Erik Jorgensen

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Gene activation using FLP recombinase in C. elegans
    M Wayne Davis
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000028. 2008
  2. pmc CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons
    Marc Hammarlund
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 180:483-91. 2008
  3. pmc Protein localization in electron micrographs using fluorescence nanoscopy
    Shigeki Watanabe
    Department of Biology and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA
    Nat Methods 8:80-4. 2011
  4. pmc Mutations in synaptojanin disrupt synaptic vesicle recycling
    T W Harris
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Cell Biol 150:589-600. 2000
  5. pmc Rapid single nucleotide polymorphism mapping in C. elegans
    M Wayne Davis
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    BMC Genomics 6:118. 2005
  6. ncbi request reprint The art and design of genetic screens: caenorhabditis elegans
    Erik M Jorgensen
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Nat Rev Genet 3:356-69. 2002
  7. ncbi request reprint Neuroscience. Vesicular glutamate transporter--shooting blanks
    Kim Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Science 304:1750-2. 2004
  8. pmc Defects in synaptic vesicle docking in unc-18 mutants
    Robby M Weimer
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 6:1023-30. 2003
  9. pmc Open syntaxin docks synaptic vesicles
    Marc Hammarlund
    Department of Biology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Biol 5:e198. 2007
  10. ncbi request reprint Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin
    Kimberly R Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Neuron 40:749-62. 2003

Research Grants

  1. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik M Jorgensen; Fiscal Year: 2010
  2. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2002
  3. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2000
  4. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2004
  5. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2001
  6. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2003
  7. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2007
  8. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2002
  9. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2001
  10. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2000

