C T Jordan
Affiliation: University of Kentucky
- Recent progress in identifying genes regulating hematopoietic stem cell function and fateC T Jordan
Blood and Marrow Transplantation Program Markey Cancer Center University of Kentucky Medical Center 800 Rose Street Room CC405 Lexington KY 40536 USA
Curr Opin Cell Biol 10:716-20. 1998..In addition, genetic mapping has identified several loci that correlate strongly with stem cell numbers and proliferation...
- The use of adenoviral vectors for genetic manipulation and analysis of primitive hematopoietic cellsC T Jordan
Division of Hematology Oncology, University of Kentucky Medical Center, Lexington, KY 40536, USA
Curr Gene Ther 1:257-65. 2001..In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types...
- Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cellsM L Guzman
Blood and Marrow Transplant Program, Markey Cancer Center, Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington, USA
Blood 97:2177-9. 2001..Expression of each gene was confirmed by reverse-transcription polymerase chain reaction and immunoblot analysis. It is proposed that tumor-suppressor proteins play a role in the biology of primitive AML cells. (Blood. 2001;97:2177-2179)..
- Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cellsM L Guzman
Blood and Marrow Transplant Program, Markey Cancer Center, Division of Hematology/Oncology, University of Kentucky Medical Center, Lexington 40536-0093, USA
Blood 98:2301-7. 2001..Taken together, these data indicate that primitive AML cells aberrantly express NF-kappaB and that the presence of this factor may provide unique opportunities to preferentially ablate LSCs...
- Unique molecular and cellular features of acute myelogenous leukemia stem cellsC T Jordan
Division of Hematology/Oncology, Markey Cancer Center, University of Kentucky Medical Center, Lexington, KY 40536, USA
Leukemia 16:559-62. 2002..This article will summarize data emerging from the study of LSCs and suggest how distinct molecular and cellular characteristics of the LSC population may provide new opportunities for AML therapy...