Kenneth L Jones

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    N Engl J Med 354:579-87. 2006
  2. doi request reprint Altered lipid metabolism in gastroschisis: a novel hypothesis
    Kenneth Lyons Jones
    Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0828, USA
    Am J Med Genet A 161:1860-5. 2013
  3. ncbi request reprint Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA 92093, USA
    Teratology 65:125-30. 2002
  4. ncbi request reprint Evaluation of the cranial base in amnion rupture sequence involving the anterior neural tube: implications regarding recurrence risk
    Kenneth Lyons Jones
    Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, USA
    Birth Defects Res A Clin Mol Teratol 76:688-91. 2006
  5. ncbi request reprint Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, California, USA
    Pediatrics 118:e1734-8. 2006
  6. ncbi request reprint X-linked cubitus valgus with mental retardation and typical face
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California, USA
    Am J Med Genet A 123:33-6. 2003
  7. ncbi request reprint Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting
    Kenneth Lyons Jones
    Division of Dysmorphology Teratology, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92093 0828, USA
    Birth Defects Res A Clin Mol Teratol 82:597-600. 2008
  8. pmc Developmental pathogenesis of short palpebral fissure length in children with fetal alcohol syndrome
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0828, USA
    Birth Defects Res A Clin Mol Teratol 85:695-9. 2009
  9. pmc Fetal alcohol spectrum disorders: Extending the range of structural defects
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0828, USA
    Am J Med Genet A 152:2731-5. 2010
  10. ncbi request reprint Vocal cord abnormalities in Williams syndrome: a further manifestation of elastin deficiency
    Keith K Vaux
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92103 8446, USA
    Am J Med Genet A 119:302-4. 2003

Research Grants

  1. Dysmorphology Core (U24 Core)
    Kenneth Jones; Fiscal Year: 2003
  2. Dysmorphology Core (U24 Core)
    Kenneth Jones; Fiscal Year: 2005
  3. Dysmorphology Core - U24
    Kenneth Jones; Fiscal Year: 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
    N Engl J Med 354:579-87. 2006
    ..We performed a case-control study to assess whether PPHN is associated with exposure to SSRIs during late pregnancy...
  2. doi request reprint Altered lipid metabolism in gastroschisis: a novel hypothesis
    Kenneth Lyons Jones
    Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0828, USA
    Am J Med Genet A 161:1860-5. 2013
    ..01). These findings suggest that early maternal inflammation possibly resulting from an imbalance of fatty acids, leading to a vascular disruption, may be the underlying mechanism responsible for at least some cases of gastroschisis...
  3. ncbi request reprint Pregnancy outcomes after first trimester exposure to phentermine/fenfluramine
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, CA 92093, USA
    Teratology 65:125-30. 2002
    ..The possible effect on the developing fetus has not been studied...
  4. ncbi request reprint Evaluation of the cranial base in amnion rupture sequence involving the anterior neural tube: implications regarding recurrence risk
    Kenneth Lyons Jones
    Department of Pediatrics, University of California San Diego, School of Medicine, La Jolla, California, USA
    Birth Defects Res A Clin Mol Teratol 76:688-91. 2006
    ..This distinction has implications regarding recurrence risk...
  5. ncbi request reprint Accuracy of the diagnosis of physical features of fetal alcohol syndrome by pediatricians after specialized training
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego, La Jolla, California, USA
    Pediatrics 118:e1734-8. 2006
    ..After a structured training program for pediatricians, we examined the ability to accurately diagnose fetal alcohol syndrome...
  6. ncbi request reprint X-linked cubitus valgus with mental retardation and typical face
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California, USA
    Am J Med Genet A 123:33-6. 2003
    ..Documentation of this disorder in two maternal male first cousins as well as in a male and his maternal uncle support an X-linked recessive mode of inheritance for this condition...
  7. ncbi request reprint Acardiac fetus: evidence in support of a vascular/hypoxia pathogenesis for isolated oral clefting
    Kenneth Lyons Jones
    Division of Dysmorphology Teratology, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92093 0828, USA
    Birth Defects Res A Clin Mol Teratol 82:597-600. 2008
    ..Although retrograde perfusion as a cause of hypoxia is unique to the acardiac fetus, there is ample evidence from animal studies that hypoxia is associated with facial clefting...
  8. pmc Developmental pathogenesis of short palpebral fissure length in children with fetal alcohol syndrome
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92093 0828, USA
    Birth Defects Res A Clin Mol Teratol 85:695-9. 2009
    ..The purpose of this study was to examine whether short palpebral fissures are independent of or determined by the OFC...