Collaborators

Detail Information

Publications49

  1. pmc Gene activation using FLP recombinase in C. elegans
    M Wayne Davis
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000028. 2008
    ..We show that we can use this to inactivate synaptic transmission in all neurons or a subset of neurons in a FLP-dependent manner...
  2. pmc CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons
    Marc Hammarlund
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 180:483-91. 2008
    ..CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations...
  3. pmc Protein localization in electron micrographs using fluorescence nanoscopy
    Shigeki Watanabe
    Department of Biology and Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, USA
    Nat Methods 8:80-4. 2011
    ..Fluorescence correlated with organelles imaged in electron micrographs from the same sections. We used these methods to localize histones, a mitochondrial protein and a presynaptic dense projection protein in electron micrographs...
  4. pmc Mutations in synaptojanin disrupt synaptic vesicle recycling
    T W Harris
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    J Cell Biol 150:589-600. 2000
    ..Luthi, W.T. Kim, K. Takei, L. Daniell, Y. Nemoto, S.B. Shears, R.A. Flavell, D.A. McCormick, and P. De Camilli. 1999. Cell. 99:179-188), and further demonstrate that synaptojanin facilitates multiple steps of synaptic vesicle recycling...
  5. pmc Rapid single nucleotide polymorphism mapping in C. elegans
    M Wayne Davis
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    BMC Genomics 6:118. 2005
    ..In C. elegans, single nucleotide polymorphisms (SNPs) can function as silent genetic markers, with applications ranging from classical two- and three-factor mapping to measuring recombination across whole chromosomes...
  6. ncbi request reprint The art and design of genetic screens: caenorhabditis elegans
    Erik M Jorgensen
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    Nat Rev Genet 3:356-69. 2002
    ..Since 1974, when Sydney Brenner published his pioneering genetic screen, researchers have developed increasingly powerful methods for identifying genes and genetic pathways in C. elegans...
  7. ncbi request reprint Neuroscience. Vesicular glutamate transporter--shooting blanks
    Kim Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Science 304:1750-2. 2004
  8. pmc Defects in synaptic vesicle docking in unc-18 mutants
    Robby M Weimer
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 6:1023-30. 2003
    ..Rather, we found a reduction of docked vesicles at the active zone in unc-18 mutants, suggesting that UNC-18 functions, directly or indirectly, as a facilitator of vesicle docking...
  9. pmc Open syntaxin docks synaptic vesicles
    Marc Hammarlund
    Department of Biology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Biol 5:e198. 2007
    ..These data provide a molecular basis for synaptic vesicle docking...
  10. ncbi request reprint Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin
    Kimberly R Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA
    Neuron 40:749-62. 2003
    ..These data suggest that endophilin is an adaptor protein required to localize and stabilize synaptojanin at membranes during synaptic vesicle recycling...
  11. ncbi request reprint UNC-46 is required for trafficking of the vesicular GABA transporter
    Kim Schuske
    Howard Hughes Medical Institute and the Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 10:846-53. 2007
    ..The vesicular GABA transporter recruits UNC-46 to synaptic vesicle precursors in the cell body, and UNC-46 sorts the transporter at the cell body and during endocytosis at the synapse...
  12. ncbi request reprint UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants
    Maelle Jospin
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Curr Biol 17:1595-600. 2007
    ..These data suggest that activation of the NCA ion channel in synaptojanin mutants leads to defects in recycling of synaptic vesicles...
  13. ncbi request reprint Controversies in synaptic vesicle exocytosis
    Robby M Weimer
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    J Cell Sci 116:3661-6. 2003
  14. pmc Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans
    Bruce A Bamber
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA
    Br J Pharmacol 138:883-93. 2003
    ..Thus, although they are most similar to other invertebrate GABA receptors, the UNC-49 receptors share significant structural and pharmacological overlap with mammalian GABA(A) receptors...
  15. pmc Detection of neuron membranes in electron microscopy images using a serial neural network architecture
    Elizabeth Jurrus
    Scientific Computing and Imaging Institute, Salt Lake City, UT 84112, United States
    Med Image Anal 14:770-83. 2010
    ..We also demonstrate advantages over previous membrane detection methods. The results are a significant step towards an automated system for the reconstruction of the connectome...
  16. ncbi request reprint EXP-1 is an excitatory GABA-gated cation channel
    Asim A Beg
    Neuroscience Program and Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Nat Neurosci 6:1145-52. 2003
    ..We conclude that some of the excitatory functions assigned to GABA are mediated by cation channels rather than by anion channels...
  17. pmc A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans
    Maelle Jospin
    Department of Biology, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Biol 7:e1000265. 2009
    ..These data indicate that the ACR-2 receptor is important for the coordinated excitation and inhibition of body muscles underlying sinusoidal movement...
  18. pmc Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans
    Mingyu Gu
    Howard Hughes Medical Institute and Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 183:881-92. 2008
    ..Collectively, these data suggest AP2 micro2 facilitates but is not essential for synaptic vesicle recycling...
  19. ncbi request reprint The plasma membrane calcium ATPase MCA-3 is required for clathrin-mediated endocytosis in scavenger cells of Caenorhabditis elegans
    Ewa M Bednarek
    Department of Biology and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
    Traffic 8:543-53. 2007
    ..Together, these data support a function for PMCAs in the regulation of endocytosis in the C. elegans coelomocytes. In addition, they suggest that endocytosis can be blocked by high calcium levels...
  20. pmc Axons break in animals lacking beta-spectrin
    Marc Hammarlund
    Department of Biology, Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
    J Cell Biol 176:269-75. 2007
    ..Because spectrin is a major target of calpain proteolysis, it is possible that some neurodegenerative disorders may involve the cleavage of spectrin followed by the breakage of neural processes...
  21. pmc Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate
    Bryan Wardell
    Department of Pharmacology and Toxicology, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
    Br J Pharmacol 148:162-72. 2006
    ..Mutating the M1 domain had little effect on sensitivity to the inhibitor picrotoxin, suggesting that these residues may mediate neurosteroid action specifically, and not allosteric regulation in general...
  22. pmc The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction
    Bruce A Bamber
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Br J Pharmacol 144:502-9. 2005
    ..Thus, the function of UNC-49B is to provide GABA responsiveness and localization to synapses, while the function of UNC-49C is to negatively modulate receptor function and precisely shape inhibitory postsynaptic currents...
  23. pmc Axon regeneration requires a conserved MAP kinase pathway
    Marc Hammarlund
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Science 323:802-6. 2009
    ..We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth...
  24. ncbi request reprint Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome
    Ann K Corsi
    Department of Biology, The Catholic University of America, Washington, DC 20064, USA
    Development 129:2761-72. 2002
    ..elegans protein. These data suggest that Saethre-Chotzen syndrome may be caused, in some cases, by dominant negative proteins, rather than by haploinsufficiency of the locus...
  25. pmc Protons act as a transmitter for muscle contraction in C. elegans
    Asim A Beg
