Research Topics
Genomes and Genes | Lynn JordeSummaryAffiliation: University of Utah Country: USA Publications
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Publications
Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysisWilfred Wu
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
BMC Genet 14:30. 2013....- Genetic analysis of ancestry, admixture and selection in Bolivian and Totonac populations of the New WorldW Scott Watkins
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 N 2030 E RM 2100, Salt Lake City, UT 84112, USA
BMC Genet 13:39. 2012.... - Genetic diversity in India and the inference of Eurasian population expansionJinchuan Xing
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA
Genome Biol 11:R113. 2010..Despite recent large-scale efforts in discovering human genetic variation, India's vast reservoir of genetic diversity remains largely unexplored... - Mobile element scanning (ME-Scan) by targeted high-throughput sequencingDavid J Witherspoon
Dept of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
BMC Genomics 11:410. 2010.... - Alu repeats increase local recombination ratesDavid J Witherspoon
Dept of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
BMC Genomics 10:530. 2009.... - Culture creates genetic structure in the Caucasus: autosomal, mitochondrial, and Y-chromosomal variation in DaghestanElizabeth E Marchani
Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA
BMC Genet 9:47. 2008.... - Genetic variation in South Indian castes: evidence from Y-chromosome, mitochondrial, and autosomal polymorphismsW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
BMC Genet 9:86. 2008..An understanding of these influences is increasingly important as gene mapping and case-control studies are initiated in South Indian populations... 
Genetic variation, classification and 'race'Lynn B Jorde
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
Nat Genet 36:S28-33. 2004..Therefore, ancestry, or even race, may in some cases prove useful in the biomedical setting, but direct assessment of disease-related genetic variation will ultimately yield more accurate and beneficial information...- Population genomics: a bridge from evolutionary history to genetic medicineL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
Hum Mol Genet 10:2199-207. 2001..We review some of the general patterns of human genetic variation, and we show how our knowledge of these patterns can aid in the mapping and cloning of disease-causing genes... - Evolution. Where we're hot, they're notLynn B Jorde
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Science 308:60-2. 2005 - Linkage disequilibrium and the search for complex disease genesL B Jorde
Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
Genome Res 10:1435-44. 2000 - The distribution of human genetic diversity: a comparison of mitochondrial, autosomal, and Y-chromosome dataL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT, 84112, USA
Am J Hum Genet 66:979-88. 2000..These results are reassuring in their consistency and offer broad support for an African origin of modern human populations... - DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selectionS P Wooding
Department of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA
Am J Hum Genet 71:528-42. 2002..90) frequencies in human populations, a trend consistent with the action of positive natural selection. These patterns have a number of implications for disease-association studies in CYP1A2 and other genes... - Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndromeM Bamshad
Department of Pediatrics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
Nat Genet 16:311-5. 1997..We suggest that during the evolution of TBX3 and TBX5 from a common ancestral gene, each has acquired specific yet complementary roles in patterning the mammalian upper limb... - Syndromic ectrodactyly with severe limb, ectodermal, urogenital, and palatal defects maps to chromosome 19J R O'Quinn
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Am J Hum Genet 62:130-5. 1998..The identification of both the gene causing EEC and its mutation may further elucidate the general signals mediating inductive mechanisms... - Human population genetic structure and diversity inferred from polymorphic L1(LINE-1) and Alu insertionsD J Witherspoon
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112 5330, USA
Hum Hered 62:30-46. 2006..L1 elements drive replication of Alu elements, and both have had far-reaching impacts on the human genome. We use L1 and Alu insertion polymorphisms to analyze human population structure... - Genetic traces of ancient demographyH C Harpending
