Peter L Jones

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors
    P L Jones
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    Curr Top Microbiol Immunol 274:237-68. 2003
  2. pmc Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein
    Chia Yun Jessica Sun
    B107 Chemical and Life Sciences Laboratory, Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    J Mol Biol 411:397-416. 2011
  3. pmc Testing the effects of FSHD candidate gene expression in vertebrate muscle development
    Ryan D Wuebbles
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Int J Clin Exp Pathol 3:386-400. 2010
  4. pmc Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein
    Meredith L Hanel
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Differentiation 81:107-18. 2011
  5. pmc FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathy
    Ryan D Wuebbles
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dis Model Mech 2:267-74. 2009
  6. pmc Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites
    Qian Liu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    J Cell Sci 123:1116-23. 2010
  7. pmc C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments
    Qian Liu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S, Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL, 61801, USA
    Cell Biosci 2:18. 2012
  8. pmc Muscular dystrophy candidate gene FRG1 is critical for muscle development
    Meredith L Hanel
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Dev Dyn 238:1502-12. 2009
  9. pmc A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
    Steven W Long
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Biosci Rep 31:333-43. 2011
  10. ncbi request reprint DNA repair in a chromatin environment
    R D Wuebbles
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 CLSL, Urbana, Illinois 61802, USA
    Cell Mol Life Sci 61:2148-53. 2004

Research Grants

  1. METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSION
    Peter Jones; Fiscal Year: 2003
  2. Molecular mechanism of FSHD pathology
    Peter Jones; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors
    P L Jones
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    Curr Top Microbiol Immunol 274:237-68. 2003
    ..Together, these data suggest that modulation of chromatin structure plays a central role in N-CoR mediated transcriptional repression from unliganded NHRs...
  2. pmc Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein
    Chia Yun Jessica Sun
    B107 Chemical and Life Sciences Laboratory, Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    J Mol Biol 411:397-416. 2011
    ....
  3. pmc Testing the effects of FSHD candidate gene expression in vertebrate muscle development
    Ryan D Wuebbles
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Int J Clin Exp Pathol 3:386-400. 2010
    ..Taken together, increased frg1 expression alone leads to a phenotype that most closely resembles the pathophysiology observed in FSHD patients...
  4. pmc Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a dynamic nuclear and sarcomeric protein
    Meredith L Hanel
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Differentiation 81:107-18. 2011
    ..Thus, FRG1 is the only FSHD candidate protein linked to the muscle contractile machinery and may address why the musculature and vasculature are specifically susceptible in FSHD...
  5. pmc FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathy
    Ryan D Wuebbles
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Dis Model Mech 2:267-74. 2009
    ..Overall, in conjunction with our previous analysis, we show that FRG1 overexpression is capable of disrupting both the musculature and vasculature, recapitulating the two most prominent features of FSHD...
  6. pmc Facioscapulohumeral muscular dystrophy region gene-1 (FRG-1) is an actin-bundling protein associated with muscle-attachment sites
    Qian Liu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    J Cell Sci 123:1116-23. 2010
    ..Together, these data further support a role for FRG1 overexpression in FSHD pathophysiology and reveal the previously unsuspected direct involvement of FRG-1 in muscle structure and integrity...
  7. pmc C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments
    Qian Liu
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S, Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL, 61801, USA
    Cell Biosci 2:18. 2012
    ..abstract:..
  8. pmc Muscular dystrophy candidate gene FRG1 is critical for muscle development
    Meredith L Hanel
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Dev Dyn 238:1502-12. 2009
    ..Developmental Dynamics 238:1502-1512, 2009. (c) 2008 Wiley-Liss, Inc...
  9. pmc A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
    Steven W Long
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Biosci Rep 31:333-43. 2011
    ..These results support a role for MeCP2 in mRNA biogenesis and suggest an additional mechanism for RTT pathophysiology...
  10. ncbi request reprint DNA repair in a chromatin environment
    R D Wuebbles
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Ave, B107 CLSL, Urbana, Illinois 61802, USA
    Cell Mol Life Sci 61:2148-53. 2004
    ..Recent studies have thus begun to address the roles of chromatin proteins in DNA repair as well as to dissect the functions of DNA repair machinery in vitro on more physiological, nucleosomal templates...
  11. ncbi request reprint Purification of MeCP2-containing deacetylase from Xenopus laevis
    Peter L Jones
    Department of Molecular Embryology, National Institute of Child Health and Human Development, Bethesda, MD, USA
    Methods Mol Biol 200:131-41. 2002
  12. pmc Nuclear receptor corepressor recruitment by unliganded thyroid hormone receptor in gene repression during Xenopus laevis development
    Laurent M Sachs
    Unit on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 5431, USA
    Mol Cell Biol 22:8527-38. 2002
    ..Our data indicate that N-CoR is recruited by unliganded TR to repress target gene expression during premetamorphic animal growth, an important process that prepares the tadpole for metamorphosis...
  13. ncbi request reprint Engineered telomeres in transgenic Xenopus laevis
    Ryan Wuebbles
    B107 Chemical and Life Sciences Laboratory, Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Transgenic Res 16:377-84. 2007
    ..Overall, this presents an efficient mechanism for generating engineered telomeres in a vertebrate system and provides an opportunity to investigate epigenetic aspects of telomere function during normal vertebrate development...
  14. ncbi request reprint Functional CpG methylation system in a social insect
    Ying Wang
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Science 314:645-7. 2006
    ..The honey bee provides an opportunity to study the roles of methylation in social contexts...
  15. ncbi request reprint Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
    K N Harikrishnan
    The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Epigenetics in Human Health and Disease Laboratory, Second Floor, Commercial Road, Prahran, Victoria 3181, Australia
    Nat Genet 37:254-64. 2005
    ..We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2...
  16. ncbi request reprint Thymosin beta4 regulation, expression and function in aortic valve interstitial cells
    Quan yi Li
    Division of Cardiology, Abramson Pediatric Research Center, The Children s Hospital of Philadelphia, PA 19104, USA
    J Heart Valve Dis 11:726-35. 2002
    ..The aim of the present study was to identify downstream targets of tenascin-C in aortic valve interstitial cells...
  17. ncbi request reprint Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor
    Evgenia V Gerasimovskaya
    Developmental Lung Biology Research Laboratory, Department of Pediatrics, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:44638-50. 2002
    ..We conclude that hypoxia induces ATP release from endothelial cells and fibroblasts and that the activation of P2 purinoceptors is involved in the regulation of DNA synthesis by fibroblasts under hypoxic conditions...
  18. pmc Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    Assam El-Osta
    Diabetes and Metabolism Division, Baker Epigenetics in Human Health and Disease, Baker IDI Heart and Diabetes Institute, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
    J Exp Med 205:2409-17. 2008
    ....

Research Grants2

  1. METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSION
    Peter Jones; Fiscal Year: 2003
    ..My long term goal is to establish myself as an independent researcher. I would like my lab to focus on studying the roles of chromatin and methylation in gene regulation through development. ..
  2. Molecular mechanism of FSHD pathology
    Peter Jones; Fiscal Year: 2007
    ..Xenopus FSHD-tadpoles develop externally and are transparent rendering them ideal for testing small molecule therapeutics to find a cure for FSHD. ..