MARY A JORDAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis
    Mary Ann Jordan
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Chem Biol 9:93-101. 2002
  2. ncbi request reprint How do microtubule-targeted drugs work? An overview
    Mary Ann Jordan
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Curr Cancer Drug Targets 7:730-42. 2007
  3. doi request reprint Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine
    Mary Ann Jordan
    Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Semin Oncol 35:S6-S12. 2008
  4. ncbi request reprint Microtubules as a target for anticancer drugs
    Mary Ann Jordan
    University of California Santa Barbara, Santa Barbara, California 93106, USA
    Nat Rev Cancer 4:253-65. 2004
  5. ncbi request reprint The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    Mary Ann Jordan
    Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 93106 9610, USA
    Mol Cancer Ther 4:1086-95. 2005
  6. ncbi request reprint Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    M A Jordan
    Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Curr Med Chem Anticancer Agents 2:1-17. 2002
  7. pmc Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
    Mythili Yenjerla
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9610, USA
    J Pharmacol Exp Ther 328:390-8. 2009
  8. ncbi request reprint BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
    Kathy Kamath
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Biol Chem 280:12902-7. 2005
  9. pmc Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability
    Jennifer A Smith
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Biochemistry 49:1331-7. 2010
  10. ncbi request reprint The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics
    Tatiana Okouneva
    Department of Molecular, Cellular, and Developmental Biology University of California Santa Barbara, Santa Barbara, California 93106, USA
    Mol Cancer Ther 2:427-36. 2003