  9. pmc Fetal alcohol spectrum disorders: Extending the range of structural defects
    Kenneth Lyons Jones
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093 0828, USA
    Am J Med Genet A 152:2731-5. 2010
    ..Prenatal alcohol exposure may produce a broad spectrum of structural defects that goes beyond FAS with implications regarding the impact of alcohol on the developing fetus, a prerequisite for ultimate prevention of FASD...
  10. ncbi request reprint Vocal cord abnormalities in Williams syndrome: a further manifestation of elastin deficiency
    Keith K Vaux
    Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92103 8446, USA
    Am J Med Genet A 119:302-4. 2003
    ....
  11. ncbi request reprint From recognition to responsibility: Josef Warkany, David Smith, and the fetal alcohol syndrome in the 21st century
    Kenneth Lyons Jones
    Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, California, USA
    Birth Defects Res A Clin Mol Teratol 67:13-20. 2003
  12. doi request reprint The effects of alcohol on fetal development
    Kenneth Lyons Jones
    Department of Pediatrics, Division of Dysmorphology Teratology, University of California, San Diego, 92093 0828, USA
    Birth Defects Res C Embryo Today 93:3-11. 2011
    ..Appreciation of both of these issues is necessary to understand the full impact of alcohol on fetal development...
  13. doi request reprint The importance of dysmorphology in the identification of new human teratogens
    Kenneth Lyons Jones
    Department of Pediatrics, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0828, USA
    Am J Med Genet C Semin Med Genet 157:188-94. 2011
    ....
  14. ncbi request reprint Neonatal phenotype in Kabuki syndrome
    Keith K Vaux
    Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
    Am J Med Genet A 132:244-7. 2005
    ..Based on these findings, it is suggested that the distinctive clinical phenotype seen in older patients is also evident in the newborn period...
  15. pmc Callosal thickness reductions relate to facial dysmorphology in fetal alcohol spectrum disorders
    Yaling Yang
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, USA
    Alcohol Clin Exp Res 36:798-806. 2012
    ..Furthermore, associations between facial dysmorphology and callosal structure remain undetermined...
  16. ncbi request reprint Developmental outcome in Kabuki syndrome
    Keith K Vaux
    Division of Dysmorphology, Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
    Am J Med Genet A 132:263-4. 2005
    ..The presence or absence of hearing loss or major malformations, other than those involving the brain, was not predictive of developmental outcome...
  17. pmc Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology
    Yaling Yang
    Laboratory of NeuroImaging LONI, Department of Neurology, University of California, Los Angeles, CA 90095, USA
    Cereb Cortex 22:1170-9. 2012
    ..Furthermore, the significant associations between thickness and dysmorphic measures suggest that the severity of brain anomalies may be reflected by that of the face...
  18. ncbi request reprint Effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on adaptive functioning
    Ashley L Ware
    Center for Behavioral Teratology, San Diego State University, San Diego, California
    Alcohol Clin Exp Res 38:1439-47. 2014
    ..Heavy prenatal alcohol exposure and attention-deficit/hyperactivity disorder (ADHD) are associated with adaptive behavior deficits. This study examined the interaction between these 2 factors on parent ratings of adaptive behavior...
  19. pmc Regional brain volume reductions relate to facial dysmorphology and neurocognitive function in fetal alcohol spectrum disorders
    Florence F Roussotte
    Developmental Cognitive Neuroimaging Laboratory, Department of Neurology, University of California, Los Angeles 90095 7332, USA
    Hum Brain Mapp 33:920-37. 2012
    ....
  20. ncbi request reprint Aberrant Pax1 and Pax9 expression in Jarcho-Levin syndrome: report of two Caucasian siblings and literature review
    Sergei I Bannykh
    Department of Pathology, University of California, San Diego Medical Center, San Diego, California 92103 8321, USA
    Am J Med Genet A 120:241-6. 2003
    ..Immunochemical analysis showed a significant reduction in levels of Pax1 and Pax9 protein expression in chondrocytes of the vertebral column. Implications for the etiology and pathogenesis of JLS and related disorders are discussed...
  21. ncbi request reprint Megalourethra: A report of three cases associated with maternal diabetes and a review of the literature--is sonic hedgehog the common pathway?
    Keith K Vaux
    Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
    Am J Med Genet A 132:314-7. 2005
    ....
  22. ncbi request reprint The dilemma of the metabolic syndrome in children and adolescents: disease or distraction?
    Kenneth L Jones
    Department of Pediatrics, University of California, San Diego, CA 92093 0831, USA
    Pediatr Diabetes 7:311-21. 2006
    ..A major component of this undertaking has been directed to adapting for children the criteria described in adults as the metabolic syndrome (MS)...