    Neuroscience Program, University of Utah, Salt Lake City, UT 84112 0840, USA
    Cell 132:149-60. 2008
    ..8. The identification of the mechanisms for release and reception of proton signals establishes a highly unusual mechanism for intercellular communication...
  26. pmc Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components
    Chan Yen Ou
    Department of Biology, Howard Hughes Medical Institute, Stanford University, 385 Serra Mall, California 94305, USA
    Cell 141:846-58. 2010
    ..Thus, PCT-1 and CDK-5 pathways direct polarized trafficking of presynaptic components by inhibiting dynein-mediated retrograde transport and setting the balance between anterograde and retrograde motors...
  27. pmc Heterozygous insertions alter crossover distribution but allow crossover interference in Caenorhabditis elegans
    Marc Hammarlund
    Department of Biology, University of Utah, Salt Lake City, Utah 84112 0840, USA
    Genetics 171:1047-56. 2005
    ..However, because crossovers are not completely eliminated distal to insertions, we propose that alignment can be reestablished after a megabase-scale gap in sequence homology...
  28. ncbi request reprint UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans
    Sean Speese
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 27:6150-62. 2007
    ..Our results suggest that CAPS/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system...
  29. pmc Graded synaptic transmission at the Caenorhabditis elegans neuromuscular junction
    Qiang Liu
    Department of Biology and Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112 0840, USA
    Proc Natl Acad Sci U S A 106:10823-8. 2009
    ..Graded release precisely transmits stimulation intensity, even hyperpolarizing inputs. Synaptic plasticity alters the balance of excitatory and inhibitory inputs into the muscle in a use-dependent manner...
  30. ncbi request reprint A calcium wave mediated by gap junctions coordinates a rhythmic behavior in C. elegans
    Maureen A Peters
    Department of Biology, Oberlin College, Oberlin, Ohio 44074, USA
    Curr Biol 17:1601-8. 2007
    ..These data demonstrate that pannexin gap junctions propagate calcium waves in the C. elegans intestine. The calcium waves instruct the motor steps and regulate the pacemaker cell's authority and reliability...
  31. pmc Characterization of Mos1-mediated mutagenesis in Caenorhabditis elegans: a method for the rapid identification of mutated genes
    Daniel C Williams
    Department of Biology, University of Utah, Salt Lake City, 84112, USA
    Genetics 169:1779-85. 2005
    ..Finally, multiple transposition events occur in individual germ cells. By using screening techniques based on these results, Mos1 mutagenicity was increased to within an order of magnitude of chemical mutagens...
  32. ncbi request reprint The sensory circuitry for sexual attraction in C. elegans males
    Jamie Q White
    Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112 0840, USA
    Curr Biol 17:1847-57. 2007
    ..Are the behavioral differences due to sex-specific or core neurons?..
  33. ncbi request reprint The GABA nervous system in C. elegans
    Kim Schuske
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Trends Neurosci 27:407-14. 2004
    ..This review discusses the strategy employed to identify these genes as well as the conclusions about GABA transmission derived from study of the mutant phenotypes...
  34. ncbi request reprint A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans
    M Wayne Davis
    Department of Biology, University of Utah, Salt Lake City, UT 84112 0840, USA
    Development 131:6001-8. 2004
    ..NAS-37 degradation of the Haemonchus cuticle suggests that the metalloproteases and the cuticle substrates involved in exsheathment of parasitic nematodes are conserved in free-living nematodes...
  35. pmc Single-copy insertion of transgenes in Caenorhabditis elegans
    Christian Frøkjaer-Jensen
    Department of Biology and Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA
    Nat Genet 40:1375-83. 2008
    ..We have successfully inserted transgenes as long as 9 kb and verified that single copies are inserted at the targeted site. Single-copy transgenes are expressed at endogenous levels and can be expressed in the female and male germlines...
  36. ncbi request reprint PKC defends crown against Munc13
    Mark Palfreyman
    Department of Biology and Howard Hughes Medical Institute, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112 0840, USA
    Neuron 54:179-80. 2007
    ..Thanks to a study by Wierda and colleagues in this issue of Neuron, PKC returns to reclaim part of the kingdom: both pathways must be active to activate presynaptic potentiation...
  37. pmc Targeted gene deletions in C. elegans using transposon excision
    Christian Frøkjaer-Jensen
    Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah, USA
    Nat Methods 7:451-3. 2010
    ..Repair can delete up to 25 kb of DNA and simultaneously insert a positive selection marker...
  38. pmc Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells
    Jason Morton
    Department of Biochemistry, University of Utah School of Medicine, 15 North Medical Drive East, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 103:16370-5. 2006
    ..DNA ligase IV is required for efficient end joining, particularly of blunt ends. In its absence, a secondary end-joining pathway relies more heavily on microhomologies in producing deletions...
  39. pmc Gene conversion and end-joining-repair double-strand breaks in the Caenorhabditis elegans germline
    Valérie J Robert
    Ecole Normale Superieure, Biologie Cellulaire de la Synapse, Paris, France
    Genetics 180:673-9. 2008
    ..Surprisingly, expression of the transposase using an intestine-specific promoter can induce repair, raising the possibility that activation of transposase expression in somatic cells can lead to transposition of Mos1 in the germline...
  40. pmc Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2
    Nadja Jung
    Department of Membrane Biochemistry, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, 14195 Berlin, Germany
    J Cell Biol 179:1497-510. 2007
    ..Synaptotagmin-binding-defective UNC-41B is unable to rescue paralysis in C. elegans stonin mutant animals, suggesting that the mechanism of stonin-mediated SV cargo recognition is conserved from worms to mammals...
  41. pmc C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless
    Chun Liang Pan
    Helen Wills Neuroscience Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3204, USA
    Dev Cell 14:132-9. 2008
    ..By contrast, MIG-14 accumulates in intracellular compartments in retromer mutants. Based on our observations, we propose that intracellular trafficking of MIG-14 by AP-2 and retromer plays an important role in Wnt secretion...
  42. pmc Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans
    Stacey L Williams
    Program in Molecular, Cell, and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Genes Dev 21:2731-46. 2007
    ..Our results show that Trio's Rho-specific GEF domain is a major Galpha(q) effector that, together with PLCbeta, mediates the Galpha(q) signaling that drives the locomotion, egg laying, and growth of the animal...
  43. pmc Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans
    Christian Abraham
    Department of Anatomy and Cell Biology, Johannes Gutenberg University, Becherweg 13, 55128 Mainz, Germany
    Proc Natl Acad Sci U S A 103:8227-32. 2006
    ..We therefore conclude that TVPs are not needed for the basic neuronal machinery and instead may contribute to subtle higher order functions...
  44. ncbi request reprint Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans
    Giovanni M Lesa
    Molecular Neuropathobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 116:4965-75. 2003
    ..These data indicate that LC-PUFAs are essential for efficient neurotransmission in C. elegans and may account for the clinical conditions associated with mis-regulation of LC-PUFAs in humans...
  45. ncbi request reprint Dopamine: should I stay or should I go now?
    Erik M Jorgensen
    Nat Neurosci 7:1019-21. 2004
  46. ncbi request reprint Preservation of immunoreactivity and fine structure of adult C. elegans tissues using high-pressure freezing
    Philippe Rostaing
    Biologie Cellulaire de la Synapse, Ecole Normale Superieure, Paris, France
    J Histochem Cytochem 52:1-12. 2004
    ..elegans tissues by using postembedding immunogold labeling...

