Research Topics
Genomes and GenesSpecies | L P JonesSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virusE A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Nat Immunol 1:398-401. 2000..RSV persisted longer in the lungs of infected TLR4-deficient mice compared to normal mice. Thus, a common receptor activation pathway can initiate innate immune responses to both bacterial and viral pathogens...- Role of toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophilsEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester 01605, USA
Blood 100:1860-8. 2002..Thus, our studies demonstrate that GM-CSF dramatically enhances the functional response of neutrophils to TLR2 ligands, including LPS-associated lipopeptides... - Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificityEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building Room 226, Worcester, Massachusetts 01605, USA
J Endotoxin Res 10:419-24. 2004..MEF cultures are homogenous and amenable to biochemical analysis and should allow rigorous studies of the contribution of individual TLRs to the innate immune response... 
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitisEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 101:1315-20. 2004..Thus, these studies suggest the TLR2-mediated cytokine response to HSV-1 is detrimental to the host...- Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responsesEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building Rm 226, Worcester, MA 01605, USA
Infect Immun 75:471-80. 2007..Our studies suggest that TFF2 not only controls gastrointestinal repair but also regulates mononuclear cell inflammatory responses... - Herpes simplex virus and toll-like receptorsRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Viral Immunol 18:457-65. 2005..This review focuses on the interaction between Toll-like receptors, a critical component of the innate immune system of mammals, and their role in herpes simplex pathogenesis and immunity... - Inhibition of TLR-4/MD-2 signaling by RP105/MD-1Senad Divanovic
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Endotoxin Res 11:363-8. 2005.... - Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivoEva Szomolanyi-Tsuda
Department of Pathology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, Massachusetts 01655, USA
J Virol 80:4286-91. 2006..Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection... - Toll like receptors and virusesRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Rev Med Virol 17:35-43. 2007..A greater understanding of relationships between viruses or viral products and TLRs should improve understanding of pathogenesis and lead to the development of new anti-viral therapies... - Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNAJennifer P Wang
Department of Medicine, University of Massachusetts, 364 Plantation, Worcester, MA 01605, USA
J Immunol 178:3363-7. 2007..These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses... - Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
J Immunol 178:5173-81. 2007..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host... - Innate immunity to respiratory virusesJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
Cell Microbiol 9:1641-6. 2007..We also provide an overview of the current knowledge of regulation of type I interferons and inflammatory cytokines in viral infection... - Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responsesShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
J Neuroimmunol 194:70-82. 2008..These results define a functional role for TLR signaling in viral infection-induced activation of CNS glial cells as well as for the immunopathology in the CNS... - Toll-like receptor-mediated activation of neutrophils by influenza A virusJennifer P Wang
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Blood 112:2028-34. 2008..These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response... - Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2Jennifer P Wang
Department of Medicine, University of Massachusetts Medical Center, Worcester, 01605, USA
J Virol 79:12658-66. 2005..Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection... - Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 6:571-8. 2005..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses... - Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transductionEicke Latz
University of Massachusetts Medical School, Division of Infectious Diseases, Worcester 01605, USA
J Biol Chem 277:47834-43. 2002..Golgi-associated TLR4 expression was disrupted by brefeldin A, yet LPS signaling was preserved. We conclude that LPS signaling may be initiated by surface aggregation of TLR4 and is not dependent upon LPS trafficking to the Golgi... - A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarizationDesiree van der Kleij
Department of Parasitology, Leiden University Medical Center, The Netherlands
J Biol Chem 277:48122-9. 2002..Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology... - Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2Teresa Compton
McArdle Laboratory for Cancer Research, University of Wisconsin Madison Medical School, Madison, Wisconsin 53706, USA
J Virol 77:4588-96. 2003..Since many of the pathological processes associated with CMV disease are facilitated or directly mediated by inflammatory cytokines, identification of the host membrane detection machinery may ultimately lead to improved therapeutics... 
Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signalingFrantisek Sandor
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605 2324, USA
J Cell Biol 162:1099-110. 2003..The domains from each receptor did not need to be contained within a single contiguous protein. Chimeric TLR analysis further defined the toll/IL-1R domains as the area of crucial intracellular TLR1-TLR2 interaction...- Linking the "two-hit" response following injury to enhanced TLR4 reactivityThomas J Murphy
Department of Surgery (Immunology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Leukoc Biol 77:16-23. 2005..These findings demonstrate the potential lethality of excessive TLR4 reactivity after injury and provide an explanation for the exaggerated inflammatory response to a second hit, which can occur following severe injury... - Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4Leisa Mandell
Department of Medicine, University of Massachusetts Medical Center, Worcester 01605, USA
Infect Immun 72:6446-54. 2004..Our studies suggest that TLR2 may be the dominant innate immune receptor for recognition of gastrointestinal Helicobacter species... - Cell activation by Toll-like receptors: role of LBP and CD14Robert W Finberg
Department of Medicine, University of Massachusetts Medical School, 264 Plantation Street, Worcester, Massachusetts 01605, USA
J Endotoxin Res 10:413-8. 2004..Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined... - Viruses and Toll-like receptorsRobert W Finberg
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, LRB 228, Worcester, MA 01605, USA
Microbes Infect 6:1356-60. 2004..Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review... - The role of toll-like receptors in herpes simplex infection in neonatesEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Infect Dis 191:746-8. 2005..This may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates... - MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, USA
Eur J Immunol 35:822-30. 2005..We demonstrate that TLR-mediated responses are important in the innate immune response to LCMV and that MyD88 is essential for the control of the LCMV infection and the maturation/activation of virus-specific CD8(+) T cells... - Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in miceShuiping Tu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Cancer Cell 14:408-19. 2008..These results demonstrate that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis... - CD14: chaperone or matchmaker?Robert W Finberg
University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Immunity 24:127-9. 2006..In this issue of Immunity, describe a physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition protein CD14. In the presence of CD14, TLR3-mediated signal transduction events are amplified... - Tolls: you pay them on the way in and on the way out!Robert W Finberg
J Infect Dis 196:497-8. 2007 - Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation toleranceThomas B Thornley
Department of Medicine, Division of Diabetes, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 179:6620-9. 2007..Blocking of type 1 IFN-dependent pathways in patients may improve allograft survival in the presence of exogenous TLR ligands...
Research Grants
- Heat Shock Proteins and Helicobacter Pylori PathogenesisEvelyn Kurt Jones; Fiscal Year: 2006..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..