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis
    Mary Ann Jordan
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Chem Biol 9:93-101. 2002
    ..They target microtubules but alter their polymerization and structure differently than paclitaxel. These differences may play a role in their enhanced cytotoxicity and efficacy...
  2. ncbi request reprint How do microtubule-targeted drugs work? An overview
    Mary Ann Jordan
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Curr Cancer Drug Targets 7:730-42. 2007
    ....
  3. doi request reprint Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine
    Mary Ann Jordan
    Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Semin Oncol 35:S6-S12. 2008
    ..Highlighted in this review are the key features of vinflunine that lead to effective suppression of microtubule dynamics and induction of cell death in cancer cells...
  4. ncbi request reprint Microtubules as a target for anticancer drugs
    Mary Ann Jordan
    University of California Santa Barbara, Santa Barbara, California 93106, USA
    Nat Rev Cancer 4:253-65. 2004
  5. ncbi request reprint The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    Mary Ann Jordan
    Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 93106 9610, USA
    Mol Cancer Ther 4:1086-95. 2005
    ..The result is formation of abnormal mitotic spindles that cannot pass the metaphase/anaphase checkpoint...
  6. ncbi request reprint Mechanism of action of antitumor drugs that interact with microtubules and tubulin
    M A Jordan
    Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Curr Med Chem Anticancer Agents 2:1-17. 2002
    ..However, by their common mechanism of suppression microtubule dynamics, they all block mitosis at the metaphase/anaphase transition, and induce cell death...
  7. pmc Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics
    Mythili Yenjerla
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, CA 93106 9610, USA
    J Pharmacol Exp Ther 328:390-8. 2009
    ..Thus, carbendazim binds to an as yet unidentified site in tubulin and inhibits tumor cell proliferation by suppressing the growing and shortening phases of microtubule dynamic instability, thus inducing mitotic arrest...
  8. ncbi request reprint BetaIII-tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability
    Kathy Kamath
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA
    J Biol Chem 280:12902-7. 2005
    ....
  9. pmc Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability
    Jennifer A Smith
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Biochemistry 49:1331-7. 2010
    ..Overall, our results indicate that eribulin binds with high affinity to microtubule plus ends and thereby suppresses dynamic instability...
  10. ncbi request reprint The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics
    Tatiana Okouneva
    Department of Molecular, Cellular, and Developmental Biology University of California Santa Barbara, Santa Barbara, California 93106, USA
    Mol Cancer Ther 2:427-36. 2003
    ..The strong correlation between suppression of kinetochore-microtubule dynamics and mitotic block indicates that the primary mechanism by which the Vinca alkaloids block mitosis is suppression of spindle microtubule dynamics...
  11. ncbi request reprint Suppression of centromere dynamics by Taxol in living osteosarcoma cells
    Jonathan Kelling
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Cancer Res 63:2794-801. 2003
    ....
  12. pmc Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
    Olga Azarenko
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Carcinogenesis 29:2360-8. 2008
    ....
  13. pmc Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase
    Tatiana Okouneva
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Cancer Ther 7:2003-11. 2008
    ..The strong correlation between suppression of kinetochore-microtubule dynamics and mitotic arrest indicates that the primary mechanism by which eribulin blocks mitosis is suppression of spindle microtubule dynamics...
  14. ncbi request reprint Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate
    Anasuya Ray
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Cancer Res 67:3767-76. 2007
    ..Tasidotin may be a relatively weak prodrug for the functionally active tasidotin C-carboxylate...
  15. ncbi request reprint 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
    Kathy Kamath
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Bio II Room 3106, Santa Barbara, CA 93106, USA
    Mol Cancer Ther 5:2225-33. 2006
    ..Taken together, the results suggest that the major mechanism of mitotic arrest at the lowest effective concentrations of 2ME2 is suppression of microtubule dynamics rather than microtubule depolymerization per se...
  16. ncbi request reprint Intrinsically slow dynamic instability of HeLa cell microtubules in vitro
    Cori N Newton
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 277:42456-62. 2002
    ....
  17. doi request reprint Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells
    Choong Jae Lee
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA
    Phytother Res 24:S15-9. 2010
    ....
  18. ncbi request reprint FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells
    Janis M Bunker
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 281:11856-63. 2006
    ....
  19. ncbi request reprint Three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration
    Sasha F Levy
    Neuroscience Research Institute and Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 280:13520-8. 2005
    ....
  20. pmc The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules
    Mythili Yenjerla
    Department of Molecular, The Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    J Alzheimers Dis 19:1377-86. 2010
    ..Thus, the neuroprotective activity of NAP does not appear to involve a direct action on the polymerization or dynamics of purified tubulin or microtubules...
  21. pmc FTDP-17 mutations in Tau alter the regulation of microtubule dynamics: an "alternative core" model for normal and pathological Tau action
    Adria C Leboeuf
    Neuroscience Research Institute and Department of Molecular and Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    J Biol Chem 283:36406-15. 2008
    ..Taken together, the data are consistent with a microtubule misregulation mechanism for Tau-mediated neuronal cell death and provide a novel mechanistic model for normal and pathological Tau action...
  22. pmc Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration
    Janis M Bunker
    Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    Mol Biol Cell 15:2720-8. 2004
    ....
  23. doi request reprint Determination of microtubule dynamic instability in living cells
    Kathy Kamath
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, California 93106, USA
    Methods Cell Biol 97:1-14. 2010
    ....
  24. doi request reprint Determination of drug binding to microtubules in vitro
    Jennifer A Smith
    Department of Molecular, Cellular, and Developmental Biology, The Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Methods Cell Biol 95:289-99. 2010
    ....
  25. ncbi request reprint Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells
    Eddy Pasquier
    Interactions Entre Systemes Proteiques Et Differenciation Dans La Cellule Tumorale, FRE Centre National de la Recherche Scientifique, Universite de la Mediterranee, Marseille, France
    Cancer Res 65:2433-40. 2005
    ....
  26. ncbi request reprint Effects of tetramethoxystilbene on hormone-resistant breast cancer cells: biological and biochemical mechanisms of action
    Hoyong Park
    Endocrinology and Metabolism, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Cancer Res 67:5717-26. 2007
    ..Our data suggest that TMS is a promising therapeutic agent because of its unique ability to block several pathways involved in the development of hormone resistance...
  27. ncbi request reprint Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest
    Kathy Kamath
    Department of Molecular Cellular and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara 93106, USA
    Cancer Res 63:6026-31. 2003
    ..Thus, the effects of epothilone B on microtubule dynamics are remarkably similar to those of paclitaxel, suggesting that both drugs induce mitotic block by a similar mechanism...
  28. ncbi request reprint Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation
    Stephane Honore
    UMR CNRS 6032, Universite de la Mediterranee, Marseille, France
    Mol Cancer Ther 2:1303-11. 2003
    ....
  29. ncbi request reprint Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization
    Charles Dumontet
    Department of Medicine, Divisions of Oncology and Clinical Pharmacology, Stanford University Medical Center, CA 94305, USA
    Bull Cancer 91:E81-112. 2004
    ....
  30. ncbi request reprint Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells
    Stephane Honore
    FRE CNRS 2737, Universite de la Mediterranee, Marseille, France
    Cancer Res 64:4957-64. 2004
    ....
  31. ncbi request reprint Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    J Med Chem 49:6425-8. 2006
    ..Several of these compounds led to arrest of HL-60 cells in the G2/M phase of the cell cycle and induction of apoptosis...
  32. pmc Microtubule assembly of isotypically purified tubulin and its mixtures
    Vahid Rezania
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Biophys J 95:1993-2008. 2008
    ..It is the main objective of this article to develop a quantitative model of tubulin polymerization for individual isotypes and their mixtures. The possible biological significance of the observed differences is addressed...

Research Grants15

  1. MECHANISM OF ACTION OF THE ANTITUMOR DRUG TAXOL
    Mary Jordan; Fiscal Year: 2002
    ..Understanding the linkage between microtubule dynamics, mitotic block, and resistance to taxol promises to lead to new drug targets that will improve the efficacy of chemotherapy. ..
  2. MECHANISM OF ACTION OF THE ANTI-TUMOR DRUG TAXOL
    Mary Jordan; Fiscal Year: 1993
    ..Finally, by computer-enhanced video microscopy, we will characterize quantitatively the effects of taxol on the dynamics of tubulin exchange at microtubule ends in vitro...
  3. Mechanisms of Action of Anti-Mitotic Drugs
    Mary Jordan; Fiscal Year: 2007
    ..The results will elucidate mechanisms and predict possible clinical efficacy of combination therapies directed at modulating mitotic microtubule regulatory proteins in combination with taxanes and Vinca alkaloids. ..