  23. ncbi request reprint Alcohol consumption patterns among pregnant women in the Moscow region of the Russian Federation
    Christina D Chambers
    Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA
    Alcohol 38:133-7. 2006
    ..These data indicate that pregnant women in these areas of the Moscow Region present an important opportunity for education and intervention for alcohol-related birth outcomes...
  24. ncbi request reprint Postmarketing surveillance for drug safety in pregnancy: the Organization of Teratology Information Services project
    Robert J Felix
    California Teratogen Information Service and Clinical Research Program, Department of Pediatrics, University of California San Diego, La Jolla, CA 92103, USA
    Birth Defects Res A Clin Mol Teratol 70:944-7. 2004
    ..Although medications are frequently used during pregnancy, premarketing studies exclude pregnant women, with the result that maternal and fetal risks of medications are largely unknown prior to marketing...
  25. pmc Birth outcomes in women who have taken leflunomide during pregnancy
    Christina D Chambers
    Rady Children s Hospital, University of California, San Diego, California 92093 0828, USA
    Arthritis Rheum 62:1494-503. 2010
    ..The present study was undertaken to investigate pregnancy outcomes in women who received leflunomide and were treated with cholestyramine during pregnancy...
  26. ncbi request reprint Novel risk factor in gastroschisis: change of paternity
    Christina D Chambers
    Division of Dysmorphology and Teratology, Department of Pediatrics, University of California San Diego, La Jolla, CA 92103, USA
    Am J Med Genet A 143:653-9. 2007
    ..Further research is needed to corroborate these findings and to elucidate possible immunologic mechanisms involved in the pathogenesis of gastroschisis...
  27. ncbi request reprint Safety of leukotriene receptor antagonists in pregnancy
    Ludmila N Bakhireva
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    J Allergy Clin Immunol 119:618-25. 2007
    ..Asthma is a chronic disorder that affects about 8% of pregnant women and may complicate pregnancy. Adequate asthma therapy in pregnancy is crucial but challenging because of safety concerns for the fetus...
  28. doi request reprint Risks and safety of pandemic H1N1 influenza vaccine in pregnancy: birth defects, spontaneous abortion, preterm delivery, and small for gestational age infants
    Christina D Chambers
    Department of Pediatrics, University of California San Diego, La Jolla, CA, United States Rady Children s Hospital, San Diego, CA, United States Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, United States Clinical Translational Research Institute, University of California San Diego, La Jolla, CA, United States Vaccines and Medications in Pregnancy Surveillance System, United States Electronic address
    Vaccine 31:5026-32. 2013
    ..There is a need for additional information on the fetal risks and relative safety of the pandemic H1N1 monovalent or trivalent influenza (pH1N1)-containing vaccines in women exposed during pregnancy...
  29. doi request reprint Time-dependent propensity score for assessing the effect of vaccine exposure on pregnancy outcomes through pregnancy exposure cohort studies
    Ronghui Xu
    Department of Family and Preventive Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0112, La Jolla, CA 92093, USA
    Int J Environ Res Public Health 11:3074-85. 2014
    ..The application of the Cox regression PS is illustrated using data from a recent study of the safety of pandemic H1N1 influenza vaccine during pregnancy. ..
  30. pmc Prenatal alcohol exposure, attention-deficit/hyperactivity disorder, and sluggish cognitive tempo
    Diana M Graham
    Center for Behavioral Teratology, San Diego State University, San Diego, California, USA
    Alcohol Clin Exp Res 37:E338-46. 2013
    ..The current study examined whether similar findings are displayed in children with prenatal alcohol exposure...
  31. ncbi request reprint Risk for fetal death after fever in pregnancy
    Christina D Chambers
    Division of Dysmorphology Teratology, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    Lancet 360:1526. 2002
  32. pmc A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria
    H Eugene Hoyme
    Department of Pediatrics, Division of Medical Genetics, H 315, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatrics 115:39-47. 2005
    ..Although both approaches have improved the clinical delineation of FASD, both suffer from significant drawbacks in their practical application in pediatric practice...
  33. pmc Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data
    Christina D Chambers
    Department of Pediatrics, University of California, San Diego, CA, USA
    Arthritis Res Ther 8:215. 2006
    ..In addition, the strengths and weaknesses of post-marketing strategies for developing new pregnancy safety information are described...
  34. ncbi request reprint Intrauterine growth restriction in like-sex twins discordant for structural defects
    Christina D Chambers
    Department of Pediatrics, Division of Dysmorphology and Teratology, University of California San Diego School of Medicine, La Jolla, 92103, USA
    Birth Defects Res A Clin Mol Teratol 76:246-8. 2006
    ....