Department of Anthropology, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 95:1961-7. 1998..This genetic evidence denies any version of the multiregional model of modern human origins. It implies instead that our ancestors were effectively a separate species for most of the Pleistocene... - Genetic similarities within and between human populationsD J Witherspoon
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
Genetics 176:351-9. 2007..This provides empirical justification for caution when using population labels in biomedical settings, with broad implications for personalized medicine, pharmacogenetics, and the meaning of race... - Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritisS Prahalad
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah, Salt Lake City, UT 84132 2206, USA
Genes Immun 7:468-75. 2006..05). Both variants are in regions under natural selection, and result in functional consequences. Our results suggest these CCR5 variants are protective against early-onset JRA... - Diversity and divergence among the tribal populations of IndiaW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Ann Hum Genet 69:680-92. 2005.... - Consanguinity and prereproductive mortality in the Utah Mormon populationL B Jorde
Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA
Hum Hered 52:61-5. 2001..Preliminary evidence is offered for the hypothesis that mortality differentials are larger in populations with low inbreeding and low mortality because nongenetic causes of death do not obscure the effects of consanguinity... - Ascertainment bias in estimates of average heterozygosityA R Rogers
Department of Anthropology, University of Utah, Salt Lake City, Utah 84112, USA
Am J Hum Genet 58:1033-41. 1996..As this argument predicts, European estimates exceed those of Africa and Asia at systems with large bias. The magnitude of this European excess is consistent with the version of our model in which mutation rates vary across loci... - Mitochondrial mismatch analysis is insensitive to the mutational processA R Rogers
Department of Anthropology, University of Utah, Salt Lake City 84112, USA
Mol Biol Evol 13:895-902. 1996..01. In addition, we evaluate and reject the proposition that mismatch waves are produced by pooling data from several subdivisions of a structured population... - A variant of Freeman-Sheldon syndrome maps to 11p15.5-pterP A Krakowiak
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
Am J Hum Genet 60:426-32. 1997..5-6.5-cM region between the marker TH and the telomere. Analysis of additional families improves the LOD score to 6.45 at theta = 0 and suggests linkage homogeneity for DA2B... - Microsatellite diversity and the demographic history of modern humansL B Jorde
Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112, USA
Proc Natl Acad Sci U S A 94:3100-3. 1997..A comparison of continental diversity differences in microsatellites and mtDNA sequences suggests earlier demographic expansion of the ancestors of Africans... - Haplotype analysis of hemochromatosis: evaluation of different linkage-disequilibrium approaches and evolution of disease chromosomesR S Ajioka
Division of Hematology Oncology, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132, USA
Am J Hum Genet 60:1439-47. 1997..Our data provide a reasonable explanation for previous difficulties in localizing the hh locus and provide an evolutionary history for disease chromosomes... - Multiple origins of the mtDNA 9-bp deletion in populations of South IndiaW S Watkins
Department of Human Genetics, University of Utah, Salt Lake City 84112 0533, USA
Am J Phys Anthropol 109:147-58. 1999..These results demonstrate varying genetic affinities of different South Indian tribes to continental populations and underscore the complex histories of the tribal populations living in South Asia... - Genetic evidence on the origins of Indian caste populationsM Bamshad
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
Genome Res 11:994-1004. 2001..We conclude that Indian castes are most likely to be of proto-Asian origin with West Eurasian admixture resulting in rank-related and sex-specific differences in the genetic affinities of castes to Asians and Europeans... - The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndromeM Bamshad
Department of Pediatrics, Eccles Institute of Human Genetics, 15 North 2030 East, Room 2100, University of Utah, Salt Lake City, UT 84112 5330, USA
Am J Hum Genet 64:1550-62. 1999..We found no obvious phenotypic differences between those who have missense mutations and those who have deletions or frameshifts... - Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritisG Pont-Kingdon
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
Scand J Rheumatol 38:91-5. 2009..Associations between variants in the gene encoding the beta 2-adrenergic receptor (ADRB2) and autoimmune disorders such as rheumatoid arthritis (RA) have been demonstrated. We aimed to investigate ADRB2 variants for association with JIA... - Linkage disequilibrium in the neurofibromatosis 1 (NF1) region: implications for gene mappingL B Jorde
