Christian Jons

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:859-65. 2009
  2. doi Risk of fatal arrhythmic events in long QT syndrome patients after syncope
    Christian Jons
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 55:783-8. 2010
  3. pmc Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:941-50. 2011
  4. pmc Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
  5. doi In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models
    Ryan Hoefen
    Division of Cardiology, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Am Coll Cardiol 60:2182-91. 2012
  6. ncbi The effect of intermittent atrial tachyarrhythmia on heart failure or death in cardiac resynchronization therapy with defibrillator versus implantable cardioverter-defibrillator patients: a MADIT-CRT substudy (Multicenter Automatic Defibrillator Implantat
    Anne Christine Ruwald
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark Electronic address
    J Am Coll Cardiol 63:1190-7. 2014
  7. pmc Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
    Alon Barsheshet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 125:1988-96. 2012
  8. doi Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
  9. ncbi Impact of carvedilol and metoprolol on inappropriate implantable cardioverter-defibrillator therapy: the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy)
    Martin H Ruwald
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark Electronic address
    J Am Coll Cardiol 62:1343-50. 2013
  10. pmc Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008

Collaborators

Detail Information

Publications21

  1. doi Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:859-65. 2009
    ..The purpose of this study was to investigate whether KCNQ1 mutations in highly conserved amino acid residues within the voltage-gated potassium channel family are associated with an increased risk of cardiac events...
  2. doi Risk of fatal arrhythmic events in long QT syndrome patients after syncope
    Christian Jons
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 55:783-8. 2010
    ..The aim of this study was to identify risk factors for fatal arrhythmias in long QT syndrome (LQTS) patients presenting with syncope...
  3. pmc Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:941-50. 2011
    ..We aimed to identify risk factors for recurrent syncope in children and adolescents with congenital long QT syndrome (LQTS)...
  4. pmc Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  5. doi In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models
    Ryan Hoefen
    Division of Cardiology, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Am Coll Cardiol 60:2182-91. 2012
    ..The study was designed to assess the ability of computer-simulated electrocardiography parameters to predict clinical outcomes and to risk-stratify patients with long QT syndrome type 1 (LQT1)...
  6. ncbi The effect of intermittent atrial tachyarrhythmia on heart failure or death in cardiac resynchronization therapy with defibrillator versus implantable cardioverter-defibrillator patients: a MADIT-CRT substudy (Multicenter Automatic Defibrillator Implantat
    Anne Christine Ruwald
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark Electronic address
    J Am Coll Cardiol 63:1190-7. 2014
    ....
  7. pmc Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
    Alon Barsheshet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 125:1988-96. 2012
    ..We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location...
  8. doi Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
    ..Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events...
  9. ncbi Impact of carvedilol and metoprolol on inappropriate implantable cardioverter-defibrillator therapy: the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy)
    Martin H Ruwald
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark Electronic address
    J Am Coll Cardiol 62:1343-50. 2013
    ....
  10. pmc Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  11. pmc Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease
    Edward Sze
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 13:327-31. 2008
    ....
  12. pmc Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  13. doi Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:212-8. 2011
    ..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
  14. doi Influence of diabetes mellitus on inappropriate and appropriate implantable cardioverter-defibrillator therapy and mortality in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) Trial
    Martin H Ruwald
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 128:694-701. 2013
    ..The effect of innovative ICD programming on therapy delivery in these patients is unknown...
  15. doi Effect of metoprolol versus carvedilol on outcomes in MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy)
    Martin H Ruwald
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Am Coll Cardiol 61:1518-26. 2013
    ..This study sought to compare the effects of metoprolol and carvedilol in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study...
  16. pmc Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  17. doi Frequency of inappropriate therapy in patients implanted with dual- versus single-chamber ICD devices in the ICD arm of MADIT-CRT
    Anne Christine H Ruwald
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 24:672-9. 2013
    ..The aim of this study is to determine whether implantation of dual-chamber ICD devices decrease the incidence of inappropriate therapy without an unacceptable increase in complications...
  18. ncbi Clinical impact, safety, and efficacy of single- versus dual-coil ICD leads in MADIT-CRT
    Valentina Kutyifa
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, NY, USA Semmelweis University Heart Center, Budapest, Hungary
    J Cardiovasc Electrophysiol 24:1246-52. 2013
    ..Current data on efficacy, safety and impact on clinical outcome of single- versus dual-coil implantable cardioverter-defibrillator (ICD) leads are limited and contradictory...
  19. doi Impact of the right ventricular lead position on clinical outcome and on the incidence of ventricular tachyarrhythmias in patients with CRT-D
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York Semmelweis University, Heart Center, Budapest, Hungary, and Brigham and Women s Hospital, Boston, Massachusetts Electronic address
    Heart Rhythm 10:1770-7. 2013
    ..Data on the impact of right ventricular (RV) lead location on clinical outcome and ventricular tachyarrhythmias in cardiac resynchronization therapy with defibrillator (CRT-D) patients are limited...
  20. doi Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
    ..Additionally, data are reported on the clinical experience with the WCD based on 354 patients from Germany hospitalized between 2000 and 2008 who wore the WCD for a mean of 3 months...
  21. ncbi Predictive capability of left atrial size measured by CT, TEE, and TTE for recurrence of atrial fibrillation following radiofrequency catheter ablation
    Sachin S Parikh
    Division of Cardiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:532-40. 2010
    ..The purpose of this study was to assess the predictive capability of LA diameter (LAD) and LA volume (LAV) by echocardiography and computed tomography (CT) to determine success in patients undergoing RFCA of AF...