  35. ncbi request reprint Interaction of maternal smoking and other in-pregnancy exposures: analytic considerations
    Sarah N Mattson
    Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, CA, USA
    Neurotoxicol Teratol 24:359-67. 2002
    ....
  36. ncbi request reprint Asthma medication use in pregnancy and fetal growth
    Ludmila N Bakhireva
    Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    J Allergy Clin Immunol 116:503-9. 2005
    ..Given the high prevalence of asthma in pregnancy, it is important to understand the relationship between asthma medications and fetal growth in the context of appropriate treatment...
  37. ncbi request reprint FG syndrome, an X-linked multiple congenital anomaly syndrome: the clinical phenotype and an algorithm for diagnostic testing
    Robin Dawn Clark
    Division of Medical Genetics, Department of Pediatrics, Loma Linda University Medical Center, Loma Linda, CA 92354, USA
    Genet Med 11:769-75. 2009
    ..This algorithm can assist the clinician in selecting the patients for testing who are most likely to have the recurrent p.R961W MED12 mutation...
  38. ncbi request reprint Cyclophosphamide, methotrexate, and cytarabine embropathy: is apoptosis the common pathway?
    Keith K Vaux
    University of California San Diego, Department of Pediatrics, San Diego, California 92103 8446, USA
    Birth Defects Res A Clin Mol Teratol 67:403-8. 2003
    ....
  39. ncbi request reprint Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: a prospective study
    Sarah N Mattson
    Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6363 Alvarado Court, Suite 209, San Diego, CA 92120, USA
    Pediatr Infect Dis J 22:819-23. 2003
    ..However, the incidence of neurobehavioral deficits in asymptomatic structurally normal children whose mothers had clinically diagnosed varicella-zoster virus infection is unknown...
  40. ncbi request reprint Umbilical cord length in urinary tract abnormalities associated with oligohydramnios: evidence regarding developmental pathogenesis
    Kosuke Izumi
    Division of Dysmorphology and Teratology, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California 92103, USA
    Fetal Pediatr Pathol 25:233-40. 2006
    ..We suggest that the length of the umbilical cord can have implications relative to the developmental pathogenesis of some congenital urinary tract abnormalities...
  41. ncbi request reprint The role of genetic susceptibility for maternal alcohol metabolism in determining pregnancy outcome
    Kenneth Lyons Jones
    J Pediatr 148:5-6. 2006
  42. ncbi request reprint Epidemiology of FASD in a province in Italy: Prevalence and characteristics of children in a random sample of schools
    Philip A May
    Center on Alcholism, Substance Abuse and Addictions CASAA, The University of New Mexico, Albuquerque, New Mexico 87106, USA
    Alcohol Clin Exp Res 30:1562-75. 2006
    ..To address these issues, an epidemiology study of FAS and other FASD was undertaken in Italian schools...
  43. ncbi request reprint Fetal sex and maternal asthma control in pregnancy
    Ludmila N Bakhireva
    Division of Pharmacy Practice and Department of Family Community Medicine, University of New Mexico, Albuquerque, New Mexico, USA
    J Asthma 45:403-7. 2008
    ..84; 95% CI: 1.05; 3.21) independent of maternal age, BMI, ethnicity, smoking, and socioeconomic status. The current study suggests that pregnant asthmatic women carrying a girl might be more susceptible to asthma exacerbations...
  44. ncbi request reprint Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy
    Kirsten D Loureiro
    Graduate School of Public Health, San Diego State University, CA 92103, USA
    Am J Med Genet A 136:117-21. 2005
    ..Although it is impossible to exclude the possibility that some women/infants may be uniquely susceptible to topical tretinoin exposure, this study provides further reassurance for women who are inadvertently exposed early in pregnancy...
  45. ncbi request reprint Is genotype important in predicting the fetal alcohol syndrome?
    Christina D Chambers
    J Pediatr 141:751-2. 2002
  46. ncbi request reprint Asthma control during pregnancy and the risk of preterm delivery or impaired fetal growth
    Ludmila N Bakhireva
    Division of Pharmacy Practice and Department of Family Community Medicine, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Ann Allergy Asthma Immunol 101:137-43. 2008
    ..Concerns regarding potential harmful effect of medications on fetuses often result in inadequate treatment of asthma in pregnancy, whereas risks posed by poorly controlled maternal asthma are often underestimated...

Research Grants4

  1. Dysmorphology Core (U24 Core)
    Kenneth Jones; Fiscal Year: 2003
    ..abstract_text> ..
  2. Dysmorphology Core (U24 Core)
    Kenneth Jones; Fiscal Year: 2005
    ..abstract_text> ..
  3. Dysmorphology Core - U24
    Kenneth Jones; Fiscal Year: 2007
    ....