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84112
Am J Hum Genet 53:1038-50. 1993..These are discussed, and guidelines for linkage disequilibrium studies are suggested... - Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritisSampath Prahalad
Division of Immunology and Rheumatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158 1289, USA
Arthritis Rheum 58:2147-52. 2008..Single-nucleotide polymorphisms (SNPs) in CTLA4 have been implicated in susceptibility to several autoimmune disorders, including JIA. This study was undertaken to test 3 functional CTLA4 variants for association with JIA... - Large-scale SNP analysis reveals clustered and continuous patterns of human genetic variationMark D Shriver
Penn State University, University Park, Pennsylvania, USA
Hum Genomics 2:81-9. 2005.... - Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor lociUnkyung Kim
Department of Biology, Kyungpook National University, Daegu, Republic of Korea
Hum Mutat 26:199-204. 2005.... - Balinese Y-chromosome perspective on the peopling of Indonesia: genetic contributions from pre-neolithic hunter-gatherers, Austronesian farmers, and Indian tradersTatiana M Karafet
Division of Biotechnology, Biosciences West, University of Arizona, Tucson, AZ 85721, USA
Hum Biol 77:93-114. 2005..These results indicate that the Austronesian expansion had a profound effect on the composition of the Balinese paternal gene pool and that cultural transmission from India to Bali was accompanied by substantial levels of gene flow... - Modeling the amplification dynamics of human Alu retrotransposonsDale J Hedges
Department of Biological Sciences, Biological Computation and Visualization Center, Center for Bio-Modular Microsystems, Louisiana State University, Baton Rouge, Louisiana, United States of America
PLoS Comput Biol 1:e44. 2005.... - Ancestral alleles and population origins: inferences depend on mutation rateAlan R Rogers
Department of Anthropology, University of Utah, USA
Mol Biol Evol 24:990-7. 2007..This is true of one data set, but not of 2 others. This also suggests the action of some factor, such as selection or ascertainment bias, that varies among data sets... - HapMap tagSNP transferability in multiple populations: general guidelinesJinchuan Xing
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
Genomics 92:41-51. 2008..In addition to our findings, we reviewed over 25 recent studies of tagSNP transferability and propose a general guideline for selecting tagSNPs from HapMap populations... - Variation in the human TAS1R taste receptor genesUn-Kyung Kim
National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
Chem Senses 31:599-611. 2006.... - Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complicationsZongzhong Tong
Department of Ophthalmology and Visual Sciences, Eccles Institute of Human Genetics
Proc Natl Acad Sci U S A 105:6998-7003. 2008..These results suggest that rs1617640 in the EPO promoter is significantly associated with PDR and ESRD. This study identifies a disease risk-associated gene and potential pathway mediating severe diabetic microvascular complications... - Genome-wide analysis of the human Alu Yb-lineageAnthony B Carter
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
Hum Genomics 1:167-78. 2004..The high copy number, level of insertion polymorphism and estimated age indicate that members of the Alu Yb elements will be useful in a wide range of genetic analyses... - Recently integrated Alu elements and human genomic diversityAbdel-Halim Salem
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, USA
Mol Biol Evol 20:1349-61. 2003..This type of Alu retroposition-mediated genomic deletion is a novel source of lineage-specific evolution within primate genomes... - A method for detecting recent selection in the human genome from allele age estimatesChristopher Toomajian
Committee on Genetics, University of Chicago, Chicago, Illinois 60637, USA
Genetics 165:287-97. 2003..This method will be useful for scanning the human genome for alleles under selection using the haplotype map now being constructed... - Genetic variation among world populations: inferences from 100 Alu insertion polymorphismsW Scott Watkins
Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA
Genome Res 13:1607-18. 2003..These analyses also demonstrate that markers with higher F(ST) values have greater resolving power and produce more consistent genetic distance estimates... - Larger genetic differences within africans than between Africans and EurasiansNing Yu
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
Genetics 161:269-74. 2002..Clearly, one must specify the geographic origins of the individuals sampled when studying pi or SNP density... - A comprehensive analysis of recently integrated human Ta L1 elementsJeremy S Myers
