Research Topics
| Peter L JonesSummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptorsP L Jones
Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
Curr Top Microbiol Immunol 274:237-68. 2003..Together, these data suggest that modulation of chromatin structure plays a central role in N-CoR mediated transcriptional repression from unliganded NHRs...
Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling proteinChia Yun Jessica Sun
B107 Chemical and Life Sciences Laboratory, Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
J Mol Biol 411:397-416. 2011....- Testing the effects of FSHD candidate gene expression in vertebrate muscle developmentRyan D Wuebbles
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
Int J Clin Exp Pathol 3:386-400. 2010..Taken together, increased frg1 expression alone leads to a phenotype that most closely resembles the pathophysiology observed in FSHD patients... - Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric proteinMeredith L Hanel
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
Differentiation 81:107-18. 2011..Thus, FRG1 is the only FSHD candidate protein linked to the muscle contractile machinery and may address why the musculature and vasculature are specifically susceptible in FSHD... - FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathyRyan D Wuebbles
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Dis Model Mech 2:267-74. 2009..Overall, in conjunction with our previous analysis, we show that FRG1 overexpression is capable of disrupting both the musculature and vasculature, recapitulating the two most prominent features of FSHD... - Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sitesQian Liu
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
J Cell Sci 123:1116-23. 2010..Together, these data further support a role for FRG1 overexpression in FSHD pathophysiology and reveal the previously unsuspected direct involvement of FRG-1 in muscle structure and integrity... - C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachmentsQian Liu
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S, Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL, 61801, USA
Cell Biosci 2:18. 2012..abstract:.. - Muscular dystrophy candidate gene FRG1 is critical for muscle developmentMeredith L Hanel
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Dev Dyn 238:1502-12. 2009..Developmental Dynamics 238:1502-1512, 2009. (c) 2008 Wiley-Liss, Inc... - A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processingSteven W Long
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
Biosci Rep 31:333-43. 2011..These results support a role for MeCP2 in mRNA biogenesis and suggest an additional mechanism for RTT pathophysiology... - DNA repair in a chromatin environmentR D Wuebbles
Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, 601 S. Goodwin Ave, B107 CLSL, Urbana, Illinois 61802, USA
Cell Mol Life Sci 61:2148-53. 2004..Recent studies have thus begun to address the roles of chromatin proteins in DNA repair as well as to dissect the functions of DNA repair machinery in vitro on more physiological, nucleosomal templates... - Purification of MeCP2-containing deacetylase from Xenopus laevisPeter L Jones
Department of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD, USA
Methods Mol Biol 200:131-41. 2002 - Nuclear receptor corepressor recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis developmentLaurent M Sachs
Unit on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
Mol Cell Biol 22:8527-38. 2002..Our data indicate that N-CoR is recruited by unliganded TR to repress target gene expression during premetamorphic animal growth, an important process that prepares the tadpole for metamorphosis... - Engineered telomeres in transgenic Xenopus laevisRyan Wuebbles
B107 Chemical and Life Sciences Laboratory, Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Transgenic Res 16:377-84. 2007..Overall, this presents an efficient mechanism for generating engineered telomeres in a vertebrate system and provides an opportunity to investigate epigenetic aspects of telomere function during normal vertebrate development... - Functional CpG methylation system in a social insectYing Wang
Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Science 314:645-7. 2006..The honey bee provides an opportunity to study the roles of methylation in social contexts... - Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencingK N Harikrishnan
The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
Nat Genet 37:254-64. 2005..We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2... - Thymosin beta4 regulation, expression and function in aortic valve interstitial cellsQuan-yi Li
Division of Cardiology, Abramson Pediatric Research Center, The Children's Hospital of Philadelphia, PA 19104, USA
J Heart Valve Dis 11:726-35. 2002..However, thymosin beta4 antisense oligonucleotide transfection did not suppress MMP-2 expression. CONCLUSION: Thymosin beta4 is up-regulated by tenascin-C, and may be involved in the primary initiation of valvular calcification... - Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factorEvgenia V Gerasimovskaya
Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:44638-50. 2002..We conclude that hypoxia induces ATP release from endothelial cells and fibroblasts and that the activation of P2 purinoceptors is involved in the regulation of DNA synthesis by fibroblasts under hypoxic conditions... - Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemiaAssam El-Osta
Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
J Exp Med 205:2409-17. 2008....
Research Grants
- METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSIONPeter Jones; Fiscal Year: 2003..My long term goal is to establish myself as an independent researcher. I would like my lab to focus on studying the roles of chromatin and methylation in gene regulation through development. ..
- Molecular mechanism of FSHD pathologyPeter Jones; Fiscal Year: 2007..Xenopus FSHD-tadpoles develop externally and are transparent rendering them ideal for testing small molecule therapeutics to find a cure for FSHD. ..