Research Grants16

  1. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik M Jorgensen; Fiscal Year: 2010
    ..By studying the basic processes of neurotransmission, we hope to understand the causes of neurodegenerative diseases as well as develop novel therapies. ..
  2. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2002
    ..Ultimately, these studies might help explain the molecular behavior of neuroactive drugs and lead to the development of new and more specific pharmaceuticals which act on individual neurotransmitter systems. ..
  3. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2000
    ..Aim 4. RIC-7. Mutations in this gene disrupt cholinergic and GABAergic-mediated behaviors. We will determine the function of this novel synaptic protein using ultrastructural and physiological tools. ..
  4. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2004
    ..Ultimately, these studies might help explain the molecular behavior of neuroactive drugs and lead to the development of new and more specific pharmaceuticals which act on individual neurotransmitter systems. ..
  5. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2001
    ..Ultimately, these studies might help explain the molecular behavior of neuroactive drugs and lead to the development of new and more specific pharmaceuticals which act on individual neurotransmitter systems. ..
  6. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2003
    ..Ultimately, these studies might help explain the molecular behavior of neuroactive drugs and lead to the development of new and more specific pharmaceuticals which act on individual neurotransmitter systems. ..
  7. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2007
    ....
  8. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2002
    ..Aim 4. RIC-7. Mutations in this gene disrupt cholinergic and GABAergic-mediated behaviors. We will determine the function of this novel synaptic protein using ultrastructural and physiological tools. ..
  9. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2001
    ..Aim 4. RIC-7. Mutations in this gene disrupt cholinergic and GABAergic-mediated behaviors. We will determine the function of this novel synaptic protein using ultrastructural and physiological tools. ..
  10. NEUROTRANSMITTER FUNCTION IN C. ELEGANS
    Erik Jorgensen; Fiscal Year: 2000
    ..Ultimately, these studies might help explain the molecular behavior of neuroactive drugs and lead to the development of new and more specific pharmaceuticals which act on individual neurotransmitter systems. ..
  11. SYNAPTIC FUNCTION IN THE NEMATODE C. ELEGANS
    Erik M Jorgensen; Fiscal Year: 2010
    ..By studying the basic processes of neurotransmission, we hope to understand the causes of neurodegenerative diseases as well as develop novel therapies. ..