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
Am J Hum Genet 71:312-26. 2002..One hundred fifteen (45%) of the Ta L1 elements were polymorphic with respect to insertion presence or absence and will serve as identical-by-descent markers for the study of human evolution... - Following the LINEs: an analysis of primate genomic variation at human-specific LINE-1 insertion sitesBethaney J Vincent
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, USA
Mol Biol Evol 20:1338-48. 2003..Therefore, L1 insertion polymorphisms appear to be essentially homoplasy free characters well suited for the study of population genetics and phylogenetic relationships within closely related species... - A strong signature of balancing selection in the 5' cis-regulatory region of CCR5Michael J Bamshad
Department of Pediatrics, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 99:10539-44. 2002.... - Affinities among Melanesians, Micronesians, and Polynesians: a neutral biparental genetic perspectiveJ Koji Lum
Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University, Japan
Hum Biol 74:413-30. 2002..Overall, geographic proximity is a better predictor of biparental genetic relationships than linguistic affinities... - LINE-1 preTa elements in the human genomeAbdel Halim Salem
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
J Mol Biol 326:1127-46. 2003..In all, 29 have two intact open reading frames and may be capable of retrotransposition... - Alu elements and hominid phylogeneticsAbdel-Halim Salem
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
Proc Natl Acad Sci U S A 100:12787-91. 2003..Here we present the strongest evidence reported to date for a sister relationship between humans and chimpanzees while clearly distinguishing the chimpanzee and human lineages... - Comprehensive analysis of Alu-associated diversity on the human sex chromosomesPauline A Callinan
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
Gene 317:103-10. 2003..The Alu insertion polymorphisms identified in this study should prove useful for the study of human population genetics... - Nucleotide diversity and haplotype structure of the human angiotensinogen gene in two populationsToshiaki Nakajima
Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Am J Hum Genet 70:108-23. 2002..These results have important implications for the usefulness of LD approaches in the mapping of genes underlying susceptibility to complex diseases... - Directional migration in the Hindu castes: inferences from mitochondrial, autosomal and Y-chromosomal dataStephen Wooding
Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112-5330, USA
Hum Genet 115:221-9. 2004..Our findings support earlier evidence that the caste system has been a significant, long-term source of population structuring in South Indian Hindu populations, and that patterns of migration differ between males and females... - Natural selection and population history in the human angiotensinogen gene (AGT): 736 complete AGT sequences in chromosomes from around the worldToshiaki Nakajima
Division of Genetic Diagnosis, The University of Tokyo, Tokyo 108 8639, Japan
Am J Hum Genet 74:898-916. 2004..Taken together, patterns of genetic diversity in AGT suggest that natural selection has generally favored the G(-6) variant over the A(-6) variant in non-African populations. However, important localized effects may also be present... - Genetics and population history of Caucasus populationsKazima Bulayeva
Daghestan Branch, Russian Academy of Sciences, Makhachkala, Daghestan, Russia
Hum Biol 75:837-53. 2003..The two approaches agree reasonably well if we assume that there was demographic growth in Africa before the diaspora of ancestors of contemporary regional human groups outside Africa... - Comprehensive analysis of two Alu Yd subfamiliesJinchuan Xing
Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA
J Mol Evol 57:S76-89. 2003..These Alu subfamilies are a source of genomic fossil relics for the study of primate phylogenetics and human population genetics... - Natural selection and molecular evolution in PTC, a bitter-taste receptor geneStephen Wooding
Department of Human Genetics, University of Utah, Salt Lake City 84112 5330, USA
Am J Hum Genet 74:637-46. 2004..01). These results combine to suggest that balancing natural selection has acted to maintain "taster" and "nontaster" alleles at the PTC locus in humans... - Gene flow from the Indian subcontinent to Australia: evidence from the Y chromosomeAlan J Redd
Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA
Curr Biol 12:673-7. 2002..These results provide strong evidence for an influx of Y chromosomes from the Indian subcontinent to Australia that may have occurred during the Holocene... - Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel allelesHuai Rong Luo
Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, People s Republic of China
Biochem Genet 40:41-51. 2002..On the basis of the sequences of the different alleles, the existence of the tandem repeats in each allele might be explained by slipped-strand mispairing during DNA replication... - Human population genetic structure and inference of group membershipMichael J Bamshad
Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
Am J Hum Genet 72:578-89. 2003..This suggests that a more flexible framework is needed for making inferences about population structure and the utility of proxies... - Microsatellites as EWS/FLI response elements in Ewing's sarcomaKunal Gangwal
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
Proc Natl Acad Sci U S A 105:10149-54. 2008..These findings illustrate an unprecedented route to specificity for ETS proteins and use of microsatellites in tumorigenesis... - Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromesSandy S Sung
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
Am J Hum Genet 72:681-90. 2003..This provides a new opportunity to directly study the etiology and pathogenesis of multiple-congenital-contracture syndromes... - Mobile DNA elements in primate and human evolutionJinchuan Xing
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
Am J Phys Anthropol . 2007..Finally, these elements have had impacts on the genome itself. We review how they have influenced fundamental ongoing processes like nonhomologous recombination, genomic deletion, and X chromosome inactivation... - Contrasting effects of natural selection on human and chimpanzee CC chemokine receptor 5Stephen Wooding
Department of Human Genetics, University of Utah, Salt Lake City UT, USA
Am J Hum Genet 76:291-301. 2005..This result suggests that chimpanzee 5'CCR5 might harbor or be linked to functional variants that influence chimpanzee resistance to disease caused by SIVcpz/HIV-1... - Trismus-pseudocamptodactyly syndrome is caused by recurrent mutation of MYH8Reha M Toydemir
Department of Human Genetics, University of Utah, Salt Lake City, UT, USA
Am J Med Genet A 140:2387-93. 2006..Our findings show that distal arthrogryposis syndromes share a similar pathogenesis and are, in general, caused by disruption of the contractile complex of muscle... - Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndromeReha M Toydemir
Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA
Nat Genet 38:561-5. 2006..Elucidation of the genetic basis of these syndromes redefines congenital contractures as unique defects of the sarcomere and provides insights about what has heretofore been a poorly understood group of disorders... - Duplication and divergence in humans and chimpanzeesStephen Wooding
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, 84112, USA
Bioessays 28:335-8. 2006..4) Further, such changes have been implicated in a number of genetic disorders, such as DiGeorge, Angelman/Prader-Willi and Charcot-Marie-Tooth syndromes.(5).. - Genetic variation and cardiovascular careLynn B Jorde
Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, USA
Manag Care 13:9-12. 2004 - A novel mutation in FGFR3 causes camptodactyly, tall stature, and hearing loss (CATSHL) syndromeReha M Toydemir
Department of Human Genetics, University of Utah, Salt Lake City, UT, USA
Am J Hum Genet 79:935-41. 2006..R621H substitution in the tyrosine kinase domain and partial loss of FGFR3 function. These findings indicate that abnormal FGFR3 signaling can cause human anomalies by promoting as well as inhibiting endochondral bone growth...
Research Grants
- POPULATION GENETICS OF MOBILE ELEMENTSLynn Jorde; Fiscal Year: 2007..Our understanding of genetic disease will also be enhanced by a better understanding of the role of these elements in DNA repair and in gene duplication and deletion. ..
- The Angiotensinogen Gene and Human HypertensionLynn Jorde; Fiscal Year: 2006..In summary, our extensive analysis of AGT variation in more than 1,600 subjects will clarify the role of this gene in essential hypertension and will test specific hypotheses about the evolution of AGT. ..
- POPULATION GENETICS OF MOBILE ELEMENTSLynn Jorde; Fiscal Year: 2003..These project will contribute to our understanding of human genetic evolution and the ways in which it influences the genetic variability that underlies complex human diseases. ..
- The Angiotensinogen Gene and Human HypertensionLynn Jorde; Fiscal Year: 2003..In summary, our extensive analysis of AGT variation in more than 1,600 subjects will clarify the role of this gene in essential hypertension and will test specific hypotheses about the evolution of AGT. ..
- POPULATION GENETICS OF MOBILE ELEMENTSLynn Jorde; Fiscal Year: 2010....