitotoxicity, oxidative stress, and mitochondrial dynamics...
  7. pmc Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury
    S Y Kim
    Laboratory for Optic Nerve Biology, Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA, USA
    Cell Death Dis 5:e1105. 2014
    ..On the basis of these observations, our findings suggest that CsA-mediated CypD inhibition may provide a promising therapeutic potential for protecting RGCs against ischemic injury-mediated mitochondrial dysfunction. ..
  8. pmc Measuring glutamate receptor activation-induced apoptotic cell death in ischemic rat retina using the TUNEL assay
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, CA, USA
    Methods Mol Biol 740:149-56. 2011
    ..We have shown that there is TUNEL-positive apoptotic cell death in the outer nuclear layer, inner nuclear layer, and ganglion cell layer of the ischemic rat retina at 12 h...
  9. ncbi request reprint Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells
    Won Kyu Ju
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 48:2145-51. 2007
    ..The purpose of this study was to determine whether elevated hydrostatic pressure induces mitochondrial fission and dysfunction in cultured retinal ganglion cells...
  10. pmc Intraocular pressure elevation induces mitochondrial fission and triggers OPA1 release in glaucomatous optic nerve
    Won Kyu Ju
    Department of Ophthalmology, Hamilton Glaucoma Center, School of Medicine, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 49:4903-11. 2008
    ..To determine whether elevation of intraocular pressure (IOP) triggers mitochondrial fission and ultrastructural changes and alters optic atrophy type 1 (OPA1) expression and distribution in the optic nerve (ON) of glaucomatous DBA/2J mice...
  11. ncbi request reprint Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage
    Quan Liu
    Hamilton Glaucoma Center and the Department of Ophthalmology, University of California San Diego, La Jolla, California 92037 0946, USA
    Invest Ophthalmol Vis Sci 48:4580-9. 2007
    ..To determine whether oxidative adduct formation or heme oxygenase-1 (HO-1) expression are altered in retinal ganglion cell (RGC) cultures exposed to elevated hydrostatic pressure and in a mouse model of glaucoma...
  12. pmc Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma
    Dongwook Lee
    Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California
    Invest Ophthalmol Vis Sci 55:993-1005. 2014
    ....
  13. pmc A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina
    Sang Woo Park
    Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 52:2837-43. 2011
    ....
  14. pmc Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats
    Yi Dai
    The Sophie and Arthur Brody Optic Nerve Laboratory, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 52:2468-76. 2011
    ....
  15. pmc Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury
    Dongwook Lee
    The Sophie and Arthur Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, United States of America
    PLoS ONE 7:e47098. 2012
    ..Our findings suggest that systemic BMD treatment protects RGCs by blockade of glutamate excitotoxicity-induced oxidative stress and subsequent preservation of Tfam/OXPHOS complex expression in ischemic retina...
  16. pmc OPA1 expression in the normal rat retina and optic nerve
    Won Kyu Ju
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Comp Neurol 488:1-10. 2005
    ..Thus, OPA1 is predominantly expressed in retinal ganglion cells of the normal rat retina and axons of the optic nerve. These findings may explain the selective vulnerability of retinal ganglion cells to OPA1 loss of function...
  17. pmc Coenzyme Q10 ameliorates oxidative stress and prevents mitochondrial alteration in ischemic retinal injury
    Dongwook Lee
    Laboratory for Optic Nerve Biology, Department of Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA
    Apoptosis 19:603-14. 2014
    ..Our results suggest that CoQ10 may provide neuroprotection against oxidative stress-mediated mitochondrial alterations in ischemic retinal injury. ..
  18. pmc Increased mitochondrial fission and volume density by blocking glutamate excitotoxicity protect glaucomatous optic nerve head astrocytes
    Won Kyu Ju
    Department of Ophthalmology, Laboratory for Optic Nerve Biology, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California
    Glia 63:736-53. 2015
    ..glia 2015;63:736-753. ..
  19. ncbi request reprint In vivo imaging of murine retinal ganglion cells
    Christopher K S Leung
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA, United States
    J Neurosci Methods 168:475-8. 2008
    ....
  20. pmc Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration
    Myoung Sup Shim
    Hamilton Glaucoma Center, Department of Ophthalmology, and Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA
    Sci Rep 6:33830. 2016
    ..These results strongly suggest that E50K is associated with mitochondrial dysfunction in RGC degeneration in synergy with environmental factors such as aging and/or oxidative stress...
  21. ncbi request reprint Role of cyclic AMP in the eye of glaucoma
    Myoung Sup Shim
    Hamilton Glaucoma Center and Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA
    BMB Rep . 2016
    ..Also, we will further focus on cAMP signaling in RGC growth and regeneration by soluble AC as well as ONH astrocytes by transmembrane ACs to understand its potential role in the pathogenesis of glaucoma neurodegeneration...
  22. ncbi request reprint Neuronal susceptibility to damage: comparison of the retinas of young, old and old/caloric restricted rats before and after transient ischemia
    Keun Young Kim
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, P O Box 8096, St Louis, MO 63110, USA
    Neurobiol Aging 25:491-500. 2004
    ....
  23. ncbi request reprint Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia
    Won Kyu Ju
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St Louis, MO 63110, USA
    Exp Eye Res 77:137-45. 2003
    ..However, the selective COX-2 inhibitor reduced infiltration of hematogenous cells into the retina. These results suggest that the early, increased activity of COX-2 signals neurodegenerative events following retinal ischemia...
  24. ncbi request reprint Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina
    Won Kyu Ju
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine St Louis, Missouri 63110, USA
    J Comp Neurol 452:392-9. 2002
    ..These results suggest that prostaglandins, synthesized by COX-1 or COX-2, may contribute to normal physiological and homeostatic functions in the retina...
  25. ncbi request reprint Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina
    Won Kyu Ju
    Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo Dong, Socho gu, Seoul 137 701, Korea
    Neuroreport 13:861-5. 2002
    ..Our findings suggest that some ganglion cells have the potential to regenerate through the up-regulation of GAP-43 in the ischemic rat retina...