Affiliation: University of California
- Molecular basis for dimer formation of TRbeta variant D355RNatalia Jouravel
Department of Biochemistry and Biophysics, University of California San Francisco UCSF, San Francisco, California 94158, USA
Proteins 75:111-7. 2009....
- Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptorEva Estebanez-Perpina
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158 2240, USA
Mol Endocrinol 21:2919-28. 2007..DHPPA represents a novel class of potent TRbeta antagonist, and its crystal structure suggests new ways to design antagonists that target the assembly of nuclear hormone receptor gene-regulatory complexes and block transcription...
- Interaction between the androgen receptor and a segment of its corepressor SHPNatalia Jouravel
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
Acta Crystallogr D Biol Crystallogr 63:1198-200. 2007..Comparisons of AR structures bound to coactivator peptides and the SHP peptide revealed structural similarity of their binding sites, suggesting that transcriptional AR activity may be inhibited by SHP by competing with AR coactivators...
- Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulatorsLeggy A Arnold
Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143, USA
J Biol Chem 280:43048-55. 2005..6 microm and thyroid signaling in cellular systems. These are the first small molecules irreversibly inhibiting the coactivator binding of a nuclear receptor and suppressing its transcriptional activity...
- Perspectives on designs of antiandrogens for prostate cancerEva Estebanez-Perpina
University of California San Francisco, Department of Biochemistry and Biophysics, San Francisco, CA941432240, USA 1 415 476 5051 1 415 476 1902
Expert Opin Drug Discov 2:1341-55. 2007..The challenges to designing these compounds are significant but so is the potential for treatment of the disease...
- Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferationCindy Benod
Department of Biochemistry and Biophysics, University of California 600 16th Street, GH S412E, San Francisco, CA 94158 2517, USA
Proc Natl Acad Sci U S A 108:16927-31. 2011..This study demonstrates the critical involvement of LRH-1 in development and progression of pancreatic cancer, suggesting the LRH-1 receptor as a plausible therapeutic target for treatment of pancreatic ductal adenocarcinomas...