Cynthia Ju

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
    Cynthia Ju
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Chem Res Toxicol 15:1504-13. 2002
  2. ncbi request reprint Tolerogenic role of Kupffer cells in allergic reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Chem Res Toxicol 16:1514-9. 2003
  3. ncbi request reprint Immunological mechanisms of drug-induced liver injury
    Cynthia Ju
    University of Colorado Health Sciences Center, Department of Pharmaceutical Sciences, Denver, CO 80262, USA
    Curr Opin Drug Discov Devel 8:38-43. 2005
  4. ncbi request reprint Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Toxicology 209:109-12. 2005
  5. ncbi request reprint The role of haptic macrophages in regulation of idiosyncratic drug reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Toxicol Pathol 37:12-7. 2009
  6. pmc Involvement of natural killer T cells in halothane-induced liver injury in mice
    Linling Cheng
    Department of Pharmaceutical Sciences, University of Colorado Denver, USA
    Biochem Pharmacol 80:255-61. 2010
  7. doi request reprint Lactoferrin protects against concanavalin A-induced liver injury in mice
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    Liver Int 30:623-32. 2010
  8. pmc Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
    Michael P Holt
    Department of Pharmaceutical Sciences, University of Colorado Denver, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Leukoc Biol 84:1410-21. 2008
  9. pmc Effect of polyI:C cotreatment on halothane-induced liver injury in mice
    Linling Cheng
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hepatology 49:215-26. 2009
  10. ncbi request reprint Role of neutrophils in a mouse model of halothane-induced liver injury
    Qiang You
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 44:1421-31. 2006

Research Grants

  1. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
    Cynthia Ju
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Chem Res Toxicol 15:1504-13. 2002
    ....
  2. ncbi request reprint Tolerogenic role of Kupffer cells in allergic reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Chem Res Toxicol 16:1514-9. 2003
    ..Perhaps genetic and/or environmental factors affecting the activities of these cells may play a role in determining individual susceptibility to DIARs...
  3. ncbi request reprint Immunological mechanisms of drug-induced liver injury
    Cynthia Ju
    University of Colorado Health Sciences Center, Department of Pharmaceutical Sciences, Denver, CO 80262, USA
    Curr Opin Drug Discov Devel 8:38-43. 2005
    ..Understanding the molecular and cellular elements in these models can help identify risk factors, and ultimately facilitate the development of prediction and prevention strategies...
  4. ncbi request reprint Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Toxicology 209:109-12. 2005
    ..Functional activities of KC, which are regulated by genetic and/or environmental factors, may play an important role in determining individual susceptibility to IADR...
  5. ncbi request reprint The role of haptic macrophages in regulation of idiosyncratic drug reactions
    Cynthia Ju
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Toxicol Pathol 37:12-7. 2009
    ..These findings suggest that KCs may play a critical role in regulating immune reactions within the liver and contributing to liver-mediated systemic immune tolerance...
  6. pmc Involvement of natural killer T cells in halothane-induced liver injury in mice
    Linling Cheng
    Department of Pharmaceutical Sciences, University of Colorado Denver, USA
    Biochem Pharmacol 80:255-61. 2010
    ..In addition, this model may yield the discovery of susceptibility factors that may control the development of liver injury in patients treated with halothane and potentially other drugs...
  7. doi request reprint Lactoferrin protects against concanavalin A-induced liver injury in mice
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO, USA
    Liver Int 30:623-32. 2010
    ..Lactoferrin (Lac) is an iron-binding glycoprotein that belongs to the transferrin family. Owing to its multiple biological functions, Lac has been evaluated in a number of clinical trials to treat infections, inflammation and cancer...
  8. pmc Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
    Michael P Holt
    Department of Pharmaceutical Sciences, University of Colorado Denver, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Leukoc Biol 84:1410-21. 2008
    ..The present study also demonstrated the ability of separating populations of macrophages and delineating distinct functions of each group in future studies of inflammatory disease in the liver and other tissues...
  9. pmc Effect of polyI:C cotreatment on halothane-induced liver injury in mice
    Linling Cheng
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hepatology 49:215-26. 2009
    ..DILI may be attenuated or exacerbated by pathogens depending on the time of infection...
  10. ncbi request reprint Role of neutrophils in a mouse model of halothane-induced liver injury
    Qiang You
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 44:1421-31. 2006
    ..In conclusion, our model provides a platform for elucidating strain-based and gender-based susceptibility factors in DILI development...
  11. doi request reprint Exacerbation of acetaminophen-induced disturbances of liver sinusoidal endothelial cells in the absence of Kupffer cells in mice
    Michael P Holt
    Department of Pharmaceutical Sciences, University of Colorado Denver, Denver, CO, USA
    Toxicol Lett 194:34-41. 2010
    ....
  12. pmc Lactoferrin protects against acetaminophen-induced liver injury in mice
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado, Denver, CO 80045, USA
    Hepatology 51:1007-16. 2010
    ..These findings reveal the significant therapeutic potential of Lac during AILI and other types of liver diseases...
  13. pmc The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice
    Brittany V Martin-Murphy
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA
    Toxicol Lett 192:387-94. 2010
    ....
  14. pmc Mechanism of T cell tolerance induction by murine hepatic Kupffer cells
    Qiang You
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO, USA
    Hepatology 48:978-90. 2008
    ..These findings suggest that KCs may play a critical role in regulating immune reactions within the liver and contributing to liver-mediated systemic immune tolerance. (HEPATOLOGY 2008.)...
  15. ncbi request reprint Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury
    Hao Yin
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hepatology 45:159-69. 2007
    ..These findings suggest that COX-2-derived PGs may have great therapeutic potentials in treating patients with inflammatory liver diseases...
  16. doi request reprint Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo
    Linling Cheng
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, 4200 East 9th Ave, Denver, CO 80262, USA
    Mol Pharmacol 73:1769-75. 2008
    ..Our findings also suggest that the immunogenicity of SMX-NO is determined by the immunogenic nature of the hapten, rather than special characteristics of the adducted protein...
  17. pmc Mechanisms of drug-induced liver injury
    Michael P Holt
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, 4200 E 9th Ave, Box C 238, Denver, CO 80262, USA
    AAPS J 8:E48-54. 2006
    ..Understanding the molecular and cellular elements associated with these pathways can help identify risk factors and may ultimately facilitate the development of strategies to predict and prevent DILI...
  18. ncbi request reprint Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis
    Ruth A Roberts
    AstraZeneca, Safety Assessment Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom
    Toxicol Sci 96:2-15. 2007
    ..Taken together, the data presented in this symposium illustrate to the toxicologist the central role played by Kupffer cells in mediating hepatotoxicity...

Research Grants1

  1. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
    ..Furthermore, studies of inhibition of HO-1 and IL-10 will be carried out to determine functional association of 15d-PGJ2 with HO-1 and IL-10. ..